CHARLES BRADBERRY

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Dynamics of extracellular dopamine in the acute and chronic actions of cocaine
    Charles W Bradberry
    Departments of Psychiatry and Laboratory Medicine, West Haven Veterans Administration Hospital, Yale University School of Medicine, WHVA 116A2, 950 Campbell Avenue, West Haven, CT 06516, USA
    Neuroscientist 8:315-22. 2002
  2. ncbi request reprint Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals
    Charles W Bradberry
    Department of Psychiatry, Yale University School of Medicine and Veterans Administration Connecticut Health Services, 950 Campbell Avenue, Mail Stop 116A2, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 165:67-76. 2002
  3. ncbi request reprint Phasic alterations in dopamine and serotonin release in striatum and prefrontal cortex in response to cocaine predictive cues in behaving rhesus macaques
    Charles W Bradberry
    Department of Psychiatry and the center for the Neural Basis of Cognition, University of Pittsburg, PA, USA
    Neuropsychopharmacology 29:676-85. 2004
  4. ncbi request reprint Dopaminergic responses to self-administered cocaine in Rhesus monkeys do not sensitize following high cumulative intake
    Charles W Bradberry
    Department of Psychiatry, 3025 E Carson St, University of Pittsburgh, Pittsburgh, PA 15203, USA
    Eur J Neurosci 23:2773-8. 2006
  5. ncbi request reprint Comparison of acute and chronic neurochemical effects of cocaine and cocaine cues in rhesus monkeys and rodents: focus on striatal and cortical dopamine systems
    Charles W Bradberry
    Departments of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA15203, USA
    Rev Neurosci 19:113-28. 2008
  6. pmc A metabolic biofuel cell: conversion of human leukocyte metabolic activity to electrical currents
    Gusphyl A Justin
    Computational Diagnostics, Inc, Pittsburgh, PA, USA
    J Biol Eng 5:5. 2011
  7. doi request reprint Cortical and sub-cortical effects in primate models of cocaine use: implications for addiction and the increased risk of psychiatric illness
    Charles W Bradberry
    Department of Psychiatry, University of Pittsburgh, VA Pittsburgh Health Services, 3501 Fifth Ave, Rm 4078, Pittsburgh, PA 15261, USA
    Neurotox Res 19:235-42. 2011
  8. ncbi request reprint Cocaine sensitization and dopamine mediation of cue effects in rodents, monkeys, and humans: areas of agreement, disagreement, and implications for addiction
    Charles W Bradberry
    Department of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 191:705-17. 2007
  9. pmc Orbitofrontal and anterior cingulate cortex neurons selectively process cocaine-associated environmental cues in the rhesus monkey
    Eun Ha Baeg
    Department of Psychiatry, University of Pittsburgh, Veterans Affairs Pittsburgh Health Services, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:11619-27. 2009
  10. ncbi request reprint NMDA antagonist effects on striatal dopamine release: microdialysis studies in awake monkeys
    Barbara W Adams
    Department of Psychiatry, Yale University School of Medicine, Veterans Administration Medical Center, West Haven, Connecticut 06516, USA
    Synapse 43:12-8. 2002

Collaborators

  • Bita Moghaddam
  • Mark E Jackson
  • Gilles Tamagnan
  • Gusphyl A Justin
  • Eun Ha Baeg
  • Shijing Liu
  • Hajime A Tokuno
  • Barbara W Adams
  • Mingui Sun
  • X Tracy Cui
  • Yingze Zhang
  • Robert J Sclabassi
  • Richard P Heitz
  • Hank P Jedema
  • Jeffery D Kocsis
  • Ronald M Baldwin
  • Brian Everill
  • Samuel K Agulian
  • Steven Wilkes

Detail Information

Publications12

  1. ncbi request reprint Dynamics of extracellular dopamine in the acute and chronic actions of cocaine
    Charles W Bradberry
    Departments of Psychiatry and Laboratory Medicine, West Haven Veterans Administration Hospital, Yale University School of Medicine, WHVA 116A2, 950 Campbell Avenue, West Haven, CT 06516, USA
    Neuroscientist 8:315-22. 2002
    ....
  2. ncbi request reprint Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals
    Charles W Bradberry
    Department of Psychiatry, Yale University School of Medicine and Veterans Administration Connecticut Health Services, 950 Campbell Avenue, Mail Stop 116A2, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 165:67-76. 2002
    ..However, little is known about the neurobiology of ethanol in primates, or how the effects of ethanol compare to those of cocaine across individual animals...
  3. ncbi request reprint Phasic alterations in dopamine and serotonin release in striatum and prefrontal cortex in response to cocaine predictive cues in behaving rhesus macaques
    Charles W Bradberry
    Department of Psychiatry and the center for the Neural Basis of Cognition, University of Pittsburg, PA, USA
    Neuropsychopharmacology 29:676-85. 2004
    ..In contrast to the lack of any change in striatal DA, a significant decrease in extracellular serotonin in the prefrontal cortex during the 10 min of cue exposure was observed...
  4. ncbi request reprint Dopaminergic responses to self-administered cocaine in Rhesus monkeys do not sensitize following high cumulative intake
    Charles W Bradberry
    Department of Psychiatry, 3025 E Carson St, University of Pittsburgh, Pittsburgh, PA 15203, USA
    Eur J Neurosci 23:2773-8. 2006
    ....
  5. ncbi request reprint Comparison of acute and chronic neurochemical effects of cocaine and cocaine cues in rhesus monkeys and rodents: focus on striatal and cortical dopamine systems
    Charles W Bradberry
    Departments of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA15203, USA
    Rev Neurosci 19:113-28. 2008
    ..To best evaluate potential models of addiction, it will be important to also consider data from non-human primates as a more proximal animal model to the human condition, particularly in the greater complexity of cortical development...
  6. pmc A metabolic biofuel cell: conversion of human leukocyte metabolic activity to electrical currents
    Gusphyl A Justin
    Computational Diagnostics, Inc, Pittsburgh, PA, USA
    J Biol Eng 5:5. 2011
    ..HPLC confirmed the release of serotonin (5-HT) from the PMA activated primary cells. It is believed that serotonin, among other biochemical species released by the activated cells, contributes to the observed BFC currents...
  7. doi request reprint Cortical and sub-cortical effects in primate models of cocaine use: implications for addiction and the increased risk of psychiatric illness
    Charles W Bradberry
    Department of Psychiatry, University of Pittsburgh, VA Pittsburgh Health Services, 3501 Fifth Ave, Rm 4078, Pittsburgh, PA 15261, USA
    Neurotox Res 19:235-42. 2011
    ....
  8. ncbi request reprint Cocaine sensitization and dopamine mediation of cue effects in rodents, monkeys, and humans: areas of agreement, disagreement, and implications for addiction
    Charles W Bradberry
    Department of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 191:705-17. 2007
    ..The implications of this comparison for expanding addiction research beyond dopaminergic mechanisms in the striatum/nucleus accumbens will be considered...
  9. pmc Orbitofrontal and anterior cingulate cortex neurons selectively process cocaine-associated environmental cues in the rhesus monkey
    Eun Ha Baeg
    Department of Psychiatry, University of Pittsburgh, Veterans Affairs Pittsburgh Health Services, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:11619-27. 2009
    ..This pattern of sustained activation in ACC is consistent with a role in reward expectation and/or in mediating behavioral effects of discrete cues paired with drug infusions...
  10. ncbi request reprint NMDA antagonist effects on striatal dopamine release: microdialysis studies in awake monkeys
    Barbara W Adams
    Department of Psychiatry, Yale University School of Medicine, Veterans Administration Medical Center, West Haven, Connecticut 06516, USA
    Synapse 43:12-8. 2002
    ..These findings suggest that in the primate, ketamine and PCP are not effective dopamine releasers, as has been suggested by previous imaging studies...
  11. pmc A touch screen based Stop Signal Response Task in rhesus monkeys for studying impulsivity associated with chronic cocaine self-administration
    Shijing Liu
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurosci Methods 177:67-72. 2009
    ..Our results are consistent with human data, and thereby establish an ideal animal model for studying the etiology and underlying neurobiology of cocaine-induced impulse control and performance monitoring deficits...
  12. ncbi request reprint Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nerves
    Hajime A Tokuno
    Department of Neurology, Yale University School of Medicine, VA Connecticut Healthcare Service, West Haven, CT 06516, USA
    Brain Res 996:159-67. 2004
    ..These studies provide a more complete understanding of the pharmaocology of potential agonist treatment candidates, and suggest a mechanism whereby cocaethylene produces a decreased euphoria in humans compared to cocaine...

Research Grants17

  1. Cognitive dysfunction and impaired inhibitory control in cocaine dependence
    Charles W Bradberry; Fiscal Year: 2010
    ..Understanding the source and mechanisms of cognitive dysfunction that predicts treatment outcome may help develop therapeutic approaches that lessen harm from addiction. ..
  2. Neurobiology of Impulsivity and Alcoholism
    CHARLES BRADBERRY; Fiscal Year: 2007
    ..The values will be compared across individuals with the imaging and microdialysis measures from aims 1, 2 and 3. Unused brain tissue will be banked for future potential uses ..
  3. CNS CONSEQUENCES OF CHRONIC COCAINE SELF-ADMINISTRATION
    CHARLES BRADBERRY; Fiscal Year: 2007
    ..Each study will be conducted 3-4 months since last cocaine exposure. ..
  4. CNS CONSEQUENCES OF CHRONIC COCAINE SELF-ADMINISTRATION
    CHARLES BRADBERRY; Fiscal Year: 2001
    ..It is hoped that these studies will provide information uniquely relevant to cocaine addiction because of clear differences between the actions of cocaine in rodents versus the phylogenetically closer primates. ..
  5. Cognitive dysfunction and impaired inhibitory control in cocaine dependence
    Charles W Bradberry; Fiscal Year: 2010
    ..Understanding the source and mechanisms of cognitive dysfunction that predicts treatment outcome may help develop therapeutic approaches that lessen harm from addiction. ..