Affiliation: University of Pittsburgh
- Dynamics of extracellular dopamine in the acute and chronic actions of cocaineCharles W Bradberry
Departments of Psychiatry and Laboratory Medicine, West Haven Veterans Administration Hospital, Yale University School of Medicine, WHVA 116A2, 950 Campbell Avenue, West Haven, CT 06516, USA
Neuroscientist 8:315-22. 2002....
- Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individualsCharles W Bradberry
Department of Psychiatry, Yale University School of Medicine and Veterans Administration Connecticut Health Services, 950 Campbell Avenue, Mail Stop 116A2, West Haven, CT 06516, USA
Psychopharmacology (Berl) 165:67-76. 2002..However, little is known about the neurobiology of ethanol in primates, or how the effects of ethanol compare to those of cocaine across individual animals...
- Phasic alterations in dopamine and serotonin release in striatum and prefrontal cortex in response to cocaine predictive cues in behaving rhesus macaquesCharles W Bradberry
Department of Psychiatry and the center for the Neural Basis of Cognition, University of Pittsburg, PA, USA
Neuropsychopharmacology 29:676-85. 2004..In contrast to the lack of any change in striatal DA, a significant decrease in extracellular serotonin in the prefrontal cortex during the 10 min of cue exposure was observed...
- Dopaminergic responses to self-administered cocaine in Rhesus monkeys do not sensitize following high cumulative intakeCharles W Bradberry
Department of Psychiatry, 3025 E Carson St, University of Pittsburgh, Pittsburgh, PA 15203, USA
Eur J Neurosci 23:2773-8. 2006....
- Comparison of acute and chronic neurochemical effects of cocaine and cocaine cues in rhesus monkeys and rodents: focus on striatal and cortical dopamine systemsCharles W Bradberry
Departments of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA15203, USA
Rev Neurosci 19:113-28. 2008..To best evaluate potential models of addiction, it will be important to also consider data from non-human primates as a more proximal animal model to the human condition, particularly in the greater complexity of cortical development...
- A metabolic biofuel cell: conversion of human leukocyte metabolic activity to electrical currentsGusphyl A Justin
Computational Diagnostics, Inc, Pittsburgh, PA, USA
J Biol Eng 5:5. 2011..HPLC confirmed the release of serotonin (5-HT) from the PMA activated primary cells. It is believed that serotonin, among other biochemical species released by the activated cells, contributes to the observed BFC currents...
- Cortical and sub-cortical effects in primate models of cocaine use: implications for addiction and the increased risk of psychiatric illnessCharles W Bradberry
Department of Psychiatry, University of Pittsburgh, VA Pittsburgh Health Services, 3501 Fifth Ave, Rm 4078, Pittsburgh, PA 15261, USA
Neurotox Res 19:235-42. 2011....
- Cocaine sensitization and dopamine mediation of cue effects in rodents, monkeys, and humans: areas of agreement, disagreement, and implications for addictionCharles W Bradberry
Department of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
Psychopharmacology (Berl) 191:705-17. 2007..Sensitization of mesocorticolimbic dopamine projections has been a valuable model of neurobiological adaptation to chronic exposure to cocaine and other psychostimulants...
- Orbitofrontal and anterior cingulate cortex neurons selectively process cocaine-associated environmental cues in the rhesus monkeyEun Ha Baeg
Department of Psychiatry, University of Pittsburgh, Veterans Affairs Pittsburgh Health Services, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 29:11619-27. 2009..This pattern of sustained activation in ACC is consistent with a role in reward expectation and/or in mediating behavioral effects of discrete cues paired with drug infusions...
- NMDA antagonist effects on striatal dopamine release: microdialysis studies in awake monkeysBarbara W Adams
Department of Psychiatry, Yale University School of Medicine, Veterans Administration Medical Center, West Haven, Connecticut 06516, USA
Synapse 43:12-8. 2002..These findings suggest that in the primate, ketamine and PCP are not effective dopamine releasers, as has been suggested by previous imaging studies...
- A touch screen based Stop Signal Response Task in rhesus monkeys for studying impulsivity associated with chronic cocaine self-administrationShijing Liu
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
J Neurosci Methods 177:67-72. 2009..Our results are consistent with human data, and thereby establish an ideal animal model for studying the etiology and underlying neurobiology of cocaine-induced impulse control and performance monitoring deficits...
- Local anesthetic effects of cocaethylene and isopropylcocaine on rat peripheral nervesHajime A Tokuno
Department of Neurology, Yale University School of Medicine, VA Connecticut Healthcare Service, West Haven, CT 06516, USA
Brain Res 996:159-67. 2004..These studies provide a more complete understanding of the pharmaocology of potential agonist treatment candidates, and suggest a mechanism whereby cocaethylene produces a decreased euphoria in humans compared to cocaine...
- CNS CONSEQUENCES OF CHRONIC COCAINE SELF-ADMINISTRATIONCHARLES BRADBERRY; Fiscal Year: 2007..Each study will be conducted 3-4 months since last cocaine exposure. ..
- Neurobiology of Impulsivity and AlcoholismCHARLES BRADBERRY; Fiscal Year: 2008..The values will be compared across individuals with the imaging and microdialysis measures from aims 1, 2 and 3. Unused brain tissue will be banked for future potential uses ..