Affiliation: University of Oklahoma Health Sciences Center
Sutaria D, Jiang J, Azevedo Pouly A, Lee E, Lerner M, Brackett D, et al. Expression Profiling Identifies the Noncoding Processed Transcript of HNRNPU with Proliferative Properties in Pancreatic Ductal Adenocarcinoma. Noncoding RNA. 2017;3: pubmed publisher
..The lncRNA HNRNPU processed transcript expression is increased in both PDAC tissues and cell lines; knockdown of this lncRNA further reduces proliferation and invasion/migration of pancreatic carcinoma cells. ..
Howard E, Been L, Lerner M, Brackett D, Lightfoot S, Bullen E, et al. Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2. BMC Genet. 2013;14:28 pubmed publisher
..However, further studies would be needed to mechanistically link the two definitively. ..