Thomas Braciale

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc CD8(+) T cell-mediated injury in vivo progresses in the absence of effector T cells
    B A Small
    Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 194:1835-46. 2001
  2. pmc Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells
    Matthew M Hufford
    Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
    PLoS ONE 7:e46581. 2012
  3. pmc Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection
    Stacey Ann Gorski
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, United States of America Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Pathog 9:e1003615. 2013
  4. pmc CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
    Nat Immunol 12:327-34. 2011
  5. pmc Antiviral CD8+ T cell effector activities in situ are regulated by target cell type
    Matthew M Hufford
    Beirne B Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22904, USA
    J Exp Med 208:167-80. 2011
  6. pmc Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Pathog 7:e1002173. 2011
  7. pmc The cell cycle time of CD8+ T cells responding in vivo is controlled by the type of antigenic stimulus
    Heesik Yoon
    The Carter Immunology Center, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 5:e15423. 2010
  8. pmc Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection
    Taeg S Kim
    Beirne B Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1161-72. 2010
  9. pmc Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
    Jie Sun
    Beirne B Carter Center for Immunology Research, University of Virginia, 409 Lane Road, Charlottesville, Virginia 22908, USA
    Nat Med 15:277-84. 2009
  10. pmc Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses
    Taeg S Kim
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 4:e4204. 2009

Research Grants

  1. T Cell Function in Pulmonary Viral Pulmonary Infection and Injury
    Thomas J Braciale; Fiscal Year: 2010
  2. T CELL FUNCTION IN PULMONARY VIRAL INFECTION AND INJURY
    Thomas Braciale; Fiscal Year: 2006
  3. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2005
  4. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2005
  5. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2004
  6. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2004
  7. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2006
  8. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2006
  9. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2006
  10. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas J Braciale; Fiscal Year: 2010

Collaborators

Detail Information

Publications48

  1. pmc CD8(+) T cell-mediated injury in vivo progresses in the absence of effector T cells
    B A Small
    Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 194:1835-46. 2001
    ....
  2. pmc Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells
    Matthew M Hufford
    Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
    PLoS ONE 7:e46581. 2012
    ....
  3. pmc Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection
    Stacey Ann Gorski
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, United States of America Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Pathog 9:e1003615. 2013
    ....
  4. pmc CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
    Nat Immunol 12:327-34. 2011
    ..These findings reveal a previously unrecognized pathway that coordinates signals derived from innate and helper T cells to control the production of a regulatory cytokine by CTLs during acute viral infection...
  5. pmc Antiviral CD8+ T cell effector activities in situ are regulated by target cell type
    Matthew M Hufford
    Beirne B Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22904, USA
    J Exp Med 208:167-80. 2011
    ....
  6. pmc Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Pathog 7:e1002173. 2011
    ..Our findings suggest a potentially critical role of effector T cell-derived IL-10 in controlling disease severity in clinical RSV infection...
  7. pmc The cell cycle time of CD8+ T cells responding in vivo is controlled by the type of antigenic stimulus
    Heesik Yoon
    The Carter Immunology Center, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 5:e15423. 2010
    ..The implication of these findings for the development of adaptive immune responses and the regulation of cell cycle in higher eukaryotic cells is discussed...
  8. pmc Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection
    Taeg S Kim
    Beirne B Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1161-72. 2010
    ..Lastly, we document preferential localization of memory T cells to the DLNs after virus clearance as a consequence of presentation of residual viral antigen by the migrant RDC...
  9. pmc Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
    Jie Sun
    Beirne B Carter Center for Immunology Research, University of Virginia, 409 Lane Road, Charlottesville, Virginia 22908, USA
    Nat Med 15:277-84. 2009
    ..We discuss the potential implications of these findings for infection with highly pathogenic influenza viruses...
  10. pmc Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses
    Taeg S Kim
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 4:e4204. 2009
    ..These results identify CD103(+) and CD11b(hi) RDC as critical regulators of the adaptive immune response to respiratory tract infection and potential targets in the design of mucosal vaccines...
  11. pmc LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection
    Jae Kwang Yoo
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 209:1853-67. 2012
    ..LAPCs appear to play a pivotal role in driving Tfh differentiation of Ag-primed CD4(+) T cells and antiviral antibody responses...
  12. pmc Regulating the adaptive immune response to respiratory virus infection
    Thomas J Braciale
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 12:295-305. 2012
    ..Recent findings on the mechanisms that underlie the increased frequency of severe pulmonary bacterial infections following respiratory virus infection are also discussed...
  13. pmc Slowing down with age: lung DCs do it too
    Thomas J Braciale
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 121:4636-9. 2011
    ..The impaired DC migration was a result of increased levels of the lipid mediator prostaglandin D(2) (PGD(2)) in the respiratory tract with age and could be partially reversed by blockade of PGD(2) synthesis or action...
  14. ncbi request reprint Respiratory syncytial virus and T cells: interplay between the virus and the host adaptive immune system
    Thomas J Braciale
    Beirne B Carter Center for Immunology Research, University of Virginia Health System, Box 801386, MR4 Bldg, Charlottesville, VA 22908, USA
    Proc Am Thorac Soc 2:141-6. 2005
    ....
  15. ncbi request reprint Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells
    S M Varga
    Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Immunity 15:637-46. 2001
    ....
  16. ncbi request reprint Visualization and characterization of respiratory syncytial virus F-specific CD8(+) T cells during experimental virus infection
    J Chang
    Beirne B. Carter Center for Immunology Research and Department of Pathology and Microbiology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 167:4254-60. 2001
    ..The significance of these results for the regulation of the CD8(+) T cell response to RSV is discussed...
  17. pmc Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection
    A Srikiatkhachorn
    Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Exp Med 186:421-32. 1997
    ..These results indicate that CD8+ T cells may play an important role in the regulation of the differentiation and activation of Th2 CD4+ T cells as well as the recruitment of eosinophils into the lungs during RSV infection...
  18. pmc Resistance to and recovery from lethal influenza virus infection in B lymphocyte-deficient mice
    M B Graham
    Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Exp Med 186:2063-8. 1997
    ..The potential implications of these results for vaccination against human influenza infection are discussed...
  19. pmc Structural and functional consequences of alveolar cell recognition by CD8(+) T lymphocytes in experimental lung disease
    R I Enelow
    The, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Invest 102:1653-61. 1998
    ....
  20. pmc Induction of Th-1 and Th-2 responses by respiratory syncytial virus attachment glycoprotein is epitope and major histocompatibility complex independent
    A Srikiatkhachorn
    The Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Virol 73:6590-7. 1999
    ..The implication of these findings for the immune mechanisms underlying the pathogenesis of RSV is discussed...
  21. ncbi request reprint Cutting edge: lipid raft integrity affects the efficiency of MHC class I tetramer binding and cell surface TCR arrangement on CD8+ T cells
    D R Drake
    Beirne B. Carter Center for Immunology Research, and Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 166:7009-13. 2001
    ....
  22. pmc Virus-specific memory and effector T lymphocytes exhibit different cytokine responses to antigens during experimental murine respiratory syncytial virus infection
    A Srikiatkhachorn
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Virol 71:678-85. 1997
    ....
  23. ncbi request reprint Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays
    Nitin Jain
    Hospital West Complex, Rm 3181, P O Box 800717, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Bioinformatics 19:1945-51. 2003
    ....
  24. pmc Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells
    Kristian M Hargadon
    Carter Immunology Center, UVA, P O Box 801386, Charlottesville, VA 22908, USA
    J Virol 85:11955-63. 2011
    ..These results suggest a potential novel role for MHC class II molecules in influenza virus infection and pathogenesis in the respiratory tract...
  25. pmc Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation
    D J Kittlesen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 106:1239-49. 2000
    ..The inhibition of T-cell responsiveness by HCV core may have important implications for HCV persistence in humans...
  26. ncbi request reprint RSV-induced immunopathology: dynamic interplay between the virus and host immune response
    Steven M Varga
    Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Virology 295:203-7. 2002
  27. ncbi request reprint Improved effector activity and memory CD8 T cell development by IL-2 expression during experimental respiratory syncytial virus infection
    Jun Chang
    Department of Life Science, Pohang University of Science and Technology, Pohang 790 784, Republic of Korea
    J Immunol 172:503-8. 2004
    ..Thus, our results show that IL-2 has potential to be used as a vaccine adjuvant against RSV infection...
  28. pmc Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV
    Teresa R Johnson
    Vaccine Research Center, NIAID, NIH, Bldg 40, Room 2614, 40 Convent Dr, MSC 3017, Bethesda, MD 20892 3017, USA
    J Virol 78:8753-60. 2004
    ....
  29. ncbi request reprint Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract
    Jun Chang
    Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Nat Med 8:54-60. 2002
    ..These data suggest a possible mechanism to explain the limited duration of protective immunity in RSV infection...
  30. pmc Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection
    Erika L Wissinger
    The Carter Immunology Center, Department of Pathology, University of Virginia Health Science Center, Charlottesville, VA 22908, USA
    J Immunol 180:2957-66. 2008
    ....
  31. pmc Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry
    Whitney W Stevens
    The Carter Immunology Center, UVa Health Sciences Center, Charlottesville, VA 22908, United States
    J Immunol Methods 327:63-74. 2007
    ..Furthermore, this flow cytometry-based method can be directly adapted to enumerate eosinophils infiltrating the inflamed lung parenchyma, thereby obviating the need for quantitative morphometry of tissue sections...
  32. pmc Preferential migration of effector CD8+ T cells into the interstitium of the normal lung
    Elena Galkina
    Department of Biomedical Engineering, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Invest 115:3473-83. 2005
    ..These results document a novel mechanism of adhesion receptor- and pulmonary chemokine-dependent regulation of the migration of activated CD8+ T cells into an important nonlymphoid peripheral site (i.e., the normal/noninflamed lung)...
  33. ncbi request reprint Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection
    Heesik Yoon
    Carter Immunology Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 179:391-9. 2007
    ..These results indicate that the tempo of CD8+ T cell activation/proliferation after viral infection is dependent on the tempo of RDC migration to the DLN and that T cell activation occurs in an ordered sequential fashion...
  34. ncbi request reprint Sensitive detection and quantitation of mouse eosinophils in tissues using an enzymatic eosinophil peroxidase assay: its use to rapidly measure pulmonary eosinophilia during experimental respiratory syncytial virus infection of mice
    Steven M Varga
    Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Immunol Methods 262:111-20. 2002
    ....
  35. ncbi request reprint Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection
    Kevin L Legge
    Carter Immunology Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Immunity 18:265-77. 2003
    ..We further demonstrate that induction of this RDC refractory state suppresses additional RDC mobilization to subsequent pulmonary virus infection and results in concomitant suppression of an antiviral pulmonary CD8(+) T cell response...
  36. ncbi request reprint LFA-1 is required for retention of effector CD8 T cells in mouse lungs
    Jayant Thatte
    Department of Biomedical Engineering, Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville, USA
    Blood 101:4916-22. 2003
    ..These results demonstrate a crucial role for LFA-1 in retention of activated CD8 T cells in normal mouse lungs and in the progression of lethal injury in HA-Tg mice...
  37. ncbi request reprint Not all effector CD8+ T cells are alike
    Donald R Drake
    The Beirne B Carter Center for Immunology Research, University of Virginia, Box 801386, MR4 Bldg, HSC Box 4012, Charlottesville, VA 22906, USA
    Microbes Infect 5:199-204. 2003
    ....
  38. ncbi request reprint Transient loss of MHC class I tetramer binding after CD8+ T cell activation reflects altered T cell effector function
    Donald R Drake
    Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 175:1507-15. 2005
    ....
  39. ncbi request reprint Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression
    Kevin L Legge
    Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Immunity 23:649-59. 2005
    ....
  40. ncbi request reprint Introduction
    Thomas J Braciale
    Department of Pathology, University of Virginia, Charlottesville, USA
    Pediatr Infect Dis J 23:S5. 2004
  41. ncbi request reprint Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infection
    Christopher W Lawrence
    Beirne B Carter Center for Immunology Research, and Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 173:1209-18. 2004
    ....
  42. ncbi request reprint Comparative activities of oseltamivir and A-322278 in immunocompetent and immunocompromised murine models of influenza virus infection
    Michael G Ison
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, 22908, USA
    J Infect Dis 193:765-72. 2006
    ..This model would be useful for elucidation of the molecular mechanisms of resistance to NA inhibitors and for testing of anti-influenza therapy options that might prevent the emergence of resistant variants...
  43. pmc A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost
    Yuhong Xiao
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6073, USA
    Vaccine 25:1214-24. 2007
    ..Long-term partial protection was also seen in mice challenged with vaccinia virus 6 months after initial vaccinations. Thus, this work represents a step toward the development of a practical subunit smallpox vaccine...
  44. ncbi request reprint Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection
    Christopher W Lawrence
    Beirne B Carter Center for Immunology Research and Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 174:5332-40. 2005
    ....
  45. pmc RSV 2007: recent advances in respiratory syncytial virus research
    Whitney W Stevens
    The Carter Immunology Center, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Viral Immunol 21:133-40. 2008
    ..Additionally, there were two posters sessions displaying more than one hundred abstracts. The following summary provides a review of the proceedings from each session...
  46. pmc Differential response of respiratory dendritic cell subsets to influenza virus infection
    Xueli Hao
    Carter Immunology Center, UVA, P O Box 801386, Charlottesville, VA 22908, USA
    J Virol 82:4908-19. 2008
    ..Our results indicate that RDC are targets of influenza virus infection and that distinct RDC subsets differ in their susceptibilities and responses to infection...
  47. ncbi request reprint Respiratory syncytial virus and other pneumoviruses: a review of the international symposium--RSV 2003
    Alexander C Schmidt
    Department of Pediatric Pulmonology and Immunology, Charite University Hospital, Berlin, Germany
    Virus Res 106:1-13. 2004
    ..Chanock Award for lifetime achievement in RSV research, an award named in honor of the person who started the field of RSV research by recovering the first human RS virus from infants with severe bronchiolitis in 1956...

Research Grants47

  1. T Cell Function in Pulmonary Viral Pulmonary Infection and Injury
    Thomas J Braciale; Fiscal Year: 2010
    ..These studies may pave the way for the development of new therapeutic approaches to prevent and limit pulmonary injury produced by the host immune system. ..
  2. T CELL FUNCTION IN PULMONARY VIRAL INFECTION AND INJURY
    Thomas Braciale; Fiscal Year: 2006
    ..Finally, this analysis may have important implications for the development of strategies to counteract the use of potentially lethal pulmonary viruses like influenza as biological weapons. ..
  3. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2005
    ..In addition these experiments may provide insight into the process of CD8+T cell activationJdifferentiatjon into CTL effector cells. ..
  4. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2005
    ..abstract_text> ..
  5. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2004
    ..In addition these experiments may provide insight into the process of CD8+T cell activationJdifferentiatjon into CTL effector cells. ..
  6. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2004
    ..abstract_text> ..
  7. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2006
    ..The study should provide new and useful information -- both for our understanding of RSV pathogenesis and for the development of an effective RSV vaccine. ..
  8. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2006
    ..abstract_text> ..
  9. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2006
    ..Finally, by understanding what influenza-specific CD8+ T cells do in the infected lungs (and how they do it), we will begin to understand how viruses like influenza can subvert/suppress the immune system and produce lethal infection. ..
  10. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas J Braciale; Fiscal Year: 2010
    ..Finally, by understanding what influenza-specific CD8+ T cells do in the infected lungs (and how they do it), we will begin to understand how viruses like influenza can subvert/suppress the immune system and produce lethal infection. ..
  11. T Cell Function in Pulmonary Viral Pulmonary Infection and Injury
    Thomas Braciale; Fiscal Year: 2009
    ..These studies may pave the way for the development of new therapeutic approaches to prevent and limit pulmonary injury produced by the host immune system. ..
  12. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2009
    ..Finally, by understanding what influenza-specific CD8+ T cells do in the infected lungs (and how they do it), we will begin to understand how viruses like influenza can subvert/suppress the immune system and produce lethal infection. ..
  13. An Interdisciplinary Training Program in Immmunology
    Kodi Ravichandran; Fiscal Year: 2007
    ..The ultimate aim of this program is to provide a training and research environment which promotes and facilities development of our trainees into future leaders in the field of Immunology. ..
  14. CD8+ T cell trafficking to the normal lung
    Thomas Braciale; Fiscal Year: 2007
    ..abstract_text> ..
  15. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2007
    ..Finally, by understanding what influenza-specific CD8+ T cells do in the infected lungs (and how they do it), we will begin to understand how viruses like influenza can subvert/suppress the immune system and produce lethal infection. ..
  16. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2007
    ..The study should provide new and useful information -- both for our understanding of RSV pathogenesis and for the development of an effective RSV vaccine. ..
  17. T CELL FUNCTION IN PULMONARY VIRAL INFECTION AND INJURY
    Thomas Braciale; Fiscal Year: 2007
    ..Finally, this analysis may have important implications for the development of strategies to counteract the use of potentially lethal pulmonary viruses like influenza as biological weapons. ..
  18. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2003
    ..The study should provide new and useful information -- both for our understanding of RSV pathogenesis and for the development of an effective RSV vaccine. ..
  19. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2003
    ..In addition these experiments may provide insight into the process of CD8+T cell activationJdifferentiatjon into CTL effector cells. ..
  20. T CELL FUNCTION IN PULMONARY VIRAL INFECTION AND INJURY
    Thomas Braciale; Fiscal Year: 2003
    ..Finally, this analysis may have important implications for the development of strategies to counteract the use of potentially lethal pulmonary viruses like influenza as biological weapons. ..
  21. T CELL FUNCITON IN PULMONARY VIRAL INFECTION AND INJURY
    Thomas Braciale; Fiscal Year: 1999
    ..b>Thomas Braciale at the University of Virginia, Charlottesville to investigate the role of T lymphocytes in recovery from ..
  22. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 1999
    ..These studies will provide new and potentially important information on the interaction of CD4+ and CD8+ T cells in the clearance of RSV infection. This information will be important for the development of an effective RSV vaccine. ..
  23. T CELL FUNCTION IN PULMONARY VIRAL INFECTION & IMMUNITY
    Thomas Braciale; Fiscal Year: 1992
    ..These studies may also provide a rational framework for the use of specific T lymphocyte populations for adoptive immunotherapy in man...
  24. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2002
    ..These studies will provide new and potentially important information on the interaction of CD4+ and CD8+ T cells in the clearance of RSV infection. This information will be important for the development of an effective RSV vaccine. ..
  25. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2002
    ..In addition these experiments may provide insight into the process of CD8+T cell activationJdifferentiatjon into CTL effector cells. ..
  26. T CELL FUNCITON IN PULMONARY VIRAL INFECTION AND INJURY
    Thomas Braciale; Fiscal Year: 2002
    ..b>Thomas Braciale at the University of Virginia, Charlottesville to investigate the role of T lymphocytes in recovery from ..
  27. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2001
    ..These studies will provide new and potentially important information on the interaction of CD4+ and CD8+ T cells in the clearance of RSV infection. This information will be important for the development of an effective RSV vaccine. ..
  28. CYTOTOXIC T LYMPHOCYTE RESPONSE TO INFLUENZA VIRUS
    Thomas Braciale; Fiscal Year: 2001
    ..In addition these experiments may provide insight into the process of CD8+T cell activationJdifferentiatjon into CTL effector cells. ..
  29. T CELL FUNCITON IN PULMONARY VIRAL INFECTION AND INJURY
    Thomas Braciale; Fiscal Year: 2001
    ..b>Thomas Braciale at the University of Virginia, Charlottesville to investigate the role of T lymphocytes in recovery from ..
  30. IMMUNOBIOLOGY OF EXPERIMENTAL RSV INFECTION
    Thomas Braciale; Fiscal Year: 2000
    ..These studies will provide new and potentially important information on the interaction of CD4+ and CD8+ T cells in the clearance of RSV infection. This information will be important for the development of an effective RSV vaccine. ..
  31. T CELL FUNCITON IN PULMONARY VIRAL INFECTION AND INJURY
    Thomas Braciale; Fiscal Year: 2000
    ..b>Thomas Braciale at the University of Virginia, Charlottesville to investigate the role of T lymphocytes in recovery from ..
  32. T CELL FUNCTION IN PULMONARY VIRAL INFECTION & INJURY
    Thomas Braciale; Fiscal Year: 1993
    ..These studies may also provide a rational framework for the use of specific T lymphocyte populations for adoptive immunotherapy in man...