Research Topics
Genomes and Genes
Species | Paige M BracciSummaryAffiliation: University of California Country: USA Publications
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Publications
Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control studyPaige M Bracci
School of Medicine, University of California San Francisco, San Francisco, CA 94118 1944, USA
Cancer 118:5384-94. 2012..Autoantibodies to tumor-associated antigens (TAAs) can be present months to years before diagnosis and hold promise as biomarkers for early detection...- Cigarette, cigar and pipe smoking, passive smoke exposure, and risk of pancreatic cancer: a population-based study in the San Francisco Bay AreaGregory J Tranah
California Pacific Medical Center Research Institute, 94107, USA
BMC Cancer 11:138. 2011..To examine the influence of cigarette, cigar and pipe smoking, cessation of cigarette smoking and passive smoke exposure on the risk of pancreatic cancer... - Chemokine polymorphisms and lymphoma: a pooled analysisPaige M Bracci
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94118 1944, USA
Leuk Lymphoma 51:497-506. 2010..The CCL5 -403A allele conferred reduced risks of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma. Results should be interpreted conservatively. Continued investigation is warranted to confirm these findings... - Pancreatitis and pancreatic cancer in two large pooled case-control studiesPaige M Bracci
Department of Epidemiology and Biostatistics, School of Medicine, University of California, 3333 California St Suite 280, San Francisco, CA 94143, USA
Cancer Causes Control 20:1723-1731. 2009..We conducted detailed analyses to determine the association between pancreatitis onset and pancreatic cancer risk... - Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphomaChristine F Skibola
School of Public Health, Division of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA
PLoS ONE 3:e2816. 2008..Non-Hodgkin lymphoma (NHL) is the fifth most common cancer in the U.S. and few causes have been identified. Genetic association studies may help identify environmental risk factors and enhance our understanding of disease mechanisms... 
Tobacco use and non-Hodgkin lymphoma: results from a population-based case-control study in the San Francisco Bay Area, CaliforniaPaige M Bracci
Department of Epidemiology and Biostatistics, School of Medicine, University of California-San Francisco, 500 Parnassus Avenue, San Francisco, CA 94143-1228, USA
Cancer Causes Control 16:333-46. 2005..Further analyses are warranted in larger studies to evaluate non-cigarette tobacco use, tobacco-related biologic markers and genetic factors in the development of NHL...- Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma riskChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Cancer Epidemiol Biomarkers Prev 14:2391-401. 2005..These results suggest that PRL, CYP17A1, and COMT may be relevant genetic loci for non-Hodgkin lymphoma and indicate a possible role for prolactin and estrogen in lymphoma pathogenesis... - Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Blood 104:2155-62. 2004..The associations of DLCL and FL with TYMS 1494del6 and MTHFR 677TT genotypes, respectively, suggest that folate metabolism may play an important role in the pathogenesis of specific subtypes of NHL... - A functional TNFRSF5 gene variant is associated with risk of lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Blood 111:4348-54. 2008..These results suggest that the TNFRSF5 -1C>T polymorphism may increase FL susceptibility through mechanisms that hinder cellular immune responses. Further studies are needed to explore these findings... - Assessment of autoantibodies to meningioma in a population-based studyJoseph L Wiemels
Department of Epidemiology and Biostatistics, School of Medicine, Helen Diller Cancer Research Building, University of California, San Francisco, 1450 3rd Street, MC 0520, San Francisco, CA 94158, USA
Am J Epidemiol 177:75-83. 2013..1, 11 (P(trend) = 0.006)). These results indicate that men with meningioma commonly react with a serologic antimeningioma response; if supported by further research, this finding suggests a distinctive etiology for meningioma in men... - Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Cancer Epidemiol Biomarkers Prev 13:779-86. 2004.... - Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphomaMatthew S Forrest
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Br J Haematol 134:180-3. 2006..8), whereas the toll-like receptor 4 1063A>G variant allele was inversely associated with diffuse large cell lymphoma (OR = 0.67, 95% CI 0.45-0.99). These results suggest that variation in innate immune genes may alter NHL susceptibility... - Anthropometric factors and pancreatic cancer in a population-based case-control study in the San Francisco Bay areaCarey A Eberle
Department of Epidemiology and Biostatistics, University of California, 3333 California Street, Suite 280, San Francisco, CA, USA
Cancer Causes Control 16:1235-44. 2005..CONCLUSIONS: These results are consistent with other cancer studies and support further research to determine the mechanism by which increased BMI may influence the development of pancreatic cancer... - Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
Nat Genet 41:873-5. 2009..7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1)... - Domestic and farm-animal exposures and risk of non-Hodgkin's lymphoma in a population-based study in the San Francisco Bay AreaGregory J Tranah
California Pacific Medical Center Research Institute, San Francisco Coordinating Center, University of California San Francisco, San Francisco, CA 94107 1728, USA
Cancer Epidemiol Biomarkers Prev 17:2382-7. 2008..To assess the association between animal exposures and non-Hodgkin's lymphoma (NHL)... - Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-AmericansKyle M Walsh
Program in Cancer Genetics, Helen Diller Family Comprehensive Cancer Cente, San Francisco, CA, USA
Cancer Epidemiol Biomarkers Prev 22:251-60. 2013..1-p21.31, and 15q25.1. We investigated whether these regions contain lung cancer susceptibly loci in African-Americans and refined previous association signals by using the reduced linkage disequilibrium observed in African-Americans... - Polymorphisms in ghrelin and neuropeptide Y genes are associated with non-Hodgkin lymphomaDanica R Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Cancer Epidemiol Biomarkers Prev 14:1251-6. 2005..4; 95% CI, 1.3-4.4), 1258G>A (OR, 2.0; 95% CI, 1.1-3.5), and 5671C>T (OR, 1.8; 95% CI, 1.1-3.0). These results add further support for the hypothesis that SNPs in energy-regulating genes affect risk of NHL... - Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph ConsortiumChristine F Skibola
237A Hildebrand Hall, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
Am J Epidemiol 171:267-76. 2010..04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology... - Association of HLA-DQB1 alleles with risk of follicular lymphomaNicholas K Akers
School of Public Health, University of California, Berkeley, CA, USA
Leuk Lymphoma 52:53-8. 2011..51, 95% CI 0.38-0.69; adjusted p-value = 4.46 × 10(-5)). Although these findings require verification, the role of HLA class II proteins in B-cell survival and proliferation makes this a biologically plausible association... - Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32Lucia Conde
School of Public Health, University of California, Berkeley, Berkeley, California, USA
Nat Genet 42:661-4. 2010..We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9))... - Intake of vitamins D and A and calcium and risk of non-Hodgkin lymphoma: San Francisco Bay Area population-based case-control studyBahar Mikhak
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California 94118 1944, USA
Nutr Cancer 64:674-84. 2012..Our results should be interpreted conservatively until further investigation in larger pooled studies can be conducted to better assess the role of vitamin D intake in lymphomagenesis... - Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult gliomaMi Zhou
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158, USA
Cancer Res 70:7534-42. 2010..These results augment the long-observed association between allergies and glioma and support a role for the innate and adaptive humoral functions of the immune system, in particular immunoregulatory proteins, in gliomagenesis... - Expert review of non-Hodgkin's lymphomas in a population-based cancer registry: reliability of diagnosis and subtype classificationsChristina A Clarke
Northern California Cancer Center, Union City, California, USA
Cancer Epidemiol Biomarkers Prev 13:138-43. 2004..Thus, overall NHL incidence and survival statistics from the early 1990s are probably accurate, but subtype-specific statistics could be substantially biased, especially because of high (15-20%) proportions of unclassified lymphomas... - Survival in population-based pancreatic cancer patients: San Francisco Bay area, 1995-1999Zhihong Gong
Department of Epidemiology and Biostatistics, University of California San Francisco, 3333 California Street, San Francisco, CA 94118 1944, USA
Am J Epidemiol 174:1373-81. 2011..Although the results provide further evidence of poor survival among patients with pancreatic cancer, the data also suggest that within-stage-of-disease patients survived somewhat longer with therapy... - Solvent exposure and non-Hodgkin lymphoma: no risk in a population-based study in the San Francisco Bay AreaGregory J Tranah
California Pacific Medical Center Research Institute, University of California San Francisco, San Francisco, California 94107 1728, USA
Cancer Epidemiol Biomarkers Prev 18:3130-2. 2009..Odds ratios and 95% confidence intervals were adjusted for potential confounders. Our results have provided no support for an association between NHL and occupational exposure to solvents... - Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay AreaZhihong Gong
Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA 94118 1944, USA
Int J Cancer 127:1893-904. 2010..These results support the hypotheses that a high intake of saturated and certain monounsaturated fatty acids may increase the risk of pancreatic cancer, whereas greater intake of omega-3 fatty acids, vitamins C and E may reduce the risk... - Farm-related exposures and childhood brain tumours in seven countries: results from the SEARCH International Brain Tumour StudyJimmy T Efird
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94118, USA
Paediatr Perinat Epidemiol 17:201-11. 2003..0) and unprocessed wool (OR = 3.0). Our findings suggest that various farm-related exposures are positively associated with CBT and warrant further investigation into the public health importance of these associations... - Residential history, family characteristics and non-Hodgkin lymphoma, a population-based case-control study in the San Francisco Bay AreaPaige M Bracci
Department of Epidemiology and Biostatistics, University of California San Francisco, 94118-1944, USA
Cancer Epidemiol Biomarkers Prev 15:1287-94. 2006..The role of the complex relationship between residential history, family characteristics, childhood infections, and immune function in the development of NHL warrants further investigation in pooled analyses... - Mitochondrial DNA sequence variation and risk of pancreatic cancerErnest T Lam
Institute for Human Genetics, University of California, San Francisco, California, USA
Cancer Res 72:686-95. 2012..Together, the results of this study provide evidence that aggregated common and rare variants and the accumulation of singleton variants are important contributors to pancreatic cancer risk... - Signs and symptoms of pancreatic cancer: a population-based case-control study in the San Francisco Bay areaElizabeth A Holly
Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 94118-1944, USA
Clin Gastroenterol Hepatol 2:510-7. 2004..The large magnitude of the risk estimates indicate that common gastrointestinal symptoms may assist clinicians in earlier diagnosis of pancreatic cancer and perhaps affect survival... - A search for overlapping genetic susceptibility loci between non-Hodgkin lymphoma and autoimmune diseasesLucia Conde
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA
Genomics 98:9-14. 2011..These results support continued investigation to further elucidate the relationship between lymphoma and autoimmune diseases... - Prior history of allergies and pancreatic cancer in the San Francisco Bay areaElizabeth A Holly
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA
Am J Epidemiol 158:432-41. 2003..0006) and severity of allergic symptoms (p = 0.003). These results provide support for the plausibility that immune function in relation to allergies may play a role in the etiology of pancreatic cancer... - Comparison of interviewed and non-interviewed non-Hodgkin's lymphoma (NHL) patients in the San Francisco Bay AreaElizabeth A Holly
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA 94118, USA
Ann Epidemiol 12:419-25. 2002..CONCLUSIONS: High-grade lymphomas associated with poor survival in homosexual men are likely to be under-represented in case-control studies of NHL... - Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-AmericansHelen M Hansen
Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Hum Mol Genet 19:3652-61. 2010..002). The identified regions contain SNPs predicted to affect gene regulation. There are multiple lung cancer risk loci in the 15q25.1 region in African-Americans... - Population-based study of non-Hodgkin lymphoma, histology, and medical history among human immunodeficiency virus-negative participants in San FranciscoElizabeth A Holly
Department of Epidemiology and Biostatistics, Box 1228, University of California School of Medicine, 500 Parnassus Avenue, San Francisco, CA 94143 1228
Am J Epidemiol 158:316-27. 2003..These data provide direction for further investigation of immune function and genetic characteristics of subtypes of non-Hodgkin lymphoma in lymphomagenesis and warrant analyses in large pooled data sets... - Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS)Paige M Bracci
Departmentsof Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California 94158, USA
J Thorac Oncol 7:1352-60. 2012..Compared with other lung cancer histologies, AIS patients are less likely to be smokers, yet associations with other lung cancer risk factors and differences by sex have not been determined... - Vitamin D, calcium, and retinol intake, and pancreatic cancer in a population-based case-control study in the San Francisco Bay areaLydia B Zablotska
Department of Epidemiology and Biostatistics, University of California San Francisco, 3333 California Street, San Francisco, CA 94118, USA
Cancer Causes Control 22:91-100. 2011..The aim of this study was to evaluate a complex association among intake of dietary vitamin D, calcium, and retinol, and pancreatic cancer risk... - Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanismsPaige M Bracci
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California 94118 1944, USA
Mol Carcinog 51:53-63. 2012..An overview of the current epidemiology and hypothesized biological mechanisms involved in the obesity-pancreatic cancer association are presented... - Intake of folate, vitamins B6, B12 and methionine and risk of pancreatic cancer in a large population-based case-control studyZhihong Gong
Division of Cancer Epidemiology, Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 3333 California Street, Suite 280, San Francisco, CA 94118 1944, USA
Cancer Causes Control 20:1317-25. 2009..We examined the association between pancreatic cancer and intake of folate, vitamins B(6), B(12) and methionine in a large population-based case-control study... 
Dietary patterns and risk of pancreatic cancer in a large population-based case-control study in the San Francisco Bay AreaJune M Chan
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94158 9001, USA
Nutr Cancer 65:157-64. 2013..Consistent with what has been recommended for several other chronic diseases, consuming a diet rich in plant-based foods, whole grains, and white meat, might reduce risk of pancreatic cancer...- Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studiesKyle M Walsh
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Genet Epidemiol 37:222-8. 2013..These results highlight that the deficiencies of the candidate-gene approach lay in selecting both appropriate genes and relevant SNPs within these genes... - Integrating GWAS and expression data for functional characterization of disease-associated SNPs: an application to follicular lymphomaLucia Conde
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
Am J Hum Genet 92:126-30. 2013..The application of integrative methods, such as those presented here, to other post-GWAS investigations will help identify causal disease variants and enhance our understanding of biological disease mechanisms... - Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-AmericansKyle M Walsh
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
Oncotarget 3:1428-38. 2012..These findings identify a novel lung cancer risk locus on 2q31.1 which correlates with CHRNA1 expression and replicate previous associations on 15q25.1 in African-Americans... - Obesity and survival in population-based patients with pancreatic cancer in the San Francisco Bay AreaZhihong Gong
Department of Epidemiology and Biostatistics, University of California San Francisco, 3333 California Street, Suite 280, San Francisco, CA 94118 1944, USA
Cancer Causes Control 23:1929-37. 2012..However, studies of obesity and overall survival in patients with pancreatic cancer are notably lacking, especially in population-based studies... - A meta-analysis of genome-wide association studies of follicular lymphomaChristine F Skibola
School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley, 94720, USA
BMC Genomics 13:516. 2012.... - West Coast study of childhood brain tumours and maternal use of hair-colouring productsElizabeth A Holly
Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 3333 California Street, Suite 280, San Francisco, CA 94118, USA
Paediatr Perinat Epidemiol 16:226-35. 2002..Together with results from previous studies, these results provide no consistent evidence of an association between risk for CBT and use of hair dyes during pregnancy...
Research Grants
- Molecular Epidemiology of Pancreatic CancerPaige M Bracci; Fiscal Year: 2010..Blood samples will be banked for future genetic studies and data will be pooled for greater statistical power. ..