J D Boyer

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine
    Sarah E Belisle
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e19681. 2011
  2. doi request reprint Therapeutic and prophylactic DNA vaccines for HIV-1
    Lorenzo Antonio Ramirez
    University of Pennsylvania, Pathology, Stellar Chance Labs, 422 Curie Blvd, Philadelphia, PA 19104, USA
    Expert Opin Biol Ther 13:563-73. 2013
  3. pmc Standardization of cytokine flow cytometry assays
    Holden T Maecker
    BD Biosciences, San Jose, USA
    BMC Immunol 6:13. 2005
  4. ncbi request reprint Initiation of antiretroviral therapy during chronic SIV infection leads to rapid reduction in viral loads and the level of T-cell immune response
    Jean D Boyer
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Med Primatol 35:202-9. 2006
  5. ncbi request reprint Molecular and immunological approaches to controlling parasitic infection
    Jean D Boyer
    University of Pennsylvania School of Medicine, 505 Stellar Chance Bldg, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    DNA Cell Biol 22:355-6. 2003
  6. ncbi request reprint IL-4 increases Simian immunodeficiency virus replication despite enhanced SIV immune responses in infected rhesus macaques
    J D Boyer
    Department of Pathology, University of Pennsylvania, 422 Curie Blvd, 505 Stellar Chance Labs, Philadelphia, PA, USA
    Int J Parasitol 32:543-50. 2002
  7. ncbi request reprint Therapeutic immunization of HIV-infected chimpanzees using HIV-1 plasmid antigens and interleukin-12 expressing plasmids
    J D Boyer
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    AIDS 14:1515-22. 2000
  8. ncbi request reprint First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response
    R R MacGregor
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6073, USA
    J Infect Dis 178:92-100. 1998
  9. ncbi request reprint Systemic and mucosal immunity is elicited after both intramuscular and intravaginal delivery of human immunodeficiency virus type 1 DNA plasmid vaccines to pregnant chimpanzees
    M L Bagarazzi
    MCP Hahnemann University, Department of Pediatrics, St Christopher s Hospital For Children, Philadelphia, PA 19134, USA
    J Infect Dis 180:1351-5. 1999
  10. ncbi request reprint Macaques co-immunized with SIVgag/pol-HIVenv and IL-12 plasmid have increased cellular responses
    T M Robinson
    Jefferson University, Philadelphia, PA, USA
    J Med Primatol 36:276-84. 2007

Collaborators

Detail Information

Publications46

  1. pmc Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine
    Sarah E Belisle
    Department of Microbiology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e19681. 2011
    ..Furthermore, activation analysis and high-throughput gene expression data may provide better insight into mechanisms of viral control than may be observed using standard immunological assays...
  2. doi request reprint Therapeutic and prophylactic DNA vaccines for HIV-1
    Lorenzo Antonio Ramirez
    University of Pennsylvania, Pathology, Stellar Chance Labs, 422 Curie Blvd, Philadelphia, PA 19104, USA
    Expert Opin Biol Ther 13:563-73. 2013
    ..DNA vaccines not only offer a safe approach for the development of an HIV-1 vaccine but they have also been shown to elicit both arms of the immune system...
  3. pmc Standardization of cytokine flow cytometry assays
    Holden T Maecker
    BD Biosciences, San Jose, USA
    BMC Immunol 6:13. 2005
    ....
  4. ncbi request reprint Initiation of antiretroviral therapy during chronic SIV infection leads to rapid reduction in viral loads and the level of T-cell immune response
    Jean D Boyer
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Med Primatol 35:202-9. 2006
    ..The results are important for understanding SIV disease progression in different MHC Mamu alleles and also for improving the interpretation and quality of pre-clinical studies in rhesus monkeys...
  5. ncbi request reprint Molecular and immunological approaches to controlling parasitic infection
    Jean D Boyer
    University of Pennsylvania School of Medicine, 505 Stellar Chance Bldg, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    DNA Cell Biol 22:355-6. 2003
  6. ncbi request reprint IL-4 increases Simian immunodeficiency virus replication despite enhanced SIV immune responses in infected rhesus macaques
    J D Boyer
    Department of Pathology, University of Pennsylvania, 422 Curie Blvd, 505 Stellar Chance Labs, Philadelphia, PA, USA
    Int J Parasitol 32:543-50. 2002
    ..Importantly, vaccination in the absence of IL-4 protected CD4 levels without increasing viral load. The data support the hypothesis that inappropriate immune bias toward a Th2 pathway would ultimately enhance disease progression...
  7. ncbi request reprint Therapeutic immunization of HIV-infected chimpanzees using HIV-1 plasmid antigens and interleukin-12 expressing plasmids
    J D Boyer
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    AIDS 14:1515-22. 2000
    ..To assess HIV-1 DNA vaccination and co-immunization with interleukin (IL)-12 and IL-10 as immunotherapy in the HIV-1 infected chimpanzee model system...
  8. ncbi request reprint First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response
    R R MacGregor
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6073, USA
    J Infect Dis 178:92-100. 1998
    ..The safety and potential immunogenicity of an HIV-directed DNA-based vaccine was demonstrated, a finding that should encourage further studies...
  9. ncbi request reprint Systemic and mucosal immunity is elicited after both intramuscular and intravaginal delivery of human immunodeficiency virus type 1 DNA plasmid vaccines to pregnant chimpanzees
    M L Bagarazzi
    MCP Hahnemann University, Department of Pediatrics, St Christopher s Hospital For Children, Philadelphia, PA 19134, USA
    J Infect Dis 180:1351-5. 1999
    ....
  10. ncbi request reprint Macaques co-immunized with SIVgag/pol-HIVenv and IL-12 plasmid have increased cellular responses
    T M Robinson
    Jefferson University, Philadelphia, PA, USA
    J Med Primatol 36:276-84. 2007
    ..Earlier work demonstrated increased numbers of antigen specific CD8 and CD4 effector cells able to secrete IFN-gamma...
  11. ncbi request reprint Protection from immunodeficiency virus challenges in rhesus macaques by multicomponent DNA immunization
    J J Kim
    Viral Genomix, Inc, Philadelphia, Pennsylvania 19104, USA
    Virology 285:204-17. 2001
    ..These studies support the finding that multicomponent DNA vaccines can directly impact viral replication and disease in a highly pathogenic challenge system, thus potentially broadening our strategies against HIV...
  12. ncbi request reprint Next generation DNA vaccines for HIV-1
    J D Boyer
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Liposome Res 12:137-42. 2002
    ..Our studies show that both costimulation as well as cytokine signals can be harnessed for more potent vaccine development. These results have important implications for the design of vaccines for prophylaxis and therapy...
  13. ncbi request reprint Issues for improving multiplasmid DNA vaccines for HIV-1
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Vaccine 20:1999-2003. 2002
    ..It is likely that the combination of such advancements will significantly improve the clinical phenotype of this important vaccine modality...
  14. ncbi request reprint Independence of granzyme B secretion and interferon- gamma production during acute simian immunodeficiency virus infection
    Sandra A Calarota
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6100, USA
    J Infect Dis 193:1441-50. 2006
    ....
  15. ncbi request reprint Rhesus macaques with high levels of vaccine induced IFN-gamma producing cells better control viral set-point following challenge with SIV239
    Jean D Boyer
    Department of Pathology and Laboratory Medicine, 505 Stellar Chance Laboratories, 422 Curie Boulevard, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6100, USA
    Vaccine 24:4498-502. 2006
    ..Further, this study demonstrates that as virus replicates the T cell immune response to SIV antigens induced by the vaccine is modulated by antigen encountered by immune cells during viral replication...
  16. pmc Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques
    David A Hokey
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Eur J Immunol 38:1435-45. 2008
    ..Our data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques...
  17. ncbi request reprint Sustained suppression of SHIV89.6P replication in macaques by vaccine-induced CD8+ memory T cells
    Jiangmei Yin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    AIDS 22:1739-48. 2008
    ..In this follow-up study, we measured viral replication 2 years after vaccination challenge and determined the mechanism by which antigen-specific CD8 T cells suppress viral replication...
  18. pmc CD8+ cell depletion of SHIV89.6P-infected macaques induces CD4+ T cell proliferation that contributes to increased viral loads
    Yvonne M Mueller
    Department of Microbiology and Immunology, and Center for Immunology and Vaccine Sciences, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Immunol 183:5006-12. 2009
    ....
  19. doi request reprint Viral reservoir is suppressed but not eliminated by CD8 vaccine specific lymphocytes
    Jiangmei Yin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd, Philadelphia, PA 19104, United States
    Vaccine 28:1924-31. 2010
    ..Furthermore, in the data presented here, we found a higher number of IFN-gamma producing vaccine specific cells did not enhance suppression of viral replication...
  20. pmc Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid
    Jean D Boyer
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:18648-53. 2007
    ..This study demonstrates that an optimized IL-15 immune adjuvant delivered with a DNA vaccine can impact the cellular immune profile in nonhuman primates and lead to enhanced suppression of viral replication...
  21. ncbi request reprint Immunogenicity of HIV-1 IIIB and SHIV 89.6P Tat and Tat toxoids in rhesus macaques: induction of humoral and cellular immune responses
    Max W Richardson
    Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    DNA Cell Biol 21:637-51. 2002
    ..The potency and cross-reactivity of these immune responses confirm Tat toxoid as an excellent candidate vaccine component...
  22. ncbi request reprint DNA prime Listeria boost induces a cellular immune response to SIV antigens in the rhesus macaque model that is capable of limited suppression of SIV239 viral replication
    Jean D Boyer
    Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Virology 333:88-101. 2005
    ..monocytogenes can induce a cellular immune response in a nonhuman primate and is able to enhance the efficacy of a DNA vaccine as well as provide modest protection against SIV239 challenge...
  23. ncbi request reprint Parasitic infection and the polarized Th2 immune response can alter a vaccine-induced immune response
    Tara M Robinson
    University of Pennsylvania, Philadelphia 19104, USA
    DNA Cell Biol 22:421-30. 2003
    ..It is believed that an antigen specific CD8 cellular immune response will be an important component of an HIV-1 vaccine...
  24. ncbi request reprint Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help
    Michele A Kutzler
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:112-23. 2005
    ..These data suggest a role for enhanced plasmid IL-15 as a candidate adjuvant for vaccine or immunotherapeutic studies...
  25. ncbi request reprint Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy
    Miguel Otero
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd, 505 Stellar Chance Bldg Philadelphia, PA 19104 6100, USA
    Vaccine 24:4461-70. 2006
    ..The VacV-DNA plasmids elicited IFN-gamma production in HLA-A2.1 transgenic mice in response to predicted HLA-A2.1 restricted peptide epitopes, providing valuable data for further vaccine development...
  26. ncbi request reprint High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model
    Jiangmei Yin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 505 SCL, 422 Curie Blvd Philadelphia, PA 19104, USA
    Virology 393:49-55. 2009
    ..Importantly, however, the higher doses of IL-15 decrease the antibody levels significantly. This study demonstrates the importance of optimizing DNA-based cytokine adjuvants...
  27. ncbi request reprint SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques
    Jean D Boyer
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Med Primatol 34:262-70. 2005
    ..The vaccine immune responses contained both a CD8 component as well a CD4 component. The adjuvanted DNA vaccines illustrate that IL-12 enhances a CD8 vaccine immune response, however, different cellular profiles...
  28. ncbi request reprint Use of interleukin 15 to enhance interferon-gamma production by antigen-specific stimulated lymphocytes from rhesus macaques
    Sandra A Calarota
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol Methods 279:55-67. 2003
    ..8 for the env peptide pools. Thus, the sensitivity of the ELISPOT assay can be enhanced by addition of IL-15. This modified assay will be useful for detection of low frequencies of IFN-gamma producing cells in rhesus macaques...
  29. doi request reprint CLTA-4 blockade in vivo promotes the generation of short-lived effector CD8 T cells and a more persistent central memory CD4 T cell response
    David A Hokey
    Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Med Primatol 37:62-8. 2008
    ..We observed that while the antibody had little effect on the IFN-gamma ELISpot response, CTLA-4 blockade enhanced antigen-specific cellular proliferation in both CD4(+) and CD8(+)T-cell compartments...
  30. ncbi request reprint Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model
    Miguel Otero
    Department of Pathology, School of Medicine, University of Pennsylvania, 422 Curie Blvd, 505 Stellar Chance Bldg, Philadelphia, PA 19104 6100, USA
    Vaccine 22:1782-90. 2004
    ..Our results show that resiquimod can have modest adjuvant activity, in a DNA formulation, driving the immune system towards a cell-mediated immune response. Additional studies involving this adjuvant for DNA vaccines are underway...
  31. ncbi request reprint HIV-1 vaccines and co-infection
    Tara M Robinson
    University of Pennsylvania, 422 Curie Blvd, 505 SCL, Philadelphia, PA 19104, USA
    Expert Opin Biol Ther 4:1483-92. 2004
    ..Such an immune profile is likely to have an adverse impact on the efficacy of an HIV-1 vaccine CD8 cellular immune response and the corresponding Th1 cytokines that are most likely to be important for clearing viral infections...
  32. ncbi request reprint Plasmid vaccination of stable HIV-positive subjects on antiviral treatment results in enhanced CD8 T-cell immunity and increased control of viral "blips"
    Rob Roy MacGregor
    Department of Medicine, University of Pennsylvania School of Medicine, 502 Johnson Pavilion, 36th and Hamilton Walk, Philadelphia, PA 19104 6073, USA
    Vaccine 23:2066-73. 2005
    ..04). The decrease in the frequency of transient viremia and failure suggests that DNA immunization with CD8-generating vaccines in HAART-controlled HIV-positive subjects may have therapeutic potential...
  33. ncbi request reprint Experimental Leishmania major infection suppresses HIV-1 DNA vaccine induced cellular immune response
    Tara M Robinson
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cells Tissues Organs 177:185-8. 2004
    ..These data suggest that parasitic infection, which results in a Th2 profile, reduces the efficacy of DNA vaccines that are designed to induce antiviral CD8+ T cell responses...
  34. ncbi request reprint T-cell responses induced in normal volunteers immunized with a DNA-based vaccine containing HIV-1 env and rev
    Rob Roy MacGregor
    Infectious Diseases Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    AIDS 16:2137-43. 2002
    ..An effective HIV-1 vaccine will likely need to induce strong cell-mediated immunity in humans. Therefore, we examined the ability of a DNA HIV-1 vaccine to induce a T-cell response in HIV-1 seronegative humans...
  35. ncbi request reprint Novel engineered HIV-1 East African Clade-A gp160 plasmid construct induces strong humoral and cell-mediated immune responses in vivo
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Virology 314:134-46. 2003
    ..This study suggests a simple strategy for improving the expression and immunogenicity of HIV subtype-specific envelope antigens as plasmid or vector-borne immunogens...
  36. ncbi request reprint Immunogenicity testing of a novel engineered HIV-1 envelope gp140 DNA vaccine construct
    Sanjeev Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    DNA Cell Biol 25:383-92. 2006
    ..4 and 1.5% proliferation was observed in CD4+, CD8+, and CCR+ memory T cells, respectively. Therefore, this engineered synthetic optimized env DNA vaccine may be useful in DNA vaccine and other studies of HIV-1 immunogenicity...
  37. ncbi request reprint Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine
    Jian Yan
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 15:411-21. 2007
    ..These properties suggest that such a synthetic immunogen deserves further examination for its potential to serve as a component antigen in an HIV vaccine cocktail...
  38. ncbi request reprint Plasmid immunization primes unique DTH responses to HIV-1MN envelope epitopes as compared to recombinant protein vaccination
    Michael A Chattergoon
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104, USA
    Hybrid Hybridomics 21:117-22. 2002
    ..Further, utilizing peptide probes that in aggregate represent the entire gp120 molecule, common and unique dominant epitopes induced by each method of immunization were identified...
  39. ncbi request reprint Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus
    Michael A Egan
    Wyeth Vaccines Research, Pearl River, New York 10965, USA
    AIDS Res Hum Retroviruses 21:629-43. 2005
    ....
  40. pmc Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization
    Agneta S von Gegerfelt
    Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Building 535, Room 210, Frederick, MD 21702 1201, USA
    J Virol 81:1972-9. 2007
    ..Several animals show a long-lasting decrease in viremia, suggesting that therapeutic vaccination may provide an additional benefit to antiretroviral therapy...
  41. pmc Sequential priming with simian immunodeficiency virus (SIV) DNA vaccines, with or without encoded cytokines, and a replicating adenovirus-SIV recombinant followed by protein boosting does not control a pathogenic SIVmac251 mucosal challenge
    Thorsten Demberg
    Vaccine Branch, National Cancer Institute, Bethesda, Maryland 208921, USA
    J Virol 82:10911-21. 2008
    ..Future experiments should address these issues to determine if this combination approach is able to control a virulent SIV challenge...
  42. ncbi request reprint Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA + IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques
    Rabih Halwani
    Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal Saint Luc, Montreal, Quebec, Canada
    J Immunol 180:7969-79. 2008
    ..These results indicate that plasmid IL-12 and IL-15 cytokines represent a significant addition to enhance the ability of therapeutic DNA vaccines to induce better immunity...
  43. ncbi request reprint A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques
    Eva B Schadeck
    Wyeth Vaccines Research, Pearl River, NY 10965, USA
    Vaccine 24:4677-87. 2006
    ..0002) between the magnitude and breadth of the immune responses in the vaccines. These results have important implications for the continuing development of an effective, safe low dose pDNA vaccine adjuvant suitable for human use...
  44. pmc Novel pathway for induction of latent virus from resting CD4(+) T cells in the simian immunodeficiency virus/macaque model of human immunodeficiency virus type 1 latency
    Anding Shen
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Virol 81:1660-70. 2007
    ..This is the first demonstration that costimulatory signals can induce latent virus without the coengagement of the T-cell receptor, and this study might provide insights into potential pathways to target latent HIV-1...
  45. ncbi request reprint Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques
    Siew Yen Chong
    Wyeth Vaccines Discovery, 401 N Middletown Road, Pearl River, NY 10965, USA
    Vaccine 25:4967-82. 2007
    ..These results have important implications for the continued development of plasmid DNA vaccines for the prevention of HIV-1 infection...
  46. ncbi request reprint Vaccine development against HIV-1: current perspectives and future directions
    Rebecca L Edgeworth
    Department of Medical Microbiology and Immunology, University of South Florida, College of Medicine, Tampa 33612, USA
    Immunol Res 25:53-74. 2002
    ..This review summarizes the vaccine strategies that have been tested in both animal models and human clinical trials...

Research Grants6

  1. Parasitic Infection Alters Quality of Immune Response
    Jean Boyer; Fiscal Year: 2003
    ..This proposal represents the initiation of a new and important area of research. ..
  2. Enhancing Mucosal Cellular Imm Resp by Co-Delivery of Plasmid IL-15 w/DNA Vaccine
    Jean Boyer; Fiscal Year: 2007
    ..AIM4 will investigate the peripheral and mucosal cellular immune responses in control and vaccinated animals following SIV challenge. ..
  3. Enhancing Mucosal Cellular Imm Resp by Co-Delivery of Plasmid IL-15 w/DNA Vaccine
    Jean Boyer; Fiscal Year: 2009
    ..AIM4 will investigate the peripheral and mucosal cellular immune responses in control and vaccinated animals following SIV challenge. ..
  4. Enhancing Mucosal Cellular Imm Resp by Co-Delivery of Plasmid IL-15 w/DNA Vaccine
    Jean D Boyer; Fiscal Year: 2010
    ..AIM4 will investigate the peripheral and mucosal cellular immune responses in control and vaccinated animals following SIV challenge. ..