Barbara D Boyan

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Osteochondral progenitor cells in acute and chronic canine nonunions
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78284 7823, USA
    J Orthop Res 17:246-55. 1999
  2. ncbi request reprint Evidence for distinct membrane receptors for 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in osteoblasts
    Barbara D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Steroids 67:235-46. 2002
  3. ncbi request reprint Osteoblast-mediated mineral deposition in culture is dependent on surface microtopography
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Calcif Tissue Int 71:519-29. 2002
  4. ncbi request reprint Both cyclooxygenase-1 and cyclooxygenase-2 mediate osteoblast response to titanium surface roughness
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Biomed Mater Res 55:350-9. 2001
  5. ncbi request reprint 24,25-(OH)(2)D(3) regulates cartilage and bone via autocrine and endocrine mechanisms
    B D Boyan
    University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Steroids 66:363-74. 2001
  6. ncbi request reprint Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Periodontol 71:1278-86. 2000
  7. ncbi request reprint Surface roughness mediates its effects on osteoblasts via protein kinase A and phospholipase A2
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Biomaterials 20:2305-10. 1999
  8. ncbi request reprint Effect of surface roughness and composition on costochondral chondrocytes is dependent on cell maturation state
    B D Boyan
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 78284 7774, USA
    J Orthop Res 17:446-57. 1999
  9. ncbi request reprint Potential of porous poly-D,L-lactide-co-glycolide particles as a carrier for recombinant human bone morphogenetic protein-2 during osteoinduction in vivo
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center, San Antonio 78284 7774, USA
    J Biomed Mater Res 46:51-9. 1999
  10. ncbi request reprint 1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78284 7774, USA
    Steroids 64:129-36. 1999

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Osteochondral progenitor cells in acute and chronic canine nonunions
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78284 7823, USA
    J Orthop Res 17:246-55. 1999
    ....
  2. ncbi request reprint Evidence for distinct membrane receptors for 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in osteoblasts
    Barbara D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Steroids 67:235-46. 2002
    ..These results demonstrate that response to 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) depends on osteoblast maturation state and suggest that specific and distinct membrane receptors are involved...
  3. ncbi request reprint Osteoblast-mediated mineral deposition in culture is dependent on surface microtopography
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Calcif Tissue Int 71:519-29. 2002
    ..This demonstrates that interactions between growth factor or hormone and surface microtopography can modulate bone cell differentiation and mineralization...
  4. ncbi request reprint Both cyclooxygenase-1 and cyclooxygenase-2 mediate osteoblast response to titanium surface roughness
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Biomed Mater Res 55:350-9. 2001
    ..While prostaglandin mediates the effects of surface roughness on alkaline phosphatase, neither Cox-1 nor Cox-2 appears to be involved, at least with respect to the two inhibitors used...
  5. ncbi request reprint 24,25-(OH)(2)D(3) regulates cartilage and bone via autocrine and endocrine mechanisms
    B D Boyan
    University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Steroids 66:363-74. 2001
    ..These studies indicate that 24(R),25(OH)(2)D(3) plays an important role in endochondral ossification by regulating less mature chondrocytes and promoting their maturation in the endochondral lineage...
  6. ncbi request reprint Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Periodontol 71:1278-86. 2000
    ....
  7. ncbi request reprint Surface roughness mediates its effects on osteoblasts via protein kinase A and phospholipase A2
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Biomaterials 20:2305-10. 1999
    ..Further downstream, prostaglandin E2 activates protein kinase A...
  8. ncbi request reprint Effect of surface roughness and composition on costochondral chondrocytes is dependent on cell maturation state
    B D Boyan
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 78284 7774, USA
    J Orthop Res 17:446-57. 1999
    ..Furthermore, the nature and extent of the cell response is dependent on cell maturation. The overriding variable in response to an implant material, however, appears to be roughness of the surface...
  9. ncbi request reprint Potential of porous poly-D,L-lactide-co-glycolide particles as a carrier for recombinant human bone morphogenetic protein-2 during osteoinduction in vivo
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center, San Antonio 78284 7774, USA
    J Biomed Mater Res 46:51-9. 1999
    ..Further, the PLG copolymers with rhBMP-2 had a greater effect in inducing new bone formation and resorbing the implanted material than active DFDBA alone...
  10. ncbi request reprint 1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78284 7774, USA
    Steroids 64:129-36. 1999
    ..1,25 stimulates MMPs in the MVs, resulting in increased proteoglycan degradation in mineralization gels, and increased activation of latent transforming growth factor-beta 1 (TGF-beta1)...
  11. ncbi request reprint Membrane mediated signaling mechanisms are used differentially by metabolites of vitamin D(3) in musculoskeletal cells
    Barbara D Boyan
    Department of Orthopaedics, MC7774, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Steroids 67:421-7. 2002
    ....
  12. ncbi request reprint Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways
    Enrique Rosado
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Biochim Biophys Acta 1590:1-15. 2002
    ..PGE(2) activates the EP2 receptor, leading to G-protein-dependent activation of PKA. PKA signaling results in increased PKC activity and PKC signaling regulates proliferation, differentiation, and matrix synthesis...
  13. ncbi request reprint Ceramic and PMMA particles differentially affect osteoblast phenotype
    Christoph H Lohmann
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Biomaterials 23:1855-63. 2002
    ..These results may indicate that the response of peri-prosthetic tissues to wear particles may be modulated by the relative contributions of the various particle types present...
  14. ncbi request reprint Nitric oxide and prostaglandin E2 production in response to ultra-high molecular weight polyethylene particles depends on osteoblast maturation state
    Christoph H Lohmann
    University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    J Bone Joint Surg Am 84:411-9. 2002
    ..We tested the hypothesis that the state of cell maturation plays a role in the response of osteogenic cells to ultra-high molecular weight polyethylene particles...
  15. ncbi request reprint Role of oral bacterial flora in calcific aortic stenosis: an animal model
    David J Cohen
    Cardiothoracic Surgery Service, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    Ann Thorac Surg 77:537-43. 2004
    ..Such bacteria are typically present as part of the normal human oral flora...
  16. ncbi request reprint Osteoblast-like cells are sensitive to submicron-scale surface structure
    Ge Zhao
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Clin Oral Implants Res 17:258-64. 2006
    ..In this study, we examined the role of different types of submicron-scale structures...
  17. ncbi request reprint Integrin beta1 silencing in osteoblasts alters substrate-dependent responses to 1,25-dihydroxy vitamin D3
    Liping Wang
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, 315 Ferst Drive NW, Georgia 30332, USA
    Biomaterials 27:3716-25. 2006
    ..The results also show that beta1 mediates, in part, the synergistic effects of surface roughness and 1alpha,25(OH)2D3...
  18. pmc Effect of micrometer-scale roughness of the surface of Ti6Al4V pedicle screws in vitro and in vivo
    Zvi Schwartz
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive N W, Atlanta, GA 30332 0363, USA
    J Bone Joint Surg Am 90:2485-98. 2008
    ..In this study, we examined the effects of micrometer-scale-structured Ti6Al4V surfaces on cell responses in vitro and on tissue responses in vivo...
  19. ncbi request reprint Membrane actions of vitamin D metabolites 1alpha,25(OH)2D3 and 24R,25(OH)2D3 are retained in growth plate cartilage cells from vitamin D receptor knockout mice
    Barbara D Boyan
    Georgia Institute of Technology, Atlanta, Georgia, USA
    J Cell Biochem 90:1207-23. 2003
    ..1alpha,25(OH)(2)D(3)-dependent regulation of DNA synthesis in GC cells requires the 1,25-nVDR, although other physiological responses to the vitamin D metabolite, such as proteoglycan sulfation, involve regulation via the 1,25-mVDR...
  20. ncbi request reprint 1alpha,25(OH)2D3 regulates chondrocyte matrix vesicle protein kinase C (PKC) directly via G-protein-dependent mechanisms and indirectly via incorporation of PKC during matrix vesicle biogenesis
    Zvi Schwartz
    Hebrew University, Jerusalem 91120, Israel
    J Biol Chem 277:11828-37. 2002
    ....
  21. ncbi request reprint Surface microtopography regulates osteointegration: the role of implant surface microtopography in osteointegration
    Zvi Schwartz
    Hebrew University Hadassah Faculty of Dental Medicine, Jerusalem
    Alpha Omegan 98:9-19. 2005
    ..This finding may lead us to a new era in dental implants...
  22. ncbi request reprint Steroid hormone action in musculoskeletal cells involves membrane receptor and nuclear receptor mechanisms
    Barbara D Boyan
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Connect Tissue Res 44:130-5. 2003
    ....
  23. ncbi request reprint Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1
    Barbara D Boyan
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
    J Bone Miner Res 21:1637-47. 2006
    ..We found that caveolae are required for rapid 1alpha,25(OH)(2)D(3)-dependent PKC signaling, and caveolin-1 must be present based on studies using chondrocytes from Cav-1(-/-) mice...
  24. pmc 1alpha,25(OH)2D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60 activated matrix vesicle metalloproteinases
    Barbara D Boyan
    Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332 0363, USA
    J Steroid Biochem Mol Biol 103:467-72. 2007
    ..However, when MVs are treated with 1alpha,25(OH)(2)D(3), PKCzeta activity is decreased and PKCalpha is unaffected, suggesting a more complex feedback mechanism, potentially involving MV lipid signaling...
  25. pmc Beta-1 integrins mediate substrate dependent effects of 1alpha,25(OH)2D3 on osteoblasts
    Zvi Schwartz
    Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332 0363, USA
    J Steroid Biochem Mol Biol 103:606-9. 2007
    ..The results also show that beta(1) mediates, in part, the synergistic effects of surface roughness and 1alpha,25(OH)(2)D(3)...
  26. ncbi request reprint Caveolin-1 knockout mice have increased bone size and stiffness
    Janet Rubin
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Bone Miner Res 22:1408-18. 2007
    ..Cell studies showed that cav-1 deficiency leads to increased osteoblast differentiation. These results suggest that cav-1 helps to maintain osteoblast progenitors in a less differentiated state...
  27. ncbi request reprint Use of growth factors to modify osteoinductivity of demineralized bone allografts: lessons for tissue engineering of bone
    Barbara D Boyan
    Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Dent Clin North Am 50:217-28, viii. 2006
    ..This article examines the use of growth factors, including platelet-rich plasma, platelet-derived growth factor, enamel matrix derivatives, and BMP-2, to enhance the osteoinductive properties of human DFDBA...