Research Topics
| Barbara D BoyanSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Osteochondral progenitor cells in acute and chronic canine nonunionsB D Boyan
Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78284 7823, USA
J Orthop Res 17:246-55. 1999....- Evidence for distinct membrane receptors for 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in osteoblastsBarbara D Boyan
Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Steroids 67:235-46. 2002..These results demonstrate that response to 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) depends on osteoblast maturation state and suggest that specific and distinct membrane receptors are involved... - Osteoblast-mediated mineral deposition in culture is dependent on surface microtopographyB D Boyan
Department of Orthopaedics, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Calcif Tissue Int 71:519-29. 2002..This demonstrates that interactions between growth factor or hormone and surface microtopography can modulate bone cell differentiation and mineralization... - Both cyclooxygenase-1 and cyclooxygenase-2 mediate osteoblast response to titanium surface roughnessB D Boyan
Department of Orthopaedics, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Biomed Mater Res 55:350-9. 2001..While prostaglandin mediates the effects of surface roughness on alkaline phosphatase, neither Cox-1 nor Cox-2 appears to be involved, at least with respect to the two inhibitors used... - 24,25-(OH)(2)D(3) regulates cartilage and bone via autocrine and endocrine mechanismsB D Boyan
University of Texas Health Science Center at San Antonio, 78229 3900, USA
Steroids 66:363-74. 2001..These studies indicate that 24(R),25(OH)(2)D(3) plays an important role in endochondral ossification by regulating less mature chondrocytes and promoting their maturation in the endochondral lineage... - Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivoB D Boyan
Department of Orthopaedics, University of Texas Health Science Center, San Antonio 78229 3900, USA
J Periodontol 71:1278-86. 2000.... - Surface roughness mediates its effects on osteoblasts via protein kinase A and phospholipase A2B D Boyan
Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78229 3900, USA
Biomaterials 20:2305-10. 1999..Further downstream, prostaglandin E2 activates protein kinase A... - Effect of surface roughness and composition on costochondral chondrocytes is dependent on cell maturation stateB D Boyan
Department of Periodontics, University of Texas Health Science Center at San Antonio, 78284 7774, USA
J Orthop Res 17:446-57. 1999..Furthermore, the nature and extent of the cell response is dependent on cell maturation. The overriding variable in response to an implant material, however, appears to be roughness of the surface... - Potential of porous poly-D,L-lactide-co-glycolide particles as a carrier for recombinant human bone morphogenetic protein-2 during osteoinduction in vivoB D Boyan
Department of Orthopaedics, University of Texas Health Science Center, San Antonio 78284 7774, USA
J Biomed Mater Res 46:51-9. 1999..Further, the PLG copolymers with rhBMP-2 had a greater effect in inducing new bone formation and resorbing the implanted material than active DFDBA alone... - 1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2B D Boyan
Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78284 7774, USA
Steroids 64:129-36. 1999..1,25 stimulates MMPs in the MVs, resulting in increased proteoglycan degradation in mineralization gels, and increased activation of latent transforming growth factor-beta 1 (TGF-beta1)... - Membrane mediated signaling mechanisms are used differentially by metabolites of vitamin D(3) in musculoskeletal cellsBarbara D Boyan
Department of Orthopaedics, MC7774, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Steroids 67:421-7. 2002.... - Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathwaysEnrique Rosado
Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA
Biochim Biophys Acta 1590:1-15. 2002..PGE(2) activates the EP2 receptor, leading to G-protein-dependent activation of PKA. PKA signaling results in increased PKC activity and PKC signaling regulates proliferation, differentiation, and matrix synthesis... - Ceramic and PMMA particles differentially affect osteoblast phenotypeChristoph H Lohmann
Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78229-3900, USA
Biomaterials 23:1855-63. 2002..These results may indicate that the response of peri-prosthetic tissues to wear particles may be modulated by the relative contributions of the various particle types present... - Nitric oxide and prostaglandin E2 production in response to ultra-high molecular weight polyethylene particles depends on osteoblast maturation stateChristoph H Lohmann
University of Texas Health Science Center at San Antonio, Texas 78229-3900, USA
J Bone Joint Surg Am 84:411-9. 2002.... - Role of oral bacterial flora in calcific aortic stenosis: an animal modelDavid J Cohen
Cardiothoracic Surgery Service, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
Ann Thorac Surg 77:537-43. 2004..Such bacteria are typically present as part of the normal human oral flora... - Osteoblast-like cells are sensitive to submicron-scale surface structureGe Zhao
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Clin Oral Implants Res 17:258-64. 2006.... - Integrin beta1 silencing in osteoblasts alters substrate-dependent responses to 1,25-dihydroxy vitamin D3Liping Wang
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, 315 Ferst Drive NW, Georgia 30332, USA
Biomaterials 27:3716-25. 2006..The results also show that beta1 mediates, in part, the synergistic effects of surface roughness and 1alpha,25(OH)2D3... - Effect of micrometer-scale roughness of the surface of Ti6Al4V pedicle screws in vitro and in vivoZvi Schwartz
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive N W, Atlanta, GA 30332 0363, USA
J Bone Joint Surg Am 90:2485-98. 2008..In this study, we examined the effects of micrometer-scale-structured Ti6Al4V surfaces on cell responses in vitro and on tissue responses in vivo... - Membrane actions of vitamin D metabolites 1alpha,25(OH)2D3 and 24R,25(OH)2D3 are retained in growth plate cartilage cells from vitamin D receptor knockout miceBarbara D Boyan
Georgia Institute of Technology, Atlanta, Georgia, USA
J Cell Biochem 90:1207-23. 2003..1alpha,25(OH)(2)D(3)-dependent regulation of DNA synthesis in GC cells requires the 1,25-nVDR, although other physiological responses to the vitamin D metabolite, such as proteoglycan sulfation, involve regulation via the 1,25-mVDR... - 1alpha,25(OH)2D3 regulates chondrocyte matrix vesicle protein kinase C (PKC) directly via G-protein-dependent mechanisms and indirectly via incorporation of PKC during matrix vesicle biogenesisZvi Schwartz
Hebrew University, Jerusalem 91120, Israel
J Biol Chem 277:11828-37. 2002.... - Surface microtopography regulates osteointegration: the role of implant surface microtopography in osteointegrationZvi Schwartz
Hebrew University Hadassah Faculty of Dental Medicine, Jerusalem
Alpha Omegan 98:9-19. 2005..This finding may lead us to a new era in dental implants... - Steroid hormone action in musculoskeletal cells involves membrane receptor and nuclear receptor mechanismsBarbara D Boyan
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Connect Tissue Res 44:130-5. 2003.... - Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1Barbara D Boyan
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 0363, USA
J Bone Miner Res 21:1637-47. 2006..We found that caveolae are required for rapid 1alpha,25(OH)(2)D(3)-dependent PKC signaling, and caveolin-1 must be present based on studies using chondrocytes from Cav-1(-/-) mice... - 1alpha,25(OH)2D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60 activated matrix vesicle metalloproteinasesBarbara D Boyan
Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332 0363, USA
J Steroid Biochem Mol Biol 103:467-72. 2007..However, when MVs are treated with 1alpha,25(OH)(2)D(3), PKCzeta activity is decreased and PKCalpha is unaffected, suggesting a more complex feedback mechanism, potentially involving MV lipid signaling... - Beta-1 integrins mediate substrate dependent effects of 1alpha,25(OH)2D3 on osteoblastsZvi Schwartz
Department of Biomedical Engineering, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA 30332 0363, USA
J Steroid Biochem Mol Biol 103:606-9. 2007..The results also show that beta(1) mediates, in part, the synergistic effects of surface roughness and 1alpha,25(OH)(2)D(3)... - Caveolin-1 knockout mice have increased bone size and stiffnessJanet Rubin
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Bone Miner Res 22:1408-18. 2007..Cell studies showed that cav-1 deficiency leads to increased osteoblast differentiation. These results suggest that cav-1 helps to maintain osteoblast progenitors in a less differentiated state... - Use of growth factors to modify osteoinductivity of demineralized bone allografts: lessons for tissue engineering of boneBarbara D Boyan
Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
Dent Clin North Am 50:217-28, viii. 2006..This article examines the use of growth factors, including platelet-rich plasma, platelet-derived growth factor, enamel matrix derivatives, and BMP-2, to enhance the osteoinductive properties of human DFDBA...