Laurence Boxer

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint How to approach neutropenia
    Laurence A Boxer
    Department of Pediatrics and Communicable Diseases, University of Michigan Health System, Ann Arbor, MI 48109 5718, USA
    Hematology Am Soc Hematol Educ Program 2012:174-82. 2012
  2. ncbi request reprint Strong evidence for autosomal dominant inheritance of severe congenital neutropenia associated with ELA2 mutations
    Laurence A Boxer
    Divison of Pediatric Hematology Oncology, Department of Pediatrics, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan 48109 0238, USA
    J Pediatr 148:633-6. 2006
  3. doi request reprint Congenital neutropenia in a newborn
    K Walkovich
    Department of Pediatrics and Communicable Disease, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5178, USA
    J Perinatol 31:S22-3. 2011
  4. ncbi request reprint Ceramide 1-phosphate, a mediator of phagocytosis
    Vania Hinkovska-Galcheva
    Department of Pediatrics, Division of Hematology Oncology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    J Biol Chem 280:26612-21. 2005
  5. ncbi request reprint Phagocytic signaling molecules in lipid rafts of COS-1 cells transfected with FcgammaRIIA
    Pamela J Mansfield
    Department of Pediatrics, Division of Hematology Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    Biochem Biophys Res Commun 331:132-8. 2005
  6. ncbi request reprint Clinical applications of hematopoietic growth factors in pediatric oncology
    John E Levine
    Division of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, Michigan 48109 0914, USA
    Curr Opin Hematol 9:222-7. 2002
  7. ncbi request reprint Large granular lymphocyte leukemia (LGL) in a child with hyper IgM syndrome and autoimmune hemolytic anemia
    Brenda J Kitchen
    Division of Hematology Oncology, Department of Pediatrics and Communicable Diseases, University of Michigan, Mott Children s Hospital, Ann Arbor, Michigan, USA
    Pediatr Blood Cancer 50:142-5. 2008
  8. ncbi request reprint Combination therapy for refractory idiopathic thrombocytopenic purpura in adolescents
    James A Williams
    University of Michigan Pediatric Hematology Oncology Hospital, Ann Arbor, Michiga 48109 0238, USA
    J Pediatr Hematol Oncol 25:232-5. 2003
  9. ncbi request reprint Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells
    Vania Hinkovska-Galcheva
    Department of Pediatrics, Division of Hematology Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Lipid Res 49:531-42. 2008
  10. ncbi request reprint Rituximab for refractory childhood autoimmune hemolytic anemia
    David G Motto
    Department of Pediatric Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
    Isr Med Assoc J 4:1006-8. 2002

Research Grants

  1. REGULATION OF GRANULOCYTE SECRETION
    Laurence Boxer; Fiscal Year: 1991
  2. REGULATION OF GRANULOCYTE SECRETION
    Laurence Boxer; Fiscal Year: 1993
  3. REGULATION OF POLYMORPHONUCLEAR LEUKOCYTE PHAGOCYTOSIS
    Laurence Boxer; Fiscal Year: 2003

Collaborators

Detail Information

Publications33

  1. doi request reprint How to approach neutropenia
    Laurence A Boxer
    Department of Pediatrics and Communicable Diseases, University of Michigan Health System, Ann Arbor, MI 48109 5718, USA
    Hematology Am Soc Hematol Educ Program 2012:174-82. 2012
    ....
  2. ncbi request reprint Strong evidence for autosomal dominant inheritance of severe congenital neutropenia associated with ELA2 mutations
    Laurence A Boxer
    Divison of Pediatric Hematology Oncology, Department of Pediatrics, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan 48109 0238, USA
    J Pediatr 148:633-6. 2006
    ..To investigate cases of severe congenital neutropenia (SCN) to ascertain SCN inheritance after determining that the same sperm donor was used by 4 different families to impregnate mothers...
  3. doi request reprint Congenital neutropenia in a newborn
    K Walkovich
    Department of Pediatrics and Communicable Disease, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5178, USA
    J Perinatol 31:S22-3. 2011
    ..Prompt identification and treatment of infants with SCN is critical to minimizing morbidity and mortality; as such, a diagnosis of SCN must be considered in all infants with neutropenia even in the absence of infection...
  4. ncbi request reprint Ceramide 1-phosphate, a mediator of phagocytosis
    Vania Hinkovska-Galcheva
    Department of Pediatrics, Division of Hematology Oncology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    J Biol Chem 280:26612-21. 2005
    ..The change in the structural order parameter of the lipid rafts probably contributes to phagocytosis by promoting phagosome formation...
  5. ncbi request reprint Phagocytic signaling molecules in lipid rafts of COS-1 cells transfected with FcgammaRIIA
    Pamela J Mansfield
    Department of Pediatrics, Division of Hematology Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    Biochem Biophys Res Commun 331:132-8. 2005
    ..These results indicate that signaling proteins for phagocytosis are either constitutively present in, or are recruited to, lipid rafts where they are readily available to activate one another...
  6. ncbi request reprint Clinical applications of hematopoietic growth factors in pediatric oncology
    John E Levine
    Division of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, Michigan 48109 0914, USA
    Curr Opin Hematol 9:222-7. 2002
    ....
  7. ncbi request reprint Large granular lymphocyte leukemia (LGL) in a child with hyper IgM syndrome and autoimmune hemolytic anemia
    Brenda J Kitchen
    Division of Hematology Oncology, Department of Pediatrics and Communicable Diseases, University of Michigan, Mott Children s Hospital, Ann Arbor, Michigan, USA
    Pediatr Blood Cancer 50:142-5. 2008
    ..Flow cytometry of the peripheral blood revealed the presence of a marked predominance of cytotoxic T lymphocytes, shown to be clonal, with concomitant natural killer (NK) antigen expression. She responded to weekly methotrexate therapy...
  8. ncbi request reprint Combination therapy for refractory idiopathic thrombocytopenic purpura in adolescents
    James A Williams
    University of Michigan Pediatric Hematology Oncology Hospital, Ann Arbor, Michiga 48109 0238, USA
    J Pediatr Hematol Oncol 25:232-5. 2003
    ..To investigate combined immunosuppressive therapy with vincristine, methylprednisolone, and prolonged cyclosporine in adolescents with refractory idiopathic thrombocytopenic purpura (ITP)...
  9. ncbi request reprint Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells
    Vania Hinkovska-Galcheva
    Department of Pediatrics, Division of Hematology Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Lipid Res 49:531-42. 2008
    ....
  10. ncbi request reprint Rituximab for refractory childhood autoimmune hemolytic anemia
    David G Motto
    Department of Pediatric Hematology Oncology, University of Michigan, Ann Arbor, MI, USA
    Isr Med Assoc J 4:1006-8. 2002
    ..Treatment with high dose steroids, splenectomy and frequent blood transfusions results in a myriad of complications including growth failure, bone demineralization, Cushing's syndrome, immunosuppression, and transfusional hemosiderosis...
  11. pmc Severe congenital neutropenia: genetics and pathogenesis
    Laurence A Boxer
    University of Michigan Hospital, L2110 Women s Hospital, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0238, USA
    Trans Am Clin Climatol Assoc 117:13-31; discussion 31-2. 2006
    ..In an unusual clinical set of studies during which SCN developed in five children from four families impregnated by the same sperm donor, we identified the responsible donor by employing genomic DNA studies...
  12. doi request reprint Introduction of the American Pediatric Society's 2008 John Howland award recipient, Richard B. Johnston Jr, M.D
    Laurence A Boxer
    Department of Pediatrics, University of Michigan, Women s Hospital, Ann Arbor, Michigan 48109, USA
    Pediatr Res 64:317-9. 2008
  13. pmc Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes
    Peter E Newburger
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Blood Cancer 55:314-7. 2010
    ..Mutations of the ELANE gene (the symbol recently replacing ELA2) are considered largely responsible for most cases of CN and SCN, but specific mutations are typically associated with one or the other...
  14. ncbi request reprint Enhanced phagocytosis through inhibition of de novo ceramide synthesis
    Vania Hinkovska-Galcheva
    Department of Pediatrics, Division of Hematology Oncology, University of Michigan, Ann Arbor 48109, USA
    J Biol Chem 278:974-82. 2003
    ..Ceramide formed by de novo synthesis may represent an important mechanism in the regulation of phagocytosis...
  15. ncbi request reprint Neutropenia: causes and consequences
    Laurence Boxer
    Department of Pediatrics, University of Washington, Seattle, WA 98195 6422, USA
    Semin Hematol 39:75-81. 2002
    ..Most severely neutropenic patients have a history of oral ulcers and inflammation and recurrent skin infections. Examination of a bone marrow aspirate and/or biopsy and cytogenetic testing are primary for diagnostic evaluation...
  16. ncbi request reprint A molecular classification of congenital neutropenia syndromes
    Laurence A Boxer
    Division of Pediatric Hematology Oncology, Department of Pediatrics, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan, USA
    Pediatr Blood Cancer 49:609-14. 2007
    ..This review describes and classifies, on a molecular basis, both primary congenital neutropenia and multifaceted syndromes associated with neutropenia...
  17. doi request reprint Role of neutrophils in genetic disorders of phagocyte function leading to IBD
    Laurence A Boxer
    Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan, USA
    J Pediatr Gastroenterol Nutr 46:E17. 2008
  18. ncbi request reprint Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D
    Pamela J Mansfield
    Department of Pediatrics, Division of Hematology Oncology, University of Michigan, Ann Arbor 48109, USA
    Blood 99:1434-41. 2002
    ..Ceramide may affect protein interactions with PLD in the plasma membrane, thereby attenuating PMN activation...
  19. ncbi request reprint Adolescents with cancer: access to clinical trials and age-appropriate care
    Peter E Newburger
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Curr Opin Pediatr 14:1-4. 2002
    ..The challenge before both the medical and pediatric health care communities is to assure adolescent patients the benefits of inclusion in clinical trials and treatment in age-appropriate settings...
  20. ncbi request reprint Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release
    Pamela J Mansfield
    Department of Pediatrics, Division of Hematology Oncology, University of Michigan Ann Arbor, 48109, USA
    J Lab Clin Med 140:9-16. 2002
    ..We conclude that translocation of cytochrome b(558) was responsible for GCSF priming of NADPH oxidase in neutrophils...
  21. ncbi request reprint Neutrophil abnormalities
    Laurence A Boxer
    Pediatric Hematology Oncology, University of Michigan and Women s Hospital, Ann Arbor, MI, USA
    Pediatr Rev 24:52-62. 2003
  22. doi request reprint The American Society of Pediatric Hematology/Oncology distinguished career award goes to Laurence A. Boxer, MD
    Peter E Newburger
    Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Blood Cancer 50:1121-2. 2008
  23. ncbi request reprint Cellular and molecular abnormalities in severe congenital neutropenia predisposing to leukemia
    Andrew A G Aprikyan
    Department of Medicine, University of Washington School of Medicine, Seattle, Wash, USA
    Exp Hematol 31:372-81. 2003
    ..Furthermore, our results suggest that acquired G-CSFR mutations may initiate signaling events that override the pro-apoptotic effect of mutant NE in primitive progenitor cells, resulting in an expansion of the abnormal AML clone...
  24. ncbi request reprint Recruitment and development of academic pediatricians: departmental commitments to promote success
    Alan H Jobe
    Division of Pulmonary Biology, Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 51:662-4. 2002
  25. pmc Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene
    Arati Khanna-Gupta
    Section of Hematology, Yale University School of Medicine, New Haven, CT 06510, USA
    Blood 109:4181-90. 2007
    ..We hypothesize that decreased Gfi-1 levels in our SGD patient, together with the mutant C/EBPepsilon, block SGP expression, thereby contributing to the underlying etiology of the disease in our patient...
  26. ncbi request reprint Mutant elastase in pathogenesis of cyclic and severe congenital neutropenia
    Andrew A G Aprikyan
    Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 6422, USA
    J Pediatr Hematol Oncol 24:784-6. 2002
    ..We hypothesize that abnormal processing and subcellular localization of mutant NE might predetermine the etiology of cyclic or severe congenital neutropenia...
  27. ncbi request reprint Who will care for tomorrow's children with benign hematological conditions?
    Max J Coppes
    Center for Cancer and Blood Disorders, Children s National Medical Center, and George Washington University, Washington, District of Columbia, USA
    Pediatr Blood Cancer 49:224. 2007
  28. ncbi request reprint Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry
    David C Dale
    Department of Medicine, Box 356422, University of Washington, Seattle, WA 98195, USA
    Am J Hematol 72:82-93. 2003
    ..The risk of leukemia, osteoporosis, other potentially adverse events, and pregnancy outcome need to be further evaluated with continuing long-term observations...
  29. pmc Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia
    Daniel C Link
    Division of Oncology, Department of Medicine, Washington University, St Louis, MO 63110, USA
    Blood 110:1648-55. 2007
    ..These data support the hypothesis that mutations of CSF3R may provide the "activated tyrosine kinase signal" that is thought to be important for leukemogenesis...
  30. pmc Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Br J Haematol 140:210-3. 2008
    ..96). Patients with either mutant or wild-type ELA2 should be followed closely for leukaemic transformation...
  31. pmc Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis
    David S Grenda
    Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 110:4179-87. 2007
    ..Collectively, these data provide strong support for a UPR model of SCN disease pathogenesis and place SCN in a growing list of human diseases caused by misfolded proteins...
  32. ncbi request reprint Chemotaxis of non-compressed blood polymorphonuclear leukocytes from an adolescent with severe leukocyte adhesion deficiency
    Stephen E Malawista
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Hematol 73:115-20. 2003
    ..These findings indicate that not all patients with severe LAD are candidates for early bone marrow transplantation...
  33. pmc The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy
    Philip S Rosenberg
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7244, USA
    Blood 107:4628-35. 2006
    ..Risk of MDS/AML may be similar in SDS and SCN. In less-responsive SCN patients, early hematopoietic stem cell transplantation may be a rational option...

Research Grants21

  1. REGULATION OF GRANULOCYTE SECRETION
    Laurence Boxer; Fiscal Year: 1991
    ..We will also examine by pulse-chase experiments the synthesis of adhesive glycoproteins and their accumulation on the plasma membrane of normal and deficient canine monocytes...
  2. REGULATION OF GRANULOCYTE SECRETION
    Laurence Boxer; Fiscal Year: 1993
    ..They will provide further biochemical understanding of the factors regulating exocytosis of SG. The knowledge of both oxidative metabolism and degranulation in PMN should lead to novel therapeutic approaches to chronic inflammation...
  3. REGULATION OF POLYMORPHONUCLEAR LEUKOCYTE PHAGOCYTOSIS
    Laurence Boxer; Fiscal Year: 2003
    ..Specific AIM 3 will examine the cellular targets of ceramide and sphingosine actin during PMN phagocytosis, focusing primarily on activation of mitogen-activated kinase (MAPK), Raf kinase and how they are linked to phagosome generation. ..