Research Topics
Genomes and GenesSpecies | DOUGLAS BOWLESSummaryAffiliation: University of Missouri Country: USA Publications
Research Grants
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Publications
Differential effects of androgens on coronary blood flow regulation and arteriolar diameter in intact and castrated swineErin K O'Connor
Department of Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA
Biol Sex Differ 3:10. 2012..abstract:..
PKCdelta mediates anti-proliferative, pro-apoptic effects of testosterone on coronary smooth muscleD K Bowles
Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
Am J Physiol Cell Physiol 293:C805-13. 2007..These findings demonstrate that the anti-proliferative, pro-apoptotic effects of testosterone on CSMCs are substantially mediated by PKCdelta...- Coronary smooth muscle and endothelial adaptations to exercise trainingD K Bowles
Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211, USA
Exerc Sport Sci Rev 28:57-62. 2000..Exercise training also increases the ability of the endothelium to release vasoactive factors, with increased expression and activity of endothelial cell nitric oxide synthase playing a key role... - Endogenous testosterone increases L-type Ca2+ channel expression in porcine coronary smooth muscleD K Bowles
E102 Veterinary Medicine, Univ of Missouri, Columbia, MO 65211, USA
Am J Physiol Heart Circ Physiol 287:H2091-8. 2004..2 expression. Furthermore, this effect was blocked by the androgen receptor antagonist cyproterone. We conclude that endogenous testosterone is a primary regulator of Cav1.2 expression and activity in coronary arteries of males... - Hypercholesterolemia inhibits L-type calcium current in coronary macro-, not microcirculationD K Bowles
Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
J Appl Physiol 96:2240-8. 2004..The inhibition of calcium channel activity in CASM of large coronary arteries is likely due to increases in membrane free cholesterol... - Gender influences coronary L-type Ca(2+) current and adaptation to exercise training in miniature swineD K Bowles
Department of Veterinary Medical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
J Appl Physiol 91:2503-10. 2001..61 +/- 0.50 and -12.04 +/- 1.07 pA/pF, respectively). Thus gender plays a significant role in determining both the magnitude and voltage dependence of I(Ca) in CSM and the adaptive response of I(Ca) to endurance training... - Hydrogen peroxide activates Na(+)-dependent Ca(2+) influx in coronary endothelial cellsD K Bowles
Vascular Biology Laboratory, University of Missouri, Columbia, Missouri 65211, USA
Biochem Biophys Res Commun 287:1134-9. 2001..Thus, in coronary arterial endothelial cells, H(2)O(2) increases Ca(2+) influx in an extracellular Na(+)-dependent manner via an agonist-insensitive pathway... - Gender-specific K(+)-channel contribution to adenosine-induced relaxation in coronary arteriolesCristine L Heaps
Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211, USA
J Appl Physiol 92:550-8. 2002..These data are consistent with a significant role for voltage-dependent K(+) channels in adenosine-mediated relaxation of coronary arterioles from males... - Endothelium-dependent and -independent relaxation in the forelimb and hindlimb vasculatures of swineSean C Newcomer
Department of Biomedical Science, University of Missouri, Columbia, Missouri, United States
Comp Biochem Physiol A Mol Integr Physiol 148:292-300. 2007..The current results of this investigation suggest that the forelimb and hindlimb vasculatures of swine have relatively similar vasorelaxation responses to both endothelium-dependent and -independent vasodilators... - PKCdelta mediates testosterone-induced increases in coronary smooth muscle Cav1.2Kamala K Maddali
Department of Biomedical Sciences, Dalton Cardiovascular Research Center, National Center for Gender Physiology, University of Missouri, Columbia, Missouri 65211, USA
J Biol Chem 280:43024-9. 2005..These results demonstrate for the first time that 1) endogenous T is a primary modulator of coronary PKCdelta protein and activity in males and 2) T increases Cav1.2 protein expression in a PKCdelta-dependent manner... - C-reactive protein correlates with macrophage accumulation in coronary arteries of hypercholesterolemic pigsJames R Turk
Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
J Appl Physiol 95:1301-4. 2003..727, P = 0.041) and accumulation of SRA-positive macrophages (R = 0.938, P < 0.001) in RCA of HF pigs. We conclude that serum CRP correlates with macrophage accumulation and coronary artery disease in hypercholesterolemic pigs... - Store-operated Ca(2+) entry is not essential for PDGF-BB induced phenotype modulation in rat aortic smooth muscleCraig A Emter
Department of Biomedical Science, University of Missouri Columbia, 1600 E Rollins, W160 Veterinary Medicine, Columbia, MO 65211, United States
Cell Calcium 48:10-8. 2010..Our results indicate SOCE is not required for PDGF-BB induced phenotype modulation in rat aortic SMCs. Rather, we implicate a novel BEL-sensitive mechanism which regulates both SOCE and phenotype modulation, independently... - Altered calcium sensitivity contributes to enhanced contractility of collateral-dependent coronary arteriesCristine L Heaps
Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
J Appl Physiol 97:310-6. 2004..Unaltered Ca(2+) sensitivity in endothelin-stimulated arteries suggests more than one mechanism regulating Ca(2+) sensitization in coronary smooth muscle... - Nonuniform changes in arteriolar myogenic tone within skeletal muscle following hindlimb unweightingCristine L Heaps
Department of Veterinary Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211, USA
J Appl Physiol 92:1145-51. 2002..Furthermore, alterations in myogenic responses were not attributable to altered VGCC density... - Exercise training decreases the size and alters the composition of the neointima in a porcine model of percutaneous transluminal coronary angioplasty (PTCA)Bradley S Fleenor
Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
J Appl Physiol 107:937-45. 2009..9%) and fibronectin was decreased (-7.9%) in the NI of both vessels (P < 0.05). In conclusion, EX following PTCA may increase event-free survival rates following PTCA by decreasing lesion size and altering ECM composition... - Endogenous testosterone attenuates neointima formation after moderate coronary balloon injury in male swineDarla L Tharp
Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
Cardiovasc Res 82:152-60. 2009..The purpose of the present study was to determine whether endogenous testosterone limits coronary neointima (NI) formation in a porcine model of post-angioplasty restenosis... - Insulin-like growth factor-induced transcriptional activity of the skeletal alpha-actin gene is regulated by signaling mechanisms linked to voltage-gated calcium channels during myoblast differentiationEspen E Spangenburg
Department of Biomedical Sciences, University of Missouri, Columbia 65211, USA
Endocrinology 145:2054-63. 2004.... - Negligible contribution of coronary adventitial fibroblasts to neointimal formation following balloon angioplasty in swineBradley S Fleenor
Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
Am J Physiol Heart Circ Physiol 296:H1532-9. 2009.... - Assessment of contractility of purified smooth muscle cells derived from embryonic stem cellsSanjay Sinha
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, 22908-0736, USA
Stem Cells 24:1678-88. 2006.... - Exercise and hypercholesterolemia produce disparate shifts in coronary PKC expressionDonna H Korzick
Noll Physiological Research Center, Intercollege Program in Physiology, The Penn State University, University Park, PA 16802, USA
Med Sci Sports Exerc 37:381-8. 2005..Thus, diet and physical inactivity may increase CHD risk by altering coronary protein kinase C (PKC) isoform profiles... - Excitation-transcription coupling in arterial smooth muscleBrian R Wamhoff
Biomedical Sciences, Veterinary School of Medicine, University of Missouri, Columbia, MO, USA
Circ Res 98:868-78. 2006..In addition, we discuss the potential role of IK channels and TRPC in ET-coupling as potential mediators of SMC phenotypic modulation, ie, negatively regulate SMC differentiation marker genes, in vascular disease... - Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase CDonna H Korzick
Department of Kinesiology, The Pennsylvania State University, 106 Noll Laboratory, University Park, PA 16802, USA
Cardiovasc Res 66:384-92. 2005..Our aim was to determine the role of endothelin-1 (ET-1) on enhanced constrictor responses in aged coronary arteries (CAs) and whether protein kinase C (PKC) signaling mechanisms impact ET-1 responses...
Research Grants
- EXERCISE AND CORONARY ADENOSINE ACTIVATED K CURRENTSDOUGLAS BOWLES; Fiscal Year: 2002....
- Coronary ion channels, gender and vasoreactivityDOUGLAS BOWLES; Fiscal Year: 2007..The goal of this research is to determine gender-related cellular and molecular differences in CSM as they relate to gender differences in propensity for coronary disease. ..
- Coronary ion channels, gender and vasoreactivityDOUGLAS BOWLES; Fiscal Year: 2007..The goal of this research is to determine gender-related cellular and molecular differences in CSM as they relate to gender differences in propensity for coronary disease. ..