DOUGLAS BOWLES

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. pmc Differential effects of androgens on coronary blood flow regulation and arteriolar diameter in intact and castrated swine
    Erin K O'Connor
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA
    Biol Sex Differ 3:10. 2012
  2. ncbi request reprint PKCdelta mediates anti-proliferative, pro-apoptic effects of testosterone on coronary smooth muscle
    D K Bowles
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Am J Physiol Cell Physiol 293:C805-13. 2007
  3. ncbi request reprint Coronary smooth muscle and endothelial adaptations to exercise training
    D K Bowles
    Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211, USA
    Exerc Sport Sci Rev 28:57-62. 2000
  4. ncbi request reprint Endogenous testosterone increases L-type Ca2+ channel expression in porcine coronary smooth muscle
    D K Bowles
    E102 Veterinary Medicine, Univ of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 287:H2091-8. 2004
  5. ncbi request reprint Hypercholesterolemia inhibits L-type calcium current in coronary macro-, not microcirculation
    D K Bowles
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 96:2240-8. 2004
  6. ncbi request reprint Gender influences coronary L-type Ca(2+) current and adaptation to exercise training in miniature swine
    D K Bowles
    Department of Veterinary Medical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 91:2503-10. 2001
  7. ncbi request reprint Hydrogen peroxide activates Na(+)-dependent Ca(2+) influx in coronary endothelial cells
    D K Bowles
    Vascular Biology Laboratory, University of Missouri, Columbia, Missouri 65211, USA
    Biochem Biophys Res Commun 287:1134-9. 2001
  8. ncbi request reprint Gender-specific K(+)-channel contribution to adenosine-induced relaxation in coronary arterioles
    Cristine L Heaps
    Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211, USA
    J Appl Physiol 92:550-8. 2002
  9. ncbi request reprint Endothelium-dependent and -independent relaxation in the forelimb and hindlimb vasculatures of swine
    Sean C Newcomer
    Department of Biomedical Science, University of Missouri, Columbia, Missouri, United States
    Comp Biochem Physiol A Mol Integr Physiol 148:292-300. 2007
  10. ncbi request reprint PKCdelta mediates testosterone-induced increases in coronary smooth muscle Cav1.2
    Kamala K Maddali
    Department of Biomedical Sciences, Dalton Cardiovascular Research Center, National Center for Gender Physiology, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 280:43024-9. 2005

Research Grants

  1. EXERCISE AND CORONARY ADENOSINE ACTIVATED K CURRENTS
    DOUGLAS BOWLES; Fiscal Year: 2002
  2. Coronary ion channels, gender and vasoreactivity
    DOUGLAS BOWLES; Fiscal Year: 2007
  3. Coronary ion channels, gender and vasoreactivity
    DOUGLAS BOWLES; Fiscal Year: 2007

Collaborators

Detail Information

Publications22

  1. pmc Differential effects of androgens on coronary blood flow regulation and arteriolar diameter in intact and castrated swine
    Erin K O'Connor
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, 65211, USA
    Biol Sex Differ 3:10. 2012
    ..abstract:..
  2. ncbi request reprint PKCdelta mediates anti-proliferative, pro-apoptic effects of testosterone on coronary smooth muscle
    D K Bowles
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Am J Physiol Cell Physiol 293:C805-13. 2007
    ..These findings demonstrate that the anti-proliferative, pro-apoptotic effects of testosterone on CSMCs are substantially mediated by PKCdelta...
  3. ncbi request reprint Coronary smooth muscle and endothelial adaptations to exercise training
    D K Bowles
    Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211, USA
    Exerc Sport Sci Rev 28:57-62. 2000
    ..Exercise training also increases the ability of the endothelium to release vasoactive factors, with increased expression and activity of endothelial cell nitric oxide synthase playing a key role...
  4. ncbi request reprint Endogenous testosterone increases L-type Ca2+ channel expression in porcine coronary smooth muscle
    D K Bowles
    E102 Veterinary Medicine, Univ of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 287:H2091-8. 2004
    ..2 expression. Furthermore, this effect was blocked by the androgen receptor antagonist cyproterone. We conclude that endogenous testosterone is a primary regulator of Cav1.2 expression and activity in coronary arteries of males...
  5. ncbi request reprint Hypercholesterolemia inhibits L-type calcium current in coronary macro-, not microcirculation
    D K Bowles
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 96:2240-8. 2004
    ..The inhibition of calcium channel activity in CASM of large coronary arteries is likely due to increases in membrane free cholesterol...
  6. ncbi request reprint Gender influences coronary L-type Ca(2+) current and adaptation to exercise training in miniature swine
    D K Bowles
    Department of Veterinary Medical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 91:2503-10. 2001
    ..61 +/- 0.50 and -12.04 +/- 1.07 pA/pF, respectively). Thus gender plays a significant role in determining both the magnitude and voltage dependence of I(Ca) in CSM and the adaptive response of I(Ca) to endurance training...
  7. ncbi request reprint Hydrogen peroxide activates Na(+)-dependent Ca(2+) influx in coronary endothelial cells
    D K Bowles
    Vascular Biology Laboratory, University of Missouri, Columbia, Missouri 65211, USA
    Biochem Biophys Res Commun 287:1134-9. 2001
    ..Thus, in coronary arterial endothelial cells, H(2)O(2) increases Ca(2+) influx in an extracellular Na(+)-dependent manner via an agonist-insensitive pathway...
  8. ncbi request reprint Gender-specific K(+)-channel contribution to adenosine-induced relaxation in coronary arterioles
    Cristine L Heaps
    Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211, USA
    J Appl Physiol 92:550-8. 2002
    ..These data are consistent with a significant role for voltage-dependent K(+) channels in adenosine-mediated relaxation of coronary arterioles from males...
  9. ncbi request reprint Endothelium-dependent and -independent relaxation in the forelimb and hindlimb vasculatures of swine
    Sean C Newcomer
    Department of Biomedical Science, University of Missouri, Columbia, Missouri, United States
    Comp Biochem Physiol A Mol Integr Physiol 148:292-300. 2007
    ..The current results of this investigation suggest that the forelimb and hindlimb vasculatures of swine have relatively similar vasorelaxation responses to both endothelium-dependent and -independent vasodilators...
  10. ncbi request reprint PKCdelta mediates testosterone-induced increases in coronary smooth muscle Cav1.2
    Kamala K Maddali
    Department of Biomedical Sciences, Dalton Cardiovascular Research Center, National Center for Gender Physiology, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 280:43024-9. 2005
    ..These results demonstrate for the first time that 1) endogenous T is a primary modulator of coronary PKCdelta protein and activity in males and 2) T increases Cav1.2 protein expression in a PKCdelta-dependent manner...
  11. ncbi request reprint C-reactive protein correlates with macrophage accumulation in coronary arteries of hypercholesterolemic pigs
    James R Turk
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 95:1301-4. 2003
    ..727, P = 0.041) and accumulation of SRA-positive macrophages (R = 0.938, P < 0.001) in RCA of HF pigs. We conclude that serum CRP correlates with macrophage accumulation and coronary artery disease in hypercholesterolemic pigs...
  12. pmc Store-operated Ca(2+) entry is not essential for PDGF-BB induced phenotype modulation in rat aortic smooth muscle
    Craig A Emter
    Department of Biomedical Science, University of Missouri Columbia, 1600 E Rollins, W160 Veterinary Medicine, Columbia, MO 65211, United States
    Cell Calcium 48:10-8. 2010
    ..Our results indicate SOCE is not required for PDGF-BB induced phenotype modulation in rat aortic SMCs. Rather, we implicate a novel BEL-sensitive mechanism which regulates both SOCE and phenotype modulation, independently...
  13. pmc Altered calcium sensitivity contributes to enhanced contractility of collateral-dependent coronary arteries
    Cristine L Heaps
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 97:310-6. 2004
    ..Unaltered Ca(2+) sensitivity in endothelin-stimulated arteries suggests more than one mechanism regulating Ca(2+) sensitization in coronary smooth muscle...
  14. ncbi request reprint Nonuniform changes in arteriolar myogenic tone within skeletal muscle following hindlimb unweighting
    Cristine L Heaps
    Department of Veterinary Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211, USA
    J Appl Physiol 92:1145-51. 2002
    ..Furthermore, alterations in myogenic responses were not attributable to altered VGCC density...
  15. pmc Exercise training decreases the size and alters the composition of the neointima in a porcine model of percutaneous transluminal coronary angioplasty (PTCA)
    Bradley S Fleenor
    Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    J Appl Physiol 107:937-45. 2009
    ..9%) and fibronectin was decreased (-7.9%) in the NI of both vessels (P < 0.05). In conclusion, EX following PTCA may increase event-free survival rates following PTCA by decreasing lesion size and altering ECM composition...
  16. pmc Endogenous testosterone attenuates neointima formation after moderate coronary balloon injury in male swine
    Darla L Tharp
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Cardiovasc Res 82:152-60. 2009
    ..The purpose of the present study was to determine whether endogenous testosterone limits coronary neointima (NI) formation in a porcine model of post-angioplasty restenosis...
  17. ncbi request reprint Insulin-like growth factor-induced transcriptional activity of the skeletal alpha-actin gene is regulated by signaling mechanisms linked to voltage-gated calcium channels during myoblast differentiation
    Espen E Spangenburg
    Department of Biomedical Sciences, University of Missouri, Columbia 65211, USA
    Endocrinology 145:2054-63. 2004
    ....
  18. pmc Negligible contribution of coronary adventitial fibroblasts to neointimal formation following balloon angioplasty in swine
    Bradley S Fleenor
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 296:H1532-9. 2009
    ....
  19. ncbi request reprint Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells
    Sanjay Sinha
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, 22908 0736, USA
    Stem Cells 24:1678-88. 2006
    ....
  20. ncbi request reprint Exercise and hypercholesterolemia produce disparate shifts in coronary PKC expression
    Donna H Korzick
    Noll Physiological Research Center, Intercollege Program in Physiology, The Penn State University, University Park, PA 16802, USA
    Med Sci Sports Exerc 37:381-8. 2005
    ..Thus, diet and physical inactivity may increase CHD risk by altering coronary protein kinase C (PKC) isoform profiles...
  21. ncbi request reprint Excitation-transcription coupling in arterial smooth muscle
    Brian R Wamhoff
    Biomedical Sciences, Veterinary School of Medicine, University of Missouri, Columbia, MO, USA
    Circ Res 98:868-78. 2006
    ..In addition, we discuss the potential role of IK channels and TRPC in ET-coupling as potential mediators of SMC phenotypic modulation, ie, negatively regulate SMC differentiation marker genes, in vascular disease...
  22. ncbi request reprint Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C
    Donna H Korzick
    Department of Kinesiology, The Pennsylvania State University, 106 Noll Laboratory, University Park, PA 16802, USA
    Cardiovasc Res 66:384-92. 2005
    ..Our aim was to determine the role of endothelin-1 (ET-1) on enhanced constrictor responses in aged coronary arteries (CAs) and whether protein kinase C (PKC) signaling mechanisms impact ET-1 responses...

Research Grants8

  1. EXERCISE AND CORONARY ADENOSINE ACTIVATED K CURRENTS
    DOUGLAS BOWLES; Fiscal Year: 2002
    ....
  2. Coronary ion channels, gender and vasoreactivity
    DOUGLAS BOWLES; Fiscal Year: 2007
    ..The goal of this research is to determine gender-related cellular and molecular differences in CSM as they relate to gender differences in propensity for coronary disease. ..
  3. Coronary ion channels, gender and vasoreactivity
    DOUGLAS BOWLES; Fiscal Year: 2007
    ..The goal of this research is to determine gender-related cellular and molecular differences in CSM as they relate to gender differences in propensity for coronary disease. ..