William J Bowers

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain
    Sara L Montgomery
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY14642, USA
    Am J Pathol 179:2053-70. 2011
  2. pmc Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice
    MICHELLE C JANELSINS
    Department of Microbiology and Immunology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Pathol 173:1768-82. 2008
  3. pmc Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform
    Suresh de Silva
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Gene Ther 21:1615-22. 2010
  4. pmc Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target
    Maya K Desai
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, USA
    Am J Pathol 177:1422-35. 2010
  5. pmc Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease
    Kelly L Sudol
    Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Ther 17:2031-40. 2009
  6. pmc Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies
    Sara L Montgomery
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Pathol 182:2285-97. 2013
  7. pmc Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice
    Michael A Mastrangelo
    Center for Neural Development and Disease, University of Rochester Medical Center, NY 14642, USA
    Am J Pathol 175:2076-88. 2009
  8. pmc Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology
    Maya K Desai
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Glia 57:54-65. 2009
  9. pmc Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo
    Suresh de Silva
    Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Gene Ther 21:1603-13. 2010
  10. pmc Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0
    Clark A Burris
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Gene Med 10:152-64. 2008

Collaborators

Detail Information

Publications62

  1. pmc Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain
    Sara L Montgomery
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY14642, USA
    Am J Pathol 179:2053-70. 2011
    ..Overall, our results demonstrate that globally ablated TNF receptor signaling exacerbates pathogenesis and argues against long-term use of pan-anti-TNF-α inhibitors for the treatment of AD...
  2. pmc Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice
    MICHELLE C JANELSINS
    Department of Microbiology and Immunology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Pathol 173:1768-82. 2008
    ..Results presented here suggest that chronic neuronal TNF-alpha expression promotes inflammation and, ultimately, neuronal cell death in this AD mouse model, advocating the development of TNF-alpha-specific agents to subvert AD...
  3. pmc Virion-associated cofactor high-mobility group DNA-binding protein-1 facilitates transposition from the herpes simplex virus/Sleeping Beauty amplicon vector platform
    Suresh de Silva
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Gene Ther 21:1615-22. 2010
    ..As a result, HSV/SB amplicon virions arrive prearmed with HMGB1 protein at levels sufficient for facilitating SB-mediated transposition in the transduced mammalian cell...
  4. pmc Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target
    Maya K Desai
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, USA
    Am J Pathol 177:1422-35. 2010
    ....
  5. pmc Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease
    Kelly L Sudol
    Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
    Mol Ther 17:2031-40. 2009
    ..This approach may provide insights into the functional relevance of intraneuronal A beta accumulation in early AD and potentially lead to the development of new therapeutics...
  6. pmc Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies
    Sara L Montgomery
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Pathol 182:2285-97. 2013
    ..In aggregate, these data further support the development of cell-, stage-, and/or receptor-specific anti-TNF-α therapeutics for AD...
  7. pmc Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice
    Michael A Mastrangelo
    Center for Neural Development and Disease, University of Rochester Medical Center, NY 14642, USA
    Am J Pathol 175:2076-88. 2009
    ..Gaining an understanding as to how these apparently divergent functions are interrelated and controlled could elucidate new therapeutic strategies designed to harness the neuroprotective activity of IFNgamma...
  8. pmc Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology
    Maya K Desai
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Glia 57:54-65. 2009
    ....
  9. pmc Herpes simplex virus/Sleeping Beauty vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo
    Suresh de Silva
    Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Gene Ther 21:1603-13. 2010
    ....
  10. pmc Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0
    Clark A Burris
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Gene Med 10:152-64. 2008
    ....
  11. pmc Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice
    Deborah A Ryan
    Interdepartmental Graduate Program in Neuroscience, University of Rochester Medical Center, Rochester, NY, USA
    Mol Ther 18:1471-81. 2010
    ..These results underscore the potential of gene-based passive vaccination for AD, and provide further rationale for the development of Abeta-targeting strategies for this debilitating disease...
  12. pmc Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor
    KEIGAN M PARK
    Center for Neural Development and Disease, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:33069-79. 2008
    ....
  13. pmc An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies
    Deborah A Ryan
    Interdepartmental Graduate Program in Neuroscience, Rochester, NY 14642, USA
    J Neurosci Methods 190:171-9. 2010
    ..These synthetic preparations should prove valuable to many studying Abeta-mediated mechanisms underlying AD...
  14. pmc Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4
    Maria E Frazer
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Ther 16:845-53. 2008
    ..Our study underscores the potential of Abeta immunotherapy for AD and highlights the potency of amplicons in facilitating the immune response modulation to a disease-relevant antigen...
  15. ncbi request reprint Targeting the central nervous system with herpes simplex virus / Sleeping Beauty hybrid amplicon vectors
    Suresh de Silva
    Department of Neurology, Center for Neural Development and Disease, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642 USA
    Curr Gene Ther 11:332-40. 2011
    ..In this review we provide a comprehensive breakdown of the characteristics of the HSV/SB vector system and how it can be efficiently employed in the derivation of CNS-targeted gene therapeutic strategies...
  16. pmc HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime
    Cindy M P Duke
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Vaccine 25:7410-21. 2007
    ..This suggests that initial priming can shape immune response quality after a boost. Overall, these findings provide insight into effective vector combinations for HIV-1 vaccine development...
  17. pmc Effects of herpes simplex virus amplicon transduction on murine dendritic cells
    Yahui Grace Chiu
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Gene Ther 20:442-52. 2009
    ....
  18. pmc Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging
    Kathlyn Santos
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    J Virol Methods 145:37-46. 2007
    ....
  19. pmc An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction
    Maya K Desai
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Glia 59:627-40. 2011
    ....
  20. pmc Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice
    Michael A Mastrangelo
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    BMC Neurosci 9:81. 2008
    ....
  21. pmc Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons
    KEIGAN M PARK
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Signal 22:519-26. 2010
    ....
  22. pmc Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction
    KEIGAN M PARK
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Signal 22:977-83. 2010
    ..This review will summarize the key events that lead to TNF-alpha elaboration in the CNS, and the effects that these inflammatory signals impart on neuronal signaling in the context of homeostasis and neuropathology...
  23. pmc Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition
    Elise B Peterson
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Ther 15:1848-55. 2007
    ....
  24. pmc Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier
    William Domm
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14627, USA
    Vaccine 29:7080-9. 2011
    ..Overall, these findings support the further exploration of the SL delivery route for HIV-1 vaccine delivery...
  25. pmc Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter
    KEIGAN M PARK
    Department of Neurology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 284:27557-66. 2009
    ..Overall, these data delineate a key pathway by which TNF-alpha in a neuronal environment modulates IP(3)R expression and intracellular Ca(2+) homeostasis...
  26. ncbi request reprint Imaging CD8+ T cell dynamics in vivo using a transgenic luciferase reporter
    Mitra Azadniv
    David H Smith Center for Microbiology and Immunology, Aab Institute for Biomedical Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Int Immunol 19:1165-73. 2007
    ....
  27. pmc Genetic therapy for the nervous system
    William J Bowers
    Department of Neurology, Center for Neural Development and Disease, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Mol Genet 20:R28-41. 2011
    ..These versatile new tools for manipulation of genetic elements provide the ability to tailor the mode of genetic intervention to specific aspects of a disease state...
  28. pmc CD4+ T cell effects on CD8+ T cell location defined using bioluminescence
    Mitra Azadniv
    David H Smith Center for Microbiology and Immunology, Aab Institute for Biomedical Research, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 6:e16222. 2011
    ..Based on these results, we propose the model that one of the functions of CD4+ T cell "help" is to program the homing potential of CD8+ T cells...
  29. doi request reprint Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system
    Sara L Montgomery
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Neuroimmune Pharmacol 7:42-59. 2012
    ....
  30. pmc Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
    Byoung Dae Lee
    Neuroregeneration Program, Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:998-1000. 2010
    ..These results establish that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for the treatment of Parkinson's disease...
  31. pmc Immune shaping and the development of Alzheimer's disease vaccines
    Howard J Federoff
    Department of Neurology, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Aging Knowledge Environ 2005:pe35. 2005
    ....
  32. ncbi request reprint Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector
    William J Bowers
    Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 645, Rochester, NY 14642, USA
    Mol Ther 13:580-8. 2006
    ....
  33. ncbi request reprint Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system
    Stephanos Kyrkanides
    Department of Dentistry, Rochester, New York 14620, USA
    Mol Ther 8:790-5. 2003
    ....
  34. ncbi request reprint Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS
    John A Olschowka
    Departments of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Ther 7:218-27. 2003
    ....
  35. pmc Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4
    Simona Bancos
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642USA
    Cell Immunol 257:44-54. 2009
    ..These findings demonstrate that the cell cycle repressor E2F4 is essential for the formation of functional memory T cells. A decrease in CD8+ T-lymphocyte compartment would diminish our capacity to control viral infections...
  36. ncbi request reprint Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors
    Kathlyn Santos
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Hum Gene Ther 18:93-105. 2007
    ..From this and previous work, we conclude that amplicons may engender a potent immune response by directly transducing dendritic cells as well as by cross-priming of antigen produced by other transduced host cells...
  37. ncbi request reprint HSV amplicons: neuro applications
    Carolyn M Tyler
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Gene Ther 6:337-50. 2006
    ..This discourse highlights the successes and challenges encountered using HSV amplicon vectors as tools for the dissection of neural network function and as therapeutics directed against a variety of neurologic disorders...
  38. ncbi request reprint HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses
    William J Bowers
    Department of Neurology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Neurobiol Aging 26:393-407. 2005
    ....
  39. ncbi request reprint Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing
    Jennifer E Snyder
    David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, New York, USA
    Nat Med 9:231-5. 2003
    ..The simultaneous enumeration of cytokine-secreting and cytotoxic cells should be invaluable for ex vivo analysis of immune responses during infection and autoimmunity...
  40. ncbi request reprint HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia
    Khaled A Tolba
    James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Ther 6:455-63. 2002
    ..In aggregate, these data suggest that hf-HSV-LIGHT transduction may be useful for induction of immune responses to CLL and other B-cell lymphoid malignancies...
  41. pmc Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses
    Peter K Hocknell
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Virol 76:5565-80. 2002
    ..Taken together, these data strongly support the use of helper-free HSV-1 amplicon particles as vaccine delivery vectors...
  42. ncbi request reprint Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea
    William J Bowers
    Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8629, USA
    Mol Ther 6:12-8. 2002
    ..The potency of NT-3 in SGN neuroprotection suggests that in vivo neurotrophin-based gene therapy is a promising preventative treatment for chemical-induced hearing disorders, and potentially for hearing degeneration due to normal aging...
  43. ncbi request reprint Reporter gene transfer induces apoptosis in primary cortical neurons
    Eric R Detrait
    Center for Aging and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York 14642, USA
    Mol Ther 5:723-30. 2002
    ..This work underscores the need for careful design of gene expression constructs. Moreover, in studies where cell injury or toxicity is being evaluated, their use should be carefully considered...
  44. ncbi request reprint Amyloid immunotherapy-engendered CNS inflammation
    William J Bowers
    Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Neurobiol Aging 23:675-6; discussion 683-4. 2002
  45. ncbi request reprint p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity
    Yan Zhang
    Department of Neurology and Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 23:7385-94. 2003
    ..Neuroprotection against Abeta is phosphatidylinositide 3-kinase dependent but Akt independent. These results are consistent with a neuroprotective role for p75NTR against extracellular Abeta toxicity in human neurons...
  46. ncbi request reprint Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming
    Xiuqing Wang
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Vaccine 21:2288-97. 2003
    ..Collectively, these results demonstrate the utility of HSV amplicon vectors in prime-boost regimens for HIV vaccine development...
  47. ncbi request reprint Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity
    Khaled A Tolba
    James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Cancer Res 62:6545-51. 2002
    ....
  48. ncbi request reprint Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle
    Issam A Halaby
    Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Ther 5:300-6. 2002
    ..This new iteration of VEGF gene delivery provides for fine-tuned angiogenic factor-based therapy for tissues requiring neovascularization...
  49. ncbi request reprint Somatic mosaic approaches and the aging brain
    Kathleen A Maguire-Zeiss
    Department of Neurology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Neurobiol Aging 23:977-84. 2002
    ..We will also highlight potential uses for this approach in Alzheimer's disease, a complex pathophysiological state involving changes in many cellular pathways...
  50. ncbi request reprint Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo
    Kyung H Yi
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, and University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    Cancer Res 67:10027-37. 2007
    ..Tumor-specific T cells stimulated ex vivo using tumor transduced with HSV.4-1BBL expand in vivo following adoptive transfer, resulting in tumor eradication and the generation of tumor-specific CD44+Ly-6C+CD62L- effector memory T cells...
  51. pmc Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag
    Kathlyn Santos
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States
    Vaccine 25:1634-46. 2007
    ..These findings may have implications for the generation of improved HSV-1 amplicon vectors for HIV-1 vaccine delivery...
  52. ncbi request reprint Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine
    Thomas D Corso
    Molecular and Structural Neurobiology and Gene Therapy Program, University at Buffalo, SUNY, Buffalo, NY 14260, USA
    Brain Res Mol Brain Res 139:361-6. 2005
    ..Thus, we conclude that reduced FGF signaling in the SN of Parkinsonian patients could play a role in the impaired dopaminergic transmission associated with the degenerative disease...
  53. ncbi request reprint Assessment of viral and non-viral gene transfer into adult rat brains using HSV-1, calcium phosphate and PEI-based methods
    Thomas D Corso
    Molecular and Structural Neurobiology and Gene Therapy Program, SUNY, University at Buffalo, Buffalo, NY 14214, USA
    Folia Morphol (Warsz) 64:130-44. 2005
    ....
  54. ncbi request reprint Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat
    Victor L Arvanian
    Department of Neurobiology and Behavior, SUNY at Stony Brook, Life Sciences Building, Stony Brook, NY 11794 5230, USA
    Exp Neurol 197:347-52. 2006
    ....
  55. pmc Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival
    Caryl E Sortwell
    Department of Neurology University of Cincinnati, PO Box 670537, ML0537, Cincinnati, OH 45267 0537, USA
    Brain Res 1134:33-44. 2007
    ..Even with highly efficient viral vector-mediated transduction, our results demonstrate that ex vivo gene transfer of bcl-2 to mesencephalic reaggregates is ineffective in increasing grafted DA neuron survival...
  56. ncbi request reprint Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy
    Ami Mankodi
    Department of Neurology, School of Medicine and Dentistry, University of Rochester, Box 673, 601 Elmwood Avenue, New York 14642, USA
    Mol Cell 10:35-44. 2002
    ..We propose that a transdominant effect of mutant RNA on RNA processing leads to chloride channelopathy and membrane hyperexcitability in DM...
  57. pmc Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 chal
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Virol 79:2124-32. 2005
    ..This mouse model may be a useful tool to evaluate human immune responses and protection against viral infection following vaccination...
  58. ncbi request reprint Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction
    Hovav Nechushtan
    Department of Medicine, Miller School of Medicine at the University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Cancer Immunol Immunother 57:663-75. 2008
    ....
  59. ncbi request reprint Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma
    Richard H Pin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Gastrointest Surg 8:812-22; discussion 822-3. 2004
    ..the control group (P < 0.000001). HSV amplicon-mediated delivery of a hypoxia-inducible soluble VEGF receptor substantially reduces new vessel formation and tumor growth in hepatoma...
  60. ncbi request reprint Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons
    Victor L Arvanian
    Dept of Neurobiology and Behavior, SUNY at Stony Brook, Life Sciences Bldg Rm 550, Stony Brook, NY 11794 5230, USA
    J Neurophysiol 92:2394-404. 2004
    ..This approach might be useful for enhancing the function of fibers surviving in the damaged spinal cord...
  61. ncbi request reprint Retinal ganglion cell differentiation in cultured mouse retinal explants
    Steven W Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Methods 28:448-56. 2002
    ....
  62. ncbi request reprint Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma
    Maura Reinblatt
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Surg Oncol 12:1025-36. 2005
    ..We attempted to attenuate angiogenesis and inhibit pancreatic tumor growth through HSV amplicon-mediated expression of sFlk-1 under hypoxic control...

Research Grants9

  1. Gene-based TNF-alpha activity modulation in 3xTg-AD mice
    William Bowers; Fiscal Year: 2007
    ..This work will provide major insight into the involvement of inflammation in the temporal and spatial progression of early AD pathogenic events and may potentially elucidate new therapeutic targets. ..
  2. Novel Mouse Model to Dissect Alzheimer's Disease Pathophysiology
    William Bowers; Fiscal Year: 2007
    ..abstract_text> ..
  3. Gene-based TNF-alpha activity modulation in 3xTg-AD mice
    William J Bowers; Fiscal Year: 2010
    ..This work will provide major insight into the involvement of inflammation in the temporal and spatial progression of early AD pathogenic events and may potentially elucidate new therapeutic targets. ..