B J Bowers

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint Microarray analysis of the effects of a gamma-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypes
    Amy M Smith
    Institute for Behavioral Genetics, University of Colorado, 447, UCB, Boulder, CO 80309, USA
    Behav Genet 36:869-81. 2006
  2. ncbi request reprint Background genotype modulates the effects of γ-PKC on the development of rapid tolerance to ethanol-induced hypothermia
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
    Addict Biol 5:47-58. 2000
  3. ncbi request reprint Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado at Boulder, 447 UCB, Boulder, CO 80309, USA
    Alcohol Clin Exp Res 29:295-302. 2005
  4. pmc Regulation of 5-HT2A/C receptors and DOI-induced behaviors by protein kinase Cgamma
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Pharmacol Biochem Behav 85:441-7. 2006
  5. ncbi request reprint Ethanol consumption and behavioral impulsivity are increased in protein kinase Cgamma null mutant mice
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 21:RC180. 2001
  6. pmc Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCgamma mice
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Alcohol 40:19-33. 2006
  7. ncbi request reprint Differential sensitivity to the anxiolytic effects of ethanol and flunitrazepam in PKCgamma null mutant mice
    B J Bowers
    Institute for Behavioral Genetics CB 447, University of Colorado, Boulder, CO 80309, USA
    Pharmacol Biochem Behav 69:99-110. 2001
  8. ncbi request reprint Mice lacking PKC gamma exhibit decreased anxiety
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    Behav Genet 30:111-21. 2000
  9. ncbi request reprint Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    Alcohol Clin Exp Res 23:387-97. 1999
  10. ncbi request reprint Open field activity and EtOH activation of gamma-PKC null mutants
    D M Hix
    Institute of Behavioral Genetics, University of Colorado, Boulder, 80309 0447, USA
    Addict Biol 8:399-412. 2003

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Microarray analysis of the effects of a gamma-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypes
    Amy M Smith
    Institute for Behavioral Genetics, University of Colorado, 447, UCB, Boulder, CO 80309, USA
    Behav Genet 36:869-81. 2006
    ..Ethanol treatment of mutants reversed the dramatic increase in transthyretin expression seen in naïve and control-diet treated mutants, but did not affect transthyretin expression in wild types...
  2. ncbi request reprint Background genotype modulates the effects of γ-PKC on the development of rapid tolerance to ethanol-induced hypothermia
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
    Addict Biol 5:47-58. 2000
    ..These results stress the necessity of understanding interactions with genetic background when interpreting the effects of single gene mutations on complex behavioral traits...
  3. ncbi request reprint Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado at Boulder, 447 UCB, Boulder, CO 80309, USA
    Alcohol Clin Exp Res 29:295-302. 2005
    ..The studies outlined here used alpha7 gene knockout (null mutant) mice to evaluate the potential role of alpha7 nAChRs in modulating selected behavioral and physiological effects produced by ethanol...
  4. pmc Regulation of 5-HT2A/C receptors and DOI-induced behaviors by protein kinase Cgamma
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Pharmacol Biochem Behav 85:441-7. 2006
    ..These data support a role for 5-HT(2A/C) receptors in the PFC in mediating some of the behavioral differences observed between PKCgamma mutant and wild-type mice...
  5. ncbi request reprint Ethanol consumption and behavioral impulsivity are increased in protein kinase Cgamma null mutant mice
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 21:RC180. 2001
    ..Therefore, PKCgamma may be an important mechanism within the cell that mediates one or more neurochemical pathways relevant to an increased predisposition to alcoholism...
  6. pmc Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCgamma mice
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Alcohol 40:19-33. 2006
    ..2 and Th, were found to be sensitive to chronic ethanol and were added to the transcription factors, JunB and Nur77, confirmed by qRT-PCR, as a subset of genes that respond to chronic ethanol...
  7. ncbi request reprint Differential sensitivity to the anxiolytic effects of ethanol and flunitrazepam in PKCgamma null mutant mice
    B J Bowers
    Institute for Behavioral Genetics CB 447, University of Colorado, Boulder, CO 80309, USA
    Pharmacol Biochem Behav 69:99-110. 2001
    ..These results suggest that PKCgamma differentially mediates anxiolytic responses to ethanol and FNZ and that this relationship interacts with each drug's efficacy in reducing anxiety-related behaviors specific to each of the three mazes...
  8. ncbi request reprint Mice lacking PKC gamma exhibit decreased anxiety
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    Behav Genet 30:111-21. 2000
    ..These results suggest that PKC gamma be considered as one factor in the etiology of anxiety, perhaps via its post-synaptic regulation of GABAA and 5-HT2 receptors, two receptors implicated in the neurobiology of anxiety...
  9. ncbi request reprint Decreased ethanol sensitivity and tolerance development in gamma-protein kinase C null mutant mice is dependent on genetic background
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    Alcohol Clin Exp Res 23:387-97. 1999
    ..These results stress the importance of including the effect of genetic background when evaluating the effects of single gene mutations on quantitative behavioral traits...
  10. ncbi request reprint Open field activity and EtOH activation of gamma-PKC null mutants
    D M Hix
    Institute of Behavioral Genetics, University of Colorado, Boulder, 80309 0447, USA
    Addict Biol 8:399-412. 2003
    ..This reflects the pleiotropic effects of the gamma-PKC null mutation on the behavioral effects of ethanol...
  11. ncbi request reprint Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
    J Neurochem 64:2737-46. 1995
    ....
  12. ncbi request reprint Isolation and sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309
    Gene 123:263-5. 1993
    ..Here, we report the cDNA sequence encoding mouse PKC-gamma isolated from a C57BL/6 brain cDNA library. The mouse and rat PKC-gamma nt and deduced amino acid sequences share 97 and 100% identity, respectively...
  13. ncbi request reprint Adrenalectomy and stress modulate GABAA receptor function in LS and SS mice
    B J Bowers
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309
    Brain Res 576:80-8. 1992
    ..Differential receptor responses to adrenal manipulation between LS and SS mice may be due to genetic variation in GABAA receptor subunit combinations in these lines of mice...
  14. ncbi request reprint Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task
    Jason J Keller
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Behav Brain Res 162:143-52. 2005
    ..These results support a role of the alpha7 nicotinic receptor in mediating appetitive learning and suggest a potential role for the alpha7 nAChRs in the regulation of behavioral disinhibition...
  15. ncbi request reprint Quantitative genetics and mouse behavior
    J M Wehner
    Institute for Behavioral Genetics and Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Annu Rev Neurosci 24:845-67. 2001
    ..Recently, quantitative trait loci methods have been applied to map the chromosomal regions that regulate variation with the goal of eventually identifying the gene polymorphisms that reside in these regions...
  16. ncbi request reprint Ethanol differentially enhances hippocampal GABA A receptor-mediated responses in protein kinase C gamma (PKC gamma) and PKC epsilon null mice
    W R Proctor
    Department of Veterans Affairs Medical Center, Research Service, Denver, Colorado, USA
    J Pharmacol Exp Ther 305:264-70. 2003
    ..These results suggest that PKCgamma and PKCepsilon signaling pathways reciprocally modulate both ethanol enhancement of GABA(A) receptor function and hypnotic sensitivity to ethanol...