William H Bowen

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Do we need to be concerned about dental caries in the coming millennium?
    William H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Crit Rev Oral Biol Med 13:126-31. 2002
  2. doi request reprint The Stephan Curve revisited
    William H Bowen
    Center for Oral Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Odontology 101:2-8. 2013
  3. doi request reprint Rodent model in caries research
    William H Bowen
    Center for Oral Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Odontology 101:9-14. 2013
  4. pmc Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
    W H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Caries Res 45:69-86. 2011
  5. ncbi request reprint Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose
    William H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Pediatrics 116:921-6. 2005
  6. ncbi request reprint Henry Klein--a forgotten icon?
    W H Bowen
    University of Rochester, Center for Oral Biology, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    J Dent Res 83:365-7. 2004
  7. ncbi request reprint Exposure to metal ions and susceptibility to dental caries
    W H Bowen
    Center for Oral Biology, University of Rochester, NY 14642, USA
    J Dent Educ 65:1046-53. 2001
  8. ncbi request reprint Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats
    H Koo
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, NY 14642, USA
    Oral Microbiol Immunol 17:337-43. 2002
  9. ncbi request reprint The effects of benzoate and fluoride on dental caries in intact and desalivated rats
    B A Davis
    Center for Oral Biology, University of Rochester, NY, USA
    Caries Res 35:331-7. 2001
  10. doi request reprint Influences of starch and sucrose on Streptococcus mutans biofilms
    S Duarte
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Oral Microbiol Immunol 23:206-12. 2008

Research Grants

Detail Information

Publications31

  1. ncbi request reprint Do we need to be concerned about dental caries in the coming millennium?
    William H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Crit Rev Oral Biol Med 13:126-31. 2002
    ..Although significant progress has been made in our understanding of the etiology, pathogenesis, and prevention of dental caries, it still remains a scientific and clinical enigma worthy of the attention of the best scientists...
  2. doi request reprint The Stephan Curve revisited
    William H Bowen
    Center for Oral Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Odontology 101:2-8. 2013
    ..Acid production is just one of many biological processes that occur within plaque when exposed to sugar. Exploration of methods to enhance alkali production could produce rich research dividends...
  3. doi request reprint Rodent model in caries research
    William H Bowen
    Center for Oral Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Odontology 101:9-14. 2013
    ..The arrival of genetically altered microorganisms along with availability of knock-out rodents offers exciting challenges to further explore the pathogenesis of this still too common disease...
  4. pmc Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms
    W H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Caries Res 45:69-86. 2011
    ..Clearly, conformational changes and reactions of Gtfs on surfaces are complex and modulate the pathogenesis of dental caries in situ, deserving further investigation...
  5. ncbi request reprint Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose
    William H Bowen
    Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA
    Pediatrics 116:921-6. 2005
    ..We chose to examine sucrose, cola drink, honey, human milk, cow milk, and water because some of these have been associated with development of early childhood caries, although direct experimental evidence is lacking...
  6. ncbi request reprint Henry Klein--a forgotten icon?
    W H Bowen
    University of Rochester, Center for Oral Biology, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    J Dent Res 83:365-7. 2004
  7. ncbi request reprint Exposure to metal ions and susceptibility to dental caries
    W H Bowen
    Center for Oral Biology, University of Rochester, NY 14642, USA
    J Dent Educ 65:1046-53. 2001
    ..Where feasible, these records should form part of health history and be available to the treating dental practitioner to ensure that extra preventive procedures may be implemented...
  8. ncbi request reprint Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats
    H Koo
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, NY 14642, USA
    Oral Microbiol Immunol 17:337-43. 2002
    ..The incidence of smooth-surface caries was significantly reduced by apigenin +tt-farnesol (60%), fluoride (70%), and chlorhexidine (72%) treatments compared to control (P < 0.05)...
  9. ncbi request reprint The effects of benzoate and fluoride on dental caries in intact and desalivated rats
    B A Davis
    Center for Oral Biology, University of Rochester, NY, USA
    Caries Res 35:331-7. 2001
    ..The results showed a combination of benzoate and fluoride reduced caries activity more effectively in rodents fed a cariogenic diet ad libitum than fluoride alone (p = 0.038)...
  10. doi request reprint Influences of starch and sucrose on Streptococcus mutans biofilms
    S Duarte
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Oral Microbiol Immunol 23:206-12. 2008
    ..The aim of this study was to examine the influence of starch and sucrose, alone or in combinations, on formation, polysaccharide composition, gene expression, and acidogenicity of Streptococcus mutans biofilms...
  11. ncbi request reprint Fluorosis: is it really a problem?
    William H Bowen
    Environmental Medicine, Center for Oral Biology, University of Rochester Medical Center, NY 14642, USA
    J Am Dent Assoc 133:1405-7. 2002
    ..To harness the protective effect of fluoride while limiting the occurrence of fluorosis, dental researchers have recommended that the fluoride level in chinking water be 1 part per million or less...
  12. ncbi request reprint Interactions of Streptococcus mutans glucosyltransferase B with lysozyme in solution and on the surface of hydroxyapatite
    H S Kho
    University of Rochester, Center for Oral Biology, Rochester, New York, N Y, USA
    Caries Res 39:411-6. 2005
    ..Therefore, the interaction of lysozyme and GtfB enzymes on HA surface may modulate the formation of glucan and dental plaque...
  13. ncbi request reprint Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms
    Simone Duarte
    Eastman Department of Dentistry Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA
    FEMS Microbiol Lett 257:50-6. 2006
    ..The flavonols are comprised of mostly quercetin glycosides, and the PAC are largely A-type oligomers of epicatechin. Our data show that proanthocyanidins and flavonols are the active constituents of cranberry against S. mutans...
  14. pmc Influence of apigenin on gtf gene expression in Streptococcus mutans UA159
    Hyun Koo
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, 625 Elmwood Ave, Box 683, Rochester, NY 14620, USA
    Antimicrob Agents Chemother 50:542-6. 2006
    ..The data show that apigenin modulates the genetic expression of virulence factors in S. mutans...
  15. ncbi request reprint The influence of a novel propolis on mutans streptococci biofilms and caries development in rats
    Simone Duarte
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, NY 14620, USA
    Arch Oral Biol 51:15-22. 2006
    ....
  16. ncbi request reprint The effect of chronic clonidine administration on salivary glands and caries in the rat
    G E Watson
    Eastman Department of Dentistry and Department of Pharmacology and Physiology, University of Rochester, NY, USA
    Caries Res 34:194-200. 2000
    ..These data show that chronic administration of clonidine significantly decreases submandibular gland weight and increases susceptibility to dental caries...
  17. ncbi request reprint Litter effects on caries in rats and implications for experimental design
    R F Raubertas
    Department of Biostatistics, University of Rochester School of Medicine and Dentistry, Rochester, N Y, USA
    Caries Res 33:164-9. 1999
    ..Based on our results and other reports of litter effects, we recommend planning for litter effects in the design and analysis of rat caries studies...
  18. ncbi request reprint Action of agents on glucosyltransferases from Streptococcus mutans in solution and adsorbed to experimental pellicle
    D Wunder
    University of Rochester, Center for Oral Biology, NY 14642, USA
    Arch Oral Biol 44:203-14. 1999
    ..These data indicate that the nature of the inhibitor is important, and also whether the Gtf enzyme is in solution or adsorbed to saliva-coated hydroxylapatite...
  19. ncbi request reprint Studies concerning the glucosyltransferase of Streptococcus sanguis
    A M Vacca Smith
    Center of Oral Biology, University of Rochester, NY 14642, USA
    Caries Res 34:295-302. 2000
    ..These results show that the GtfSs of S. sanguis is active on sHA beads, that the pH optimum for activity on a surface differs slightly from that in solution, and that its product glucan can support the adherence of oral microorganisms...
  20. ncbi request reprint Influence of cranberry juice on glucan-mediated processes involved in Streptococcus mutans biofilm development
    H Koo
    Center for Oral Biology and Eastman Department of Dentistry, 601 Elmwood Avenue, Box 611, University of Rochester Medical Center, Rochester, NY 14642, USA
    Caries Res 40:20-7. 2006
    ..05). Our data show that cranberry juice inhibited glucan-mediated biofilm development and acid production, and holds promise as a natural product to prevent biofilm-related oral diseases...
  21. ncbi request reprint A mouse caries model and evaluation of aqp5-/- knockout mice
    D J Culp
    University of Rochester Medical Center, Center for Oral Biology, Rochester, NY 14642 8611, USA
    Caries Res 39:448-54. 2005
    ..Results indicate that caries susceptibility increases with a reduced salivary flow that is associated with decreased water content of saliva...
  22. pmc Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries
    H Koo
    Center for Oral Biology and Eastman Dept of Dentistry, University of Rochester Medical Center, 625 Elmwood Avenue, Box 683, Rochester, NY 14620, USA
    J Dent Res 84:1016-20. 2005
    ..Results from these studies showed that apigenin and tt-farnesol may enhance the cariostatic effectiveness of fluoride...
  23. ncbi request reprint The effects of milk and kappa-casein on salivary pellicle formed on hydroxyapatite discs in situ
    A M Vacca Smith
    Center of Oral Biology, University of Rochester, N Y 14642, USA
    Caries Res 34:88-93. 2000
    ..These data suggest that milk and kappa-casein may influence pellicle formation in vivo...
  24. ncbi request reprint In situ studies of pellicle formation on hydroxyapatite discs
    A M Vacca Smith
    Center for Oral Biology, University of Rochester, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Arch Oral Biol 45:277-91. 2000
    ..It is apparent that this in situ model could be used in screening potential antiplaque agents...
  25. ncbi request reprint Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol
    H Koo
    Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Antimicrob Chemother 52:782-9. 2003
    ..We investigated the influence of apigenin and tt-farnesol, alone and in combination, on the accumulation, polysaccharide composition and viability of S. mutans UA159 biofilms...
  26. ncbi request reprint Response to Seow: biological mechanisms of early childhood caries
    W H Bowen
    University of Rochester, Department of Dental Research, New York 14642 8611, USA
    Community Dent Oral Epidemiol 26:28-31. 1998
    ..Recent evidence shows that salivary gland function is impaired by iron deficiency and by prenatal exposure to lead. Clearly, early childhood caries is a complex disease that requires careful and extensive investigation...
  27. ncbi request reprint Influence of antibody on the structure of glucans
    Leslie K Kopec
    Center for Oral Biology, University of Rochester, NY 14624, USA
    Caries Res 36:108-15. 2002
    ..The results have implications for the formation and properties of biofilms formed in other environments...
  28. pmc Salivary glucosyltransferase B as a possible marker for caries activity
    A M Vacca Smith
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA
    Caries Res 41:445-50. 2007
    ..These observations may have important clinical implications, may lead to development of a chair side caries activity test and support the importance of GtfB in the pathogenesis of dental caries...
  29. pmc Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activity
    Hyun Koo
    Center for Oral Biology and Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antimicrob Agents Chemother 46:1302-9. 2002
    ..Several of the compounds identified in propolis inhibit GTF activities and bacterial growth. Apigenin is a novel and potent inhibitor of GTF activity, and tt-farnesol was found to be an effective antibacterial agent...
  30. ncbi request reprint In vitro and in vivo effects of isolated fractions of Brazilian propolis on caries development
    Mitsue F Hayacibara
    Department of Physiological Sciences, Dentistry Faculty of Piracicaba, State University of Campinas, Av Limeira, 901 PIRACICABA SP, CEP 13414 903, Brazil
    J Ethnopharmacol 101:110-5. 2005
    ..The data suggest that the putative cariostatic compounds of propolis type-3 and -12 are mostly non-polar; and H-fr should be the fraction of choice for identifying further potentially novel anti-caries agents...
  31. ncbi request reprint The influence of mutanase and dextranase on the production and structure of glucans synthesized by streptococcal glucosyltransferases
    Mitsue F Hayacibara
    Faculty of Dentistry of Piracicaba, UNICAMP, Piracicaba, São Paulo 13414 018, Brazil
    Carbohydr Res 339:2127-37. 2004
    ..Our data have relevance for the formation of polysaccharide matrix of other biofilms...

Research Grants2

  1. SALIVA/GLUCOSYLTRANSFERASE INTERACTIONS ON SURFACES
    William Bowen; Fiscal Year: 2002
    ..Such information may make it possible to design molecules which will compete with S. mutans and certain actinomyces for sites on glucan-coated pellicle. ..
  2. Glucosyltransferase as a Marker for Caries Activity
    William Bowen; Fiscal Year: 2005
    ..Our eventual goal (in a future application) is to determine caries risk well before the onset of lesions and to identify those who are caries active short of cavitation or even white spot formation. ..