Research Topics
Species | Deborah BowenSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
Hereditary hemochromatosis: gene discovery and its implications for population-based screeningW Burke
Department of Medicine, University of Washington, Seattle 98105, USA
JAMA 280:172-8. 1998..To evaluate the role of genetic testing in screening for hereditary hemochromatosis to help guide clinicians, policymakers, and researchers...- Family history as a predictor of asthma riskWylie Burke
Department of Medical History and Ethics, University of Washington, Box 357120, 1959 NE Pacific, Seattle, WA 98195, USA
Am J Prev Med 24:160-9. 2003..Positive family history may have utility in targeting some individual prevention efforts, but the low positive predictive value limits its value as a means to direct environmental remediation efforts... 
Debating clinical utilityWylie Burke
Department of Bioethics and Humanities, University of Washington, Seattle, Wash 98195 7120, USA
Public Health Genomics 13:215-23. 2010..Addressing each of these issues requires attention to stakeholder values and methods for effective deliberation that incorporate consumer as well as health professional perspectives...- Contributions of public health to genetics education for health care professionalsWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, WA 98195 7120, USA
Health Educ Behav 32:668-75. 2005.... - Genetic assessment of breast cancer risk in primary care practiceWylie Burke
Department of Bioethics and Humanities, University of Washington, Seattle, Washington 98195 7120, USA
Am J Med Genet A 149:349-56. 2009..Educational efforts may be most successful when they emphasize the value of genetic counseling for individuals at risk for inherited cancer and the connection between genetic risk and specific prevention measures... - Translational genomics: seeking a shared vision of benefitWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, WA 98195, USA
Am J Bioeth 8:54-6; discussion W1-3. 2008 - Defining purpose: a key step in genetic test evaluationWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195-7120, USA
Genet Med 9:675-81. 2007 - Ethical issues arising from the participation of children in genetic researchWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle 98195 7120, USA
J Pediatr 149:S34-8. 2006..Because genetic information is often accorded special power in our society, careful attention should be paid to how genetic information is collected and used in research involving pediatric participants... - Genetics as a tool to improve cancer outcomes: ethics and policyWylie Burke
Department of Medical History and Ethics, University of Washington, Box 357120, 1959 North East Pacific, Room A204, Seattle, Washington 98195 7120, USA
Nat Rev Cancer 6:476-82. 2006..When the benefits of testing are well established, efforts must also be made to ensure access to genetic services for all who can benefit... - Ethical obligations and counseling challenges in cancer geneticsWylie Burke
Department of Medical History and Ethics, University of Washington, Box 356120, 1959 NE Pacific, Room A204, Seattle, WA 98195 7120, USA
J Natl Compr Canc Netw 4:185-91. 2006..Clinicians must also provide emotional support and accurate information about cancer risks and cancer risk reduction measures, including uncertainties. Teamwork among different specialties is important in addressing these challenges... - Genetic testing in primary careWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195 7120, USA
Annu Rev Genomics Hum Genet 5:1-14. 2004..A partnership between medical genetics and primary care will help to ensure the development of effective policies, educational tools, and practice guidelines for the coming era of genomic health care... - Ensuring the appropriate use of genetic testsWylie Burke
Department of Medical History and Ethics, Box 357120, University of Washington, 1959 NE Pacific, Room A204, Seattle, Washington 98195, USA
Nat Rev Genet 5:955-9. 2004..Other strategies, including resource allocation and matters related to clinical governance - such as practice-guideline development and health-provider education - are also important... - Genetic testingWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, WA 98195, USA
N Engl J Med 347:1867-75. 2002 - Hereditary haemochromatosis: a realistic approach to prevention of iron overload disease in the populationWylie Burke
Department of Medical History and Ethics, Box 357120, University of Washington, 1959 NE Pacific, Room A204, Seattle, WA 98195, USA
Best Pract Res Clin Haematol 15:315-28. 2002.... - Genetic screeningWylie Burke
Department of Bioethics and Humanities, A204 Health Sciences Building, Box 357120, University of Washington, Seattle, WA 98195, USA
Epidemiol Rev 33:148-64. 2011.... - Screening for hereditary hemochromatosis: are DNA-based tests the answer?W Burke
Department of Medicine Box 354765, University of Washington, 4245 Roosevelt Way NE, Seattle, WA 98105, USA
Mol Med Today 5:428-30. 1999..DNA-based tests do not provide a simple resolution to these questions... - Iron deficiency and iron overload: effects of diet and genesW Burke
Department of Medical History and Ethics, University of Washington, Seattle 98195, USA
Proc Nutr Soc 60:73-80. 2001..This work is likely to lead to new insights into Fe disorders and potentially to new therapeutic approaches. It will not be complete, however, until coordinated study of both genetic and nutritional factors is undertaken... - Misleading presentation of breast cancer in popular magazinesW Burke
Department of Medical History and Ethics, University of Washington, Seattle, Wash, USA
Eff Clin Pract 4:58-64. 2001..Women commonly misunderstand their risk for breast cancer, overestimating both their risk for developing the disease at a young age and their lifetime risk... - Contribution of different HFE genotypes to iron overload disease: a pooled analysisW Burke
Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195, USA
Genet Med 2:271-7. 2000..To determine the contribution of the C282Y and H63D mutations in the HFE gene to clinical expression of hereditary hemochromatosis... - Categorizing genetic tests to identify their ethical, legal, and social implicationsW Burke
Department of Medical History and Ethics, University of Washington, Seattle 98195, USA
Am J Med Genet 106:233-40. 2001..This approach to test categorization allows a rapid determination of the predominant ELSI concerns for different kinds of genetic tests and identifies the data most urgently needed for test evaluation... - Application of population screening principles to genetic screening for adult-onset conditionsW Burke
Department of Medical History and Ethics, University of Washington, 1959 NE Pacific, Room A204, Seattle, WA 98195
Genet Test 5:201-11. 2001.... - Hemochromatosis: genetics helps to define a multifactorial diseaseW Burke
University of Washington, Seattle 98105, USA
Clin Genet 54:1-9. 1998..HH is an important paradigm for medical genetics because it offers an opportunity to explore the complexity of gene gene and gene environment interactions... - Genomics as a probe for disease biologyWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle 98195, USA
N Engl J Med 349:969-74. 2003 - Genetics education for primary-care providersWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, Washington 98195, USA
Nat Rev Genet 3:561-6. 2002..Although most have little knowledge of genetics, their expertise in the prudent use of technology is relevant to the task. Successful educational programmes will need to forge partnerships between primary care and genetics... - Systems medicine and the public's healthWylie Burke
Department of Bioethics and Humanities, University of Washington, Box 357120, 1959 NE Pacific, Room A204, Seattle, WA 98195 7120, USA
Genome Med 3:47. 2011..See correspondence article: http://genomemedicine.com/content/3/7/43... - Genetic counseling for women with an intermediate family history of breast cancerW Burke
Department of Medicine, Fred Hutchinson Cancer Research Center, University of Washington, Seattle 98195, USA
Am J Med Genet 90:361-8. 2000.... - Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trialLaura Lewis Frank
Fred Hutchinson Cancer Research Center, Cancer Prevention, Seattle, WA 98109-1024, USA
Obes Res 13:615-25. 2005..These results are promising for health care providers providing advice to postmenopausal women for lifestyle changes to reduce risk of insulin resistance, coronary heart disease, and diabetes... - Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trialAnne McTiernan
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
Cancer Epidemiol Biomarkers Prev 13:1099-105. 2004..The association between exercise and breast cancer risk may be partly explained by the effects of exercise on these hormones... - Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal womenCharlotte Atkinson
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P. O. Box 19024, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 13:868-74. 2004..Thus, this 12-month moderate intensity exercise intervention did not significantly alter urinary excretion of 2-OH E(1), 16alpha-OH E(1), or their ratio in this population of women... - Effect of a yearlong, moderate-intensity exercise intervention on the occurrence and severity of menopause symptoms in postmenopausal womenErin J Aiello
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
Menopause 11:382-8. 2004..CONCLUSIONS: Exercise does not seem to decrease the risk of having menopause symptoms in overweight, postmenopausal women not taking hormone therapy and may increase the severity of some symptoms in a small number of women... - Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trialAnne McTiernan
Cancer Prevention Research Program, The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cancer Res 64:2923-8. 2004..The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens... 
Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trialAndrea Z LaCroix
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M3 A410, PO 19024, Seattle, WA 98109
JAMA 305:1305-14. 2011..1 years of follow-up because of an increased risk of stroke and little likelihood of altering the balance of risk to benefit by the planned trial termination date. Postintervention health outcomes have not been reported...- Worry about ovarian cancer risk and use of screening by high-risk women: how you recruit affects what you findM Robyn Andersen
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Am J Med Genet A 129:130-5. 2004..High-risk women recruited via mass mailing were less likely than those recruited via physicians or affected relatives to report either worry about their risk or use of ovarian cancer screening tests... - Breast cancer risk communication: assessment of primary care physicians by standardized patientsJulie O Culver
Department of Bioethics and Humanities, University of Washington, Seattle, Washington 98195, USA
Genet Med 11:735-41. 2009..To assess primary care providers' communication about breast cancer risk... - Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women's Health Initiative Dietary Modification TrialAnne McTiernan
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98019, USA
Am J Clin Nutr 89:1864-76. 2009..The effects of dietary changes on osteoporosis, low bone density, and frequent falls are unestablished... - Family history assessment to detect increased risk for colorectal cancer: conceptual considerations and a preliminary economic analysisScott D Ramsey
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M2 B230, P O Box 19024, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 14:2494-500. 2005..Although the rationale for earlier screening of persons with a family history of colorectal cancer is plausible, there is no direct evidence that earlier assessment is either effective or cost-effective... - Gene expression profiling and breast cancer care: what are the potential benefits and policy implications?Nina Oestreicher
University of Washington, Seattle, Washington, USA
Genet Med 7:380-9. 2005..However, the outcomes associated with gene expression profiling are not clear, and guidelines for the appropriate use of genomic technologies have not been established... - Awareness and concern about ovarian cancer among women at risk because of a family history of breast or ovarian cancerM Robyn Andersen
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Obstet Gynecol 189:S42-7. 2003..Almost 75% have not heard much about their risk for ovarian cancer. More than 90% failed to use 1 or another of 2 possible tests used for ovarian cancer screening regularly... - A formal risk-benefit framework for genomic tests: facilitating the appropriate translation of genomics into clinical practiceDavid L Veenstra
Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Genet Med 12:686-93. 2010..To address these issues, this study presents a risk-benefit framework for assessing the health-related utility of genomic tests... - Personalized medicine in the era of genomicsWylie Burke
Center for Genomics and Healthcare Equality and Department of Medical History and Ethics, University of Washington, Seattle, WA 98195, USA
JAMA 298:1682-4. 2007 - Educational needs in genetic medicine: primary care perspectivesSusan B Trinidad
Department of Medical History and Ethics, University of Washington, Seattle, Wash 98195 7120, USA
Community Genet 11:160-5. 2008..This study was performed to identify primary care physicians' (PCPs) attitudes toward genetic medicine and their perceived needs for education in this area... - Clinical validity and clinical utility of genetic testsWylie Burke
University of Washington, Seattle, Washington, USA
Curr Protoc Hum Genet . 2004..This unit defines clinical validity and clinical utility, provides examples, and considers the implications of these test properties for clinical practice... - Potential for genetics to promote public health: genetics research on smoking suggests caution about expectationsChris Carlsten
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Occupational and Environmental Medicine Program, University of Washington, Seattle, USA
JAMA 296:2480-2. 2006 - Pharmacogenomic testing to prevent aminoglycoside-induced hearing loss in cystic fibrosis patients: potential impact on clinical, patient, and economic outcomesDavid L Veenstra
Institute for Public Health Genetics, Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Genet Med 9:695-704. 2007..Although the A1555G variant is very rare, it seems to confer a high risk of severe hearing loss in patients exposed to aminoglycosides... - Effects of risk counseling on interest in breast cancer genetic testing for lower risk womenDeborah J Bowen
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genet Med 4:359-65. 2002..CONCLUSION: These results indicate that counseling can change interest in genetic testing only slightly and that changing women's beliefs about the properties of testing might be one mechanism of doing so... - Breast cancer risk counseling improves women's functioningDeborah J Bowen
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 900, Seattle, WA 98109, USA
Patient Educ Couns 53:79-86. 2004..Cancer worry decreased in both counseling groups by one scale point (P < 0.05). These results indicate that counseling can relieve women's negative reactions to breast cancer risk... - Diabetes and HFE mutations: cause or coincidence?Linda E Pinsky
Department of Medicine, Division of General Internal Medicine, University of Washington Medical Center, 4245 Roosevelt Way, NE Seattle, WA 98105 6920, USA
West J Med 176:114-5. 2002 - Population description and its role in the interpretation of genetic associationStephanie M Fullerton
Department of Bioethics and Humanities, Center for Genomics and Healthcare Equality, University of Washington School of Medicine, Box 357120, Seattle, WA 98195, USA
Hum Genet 127:563-72. 2010..Instead, criteria which help investigators better distinguish justified and unjustified forms of population generalization may be required... - Physician-patient colorectal cancer screening discussions by physicians' screening ratesCathleen M O'Farrell
Department of Family Medicine, University of Washington, Seattle, WA 98195 4982, USA
J Am Board Fam Med 25:771-81. 2012..To better understand this finding, we explored the relationship between the content of hypothetical patient-physician CRC screening discussions and CRC screening rates in physicians' practices... - Effects of a yearlong moderate-intensity exercise and a stretching intervention on sleep quality in postmenopausal womenShelley S Tworoger
The Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, Wash 98109-1024, USA
Sleep 26:830-6. 2003..Increased fitness was associated with improvements in sleep. However, the effect of moderate-intensity exercise may depend on the amount of exercise and time of day it is performed... - Evaluation of Cancer 101: an educational program for native settingsTeresa Garrett Hill
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
J Cancer Educ 25:329-36. 2010..Cancer 101 provides a critical pathway to increase knowledge and promote action to reduce the burden and improve survival of cancer within tribal communities... - Reconsidering the family history in primary careEugene C Rich
Department of Medicine, Creighton University, 601 N 30th Street, Suite 8850, Omaha, NE 68131, USA
J Gen Intern Med 19:273-80. 2004.... - Clinical validity and clinical utility of genetic testsWylie Burke
University of Washington, Seattle, Washington, USA
Curr Protoc Hum Genet . 2009..This unit defines clinical validity and clinical utility, provides examples, and considers the implications of these test properties for clinical practice... - Motivating factors for physician ordering of factor V Leiden genetic testsLucia A Hindorff
Department of Epidemiology, University of Washington, Seattle, USA
Arch Intern Med 169:68-74. 2009..The factor V Leiden (FVL) genetic test is used by many physicians despite its uncertain clinical utility... - Practicing moral medicine: patient care to public healthDenise M Dudzinski
University of Washington, USA
Am J Bioeth 6:75-6. 2006 - Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification TrialShirley A A Beresford
Department of Epidemiology, University of Washington, Seattle, WA 98195 7236, USA
JAMA 295:643-54. 2006..Observational studies and polyp recurrence trials are not conclusive regarding the effects of a low-fat dietary pattern on risk of colorectal cancer, necessitating a primary prevention trial... - A case study of the South Puget Intertribal Planning Agency's comprehensive cancer control planning and community mobilization processCarrie Nass
National Cancer Institute s Cancer Information Service Northwest Region, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, J2 400, P O Box 19024, Seattle, WA 98109, USA
Prev Chronic Dis 5:A53. 2008..The high rates of cancer among American Indians and Alaska Natives are of growing concern... - Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trialLesley F Tinker
Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
Arch Intern Med 168:1500-11. 2008..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women... - The asthma consultative process: a collaborative approach to integrating genomics into public health practiceTabitha A Harrison
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98105, USA
Prev Chronic Dis 2:A27. 2005..This paper describes the methods used to conduct these professional and community consultations, referred to as the asthma consultative process, and discusses the lessons learned from this activity... - Genetic test evaluation: information needs of clinicians, policy makers, and the publicWylie Burke
University of Washington, Seattle, WA, USA
Am J Epidemiol 156:311-8. 2002.... - Researcher perspectives on disclosure of incidental findings in genetic researchMeredith C Meacham
University of Washington s Institute of Public Health Genetics Master of Public Health program, Seattle, WA 98195 7120, USA
J Empir Res Hum Res Ethics 5:31-41. 2010.... - Effects of individual and family functioning on interest in genetic testingDeborah J Bowen
Fred Hutchinson Cancer Research Center, Seattle, Wash 98109, USA
Community Genet 7:25-32. 2004..The present study reports on the important issue of how family communication and support regarding breast cancer risk affects interest in genetic testing and mental health... - Jewish identity and intentions to obtain breast cancer screeningDeborah J Bowen
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP900, Seattle, Washington 98109, USA
Cultur Divers Ethnic Minor Psychol 9:79-87. 2003..Religious identity was a significant predictor of intention to adhere to mammography recommendations. Findings show that culture and religion, although correlated, may have different associations with health attitudes... - The path from genome-based research to population health: development of an international public health genomics networkWylie Burke
Department of Medical History and Ethics, University of Washington, Seattle, WA 98195-7120, USA
Genet Med 8:451-8. 2006 - Achieving utility with family history: colorectal cancer riskDeborah J Bowen
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, MP900, Seattle, WA 98109, USA
Am J Prev Med 24:177-82. 2003..Where available, we cite data to support the issues that could arise. Where there are no studies, we invite further research. The potential of family history as a health improvement tool is still under review... - Predictors of women's Internet access and Internet health seekingDeborah Bowen
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Health Care Women Int 24:940-51. 2003..Internet use motivators are complex; these findings have relevance to the design of Internet-based interventions... - Does genomic risk information motivate people to change their behavior?Nora B Henrikson
Group Health Cooperative, Center for Health Studies, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA
Genome Med 1:37. 2009.... - Genomic research and wide data sharing: views of prospective participantsSusan Brown Trinidad
Department of Bioethics and Humanities, University of Washington, Seattle, WA 98195 7120, USA
Genet Med 12:486-95. 2010..This study was designed to explore the perceptions, beliefs, and attitudes of research participants and possible future participants regarding genome-wide association studies and repository-based research... - Incorporating principles and practical wisdom in research ethics education: a preliminary studyNicole Deming
Department of Medical History and Ethics, University of Washington School of Medicine, Seattle, WA 98195 7120, USA
Acad Med 82:18-23. 2007..This study characterized researchers' responses to ethical dilemmas with the goal of aligning research ethics education programs with the demands of practice... - Effects of counseling Ashkenazi Jewish women about breast cancer riskDeborah J Bowen
Department of Health Services, University of Washington, Seattle, WA 98109, USA
Cultur Divers Ethnic Minor Psychol 12:45-56. 2006..Counseling can help women gain a more accurate perception of their risk, expose them to the benefits and limitations of genetic testing, and reduce their worry about cancer... - Use of Factor V Leiden genetic testing in practice and impact on managementAnne Marie Laberge
Institute for Public Health Genetics, Center for Genomics and Healthcare Equality, University of Washington, Seattle, Washington, USA
Genet Med 11:750-6. 2009..To assess the use of the genetic test for Factor V Leiden in clinical practice, physician adherence to national and local guidelines, and impacts of test results on patient management... - An economic viewpoint on alternative strategies for identifying persons with hereditary nonpolyposis colorectal cancerScott D Ramsey
Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle, Washington, USA
Genet Med 5:353-63. 2003..CONCLUSIONS: The Bethesda guidelines are the most cost-effectiveness approach to screen persons for HNPCC... - Genetic information: Special or not? Responses from focus groups with members of a health maintenance organizationBrenda Diergaarde
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Am J Med Genet A 143:564-9. 2007..These data may guide future research and policy concerning the use and protection of medical information, including genetic information... - Cytochrome p450 enzyme polymorphism frequency in indigenous and native american populations: a systematic reviewCheedy Jaja
Center for Genomics and Healthcare Equality, University of Washington, Seattle, Wash, USA
Community Genet 11:141-9. 2008..The purpose of our study was to evaluate the evidence on the prevalence of cytochrome P450 enzyme polymorphisms as potential genetic factors influencing drug efficacy and safety in the indigenous populations of the American hemispheres...
Research Grants
- Genomic Health Care and the Medically UnderservedWylie Burke; Fiscal Year: 2007..abstract_text> ..
- EVALUATING USE OF GENETIC INFORMATION: A MODEL PROCESSWylie Burke; Fiscal Year: 2003..5. To conduct an evaluation of the model process within a large health care system. ..
- Motivating Integrity in Research with Human SubjectsWylie Burke; Fiscal Year: 2003..abstract_text> ..
- Genomic Health Care and the Medically UnderservedWylie Burke; Fiscal Year: 2007..abstract_text> ..