C L Bowden

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
    Biol Psychiatry 63:125-30. 2008
  2. doi request reprint Lamotrigine vs. lamotrigine plus divalproex in randomized, placebo-controlled maintenance treatment for bipolar depression
    C L Bowden
    University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Acta Psychiatr Scand 126:342-50. 2012
  3. doi request reprint Lamotrigine (Lamictal IR) for the treatment of bipolar disorder
    Charles L Bowden
    The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Expert Opin Pharmacother 13:2565-71. 2012
  4. doi request reprint Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD)
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    CNS Neurosci Ther 18:243-9. 2012
  5. ncbi request reprint A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78284 7792, USA
    Arch Gen Psychiatry 57:481-9. 2000
  6. ncbi request reprint Atypical antipsychotic augmentation of mood stabilizer therapy in bipolar disorder
    Charles L Bowden
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    J Clin Psychiatry 66:12-9. 2005
  7. doi request reprint A 12-week, open, randomized trial comparing sodium valproate to lithium in patients with bipolar I disorder suffering from a manic episode
    Charles Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Int Clin Psychopharmacol 23:254-62. 2008
  8. pmc Bipolar pathophysiology and development of improved treatments
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7792, San Antonio, Texas 78229 3900, USA
    Brain Res 1235:92-7. 2008
  9. ncbi request reprint Safety and tolerability of lamotrigine for bipolar disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Drug Saf 27:173-84. 2004
  10. ncbi request reprint A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute mania
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284 7792, USA
    J Clin Psychiatry 67:1501-10. 2006

Research Grants

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
    Biol Psychiatry 63:125-30. 2008
    ..The anticonvulsant lamotrigine has demonstrated efficacy for relapse prevention in bipolar disorder, but its possible mood-stabilizing properties on a day-to-day or week-to-week basis have not previously been investigated...
  2. doi request reprint Lamotrigine vs. lamotrigine plus divalproex in randomized, placebo-controlled maintenance treatment for bipolar depression
    C L Bowden
    University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Acta Psychiatr Scand 126:342-50. 2012
    ..To compare the maintenance efficacy of lamotrigine (Lam) to combination therapy of Lam+divalproex ER (Div) in recently depressed patients with bipolar disorder (BD)...
  3. doi request reprint Lamotrigine (Lamictal IR) for the treatment of bipolar disorder
    Charles L Bowden
    The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Expert Opin Pharmacother 13:2565-71. 2012
    ..Over the past decade the use of lamotrigine in bipolar disorder has increased. However, the evidence base suggests a more limited role for lamotrigine as part of an overall treatment regimen in bipolar disorder...
  4. doi request reprint Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD)
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    CNS Neurosci Ther 18:243-9. 2012
    ..STEP-BD has established procedures that are relevant to future collaborative research programs aimed at the systematic study of the complex, intrinsically important elements of bipolar disorders...
  5. ncbi request reprint A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78284 7792, USA
    Arch Gen Psychiatry 57:481-9. 2000
    ..This study compared the efficacy of divalproex, lithium, and placebo as prophylactic therapy...
  6. ncbi request reprint Atypical antipsychotic augmentation of mood stabilizer therapy in bipolar disorder
    Charles L Bowden
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    J Clin Psychiatry 66:12-9. 2005
    ..The atypical antipsychotics also have relatively mild side effect profiles, although augmentation therapy with some antipsychotics and mood stabilizers has been associated with excessive weight gain...
  7. doi request reprint A 12-week, open, randomized trial comparing sodium valproate to lithium in patients with bipolar I disorder suffering from a manic episode
    Charles Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Int Clin Psychopharmacol 23:254-62. 2008
    ..Adverse events were reported in 44% of patients in both groups. Valproate and lithium showed comparable efficacy and tolerability in the treatment of acute mania over 12 weeks...
  8. pmc Bipolar pathophysiology and development of improved treatments
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7792, San Antonio, Texas 78229 3900, USA
    Brain Res 1235:92-7. 2008
    ..anxiety, psychosis, impulsivity, elevated psychomotor and cognitive processing speed, rather than strictly depressive or manic syndromes can provide more homogeneous samples for study, and increase the focus of experimental hypotheses...
  9. ncbi request reprint Safety and tolerability of lamotrigine for bipolar disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Drug Saf 27:173-84. 2004
    ..These findings - considered in the context of data showing lamotrigine to be effective for bipolar depression - establish lamotrigine as a well-tolerated addition to the psychotropic armamentarium...
  10. ncbi request reprint A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute mania
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284 7792, USA
    J Clin Psychiatry 67:1501-10. 2006
    ..The efficacy and safety of divalproex sodium extended release (divalproex ER) were evaluated in patients hospitalized for acute mania associated with bipolar I disorder, manic or mixed type (DSM-IV-TR criteria)...
  11. ncbi request reprint A different depression: clinical distinctions between bipolar and unipolar depression
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, 7th Floor Mail Code 7792, San Antonio, TX 78229 3900, USA
    J Affect Disord 84:117-25. 2005
    ..Awareness of these distinctions can greatly improve diagnosis of bipolar disorder and provide an opportunity for effective therapeutic intervention...
  12. ncbi request reprint The effectiveness of divalproate in all forms of mania and the broader bipolar spectrum: many questions, few answers
    C Bowden
    Department of Psychiatry, University of Texas Health Science Center, Mail Code 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Affect Disord 79:S9-14. 2004
    ..In general, VPA provides a well-tolerated treatment that is efficacious for a broad spectrum of manic states and improves outcomes during maintenance treatment...
  13. doi request reprint Anticonvulsants in bipolar disorders: current research and practice and future directions
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Bipolar Disord 11:20-33. 2009
    ....
  14. ncbi request reprint Treatment options for bipolar depression
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Clin Psychiatry 66:3-6. 2005
    ....
  15. ncbi request reprint Risperidone in combination with mood stabilizers: a 10-week continuation phase study in bipolar I disorder
    Charles L Bowden
    University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Clin Psychiatry 65:707-14. 2004
    ..Combination therapy (risperidone and a mood stabilizer) for patients with a history of bipolar disorder (DSM-IV) and hospitalized for treatment of a manic episode was assessed in a 13-week study...
  16. ncbi request reprint Introduction: managing bipolar depression
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Sciences Center at San Antonio, 78299 3900, USA
    J Clin Psychiatry 65:3-4. 2004
  17. ncbi request reprint A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Clin Psychiatry 66:111-21. 2005
    ..To evaluate the efficacy and tolerability of quetiapine monotherapy versus placebo for the treatment of mania associated with bipolar disorder...
  18. ncbi request reprint Relationship of acute mania symptomatology to maintenance treatment response
    Charles L Bowden
    The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive Mail Code 7792, San Antonio, TX 78229, USA
    Curr Psychiatry Rep 6:473-7. 2004
    ..Some findings have been unexpected. Mixed mania did not predict different maintenance response to divalproex or lithium but predicted more side effects with either drug, and reduced efficacy of olanzapine or lamotrigine...
  19. doi request reprint Efficacy of valproate versus lithium in mania or mixed mania: a randomized, open 12-week trial
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Int Clin Psychopharmacol 25:60-7. 2010
    ..Adverse events were reported in 42.8% of patients in the lithium group and 41.5% in the valproate group. Valproate and lithium showed comparable efficacy and tolerability in the treatment of acute mania over 12 weeks...
  20. ncbi request reprint Acute and maintenance treatment with mood stabilizers
    Charles L Bowden
    The University of Texas Health Science Center at San Antonio, Department of Psychiatry, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Int J Neuropsychopharmacol 6:269-75. 2003
    ..Systematic studies are needed to clarify treatment guidelines for youth with bipolar disorder, and for other special populations, e.g. pregnant women and the elderly...
  21. ncbi request reprint The ability of lithium and other mood stabilizers to decrease suicide risk and prevent relapse
    C L Bowden
    The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Curr Psychiatry Rep 2:490-4. 2000
    ..Both lithium and divalproex appear beneficial in prevention of relapse, although recent studies indicate more modest effects for lithium than did early studies from the 1970s...
  22. ncbi request reprint Strategies to reduce misdiagnosis of bipolar depression
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78229 3900, USA
    Psychiatr Serv 52:51-5. 2001
    ..It is important that clinicians be alert to any hint of bipolarity developing in the course of antidepressant therapy, especially among patients with first-episode major depression...
  23. ncbi request reprint Novel treatments for bipolar disorder
    C L Bowden
    University of Texas Health Science Center at San Antonio, Department of Psychiatry Mail Code 7792, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Expert Opin Investig Drugs 10:661-71. 2001
    ..Several other drugs that were reported as beneficial in various facets of bipolar disorder in open trials have not differed from placebo when studied in randomised, placebo-controlled trials...
  24. ncbi request reprint Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Am J Psychiatry 163:1199-201. 2006
    ..This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies...
  25. ncbi request reprint Anticonvulsants in bipolar disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Aust N Z J Psychiatry 40:386-93. 2006
    ..To review the literature on the effectiveness of anticonvulsant drugs in the management of bipolar disorder...
  26. ncbi request reprint Development of the bipolar inventory of symptoms scale
    C L Bowden
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Acta Psychiatr Scand 116:189-94. 2007
    ..We report the rationale, format, reliability and initial validity studies of the Bipolar Inventory of Symptoms Scale (BISS), a 44-item scale designed to encompass the spectrum of behavioral disturbances in BDs...
  27. ncbi request reprint Making optimal use of combination pharmacotherapy in bipolar disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229, USA
    J Clin Psychiatry 65:21-4. 2004
    ..Agents should be added carefully, with continued monitoring of adverse effects. Physicians should give patients only as much medication as needed...
  28. ncbi request reprint Spectrum of effectiveness of valproate in neuropsychiatry
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Expert Rev Neurother 7:9-16. 2007
    ..Valproate appears useful in other disorders that have behavioral dimensions inclusive of the domains that valproate benefits in bipolar disorders, such as schizophrenia...
  29. ncbi request reprint Introduction: the burden of bipolar depression
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Clin Psychiatry 66:3-4. 2005
  30. ncbi request reprint A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229, USA
    Arch Gen Psychiatry 60:392-400. 2003
    ....
  31. doi request reprint Ziprasidone plus a mood stabilizer in subjects with bipolar I disorder: a 6-month, randomized, placebo-controlled, double-blind trial
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Clin Psychiatry 71:130-7. 2010
    ..To evaluate the efficacy and safety of ziprasidone adjunctive to a mood stabilizer for the maintenance treatment of bipolar mania...
  32. ncbi request reprint Valproate
    Charles L Bowden
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229, USA
    Bipolar Disord 5:189-202. 2003
    ..This article summarizes the role of valproate as a treatment for bipolar disorder and related conditions...
  33. ncbi request reprint Open-label, concomitant use of lamotrigine and other medications for bipolar disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    CNS Spectr 13:75-83. 2008
    ..A post-hoc, descriptive analysis was undertaken to assess the tolerability of and changes in psychiatric rating scales with lamotrigine (LTG) administered concomitantly with commonly prescribed bipolar medications...
  34. ncbi request reprint Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety
    Gary S Sachs
    Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Suite 580, Boston, MA 02114, USA
    Am J Psychiatry 159:1146-54. 2002
    ..The study assessed the efficacy and safety of risperidone as an adjunctive agent to mood stabilizers in the treatment of acute mania...
  35. ncbi request reprint Clinical correlates of therapeutic response in bipolar disorder
    C L Bowden
    The University of Texas Health Science Center at San Antonio, Department of Psychiatry, 7703 Floyd Curl Drive, San Antonio, TX 78284 7792, USA
    J Affect Disord 67:257-65. 2001
    ..Patients unresponsive to a single agent may show improvement with combined regimens, though this impression is based more on clinical experience than controlled randomized assignment...
  36. ncbi request reprint Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement Program
    Christopher D Schneck
    Department of Psychiatry, University of Colorado Health Sciences Center, 4455 East 12th Ave, Box A011 15, Denver, CO 80220, USA
    Am J Psychiatry 161:1902-8. 2004
    ..This study compared demographic and phenomenological variables between bipolar patients with and without rapid cycling as a function of bipolar I versus bipolar II status...
  37. ncbi request reprint Maintenance efficacy of divalproex in the prevention of bipolar depression
    Laszlo Gyulai
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1374-82. 2003
    ....
  38. doi request reprint A randomized, placebo-controlled, multicenter study of divalproex sodium extended-release in the acute treatment of mania
    Robert M A Hirschfeld
    The University of Texas Medical Branch, Department of Psychiatry, 301 University Blvd, Galveston, TX 77555, USA
    J Clin Psychiatry 71:426-32. 2010
    ..One study demonstrated statistically significant improvements in mania symptoms compared to placebo, while an earlier study did not. Results of the earlier study are presented here...
  39. doi request reprint Discriminating primary clinical states in bipolar disorder with a comprehensive symptom scale
    V Singh
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Acta Psychiatr Scand 127:145-52. 2013
    ..We addressed symptoms differentiating mixed states from depression or mania/hypomania...
  40. ncbi request reprint A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder
    Joseph R Calabrese
    University Hospitals of Cleveland Case Western Reserve School of Medicine, Department of Psychiatry, 11400 Euclid Ave, Ste 200, Cleveland, OH 44106, USA
    J Clin Psychiatry 64:1013-24. 2003
    ..This study assessed the efficacy and tolerability of lamotrigine and lithium compared with placebo for the prevention of mood episodes in bipolar disorder...
  41. ncbi request reprint Structure of mania: depressive, irritable, and psychotic clusters with different retrospectively-assessed course patterns of illness in randomized clinical trial participants
    A C Swann
    Department of Psychiatry, University of Texas Houston Health Science Center, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
    J Affect Disord 67:123-32. 2001
    ..We investigated the structure of manic episodes by determining whether there was evidence for distinct groups of patients differing in clinical characteristics and course of illness...
  42. ncbi request reprint The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9121, USA
    J Clin Psychiatry 66:870-86. 2005
    ..The guidelines for evaluating possible medications, the criteria for selection and ranking, and the updated algorithms are described...
  43. ncbi request reprint Relationship of open acute mania treatment to blinded maintenance outcome in bipolar I disorder
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Affect Disord 107:127-33. 2008
    ..No published studies have statistically evaluated the relationship between the outcomes in maintenance treatment and the principal acute agent...
  44. ncbi request reprint Lamotrigine combined with divalproex or lithium for bipolar disorder: a case series
    James R Redmond
    University of Texas Health Science Center, San Antonio, TX 78229, USA
    CNS Spectr 11:915-8. 2006
    ..Combination therapy may provide more efficacious treatment for many patients with bipolar disorder...
  45. doi request reprint Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double-blind, randomized, placebo-controlled study
    Fabiano G Nery
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Hum Psychopharmacol 23:87-94. 2008
    ..To investigate whether the cox-2 inhibitor celecoxib has antidepressant effects in bipolar disorder (BD) patients during depressive or mixed phases...
  46. ncbi request reprint Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  47. ncbi request reprint Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Clin Psychiatry 63:1012-9. 2002
    ..The objective of this report was to determine rash rates in clinical trials of lamotrigine in DSM-IV unipolar depression or bipolar disorder...
  48. ncbi request reprint Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 56:703-13. 2004
  49. pmc Suicidal ideation and depressive symptoms among bipolar patients as predictors of the health and well-being of caregivers
    Cheryl A Chessick
    Department of Psychiatry, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    Bipolar Disord 11:876-84. 2009
    ..This study examined whether caregivers' health is associated with changes in suicidal ideation and depressive symptoms among bipolar patients observed over one year...
  50. doi request reprint The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders
    Mauricio Tohen
    Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7792, San Antonio, TX 78229, USA
    Bipolar Disord 11:453-73. 2009
    ....
  51. ncbi request reprint The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness
    Dawn I Velligan
    University of Texas Health Science Center, San Antonio, TX, USA
    J Clin Psychiatry 70:1-46; quiz 47-8. 2009
    ..Poor adherence to medication treatment can have devastating consequences for patients with mental illness. The goal of this project was to develop recommendations for addressing adherence problems to improve patient outcomes...
  52. pmc One-year treatment outcomes of African-American and Hispanic patients with bipolar I or II disorder in STEP-BD
    Jodi M Gonzalez
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Psychiatr Serv 61:164-72. 2010
    ..The U.S. Systematic Treatment Enhancement Program for Bipolar Disorder compared one-year outcomes for bipolar I or II disorder from each of these racial-ethnic groups...
  53. ncbi request reprint Factors associated with stigma among caregivers of patients with bipolar disorder in the STEP-BD study
    Jodi M Gonzalez
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Psychiatr Serv 58:41-8. 2007
    ..Little is known about the factors contributing to mental illness stigma among caregivers of people with bipolar disorder...
  54. doi request reprint Development of the Bipolar Inventory of Symptoms Scale: concurrent validity, discriminant validity and retest reliability
    Jodi M Gonzalez
    Department of Psychiatry, UT Health Science Center, San Antonio, TX 78229, USA
    Int J Methods Psychiatr Res 17:198-209. 2008
    ..Future directions include factor analysis and sensitivity to change from treatment studies...
  55. doi request reprint Principal domains of behavioral psychopathology identified by the Bipolar Inventory of Signs and Symptoms Scale (BISS)
    Peter M Thompson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78290 3900, USA
    Psychiatry Res 175:221-6. 2010
    ..Despite the common occurrence of anxiety in BD, it has not been identified in most prior factor analyses, in part due to limited coverage of anxiety symptoms in the source scales...
  56. ncbi request reprint Focus on bipolar disorder treatment
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX, USA
    J Clin Psychiatry 66:1598-609. 2005
  57. ncbi request reprint A video method for the evaluation of antidepressant clinical and behavioural actions
    Martin M Katz
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 9:327-36. 2006
    ..e. effect motor activity and depressed mood, and paroxetine to reduce global severity and anxiety. The study shows the VIBES to be capable of uncovering behavioural mechanisms underlying AD's capacity to resolve depressive disorder...
  58. ncbi request reprint Pharmacotherapy for bipolar depression: an economic assessment
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Expert Opin Pharmacother 5:1101-7. 2004
    ..Maintenance pharmacotherapy can reduce rates of future episodes, and subsequently, the associated risks, functional disability and economic burden of bipolar illness...
  59. ncbi request reprint Relationship of mania symptomatology to maintenance treatment response with divalproex, lithium, or placebo
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuropsychopharmacology 30:1932-9. 2005
    ..Dysphoric mania appeared to predispose patients to more side effects when treated with either divalproex or lithium during maintenance therapy...
  60. ncbi request reprint Treatment characteristics and illness burden among European Americans, African Americans, and Latinos in the first 2,000 patients of the systematic treatment enhancement program for bipolar disorder
    Jodi M Gonzalez
    University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Psychopharmacol Bull 40:31-46. 2007
    ..This study compared illness characteristics, treatment history, and overall functioning in a sample of European American, African American, and Latino patients with bipolar disorder...
  61. ncbi request reprint Oral topiramate for treatment of alcohol dependence: a randomised controlled trial
    Bankole A Johnson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Lancet 361:1677-85. 2003
    ..We aimed to see whether topiramate was more effective than placebo as a treatment for alcohol dependence...
  62. ncbi request reprint Reduced educational attainment in bipolar disorder
    David C Glahn
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229, USA
    J Affect Disord 92:309-12. 2006
    ..To document educational attainment in relation to IQ in patients with bipolar disorder, in order to establish guidelines for matching patients with appropriate comparison subjects...
  63. ncbi request reprint Lamotrigine in the treatment of bipolar disorder
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Expert Opin Pharmacother 3:1513-9. 2002
    ..Lamotrigine appears not to have acute antimanic properties. A small number of studies suggest a broader spectrum of efficacy, including in some axis I disorders that are comorbidly associated with bipolar disorder...
  64. ncbi request reprint Lamotrigine treatment of bipolar disorder: data from the first 500 patients in STEP-BD
    Lauren B Marangell
    Mood Disorders Program, Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
    Bipolar Disord 6:139-43. 2004
    ..To describe the frequency and correlates of lamotrigine therapy among the first 500 patients enrolled into the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study...
  65. pmc Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia
    Hader A Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:701-10. 2009
    ..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...
  66. ncbi request reprint A multivantaged behavioural method for measuring onset and sequence of the clinical actions of antidepressants
    Martin M Katz
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 7:471-9. 2004
    ..Thus, the Brief MV, in uncovering underlying behavioural actions, represents an important addition to the current unidimensional HAMD approach in drug research...
  67. doi request reprint Diagnosis, treatment, and recovery maintenance in bipolar depression
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, and the Center for Bipolar Illness Interventions in Hispanic Communities, San Antonio, USA
    J Clin Psychiatry 71:e01. 2010
    ..Clinicians must consider the existing evidence on the long-term efficacy of various pharmacologic and psychosocial interventions for preventing and treating bipolar mood episodes...
  68. doi request reprint Lithium treatment -- moderate dose use study (LiTMUS) for bipolar disorder: rationale and design
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Trials 6:637-48. 2009
    ..Recent data indicate that lithium use for bipolar disorder has declined over the last decade and that lithium largely has been replaced with alternate, commercially promoted medications that may or may not result in better outcomes...
  69. pmc Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders
    Fabiano G Nery
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Psychiatr Res 42:569-77. 2008
    ..These findings suggest that personality, at least to some extent, mediates the comorbidity phenomena in bipolar disorder...
  70. doi request reprint Anterior cingulate volumes associated with trait impulsivity in individuals with bipolar disorder
    Koji Matsuo
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 77030, USA
    Bipolar Disord 11:628-36. 2009
    ....
  71. ncbi request reprint Enhancing the technology of clinical trials and the trials model to evaluate newly developed, targeted antidepressants
    Martin M Katz
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Neuropsychopharmacology 27:319-28. 2002
    ..This article discusses these four areas and presents the consensus of the panel participants...
  72. ncbi request reprint Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression
    Martin M Katz
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 29:566-79. 2004
    ..Early drug-specific behavioral changes were highly predictive of ultimate clinical response to the different ADs, results that could eventually be applied directly to clinical practice...
  73. doi request reprint Diagnosis and impact of bipolar depression
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, and the Center for Bipolar Illness Interventions in Hispanic Communities, San Antonio, TX, USA
    J Clin Psychiatry 70:e32. 2009
    ..Clinicians must take steps to differentiate bipolar depression from other depressive disorders. Screening for manic/hypomanic symptoms during index episodes of depression can help in this endeavor...
  74. ncbi request reprint The neurocognitive signature of psychotic bipolar disorder
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 62:910-6. 2007
    ..We sought to ascertain the profile of cognitive impairment in patients with bipolar disorder and to determine whether a distinct profile of cognitive deficits characterizes bipolar patients with a history of psychosis...
  75. doi request reprint Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study
    Roy H Perlis
    Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, ACC 812 15 Parkman Street, Boston, MA 02114, USA
    Bipolar Disord 11:391-400. 2009
    ..Symptoms of bipolar disorder are increasingly recognized among children and adolescents, but little is known about the course of bipolar disorder among adults who experience childhood onset of symptoms...
  76. ncbi request reprint Trait impulsivity in patients with mood disorders
    M A M Peluso
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, USA
    J Affect Disord 100:227-31. 2007
    ..We assessed impulsivity in depressed and euthymic bipolar and unipolar patients and healthy controls. We hypothesized that bipolar subjects would have higher levels of trait impulsivity than the comparison groups...
  77. ncbi request reprint Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder
    Benicio N Frey
    Department of Psychiatry, Psychiatric Genetics Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Neuroreport 18:1567-70. 2007
    ..These results indicate that bipolar disorder met-carriers have abnormal energy metabolism in the left dorsolateral prefrontal cortex...
  78. ncbi request reprint Discovery and development of lamotrigine for bipolar disorder: a story of serendipity, clinical observations, risk taking, and persistence
    Richard H Weisler
    University of North Carolina at Chapel Hill and Duke University Medical Center, United States
    J Affect Disord 108:1-9. 2008
    ..The development of lamotrigine provides one example of the importance of prescience, patience and persistence in bringing a novel idea to clinical fruition...
  79. ncbi request reprint Linear relationship of valproate serum concentration to response and optimal serum levels for acute mania
    Michael H Allen
    University of Colorado School of Medicine, 4200 East 9th Ave, Box A011 95, Denver, CO 80220, USA
    Am J Psychiatry 163:272-5. 2006
    ....
  80. ncbi request reprint Influence of sub-syndromal symptoms after remission from manic or mixed episodes
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Br J Psychiatry 189:515-9. 2006
    ..Sub-syndromal symptoms in bipolar disorder impair functioning and diminish quality of life...
  81. ncbi request reprint Initial symptoms of manic relapse in manic or mixed-manic bipolar disorder: post hoc analysis of patients treated with olanzapine or lithium
    John P Houston
    Lilly Corporate Center, Lilly Research Laboratories, Drop Code 4133, Indianapolis, IN 46285, United States
    J Psychiatr Res 41:616-21. 2007
    ....
  82. ncbi request reprint Suicidal ideation and pharmacotherapy among STEP-BD patients
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, 208 Valley Road, New Canaan, Connecticut 06840, and Department of Psychiatry, University of Colorado School of Medicine, Denver, USA
    Psychiatr Serv 56:1534-40. 2005
    ..Little is known about the effects of lithium on suicidal ideation or about the possible antisuicidal effects of divalproex, second-generation antipsychotics, or antidepressants among persons with bipolar disorder...
  83. ncbi request reprint Report of the Texas Consensus Conference Panel on medication treatment of bipolar disorder 2000
    Trisha Suppes
    Department of Psychiatry The University of Texas Southwestern Medical Center Dallas, 75390 9070, USA
    J Clin Psychiatry 63:288-99. 2002
    ....
  84. ncbi request reprint Pattern of response to divalproex, lithium, or placebo in four naturalistic subtypes of mania
    Alan C Swann
    University of Texas Houston Health Science Center, P O Box 20708, Houston, TX 77225, USA
    Neuropsychopharmacology 26:530-6. 2002
    ..These data suggest that there are naturalistic subtypes of manic episodes with different responses to treatment...
  85. ncbi request reprint Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy
    Mauricio Tohen
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Arch Gen Psychiatry 59:62-9. 2002
    ....
  86. ncbi request reprint Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials
    Mark A Frye
    Mood Disorders Research Program, University of California at Los Angeles, USA
    J Clin Psychiatry 67:1721-8. 2006
    ..Subsyndromal symptoms in bipolar disorder can cause significant functional impairment and are associated with relapse...
  87. ncbi request reprint Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 163:247-56. 2006
    ..In a placebo-controlled, double-blind study, the authors investigated the efficacy and safety of olanzapine as monotherapy in relapse prevention in bipolar I disorder...
  88. ncbi request reprint Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 162:1281-90. 2005
    ..The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence...
  89. doi request reprint Olanzapine plus carbamazepine v. carbamazepine alone in treating manic episodes
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Br J Psychiatry 192:135-43. 2008
    ..Combinations of olanzapine and carbamazepine are often used in clinical practice in the management of mania...
  90. ncbi request reprint Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Roy H Perlis
    Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:875-81. 2004
    ..Early onset of mood symptoms in bipolar disorder has been associated with poor outcome in many studies; however, the factors that might contribute to poor outcome have not been adequately investigated...
  91. ncbi request reprint A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder
    Guy M Goodwin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, England, UK
    J Clin Psychiatry 65:432-41. 2004
    ..Two clinical trials, prospectively designed for combined analysis, compared placebo, lithium, and lamotrigine for treatment of bipolar I disorder in recently depressed or manic patients...
  92. ncbi request reprint Atypical antipsychotics in bipolar depression: potential mechanisms of action
    Lakshmi N Yatham
    Department of Psychiatry, The University of British Columbia, UBC Hospital, Vancouver, Canada
    J Clin Psychiatry 66:40-8. 2005
    ..Further studies should be conducted to examine these hypotheses...
  93. ncbi request reprint Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut, USA
    Am J Psychiatry 164:1348-55. 2007
    ..However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs...
  94. ncbi request reprint Effectiveness of adjunctive antidepressant treatment for bipolar depression
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 356:1711-22. 2007
    ..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania...
  95. ncbi request reprint Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Br J Psychiatry 184:337-45. 2004
    ..Aims To evaluate whether olanzapine plus either lithium or valproate reduces the rate of relapse, compared with lithium or valproate alone...
  96. doi request reprint Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population
    Lori L Davis
    Veterans Affairs Medical Center, Tuscaloosa, AL 35404, USA
    J Clin Psychopharmacol 28:84-8. 2008
    ..To evaluate the efficacy of divalproex for the treatment of posttraumatic stress disorder (PTSD) hyperarousal symptom cluster...

Research Grants3

  1. Bipolar Illness Intervention in Hispanic Communities
    Charles Bowden; Fiscal Year: 2007
    ..abstract not provided ..