Research Topics
Genomes and Genes | Amy BoutonSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Regulation of c-SRC activity and function by the adapter protein CASM R Burnham
Department of Microbiology and Cancer Center, Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908, Trinity College, Dublin 2, Ireland
Mol Cell Biol 20:5865-78. 2000..These data suggest that CAS plays an important role in regulating specific signaling pathways governing cell growth and/or survival, in part through its ability to interact with and modulate the activity of c-SRC...
Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3Rebecca B Riggins
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908-0735, USA
J Biol Chem 278:28264-73. 2003..These data thus provide insight into how Cas and AND-34 may function together to stimulate Src signaling pathways and promote cell migration...- Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane rufflingRandy S Schrecengost
Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Cancer Res 67:6174-82. 2007..Based on these data, we propose that the spatial and temporal regulation of BCAR3/p130(Cas) interactions within the cell is important for controlling breast cancer cell motility... - Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinaseKatherine A Owen
Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
J Cell Biol 179:1275-87. 2007..However, the combined loss of FAK and Pyk2 had no greater effect than the loss of either molecule alone, indicating that both kinases function within the same pathway to promote invasion... - Regulation of osteoclast structure and function by FAK family kinasesBrianne J Ray
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA
J Leukoc Biol 92:1021-8. 2012..We conclude that FAK contributes to cytokine signaling and bone resorption in osteoclasts and partially compensates for the absence of Pyk2 to maintain proper adhesion structures in these cells... - Functions of the adapter protein Cas: signal convergence and the determination of cellular responsesA H Bouton
Department of Microbiology, University of Virginia School of Medicine, Box 800734, Charlottesville, Virginia VA 22908, USA
Oncogene 20:6448-58. 2001..Therefore, in its capacity as an adapter protein, Cas serves as a point of convergence for many distinct signaling inputs, ultimately contributing to the generation of specific cellular responses... - Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling eventsMichelle Y Abshire
Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908, USA
J Leukoc Biol 89:251-7. 2011..These studies expand our understanding of β1 integrin signaling networks that regulate motility and invasion in macrophages and thus, provide important new insights into mechanisms by which macrophages perform their diverse functions... - Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptakePamela J Bruce-Staskal
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908-0734, USA
J Cell Sci 115:2689-700. 2002..pseudotuberculosis. Importantly, these findings also contribute to a better understanding of other cellular processes that involve actin remodeling, including the host response to other microbial pathogens, cell adhesion and migration... - Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cellsRebecca B Riggins
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908, USA
Mol Cancer Res 1:428-37. 2003..This suggests that the association of Cas with p85 PI3K may play a role in uncoupling growth regulatory pathways through v-Crk... - Cell adhesion promotes Ebola virus envelope glycoprotein-mediated binding and infectionDerek Dube
Department of Microbiology, University of Virginia, 1300 Jefferson Park Ave, Charlottesville, Virginia 22908 0734, USA
J Virol 82:7238-42. 2008..Furthermore, with 293F cells the acquisition of EboV RBD binding paralleled cell spreading and did not require new mRNA or protein synthesis...
Research Grants
- Mechanisms of Breast Tumor Cell Growth, Motility, and Antiestrogen ResponseAmy Bouton; Fiscal Year: 2009....
- Mechanisms of breast cancer cell growth & tumorigenicityAmy Bouton; Fiscal Year: 2007..abstract_text> ..
- Mechanistic aspects of integrin-mediated Yersinia uptakeAmy Bouton; Fiscal Year: 2007..abstract_text> ..
- Mechanisms of Breast Tumor Cell Growth, Motility, and Antiestrogen ResponseAmy H Bouton; Fiscal Year: 2010....