H R Bourne

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint How receptors talk to trimeric G proteins
    H R Bourne
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Curr Opin Cell Biol 9:134-42. 1997
  2. ncbi request reprint Structure. Rhodopsin sees the light
    H R Bourne
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA
    Science 289:733-4. 2000
  3. ncbi request reprint Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation
    B R Conklin
    Department of Medicine, University of California, San Francisco 94143, USA
    Mol Pharmacol 50:885-90. 1996
  4. pmc Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?
    P Rondard
    Departments of Cellular and Molecular Pharmacology, Medicine, and the Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0450, USA
    Proc Natl Acad Sci U S A 98:6150-5. 2001
  5. ncbi request reprint Receptor activation: what does the rhodopsin structure tell us?
    E C Meng
    Dept of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 0450, USA
    Trends Pharmacol Sci 22:587-93. 2001
  6. ncbi request reprint An activation switch in the ligand binding pocket of the C5a receptor
    B O Gerber
    Departments of Cellular and Molecular Pharmacology and Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA
    J Biol Chem 276:3394-400. 2001
  7. pmc Conditional activation defect of a human Gsalpha mutant
    T Iiri
    Department of Cellular and Molecular Pharmacology, S 1212, Box 0450, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 94:5656-61. 1997
  8. ncbi request reprint G-proteins and GPCrs: from the beginning
    H R Bourne
    UCSF, San Francisco 94143 2140, USA
    Ernst Schering Found Symp Proc . 2006
  9. ncbi request reprint Pseudohypoparathyroidism, a novel mutation in the betagamma-contact region of Gsalpha impairs receptor stimulation
    Z Farfel
    Laboratory of Biochemical Pharmacology, Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    J Biol Chem 271:19653-5. 1996
  10. ncbi request reprint Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha
    P B Wedegaertner
    Department of Pharmacology, University of California, San Francisco 94143
    J Biol Chem 268:25001-8. 1993

Collaborators

  • B R Conklin
  • F McCormick
  • T Iiri
  • E C Meng
  • P Rondard
  • B O Gerber
  • Z Farfel
  • P B Wedegaertner
  • S Srinivasan
  • E Meng
  • T Fujita
  • V Dotsch
  • T J Baranski
  • D R Benjamin
  • P T Wilson
  • H Shapira
  • M Mouallem
  • A Roitman
  • I D Kuntz
  • D W Markby
  • J M Nakamoto
  • P Herzmark
  • C Van Dop
  • D H Chu
  • K A Sullivan
  • M J Levis
  • C A Landis
  • J Lyons
  • P L Ashley
  • L Vallar
  • S B Masters
  • Q Y Duh
  • F H Chang
  • J Ellison
  • A Alborzi
  • K Grunewald
  • D R Cox
  • A D Levinson
  • H Feichtinger
  • B Beiderman
  • E Kawasaki
  • A M Pace
  • O H Clark
  • Y C Liao
  • A Spada
  • G Harsh

Detail Information

Publications18

  1. ncbi request reprint How receptors talk to trimeric G proteins
    H R Bourne
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Curr Opin Cell Biol 9:134-42. 1997
    ....
  2. ncbi request reprint Structure. Rhodopsin sees the light
    H R Bourne
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA
    Science 289:733-4. 2000
    ....
  3. ncbi request reprint Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation
    B R Conklin
    Department of Medicine, University of California, San Francisco 94143, USA
    Mol Pharmacol 50:885-90. 1996
    ..These studies refine our understanding and provide new tools with which to study the fidelity of receptor/G alpha activation...
  4. pmc Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?
    P Rondard
    Departments of Cellular and Molecular Pharmacology, Medicine, and the Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0450, USA
    Proc Natl Acad Sci U S A 98:6150-5. 2001
    ..We speculate that receptors use a similar mechanism to activate trimeric G proteins...
  5. ncbi request reprint Receptor activation: what does the rhodopsin structure tell us?
    E C Meng
    Dept of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 0450, USA
    Trends Pharmacol Sci 22:587-93. 2001
    ..Furthermore, lessons learned from rhodopsin might also apply to other members of this essential family of receptors. (For an animation of the crystal structure of rhodopsin see http://archive.bmn.com/supp/tips/tips2211a.html)..
  6. ncbi request reprint An activation switch in the ligand binding pocket of the C5a receptor
    B O Gerber
    Departments of Cellular and Molecular Pharmacology and Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA
    J Biol Chem 276:3394-400. 2001
    ..We propose that agonists induce a small change in the relative orientations of helices III and VII and that these helices work together to allow movement of helix VI away from the receptor core, thereby triggering G protein activation...
  7. pmc Conditional activation defect of a human Gsalpha mutant
    T Iiri
    Department of Cellular and Molecular Pharmacology, S 1212, Box 0450, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 94:5656-61. 1997
    ....
  8. ncbi request reprint G-proteins and GPCrs: from the beginning
    H R Bourne
    UCSF, San Francisco 94143 2140, USA
    Ernst Schering Found Symp Proc . 2006
    ..Because these pivotally important signaling molecules were discovered before the recombinant DNA revolution, today's well-trained molecular biologist may find it amazing that we learned anything at all...
  9. ncbi request reprint Pseudohypoparathyroidism, a novel mutation in the betagamma-contact region of Gsalpha impairs receptor stimulation
    Z Farfel
    Laboratory of Biochemical Pharmacology, Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    J Biol Chem 271:19653-5. 1996
    ..Thus, the R231H phenotype suggests that switch 2 (perhaps in concert with betagamma) mediates G protein activation by receptors at a site distant from the receptor-G protein contact surface...
  10. ncbi request reprint Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha
    P B Wedegaertner
    Department of Pharmacology, University of California, San Francisco 94143
    J Biol Chem 268:25001-8. 1993
    ..These findings identify palmitoylation as a critical determinant of membrane attachment for alpha q and alpha s and show that this modification is required for normal signaling by these proteins...
  11. ncbi request reprint Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function
    T Iiri
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Nature 371:164-8. 1994
    ..In vitro experiments indicate that accelerated release of GDP causes both the constitutive activity and the thermolability of alpha s-A366S...
  12. ncbi request reprint Lipid modifications of trimeric G proteins
    P B Wedegaertner
    Department of Pharmacology, University of California, San Francisco 94143
    J Biol Chem 270:503-6. 1995
    ..In addition, regulation of these modifications, particularly palmitoylation, can provide new ways to regulate signals transmitted by G proteins...
  13. ncbi request reprint Solution structure of the GTPase activating domain of alpha s
    D R Benjamin
    Department of Pharmaceutical Chemistry University of California at San Francisco 94143 0446, USA
    J Mol Biol 254:681-91. 1995
    ..This structural divergence, along with functional studies of chimeric proteins, suggests that this region of the domain interacts with either the downstream effector adenylyl cyclase or with some other intermediary protein...
  14. ncbi request reprint Chromosomal assignment of the murine Gi alpha and Gs alpha genes. Implications for the obese mouse
    P L Ashley
    Department of Pediatrics, University of California, San Francisco 94143
    J Biol Chem 262:15299-301. 1987
    ..Furthermore, our findings indicate that certain members of the murine G protein alpha gene family have dispersed to different chromosomes since diverging from a common ancestral gene...
  15. pmc Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains
    K A Sullivan
    Proc Natl Acad Sci U S A 83:6687-91. 1986
    ..Further comparison of the alpha-chain sequences suggests additional regions that may contribute to interactions with beta gamma subunits and the receptor and effector components of different signal transduction systems...
  16. ncbi request reprint GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
    C A Landis
    Department of Pharmacology, University of California, San Francisco 94143
    Nature 340:692-6. 1989
    ..This domain may serve as a built-in counter-part of the separate GTPase-activating proteins required for GTP hydrolysis by small GTP-binding proteins such as p21ras...
  17. ncbi request reprint Two G protein oncogenes in human endocrine tumors
    J Lyons
    Department of Human Genetics, Cetus Corporation, Emeryville CA 94608
    Science 249:655-9. 1990
    ..These findings suggest that human tumors may harbor oncogenic mutations in various G protein alpha chain genes...
  18. ncbi request reprint The GTPase superfamily: conserved structure and molecular mechanism
    H R Bourne
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Nature 349:117-27. 1991
    ....