L Y Bourguignon

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Cell Biol 150:177-91. 2000
  2. ncbi CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101, USA
    J Biol Chem 276:7327-36. 2001
  3. ncbi CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Biol Chem 275:1829-38. 2000
  4. ncbi Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, Miami, Florida 33136, USA
    Cell Motil Cytoskeleton 43:269-87. 1999
  5. ncbi Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells
    F Diaz
    Department of Cell Biology and Anatomy, University of Miami Medical School, Miami, USA
    Cell Calcium 27:315-28. 2000
  6. ncbi A novel CD44 v3 isoform is involved in head and neck squamous cell carcinoma progression
    E J Franzmann
    Department of Otolaryngology, School of Medicine, University of Miami, FL 33101, USA
    Otolaryngol Head Neck Surg 124:426-32. 2001
  7. ncbi CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, Florida 33136, USA
    J Mammary Gland Biol Neoplasia 6:287-97. 2001
  8. ncbi The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101
    J Biol Chem 268:7290-7. 1993
  9. ncbi Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth
    L Y Bourguignon
    Enocrine Unit, Department of Medicine, University of California and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 276:48679-92. 2001
  10. ncbi Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, FL 33101
    J Immunol 151:6634-44. 1993

Collaborators

Detail Information

Publications12

  1. ncbi Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Cell Biol 150:177-91. 2000
    ..These findings suggest that ankyrin-Tiam1 interaction plays a pivotal role in regulating Rac1 signaling and cytoskeleton function required for oncogenic signaling and metastatic breast tumor cell progression...
  2. ncbi CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101, USA
    J Biol Chem 276:7327-36. 2001
    ....
  3. ncbi CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Biol Chem 275:1829-38. 2000
    ..Taken together, we believe that the linkage between CD44v3 isoform and the PHn-CC-EX domain of Tiam1 is required for HA stimulated Rac1 signaling and cytoskeleton-mediated tumor cell migration during breast cancer progression...
  4. ncbi Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, Miami, Florida 33136, USA
    Cell Motil Cytoskeleton 43:269-87. 1999
    ..These findings support the hypothesis that ROK plays a pivotal role in CD44v(3,8-10)-ankyrin interaction and RhoA-mediated oncogenic signaling required for membrane-cytoskeleton function and metastatic tumor cell migration...
  5. ncbi Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells
    F Diaz
    Department of Cell Biology and Anatomy, University of Miami Medical School, Miami, USA
    Cell Calcium 27:315-28. 2000
    ..We propose that the selective down-regulation of IP(3)R subtype-mediated Ca(2+)function by caspase-dependent and calpain-sensitive mechanisms may be responsible for the early onset of the apoptotic signal by TNFalpha in human T-cells...
  6. ncbi A novel CD44 v3 isoform is involved in head and neck squamous cell carcinoma progression
    E J Franzmann
    Department of Otolaryngology, School of Medicine, University of Miami, FL 33101, USA
    Otolaryngol Head Neck Surg 124:426-32. 2001
    ..CD44 comprises a family of isoforms involved in tumorigenesis. Here we investigate the role of CD44 isoforms in head and neck squamous cell carcinoma (HNSCC) progression...
  7. ncbi CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, Florida 33136, USA
    J Mammary Gland Biol Neoplasia 6:287-97. 2001
    ..g., Rho/Ras signaling and receptor-linked/non-receptor-linked tyrosine kinase pathways), leading to a concomitant onset of multiple cellular functions (e.g., tumor cell growth, migration and invasion) and breast tumor progression...
  8. ncbi The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101
    J Biol Chem 268:7290-7. 1993
    ..These findings suggest that the cytoskeleton plays a pivotal role in the regulation of IP3 receptor-mediated internal Ca2+ release during lymphocyte activation...
  9. ncbi Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth
    L Y Bourguignon
    Enocrine Unit, Department of Medicine, University of California and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 276:48679-92. 2001
    ....
  10. ncbi Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, FL 33101
    J Immunol 151:6634-44. 1993
    ..These findings strongly suggest that ankyrin plays an important role in linking the HA receptor, GP85(CD44), to the membrane-associated actomyosin contractile system during hyaluronic acid-mediated lymphocyte activation...
  11. ncbi A new splice variant of the inositol-1,4,5-triphosphate (IP3) receptor
    N Iida
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, FL 33101
    Cell Signal 6:449-55. 1994
    ..The selective expression of these two IP3R isoforms (IP3RV-S2 and non-neuronal IP3R) may be critically important for the onset of signal transduction and cell activation...
  12. ncbi The role of caldesmon in the regulation of receptor capping in mouse T-lymphoma cell
    G Walker
    Department of Anatomy and Cell Biology, University of Miami, Florida 33101
    J Biol Chem 264:496-500. 1989
    ..These findings suggest that actin-linked regulatory proteins such as caldesmon may be critically important to actomyosin-mediated contraction which, in turn, is responsible for collecting receptors into cap structures...