L Y Bourguignon

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Cell Biol 150:177-91. 2000
  2. ncbi request reprint CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101, USA
    J Biol Chem 276:7327-36. 2001
  3. ncbi request reprint CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Biol Chem 275:1829-38. 2000
  4. ncbi request reprint Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, Miami, Florida 33136, USA
    Cell Motil Cytoskeleton 43:269-87. 1999
  5. ncbi request reprint Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells
    F Diaz
    Department of Cell Biology and Anatomy, University of Miami Medical School, Miami, USA
    Cell Calcium 27:315-28. 2000
  6. ncbi request reprint A novel CD44 v3 isoform is involved in head and neck squamous cell carcinoma progression
    E J Franzmann
    Department of Otolaryngology, School of Medicine, University of Miami, FL 33101, USA
    Otolaryngol Head Neck Surg 124:426-32. 2001
  7. ncbi request reprint CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, Florida 33136, USA
    J Mammary Gland Biol Neoplasia 6:287-97. 2001
  8. ncbi request reprint The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101
    J Biol Chem 268:7290-7. 1993
  9. ncbi request reprint Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth
    L Y Bourguignon
    Enocrine Unit, Department of Medicine, University of California and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 276:48679-92. 2001
  10. ncbi request reprint Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, FL 33101
    J Immunol 151:6634-44. 1993

Collaborators

Detail Information

Publications12

  1. pmc Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Cell Biol 150:177-91. 2000
    ..These findings suggest that ankyrin-Tiam1 interaction plays a pivotal role in regulating Rac1 signaling and cytoskeleton function required for oncogenic signaling and metastatic breast tumor cell progression...
  2. ncbi request reprint CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101, USA
    J Biol Chem 276:7327-36. 2001
    ....
  3. ncbi request reprint CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Biol Chem 275:1829-38. 2000
    ..Taken together, we believe that the linkage between CD44v3 isoform and the PHn-CC-EX domain of Tiam1 is required for HA stimulated Rac1 signaling and cytoskeleton-mediated tumor cell migration during breast cancer progression...
  4. ncbi request reprint Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, Miami, Florida 33136, USA
    Cell Motil Cytoskeleton 43:269-87. 1999
    ..These findings support the hypothesis that ROK plays a pivotal role in CD44v(3,8-10)-ankyrin interaction and RhoA-mediated oncogenic signaling required for membrane-cytoskeleton function and metastatic tumor cell migration...
  5. ncbi request reprint Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells
    F Diaz
    Department of Cell Biology and Anatomy, University of Miami Medical School, Miami, USA
    Cell Calcium 27:315-28. 2000
    ..We propose that the selective down-regulation of IP(3)R subtype-mediated Ca(2+)function by caspase-dependent and calpain-sensitive mechanisms may be responsible for the early onset of the apoptotic signal by TNFalpha in human T-cells...
  6. ncbi request reprint A novel CD44 v3 isoform is involved in head and neck squamous cell carcinoma progression
    E J Franzmann
    Department of Otolaryngology, School of Medicine, University of Miami, FL 33101, USA
    Otolaryngol Head Neck Surg 124:426-32. 2001
    ..CD44 comprises a family of isoforms involved in tumorigenesis. Here we investigate the role of CD44 isoforms in head and neck squamous cell carcinoma (HNSCC) progression...
  7. ncbi request reprint CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, Florida 33136, USA
    J Mammary Gland Biol Neoplasia 6:287-97. 2001
    ..g., Rho/Ras signaling and receptor-linked/non-receptor-linked tyrosine kinase pathways), leading to a concomitant onset of multiple cellular functions (e.g., tumor cell growth, migration and invasion) and breast tumor progression...
  8. ncbi request reprint The involvement of ankyrin in the regulation of inositol 1,4,5-trisphosphate receptor-mediated internal Ca2+ release from Ca2+ storage vesicles in mouse T-lymphoma cells
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101
    J Biol Chem 268:7290-7. 1993
    ..These findings suggest that the cytoskeleton plays a pivotal role in the regulation of IP3 receptor-mediated internal Ca2+ release during lymphocyte activation...
  9. ncbi request reprint Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth
    L Y Bourguignon
    Enocrine Unit, Department of Medicine, University of California and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 276:48679-92. 2001
    ....
  10. ncbi request reprint Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction
    L Y Bourguignon
    Department of Cell Biology and Anatomy, University of Miami Medical School, FL 33101
    J Immunol 151:6634-44. 1993
    ..These findings strongly suggest that ankyrin plays an important role in linking the HA receptor, GP85(CD44), to the membrane-associated actomyosin contractile system during hyaluronic acid-mediated lymphocyte activation...
  11. ncbi request reprint A new splice variant of the inositol-1,4,5-triphosphate (IP3) receptor
    N Iida
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, FL 33101
    Cell Signal 6:449-55. 1994
    ..The selective expression of these two IP3R isoforms (IP3RV-S2 and non-neuronal IP3R) may be critically important for the onset of signal transduction and cell activation...
  12. ncbi request reprint The role of caldesmon in the regulation of receptor capping in mouse T-lymphoma cell
    G Walker
    Department of Anatomy and Cell Biology, University of Miami, Florida 33101
    J Biol Chem 264:496-500. 1989
    ..These findings suggest that actin-linked regulatory proteins such as caldesmon may be critically important to actomyosin-mediated contraction which, in turn, is responsible for collecting receptors into cap structures...