Sihem Boudina

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target?
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes, Program in Human Molecular Biology and Genetics, 15 N 2030 E Bldg 533 Rm 3410B, Salt Lake City, Utah 84112, USA
    Curr Pharm Des 19:5684-94. 2013
  2. pmc UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 61:3260-9. 2012
  3. pmc Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes, Salt Lake City, Utah 84112, USA
    Endocrinology 153:2677-88. 2012
  4. pmc Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart
    Sihem Boudina
    University of Utah School of Medicine, Salt Lake City, 84112, USA
    Circulation 119:1272-83. 2009
  5. pmc Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding
    Jordan J Wright
    Division of Endocrinology, Metabolism and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, 15 N 2030 East, Bldg 533, Rm 3110B, Salt Lake City, UT 84112, USA
    Cardiovasc Res 82:351-60. 2009
  6. pmc Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3
    Heiko Bugger
    Division of Endocrinology, Metabolism, and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 57:2924-32. 2008
  7. pmc Genetic loss of insulin receptors worsens cardiac efficiency in diabetes
    Heiko Bugger
    Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    J Mol Cell Cardiol 52:1019-26. 2012
  8. ncbi request reprint Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Circulation 112:2686-95. 2005
  9. pmc Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice
    Yan Li
    University of Utah, Salt Lake City, UT, USA
    FEBS J 279:599-611. 2012
  10. pmc Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis
    Hani A Jouihan
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Mol Med 14:98-108. 2008

Collaborators

  • Jaetaek Kim
  • Jared Rutter
  • Xiaohui Wang
  • Yan Li
  • Yi Zhu
  • Paul A Cobine
  • Noah Dephoure
  • Tetsuo Shioi
  • Martin E Young
  • Thunder Jalili
  • Seigo Izumo
  • Oleh Khalimonchuk
  • Elisabeth S Christians
  • E Dale Abel
  • Karla M Pires
  • Olesya Ilkun
  • Heiko Bugger
  • Heather A Theobald
  • Robert C Cooksey
  • Joseph Tuinei
  • Sheldon E Litwin
  • Benjamin Wayment
  • Ivor J Benjamin
  • Jonathan Buchanan
  • Brian T O'Neill
  • Tanner M Fullmer
  • James E Cox
  • Takahiro Ishiwata
  • Daniel K Bricker
  • John C Schell
  • Caleb M Cardon
  • Adam R Wende
  • Jordan J Wright
  • Hani A Jouihan
  • Vlad G Zaha
  • Donald A McClain
  • Huai Xiang Hao
  • Ui Jeong Yun
  • Pradip K Mazumder
  • Marina Valente
  • Brandon Henrie
  • Robert Manzanares
  • Shaobo Pei
  • Crystal Sloan
  • Andras Orosz
  • Thomas Orsak
  • Gregory W Pratt
  • Dong Chen
  • Audrey Boutron
  • Bart C Weimer
  • Claire Redin
  • Carl S Thummel
  • Yu Chan Chen
  • Bharat Jaishy
  • Jonathan G Van Vranken
  • Steven P Gygi
  • Jamie Soto
  • Soumyajit Banerjee Mustafi
  • Ivan Luptak
  • Christian Riehle
  • Michele Brivet
  • Eric B Taylor
  • Kyriaki Bakirtzi
  • Kostantin V Kandror
  • Sandra Sena
  • Emily A Hoagland
  • Xiao Xuan Hu
  • Alfred P McQueen
  • Dennis R Winge
  • Sathyanarayanan Srinivasan
  • Tammy L Smith
  • Roberto Bolli
  • Yiru Guo
  • Ryan P Taylor
  • Aili Guo
  • James Wilde
  • Morris J Birnbaum
  • Don K Davis
  • Namakkal S Rajasekaran
  • Wojtek Swiatek
  • Eric F Wawrousek
  • Roberta Gottlieb
  • Matthew W Roberts

Detail Information

Publications23

  1. pmc Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target?
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes, Program in Human Molecular Biology and Genetics, 15 N 2030 E Bldg 533 Rm 3410B, Salt Lake City, Utah 84112, USA
    Curr Pharm Des 19:5684-94. 2013
    ..In this review, we describe the impact of aging on the cardiovascular system and discuss the mounting evidence that reduced insulin/IGF signaling in the heart could alleviate age-associated alterations and preserve cardiac performance. ..
  2. pmc UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 61:3260-9. 2012
    ..These studies show that although UCP3 may mediate mitochondrial uncoupling and reduced CE after HF feeding, it does not mediate uncoupling in leptin-deficient states...
  3. pmc Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes, Salt Lake City, Utah 84112, USA
    Endocrinology 153:2677-88. 2012
    ....
  4. pmc Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart
    Sihem Boudina
    University of Utah School of Medicine, Salt Lake City, 84112, USA
    Circulation 119:1272-83. 2009
    ..The present study tested the hypothesis that perinatal loss of insulin signaling in the heart impairs mitochondrial function...
  5. pmc Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding
    Jordan J Wright
    Division of Endocrinology, Metabolism and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, 15 N 2030 East, Bldg 533, Rm 3110B, Salt Lake City, UT 84112, USA
    Cardiovasc Res 82:351-60. 2009
    ..The study was designed to test the hypothesis that impaired glucose utilization accounts for initial changes in FA metabolism...
  6. pmc Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3
    Heiko Bugger
    Division of Endocrinology, Metabolism, and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 57:2924-32. 2008
    ..We hypothesized that mitochondrial uncoupling may also contribute to reduced cardiac efficiency and contractile dysfunction in the type 1 diabetic Akita mouse model (Akita)...
  7. pmc Genetic loss of insulin receptors worsens cardiac efficiency in diabetes
    Heiko Bugger
    Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    J Mol Cell Cardiol 52:1019-26. 2012
    ....
  8. ncbi request reprint Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Circulation 112:2686-95. 2005
    ..The present study was performed to determine whether mitochondrial dysfunction and uncoupling are responsible for reduced cardiac performance and efficiency in ob/ob mice...
  9. pmc Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice
    Yan Li
    University of Utah, Salt Lake City, UT, USA
    FEBS J 279:599-611. 2012
    ..The ability of tempol to attenuate cardiac hypertrophy suggests that a cytosolic source of reactive oxygen species, probably NOX2, may contribute to the hypertrophic phenotype in G4H(-/-) mice...
  10. pmc Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis
    Hani A Jouihan
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Mol Med 14:98-108. 2008
    ..These data suggest a novel mechanism of iron-induced cellular dysfunction, namely altered mitochondrial uptake of other metal ions...
  11. pmc Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms
    Tanner M Fullmer
    Division of Endocrinology, Metabolism and Diabetes, Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    J Mol Cell Cardiol 64:20-9. 2013
    ..These data provide evidence that excessive insulin signaling to Akt is detrimental for cardioprotection by IPC and could explain the failure of the diabetic myocardium to precondition. ..
  12. pmc A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy
    Brian T O'Neill
    Program in Human Molecular Biology and Genetics and Division of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Cell Metab 6:294-306. 2007
    ..Although PI3K signaling to Akt1 is required for cellular growth, Akt-independent pathways mediate the accompanying mitochondrial adaptations...
  13. pmc Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies
    Olesya Ilkun
    Division of Endocrinology, Metabolism and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Curr Pharm Des 19:4806-17. 2013
    ..Finally, we will update the reader on the results obtained with natural antioxidant and mitochondria-targeted antioxidant therapies for the treatment of CVD in the MetS. ..
  14. pmc Diabetic cardiomyopathy, causes and effects
    Sihem Boudina
    Division of Endocrinology Metabolism and Diabetes, Program in Molecular Medicine, University of Utah School of Medicine, 15 North 2030 East, Bldg 533 Room 3110B, Salt Lake City, UT 84112, USA
    Rev Endocr Metab Disord 11:31-9. 2010
    ....
  15. pmc PAS kinase is required for normal cellular energy balance
    Huai Xiang Hao
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 104:15466-71. 2007
    ..We therefore hypothesize that PASK acts in a cell-autonomous manner to maintain cellular energy homeostasis and is a potential therapeutic target for metabolic disease...
  16. ncbi request reprint Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes, and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Physiology (Bethesda) 21:250-8. 2006
    ..Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling...
  17. pmc HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice
    Takahiro Ishiwata
    Laboratory of Cardiac Disease, Redox Signaling and Cell Regeneration, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e42118. 2012
    ..To determine the specific requirements of HSPB2 in heart, we generated cardiac-specific HSPB2 deficient (HSPB2cKO) mice and examined their cardiac function under basal conditions and following cardiac pressure overload...
  18. ncbi request reprint Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Diabetes 56:2457-66. 2007
    ..Mitochondrial uncoupling has been proposed to contribute to these metabolic abnormalities but has not been directly demonstrated...
  19. ncbi request reprint Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts
    Pradip K Mazumder
    Program in Human Molecular Biology and Genetics, Division of Endocrinology, Metabolism and Diabetes, University of Utah, 15 North 2030 East, Building 533, Room 3410B, Salt Lake City, UT 84112, USA
    Diabetes 53:2366-74. 2004
    ....
  20. pmc CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice
    Ivor J Benjamin
    Center for Cardiovascular Translational Biomedicine, University of Utah, School of Medicine, Salt Lake City, UT, USA
    Am J Physiol Heart Circ Physiol 293:H3201-9. 2007
    ..We discuss the implications of these disparate results in the context of phenotypic responses reported for CRYAB/HSPB2-deficient mice to different ischemic challenges...
  21. pmc A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans
    Daniel K Bricker
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Science 337:96-100. 2012
    ..These data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier...
  22. ncbi request reprint Diabetic cardiomyopathy revisited
    Sihem Boudina
    Division of Endocrinology, Metabolism and Diabetes and Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Circulation 115:3213-23. 2007
    ..This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes...
  23. pmc Treatment with a SOD mimetic reduces visceral adiposity, adipocyte death, and adipose tissue inflammation in high fat-fed mice
    Karla M Pires
    Division of Endocrinology, Metabolism and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Obesity (Silver Spring) 22:178-87. 2014
    ....