K Bostrom

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Concise review: applying stem cell biology to vascular structures
    KRISTINA I BOSTROM
    Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Stem Cells 30:386-91. 2012
  2. ncbi request reprint Cell differentiation in vascular calcification
    K I Bostrom
    Division of Cardiology, UCLA School of Medicine 90095 1679, USA
    Z Kardiol 89:69-74. 2000
  3. ncbi request reprint HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells
    K Bostrom
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1679, USA
    J Cell Biochem 78:210-21. 2000
  4. ncbi request reprint Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells
    K Bostrom
    Division of Cardiology, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California 90095 1679, USA
    J Biol Chem 276:14044-52. 2001
  5. ncbi request reprint Insights into the mechanism of vascular calcification
    K Bostrom
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 1679, USA
    Am J Cardiol 88:20E-22E. 2001
  6. ncbi request reprint Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells
    KRISTINA BOSTROM
    Division of Cardiology, David Geffen School of Medicine, University of California, Box 951679, Rm 47 123 CHS, Los Angeles, CA 90095 1679, USA
    J Biol Chem 279:52904-13. 2004
  7. pmc The regulation of valvular and vascular sclerosis by osteogenic morphogens
    KRISTINA I BOSTROM
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Circ Res 109:564-77. 2011
  8. ncbi request reprint Calcifying subpopulation of bovine aortic smooth muscle cells is responsive to 17 beta-estradiol
    M Balica
    Department of Medicine, UCLA School of Medicine 90095 1679, USA
    Circulation 95:1954-60. 1997
  9. pmc Activation of vascular bone morphogenetic protein signaling in diabetes mellitus
    KRISTINA I BOSTROM
    Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Circ Res 108:446-57. 2011

Research Grants

  1. MOLECULAR MECHANISMS OF MATRIX GLA PROTEIN
    KRISTINA BOSTROM; Fiscal Year: 2004
  2. Molecular Mechanism of Matrix GLA Protein (MGP)
    KRISTINA BOSTROM; Fiscal Year: 2007
  3. Molecular Mechanism of Matrix GLA Protein (MGP)
    KRISTINA I BOSTROM; Fiscal Year: 2010

Collaborators

Detail Information

Publications9

  1. pmc Concise review: applying stem cell biology to vascular structures
    KRISTINA I BOSTROM
    Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Stem Cells 30:386-91. 2012
    ..Loss and dysregulation of feedback control cause a variety of diseases that involve ectopic tissue formation, including atherosclerotic lesion formation and calcification, diabetic vasculopathies, and arteriovenous malformations...
  2. ncbi request reprint Cell differentiation in vascular calcification
    K I Bostrom
    Division of Cardiology, UCLA School of Medicine 90095 1679, USA
    Z Kardiol 89:69-74. 2000
    ..Alternatively, MGP expression may be an attempt to regulate cell differentiation in the vascular wall, possibly by acting as an inhibitor to a factor able to induce cartilage and bone such as bone morphogenetic proteins (BMPs)...
  3. ncbi request reprint HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells
    K Bostrom
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1679, USA
    J Cell Biochem 78:210-21. 2000
    ..These findings suggest that HOXB7 plays a role in expansion of immature cell populations or dedifferentiation of mature cells...
  4. ncbi request reprint Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells
    K Bostrom
    Division of Cardiology, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California 90095 1679, USA
    J Biol Chem 276:14044-52. 2001
    ..Thus, two subdomains had the opposite effect of full-length hMGP, possibly due to different expression levels or domain characteristics...
  5. ncbi request reprint Insights into the mechanism of vascular calcification
    K Bostrom
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 1679, USA
    Am J Cardiol 88:20E-22E. 2001
    ..A potential mechanism that explains these findings is MGP interference with bone morphogenetic proteins-potent inducers of cartilage and bone...
  6. ncbi request reprint Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells
    KRISTINA BOSTROM
    Division of Cardiology, David Geffen School of Medicine, University of California, Box 951679, Rm 47 123 CHS, Los Angeles, CA 90095 1679, USA
    J Biol Chem 279:52904-13. 2004
    ..Together, the results suggest that MGP plays a role in EC function, altering the response to TGF-beta superfamily growth factors...
  7. pmc The regulation of valvular and vascular sclerosis by osteogenic morphogens
    KRISTINA I BOSTROM
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Circ Res 109:564-77. 2011
    ..These inhibitory pathways and their regulators afford the development of novel therapeutic strategies to prevent and treat valve and vascular sclerosis...
  8. ncbi request reprint Calcifying subpopulation of bovine aortic smooth muscle cells is responsive to 17 beta-estradiol
    M Balica
    Department of Medicine, UCLA School of Medicine 90095 1679, USA
    Circulation 95:1954-60. 1997
    ....
  9. pmc Activation of vascular bone morphogenetic protein signaling in diabetes mellitus
    KRISTINA I BOSTROM
    Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Circ Res 108:446-57. 2011
    ..Diabetes mellitus is frequently complicated by cardiovascular disease, such as vascular calcification and endothelial dysfunction, which have been associated with bone morphogenetic proteins (BMPs)...

Research Grants6

  1. MOLECULAR MECHANISMS OF MATRIX GLA PROTEIN
    KRISTINA BOSTROM; Fiscal Year: 2004
    ..Understanding the molecular mechanisms of MGP will provide information that is widely applicable to the development of vascular disease. ..
  2. Molecular Mechanism of Matrix GLA Protein (MGP)
    KRISTINA BOSTROM; Fiscal Year: 2007
    ..Our results will add insight to calcification of vessels and heart valves, a common problem in heart disease. In addition, it may provide information on how to design new treatments for unwanted calcification. ..
  3. Molecular Mechanism of Matrix GLA Protein (MGP)
    KRISTINA I BOSTROM; Fiscal Year: 2010
    ..Our results will add insight to calcification of vessels and heart valves, a common problem in heart disease. In addition, it may provide information on how to design new treatments for unwanted calcification. ..