Giovanni Bosco

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila
    Julie M Claycomb
    Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Dev Cell 6:145-55. 2004
  2. pmc Human 14-3-3 gamma protein results in abnormal cell proliferation in the developing eye of Drosophila melanogaster
    Sophia W Hong
    Department of Cell Biology and Anatomy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Cell Div 3:2. 2008
  3. pmc Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species
    Celine A Hayden
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
    BMC Genomics 9:61. 2008
  4. pmc Analysis of Drosophila species genome size and satellite DNA content reveals significant differences among strains as well as between species
    Giovanni Bosco
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 177:1277-90. 2007
  5. doi request reprint Chromosome alignment and transvection are antagonized by condensin II
    Tom A Hartl
    Department of Molecular and Cellular Biology, University of Arizona, 1007 East Lowell Street, Tucson, AZ 85721 0106, USA
    Science 322:1384-7. 2008
  6. pmc Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks
    Christopher R Bauer
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA
    BMC Syst Biol 2:101. 2008
  7. pmc Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes
    Christopher R Bauer
    Department of Molecular and Cellular Biology, The University of Arizona, Tucson, Arizona, United States of America
    PLoS Genet 8:e1002873. 2012
  8. pmc SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2
    Daniel W Buster
    Department of Cellular and Molecular Medicine, Arizona Cancer Center, University of Arizona, Tucson, AZ 85721, USA
    J Cell Biol 201:49-63. 2013
  9. pmc The N-terminal domain of the Drosophila retinoblastoma protein Rbf1 interacts with ORC and associates with chromatin in an E2F independent manner
    Joseph Ahlander
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 3:e2831. 2008
  10. doi request reprint Sqd interacts with the Drosophila retinoblastoma tumor suppressor Rbf
    Joseph Ahlander
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, 85721, USA
    Biochem Biophys Res Commun 383:363-7. 2009

Research Grants

  1. Fos, Jun and transcriptional control of synaptic plasticity
    Giovanni Bosco; Fiscal Year: 2007
  2. Developmental control of replication by Drosophila RB
    Giovanni Bosco; Fiscal Year: 2007
  3. Chromosome pairing and condensins
    Giovanni Bosco; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila
    Julie M Claycomb
    Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Dev Cell 6:145-55. 2004
    ..Thus, during follicle cell differentiation the entire genome is overreplicated as the cells become polyploid, and subsequently specific genomic intervals are overreplicated to facilitate gene expression...
  2. pmc Human 14-3-3 gamma protein results in abnormal cell proliferation in the developing eye of Drosophila melanogaster
    Sophia W Hong
    Department of Cell Biology and Anatomy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Cell Div 3:2. 2008
    ..However, the mechanism through which these proteins act in tumorigenesis is uncertain...
  3. pmc Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species
    Celine A Hayden
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
    BMC Genomics 9:61. 2008
    ..In Drosophila, approximately 40% of transcripts contain upstream start codons (uAUGs) but there is little evidence that these are translated and affect their associated mORF...
  4. pmc Analysis of Drosophila species genome size and satellite DNA content reveals significant differences among strains as well as between species
    Giovanni Bosco
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 177:1277-90. 2007
    ..Addition and loss of heterochromatin satellite repeat elements appear to have made major contributions to the large differences in genome size observed in the Drosophilidae...
  5. doi request reprint Chromosome alignment and transvection are antagonized by condensin II
    Tom A Hartl
    Department of Molecular and Cellular Biology, University of Arizona, 1007 East Lowell Street, Tucson, AZ 85721 0106, USA
    Science 322:1384-7. 2008
    ..We propose that condensin II restricts trans-chromosomal interactions that affect transcription through its ability to spatially separate aligned interphase chromosomes...
  6. pmc Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks
    Christopher R Bauer
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA
    BMC Syst Biol 2:101. 2008
    ..Given these genetic and functional similarities, we tested Drosophila sticky and dFmr1 for a genetic interaction and measured whole genome expression in both mutants to assess similarities in gene regulation...
  7. pmc Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes
    Christopher R Bauer
    Department of Molecular and Cellular Biology, The University of Arizona, Tucson, Arizona, United States of America
    PLoS Genet 8:e1002873. 2012
    ..These Condensin II activities compartmentalize the nucleus into discrete chromosome territories and indicate commonalities in the mechanisms that regulate the spatial structure of the genome during mitosis and interphase...
  8. pmc SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2
    Daniel W Buster
    Department of Cellular and Molecular Medicine, Arizona Cancer Center, University of Arizona, Tucson, AZ 85721, USA
    J Cell Biol 201:49-63. 2013
    ..Therefore, SCF(Slimb)-mediated down-regulation of condensin II is required to maintain proper organization and morphology of the interphase nucleus...
  9. pmc The N-terminal domain of the Drosophila retinoblastoma protein Rbf1 interacts with ORC and associates with chromatin in an E2F independent manner
    Joseph Ahlander
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 3:e2831. 2008
    ..The retinoblastoma (Rb) tumor suppressor protein can function as a DNA replication inhibitor as well as a transcription factor. Regulation of DNA replication may occur through interaction of Rb with the origin recognition complex (ORC)...
  10. doi request reprint Sqd interacts with the Drosophila retinoblastoma tumor suppressor Rbf
    Joseph Ahlander
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, 85721, USA
    Biochem Biophys Res Commun 383:363-7. 2009
    ..We conclude from our studies that Rbf physically and genetically interacts with Sqd. We propose that the retinoblastoma tumor suppressor may play a novel role in RNA processing through interaction with RNA-binding proteins...
  11. doi request reprint Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary
    Andrew M Epstein
    Department of Molecular and Cellular Biology, Life Sciences South, University of Arizona, Tucson, AZ 85721, USA
    Dev Biol 330:83-92. 2009
    ..These data support a model whereby FMRP controls germline proliferation by regulating the expression of cbl in the developing ovary...
  12. pmc Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis
    Tom A Hartl
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS Genet 4:e1000228. 2008
    ..Furthermore, persistence of homologous and heterologous interchromosomal associations lead to anaphase I chromatin bridging and the generation of aneuploid gametes...
  13. pmc Drosophila sticky/citron kinase is a regulator of cell-cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing
    Sarah J Sweeney
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 178:1311-25. 2008
    ....
  14. ncbi request reprint Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation
    Tom Hartl
    Department of Molecular and Cellular Biology, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Chromosoma 116:197-214. 2007
    ..These data suggest that amplification origins are able to initiate when the cells are in a late S-phase, when the genome is normally not licensed for replication...
  15. doi request reprint The RB/E2F pathway and regulation of RNA processing
    Joseph Ahlander
    Department of Molecular and Cellular Biology, 1007 East Lowell Street, University of Arizona, Tucson, AZ 85721, USA
    Biochem Biophys Res Commun 384:280-3. 2009
    ..The elucidation of a novel role of RB in RNA processing will have a profound impact on our understanding of the role of this tumor suppressor family in cell and developmental biology...
  16. doi request reprint Segmentation and detection of fluorescent 3D spots
    Sundaresh Ram
    Department of Electrical and Computer Engineering, University of Arizona, Tucson, Arizona 85721, USA
    Cytometry A 81:198-212. 2012
    ..Quantitative assessment of the proposed algorithm demonstrates improved segmentation and detection accuracy compared to other techniques...
  17. ncbi request reprint The E2F cell cycle regulator is required for Drosophila nurse cell DNA replication and apoptosis
    Irena Royzman
    Whitehead Institute, Nine Cambridge Center, Cambridge, MA 02142, USA
    Mech Dev 119:225-37. 2002
    ..We also find that dDP and dE2F1 are needed for nurse cell apoptosis, implicating transcriptional activation of E2F target genes in this process...

Research Grants9

  1. Fos, Jun and transcriptional control of synaptic plasticity
    Giovanni Bosco; Fiscal Year: 2007
    ..Finally, results from these experiments may identify and validate new molecules to target for pharmacological therapy. ..
  2. Developmental control of replication by Drosophila RB
    Giovanni Bosco; Fiscal Year: 2007
    ....
  3. Chromosome pairing and condensins
    Giovanni Bosco; Fiscal Year: 2010
    ..The experiments proposed in this grant application will have a direct and significant impact on the advancement of biomedical research and human health. ..