Daryl A Bosco

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Paraoxonase gene mutations in amyotrophic lateral sclerosis
    Nicola Ticozzi
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Ann Neurol 68:102-7. 2010
  2. pmc Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics
    Desiree M Baron
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Mol Neurodegener 8:30. 2013
  3. pmc Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Hum Mol Genet 19:4160-75. 2010
  4. ncbi Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    CNS Neurol Disord Drug Targets 9:779-90. 2010
  5. pmc Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Nat Neurosci 13:1396-403. 2010
  6. pmc FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress
    Reddy Ranjith K Sama
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 228:2222-31. 2013
  7. pmc Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
    Chi Hong Wu
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 488:499-503. 2012
  8. pmc Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1
    Teresa J Broering
    MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e61210. 2013
  9. ncbi Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation
    Jared R Auclair
    Department of Chemistry and Chemical Biology, Barnett Institute, Northeastern University, Boston, MA, USA Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA Department of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA Department of Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA
    Proteomics 14:1152-7. 2014
  10. pmc Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis
    Marka van Blitterswijk
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Amyotroph Lateral Scler 12:430-8. 2011

Collaborators

  • Robert H Brown
  • Dagmar Ringe
  • John E Landers
  • Yang Wang
  • David B Goldstein
  • Matthew J LaVoie
  • Piera Pasinelli
  • Leonard H van den Berg
  • Can Kayatekin
  • Fumihiko Urano
  • Wilfried Rossoll
  • Nicola Ticozzi
  • Jean Pierre Julien
  • Vincenzo Silani
  • Lawrence Hayward
  • Reddy Ranjith K Sama
  • Desiree M Baron
  • Jared R Auclair
  • Teresa J Broering
  • Catherine L Ward
  • Laura J Kaushansky
  • Chi Hong Wu
  • Marka van Blitterswijk
  • Nathalie Y R Agar
  • Joseph P Salisbury
  • Jeffrey N Agar
  • Heather D Durham
  • Sandro Santagata
  • Gregory A Petsko
  • Joshua L Johnson
  • Donna M Ambrosino
  • Gregory J Babcock
  • Kristin J Boggio
  • Jeffrey A Nickerson
  • Ru Ju Chian
  • Hongyan Wang
  • C Robert Matthews
  • Gilda Shayan
  • Katherine Baptista
  • Naomi K Boatright
  • Nathan Lemay
  • Shinsuke Ishigaki
  • Zuoshang Xu
  • Alexandre J C Quaresma
  • KERRY A GARRITY
  • Elizabeth T Cirulli
  • Dev Mangroo
  • Cinzia Gellera
  • Katarzyna Piotrowska
  • Ashley Lyn LeClerc
  • Andrew D Fox
  • Francois Salachas
  • Cinzia Tiloca
  • Jill A Zitzewitz
  • Jason E Kost
  • Shawn C Chafe
  • Patrick Lowe
  • Claudia Fallini
  • Antonia Ratti
  • Vivian E Drory
  • Zuo Shang Xu
  • Pamela J Keagle
  • Melissa J Moore
  • Peter C Sapp
  • Vincent Meininger
  • Jenni Adams
  • Gary J Bassell
  • Gabriele Siciliano
  • Diane McKenna-Yasek
  • Paloma González-Pérez
  • Max Koppers
  • Jonathan D Glass
  • Franco Taroni
  • Sunita Gulati
  • Merit E Cudkowicz
  • David A Schoenfeld
  • Bradley T Hyman
  • Elizabeth Smoot
  • Clemens R Scherzer
  • Nancy Maher
  • Matthew Jaffa
  • Adrian J Ivinson

Detail Information

Publications12

  1. pmc Paraoxonase gene mutations in amyotrophic lateral sclerosis
    Nicola Ticozzi
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Ann Neurol 68:102-7. 2010
    ..We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function...
  2. pmc Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics
    Desiree M Baron
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA
    Mol Neurodegener 8:30. 2013
    ..Here we investigated the effect of mutant-FUS on stress granule formation and dynamics under conditions of oxidative stress...
  3. pmc Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Hum Mol Genet 19:4160-75. 2010
    ..These findings demonstrate a potential link between FUS mutations and cellular pathways involved in stress responses that may be relevant to altered motor neuron homeostasis in ALS...
  4. ncbi Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    CNS Neurol Disord Drug Targets 9:779-90. 2010
    ..In this review, we present several of the genetic contributors to both sporadic and familial forms of ALS and discuss their potential as therapeutic targets for this devastating disease...
  5. pmc Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Nat Neurosci 13:1396-403. 2010
    ..Our findings suggest that wild-type SOD1 can be pathogenic in SALS and identify an SOD1-dependent pathogenic mechanism common to FALS and SALS...
  6. pmc FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress
    Reddy Ranjith K Sama
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 228:2222-31. 2013
    ..Intriguingly, cells with reduced expression of FUS exhibit a loss of cell viability in response to sorbitol, indicating a prosurvival role for endogenous FUS in the cellular response to hyperosmolar stress...
  7. pmc Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
    Chi Hong Wu
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 488:499-503. 2012
    ..Furthermore, primary motor neurons expressing mutant PFN1 display smaller growth cones with a reduced F/G-actin ratio. These observations further document that cytoskeletal pathway alterations contribute to ALS pathogenesis...
  8. pmc Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1
    Teresa J Broering
    MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e61210. 2013
    ..Therefore, additional testing will be required to determine therapeutic potential for SOD1 mutant ALS and potentially some subset of sporadic ALS...
  9. ncbi Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation
    Jared R Auclair
    Department of Chemistry and Chemical Biology, Barnett Institute, Northeastern University, Boston, MA, USA Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA Department of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA Department of Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA, USA
    Proteomics 14:1152-7. 2014
    ..This study demonstrates that without taking extraordinary precaution, artifactual S-thiolation of highly reactive, surface-exposed, cysteine residues can result. ..
  10. pmc Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis
    Marka van Blitterswijk
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Amyotroph Lateral Scler 12:430-8. 2011
    ..g. oxidized SOD1) in SALS pathogenesis. In contrast, an immune response against the normal WT-SOD1 appears to be disadvantageous in SALS, possibly because the anti-oxidizing activity of normal WT-SOD1 is beneficial to SALS individuals...
  11. pmc Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    Cold Spring Harb Perspect Biol 3:a007500. 2011
    ..Applying proteostasis approaches to this disease may require rethinking or broadening the concept of what proteostasis means...