Daryl A Bosco

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Paraoxonase gene mutations in amyotrophic lateral sclerosis
    Nicola Ticozzi
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Ann Neurol 68:102-7. 2010
  2. pmc Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Hum Mol Genet 19:4160-75. 2010
  3. ncbi Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    CNS Neurol Disord Drug Targets 9:779-90. 2010
  4. pmc Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Nat Neurosci 13:1396-403. 2010
  5. pmc Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
    Chi Hong Wu
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 488:499-503. 2012
  6. pmc Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis
    Marka van Blitterswijk
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Amyotroph Lateral Scler 12:430-8. 2011
  7. pmc Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    Cold Spring Harb Perspect Biol 3:a007500. 2011
  8. doi FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress
    Reddy Ranjith K Sama
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts
    J Cell Physiol 228:2222-31. 2013

Collaborators

  • Robert H Brown
  • John E Landers
  • Fumihiko Urano
  • Wilfried Rossoll
  • Nicola Ticozzi
  • Piera Pasinelli
  • Jean Pierre Julien
  • Vincenzo Silani
  • Lawrence Hayward
  • Reddy Ranjith K Sama
  • Chi Hong Wu
  • Marka van Blitterswijk
  • Shinsuke Ishigaki
  • Laura J Kaushansky
  • Nathan Lemay
  • Catherine L Ward
  • David B Goldstein
  • Shawn C Chafe
  • Vincent Meininger
  • Patrick Lowe
  • Claudia Fallini
  • Jenni Adams
  • Elizabeth T Cirulli
  • Dev Mangroo
  • Antonia Ratti
  • Cinzia Gellera
  • Gary J Bassell
  • Gabriele Siciliano
  • Vivian E Drory
  • Leonard H van den Berg
  • Katarzyna Piotrowska
  • Diane McKenna-Yasek
  • Zuo Shang Xu
  • Ashley Lyn LeClerc
  • Andrew D Fox
  • Francois Salachas
  • Desiree M Baron
  • Cinzia Tiloca
  • Paloma González-Pérez
  • Jill A Zitzewitz
  • Max Koppers
  • Pamela J Keagle
  • Jason E Kost
  • Melissa J Moore
  • Jonathan D Glass
  • Peter C Sapp
  • Franco Taroni
  • Elizabeth Smoot
  • Sunita Gulati
  • Merit E Cudkowicz
  • Nancy Maher
  • David A Schoenfeld
  • Matthew Jaffa
  • Bradley T Hyman
  • Clemens R Scherzer
  • Adrian J Ivinson

Detail Information

Publications8

  1. pmc Paraoxonase gene mutations in amyotrophic lateral sclerosis
    Nicola Ticozzi
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Ann Neurol 68:102-7. 2010
    ..We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function...
  2. pmc Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Hum Mol Genet 19:4160-75. 2010
    ..These findings demonstrate a potential link between FUS mutations and cellular pathways involved in stress responses that may be relevant to altered motor neuron homeostasis in ALS...
  3. ncbi Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    CNS Neurol Disord Drug Targets 9:779-90. 2010
    ..In this review, we present several of the genetic contributors to both sporadic and familial forms of ALS and discuss their potential as therapeutic targets for this devastating disease...
  4. pmc Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Nat Neurosci 13:1396-403. 2010
    ..Our findings suggest that wild-type SOD1 can be pathogenic in SALS and identify an SOD1-dependent pathogenic mechanism common to FALS and SALS...
  5. pmc Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
    Chi Hong Wu
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 488:499-503. 2012
    ..Furthermore, primary motor neurons expressing mutant PFN1 display smaller growth cones with a reduced F/G-actin ratio. These observations further document that cytoskeletal pathway alterations contribute to ALS pathogenesis...
  6. pmc Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis
    Marka van Blitterswijk
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Amyotroph Lateral Scler 12:430-8. 2011
    ..g. oxidized SOD1) in SALS pathogenesis. In contrast, an immune response against the normal WT-SOD1 appears to be disadvantageous in SALS, possibly because the anti-oxidizing activity of normal WT-SOD1 is beneficial to SALS individuals...
  7. pmc Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis
    Daryl A Bosco
    Department of Neurology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, USA
    Cold Spring Harb Perspect Biol 3:a007500. 2011
    ..Applying proteostasis approaches to this disease may require rethinking or broadening the concept of what proteostasis means...
  8. doi FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress
    Reddy Ranjith K Sama
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts
    J Cell Physiol 228:2222-31. 2013
    ..J. Cell. Physiol. 228: 2222-2231, 2013. © 2013 Wiley Periodicals, Inc. ..