R Bortell

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. doi request reprint The BB rat as a model of human type 1 diabetes
    Rita Bortell
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 933:31-44. 2012
  2. pmc Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes
    Rita Bortell
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Ann N Y Acad Sci 1150:112-22. 2008
  3. ncbi request reprint Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat
    R Bortel
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    Autoimmunity 33:199-211. 2001
  4. ncbi request reprint Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities
    R Bortell
    Diabetes Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 167:2049-59. 2001
  5. ncbi request reprint Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity
    M R Rigby
    The Program in Biomedical Sciences, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    J Immunol 156:4259-65. 1996
  6. ncbi request reprint The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal
    M R Rigby
    Department of Medicine, University of Massachusetts Medical Center, Worcester, USA
    Diabetes 45:1419-26. 1996
  7. ncbi request reprint A new isolation method for rat intraepithelial lymphocytes
    D Todd
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Immunol Methods 224:111-27. 1999
  8. ncbi request reprint The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse
    R Bortell
    Department of Medicine, University of Massachusetts Medical Center, Worcester, USA
    Mol Cell Biochem 193:61-8. 1999
  9. ncbi request reprint Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout
    T Kanaitsuka
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    J Immunol 159:2741-9. 1997
  10. ncbi request reprint Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity
    R Bortell
    Diabetes Division, University of Massachusetts Medical School, Worcester 01605, USA
    Adv Exp Med Biol 419:169-73. 1997

Collaborators

Detail Information

Publications16

  1. doi request reprint The BB rat as a model of human type 1 diabetes
    Rita Bortell
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 933:31-44. 2012
    ....
  2. pmc Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes
    Rita Bortell
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Ann N Y Acad Sci 1150:112-22. 2008
    ..These investigations may uncover new therapies and strategies to prevent type 1A diabetes...
  3. ncbi request reprint Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat
    R Bortel
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    Autoimmunity 33:199-211. 2001
    ..The source of the soluble ART2 protein in the rat appeared to be the gut. The results suggest that ART2+ T cells and soluble ART2 protein may subserve different immunomodulatory functions...
  4. ncbi request reprint Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities
    R Bortell
    Diabetes Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 167:2049-59. 2001
    ..These data suggest that T cells express multiple NAD and adenine nucleotide-metabolizing activities that together modulate immune function...
  5. ncbi request reprint Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity
    M R Rigby
    The Program in Biomedical Sciences, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    J Immunol 156:4259-65. 1996
    ..The data suggest that lymphocyte surface ADP ribosyltransferases could be involved in signaling and immunoregulatory processes...
  6. ncbi request reprint The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal
    M R Rigby
    Department of Medicine, University of Massachusetts Medical Center, Worcester, USA
    Diabetes 45:1419-26. 1996
    ..These data indicate that RT6-mediated signaling events may prime T-cells to respond to exogenous cytokines, suggesting a possible mechanism by which surface RT6 may influence T-cell function...
  7. ncbi request reprint A new isolation method for rat intraepithelial lymphocytes
    D Todd
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Immunol Methods 224:111-27. 1999
    ..The isolation of IEL sub-populations using this methodology should facilitate studies of the function of these cells in gut immunity...
  8. ncbi request reprint The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse
    R Bortell
    Department of Medicine, University of Massachusetts Medical Center, Worcester, USA
    Mol Cell Biochem 193:61-8. 1999
    ..In the present manuscript, we review recent data on RT6/Rt6, and discuss the potential mechanisms by which RT6-expressing cells, and perhaps RT6 protein itself, may mediate immune regulation...
  9. ncbi request reprint Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout
    T Kanaitsuka
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    J Immunol 159:2741-9. 1997
    ..Expression of Rt6-2 or another redundant ART may compensate for the lack of enzymatically active Rt6-1 in C57BL/6 mice...
  10. ncbi request reprint Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity
    R Bortell
    Diabetes Division, University of Massachusetts Medical School, Worcester 01605, USA
    Adv Exp Med Biol 419:169-73. 1997
    ..The data suggest that lymphocyte surface ADP-ribosyltransferases could be involved in signaling and immunoregulatory processes...
  11. ncbi request reprint Loss of RT6 message and most circulating T cells after thymectomy of diabetes prone BB rats
    P Sarkar
    Diabetes Division, University of Massachusetts Medical Center, Worcester
    Autoimmunity 18:15-22. 1994
    ..We conclude that the deficiency of RT6+ peripheral T cells in the DP-BB rat is due either to their short life span or to their reduced proliferative capacity following release from the thymus...
  12. pmc Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression
    R Bortell
    Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655
    Proc Natl Acad Sci U S A 89:6119-23. 1992
    ..The vitamin D receptor plus accessory proteins may function cooperatively with basal regulatory factors to modulate the extent to which the OC gene is transcribed...
  13. pmc Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex
    M A King
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Clin Exp Immunol 157:104-18. 2009
    ..This model now provides the opportunity to investigate in vivo mechanisms of xenogeneic GVHD as well as to assess the efficacy of therapeutic agents rapidly...
  14. ncbi request reprint Identification of multiple glucocorticoid receptor binding sites in the rat osteocalcin gene promoter
    A A Heinrichs
    Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655
    Biochemistry 32:11436-44. 1993
    ....
  15. ncbi request reprint An atypical population of NK cells that spontaneously secrete IFN-gamma and IL-4 is present in the intraepithelial lymphoid compartment of the rat
    D J Todd
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Immunol 167:3600-9. 2001
    ..Their phenotypic and functional characteristics suggest that these distinctive IENK cells may participate in the regulation of mucosal immunity...
  16. pmc AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1
    S Ishigaki
    University of Massachusetts Medical School, Worcester, 01605 2324, USA
    Cell Death Differ 17:774-86. 2010
    ..Thus, WFS1 deficiency or AATF deficiency mediates a self-perpetuating cycle of cell death. Our results reveal a novel antiapoptotic program relevant to the treatment of diseases caused by ER stress-mediated cell death...