Stephen E Borst

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Testosterone replacement therapy for older men
    Stephen E Borst
    Geriatrics Research, Education, and Clinical Center, North Florida South Georgia Veterans Health System, Gainesville, FL, USA
    Clin Interv Aging 2:561-6. 2007
  2. ncbi request reprint Association of resistin with visceral fat and muscle insulin resistance
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611 8206, USA
    Cytokine 32:39-44. 2005
  3. ncbi request reprint Orchiectomized Fischer 344 male rat models body composition in hypogonadal state
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Life Sci 79:411-5. 2006
  4. ncbi request reprint Interventions for sarcopenia and muscle weakness in older people
    Stephen E Borst
    VA Medical Center, GRECC 182, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
    Age Ageing 33:548-55. 2004
  5. ncbi request reprint Inhibition of 5alpha-reductase blocks prostate effects of testosterone without blocking anabolic effects
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Endocrinol Metab 288:E222-7. 2005
  6. ncbi request reprint Neutralization of tumor necrosis factor-alpha reverses insulin resistance in skeletal muscle but not adipose tissue
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Endocrinol Metab 287:E934-8. 2004
  7. ncbi request reprint Adipose tumor necrosis factor-alpha is reduced during onset of insulin resistance in Sprague-Dawley rats
    Stephen E Borst
    Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112 1394, USA
    Cytokine 26:217-22. 2004
  8. ncbi request reprint The role of TNF-alpha in insulin resistance
    Stephen E Borst
    Department of Exercise and Sport Sciences, University of Florida, Malcom Randall VA Medical Center, Gainesville, Florida 32608 1197, USA
    Endocrine 23:177-82. 2004
  9. ncbi request reprint Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase
    Stephen E Borst
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Gainesville, Florida 32608 1197, USA
    Am J Physiol Endocrinol Metab 293:E507-14. 2007
  10. ncbi request reprint 17β-Hydroxyestra-4,9,11-trien-3-one (Trenbolone) preserves bone mineral density in skeletally mature orchiectomized rats without prostate enlargement
    Sean C McCoy
    Geriatric Research, Education and Clinical Center, VA Medical Center, Gainesville, FL 32608, USA
    Bone 51:667-73. 2012

Detail Information

Publications35

  1. pmc Testosterone replacement therapy for older men
    Stephen E Borst
    Geriatrics Research, Education, and Clinical Center, North Florida South Georgia Veterans Health System, Gainesville, FL, USA
    Clin Interv Aging 2:561-6. 2007
    ..Testosterone therapy produces a number of adverse effects, including worsening of sleep apnea, gynecomastia, polycythemia and elevation of PSA. Efficacy and adverse effects should be assessed frequently throughout the course of therapy...
  2. ncbi request reprint Association of resistin with visceral fat and muscle insulin resistance
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611 8206, USA
    Cytokine 32:39-44. 2005
    ..Elevation of circulating cytokines may play a role in the development of muscle insulin resistance...
  3. ncbi request reprint Orchiectomized Fischer 344 male rat models body composition in hypogonadal state
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
    Life Sci 79:411-5. 2006
    ..We conclude that the F344 rat displays a broad range of catabolic effects following ORX and is the best rat model for studying the androgenic pathway and strategies for reversing catabolic changes induced by hypogonadism...
  4. ncbi request reprint Interventions for sarcopenia and muscle weakness in older people
    Stephen E Borst
    VA Medical Center, GRECC 182, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
    Age Ageing 33:548-55. 2004
    ..Those strategies are testosterone replacement for men, growth hormone replacement and resistance exercise training. This review will cover the risks and benefits associated with each of these interventions...
  5. ncbi request reprint Inhibition of 5alpha-reductase blocks prostate effects of testosterone without blocking anabolic effects
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Endocrinol Metab 288:E222-7. 2005
    ..0001). This study demonstrates that 5alpha-reductase inhibitors may block the undesirable effects of T on the prostate, without blocking the desirable anabolic effects of T on muscle, bone, and fat...
  6. ncbi request reprint Neutralization of tumor necrosis factor-alpha reverses insulin resistance in skeletal muscle but not adipose tissue
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Endocrinol Metab 287:E934-8. 2004
    ..TNF-alpha neutralization was accompanied by reduced TNF-alpha bioactivity without tissue depletion of TNF-alpha protein...
  7. ncbi request reprint Adipose tumor necrosis factor-alpha is reduced during onset of insulin resistance in Sprague-Dawley rats
    Stephen E Borst
    Department of Physiology, Louisiana State University Health Science Center, New Orleans, LA 70112 1394, USA
    Cytokine 26:217-22. 2004
    ..Our findings do not support the adipose-endocrine model of TNF-alpha in insulin resistance. Our findings do support a paracrine role for TNF-alpha or for a reduction in endogenous TNF-alpha inhibitors in insulin resistance...
  8. ncbi request reprint The role of TNF-alpha in insulin resistance
    Stephen E Borst
    Department of Exercise and Sport Sciences, University of Florida, Malcom Randall VA Medical Center, Gainesville, Florida 32608 1197, USA
    Endocrine 23:177-82. 2004
    ..This review will discuss the regulation of insulin responses by TNF-alpha and evidence supporting the hypothesis that over expression of TNF-alpha plays a role in the pathophysiology of insulin resistance...
  9. ncbi request reprint Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase
    Stephen E Borst
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Gainesville, Florida 32608 1197, USA
    Am J Physiol Endocrinol Metab 293:E507-14. 2007
    ..Our study demonstrates that the effects of testosterone on muscle and bone can be separated from the prostate effects and provides a testable strategy for combating sarcopenia and osteopenia in older hypogonadal men...
  10. ncbi request reprint 17β-Hydroxyestra-4,9,11-trien-3-one (Trenbolone) preserves bone mineral density in skeletally mature orchiectomized rats without prostate enlargement
    Sean C McCoy
    Geriatric Research, Education and Clinical Center, VA Medical Center, Gainesville, FL 32608, USA
    Bone 51:667-73. 2012
    ..These findings indicate that TREN may be an advantageous agent for future clinical trials evaluating agents capable of preventing bone loss resulting from androgen deficiency...
  11. doi request reprint 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone) exhibits tissue selective anabolic activity: effects on muscle, bone, adiposity, hemoglobin, and prostate
    Joshua F Yarrow
    VA Medical Center, University of Florida, Gainesville, 32608 1197, USA
    Am J Physiol Endocrinol Metab 300:E650-60. 2011
    ..Our findings indicate that TREN has advantages over supraphysiological testosterone and supports the need for future preclinical studies examining the viability of TREN as an option for androgen replacement therapy...
  12. doi request reprint A rehabilitation exercise program induces severe bone mineral deficits in estrogen-deficient rats after extended disuse
    Joshua F Yarrow
    1VA Medical Center, Gainesville, FL 32607, USA
    Menopause 19:1267-76. 2012
    ..The aim of this study was to determine whether estradiol (E2) influences early-phase bone adaptations to reambulation (REAMB) and/or rehabilitation exercises after hindlimb unloading (HLU) of ovariectomized rats...
  13. doi request reprint Supraphysiological testosterone enanthate administration prevents bone loss and augments bone strength in gonadectomized male and female rats
    Joshua F Yarrow
    Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Gainesville, Florida, USA
    Am J Physiol Endocrinol Metab 295:E1213-22. 2008
    ..In conclusion, TE administration appears protective of cancellous bone in male rats and augments cortical bone strength in both sexes...
  14. ncbi request reprint Impact of treadmill locomotor training on skeletal muscle IGF1 and myogenic regulatory factors in spinal cord injured rats
    Min Liu
    Department of Physical Therapy, University of Florida, P O Box 100154, Rm 1142 PHHP Bldg, Gainesville, FL 32610, USA
    Eur J Appl Physiol 109:709-20. 2010
    ..Training-induced muscle regeneration and fiber hypertrophy following SCI was associated with an increase in IGF1, an increase in Pax7 positive nuclei, and upregulation of MRFs...
  15. ncbi request reprint Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial
    Stephen E Borst
    Geriatric Research, Education and Clinical Center, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida
    Am J Physiol Endocrinol Metab 306:E433-42. 2014
    ..These results demonstrate that elevated DHT mediates testosterone-induced prostate enlargement but is not required for benefits in musculoskeletal or adipose tissue. ..
  16. ncbi request reprint High-fat diet induces increased tissue expression of TNF-alpha
    Stephen E Borst
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32608 1197, USA
    Life Sci 77:2156-65. 2005
    ..055). TNF-alpha was undetectable in serum. We conclude that muscle over expression of TNF-alpha occurs during the development of diet-induced obesity and may, in part cause insulin resistance by an autocrine mechanism...
  17. doi request reprint Overexpression of insulin-like growth factor-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse
    Fan Ye
    Department of Physical Therapy, PO Box 100154, Room 1142, PHHP Building, University of Florida, Gainesville, FL 32610, USA
    Exp Physiol 98:1038-52. 2013
    ..05). These findings demonstrate a potential role of IGF-1 in protecting unloaded skeletal muscles from damage and accelerating muscle repair and regeneration...
  18. doi request reprint Early-phase neuroendocrine responses and strength adaptations following eccentric-enhanced resistance training
    Joshua F Yarrow
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
    J Strength Cond Res 22:1205-14. 2008
    ..In conclusion, TRAD training and ECC+ training appear to result in similar muscular strength adaptations and neuroendocrine responses, while postexercise lactate clearance is enhanced following ECC+ training...
  19. doi request reprint Methods to quantify sex steroid hormones in bone: applications to the study of androgen ablation and administration
    Joshua F Yarrow
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
    Am J Physiol Endocrinol Metab 299:E841-7. 2010
    ..We report the validation of a novel method for measuring intraskeletal sex hormones. Our findings demonstrate that the intraskeletal sex steroid reservoirs are modifiable and only partially influenced by circulating sex hormones...
  20. doi request reprint Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults
    Silvia Giovannini
    Department of Aging and Geriatric Research, University of Florida, Gainesville, USA
    Mech Ageing Dev 129:593-601. 2008
    ....
  21. ncbi request reprint Metformin restores responses to insulin but not to growth hormone in Sprague-Dawley rats
    Stephen E Borst
    VA Medical Center, Education and Clinical Center, Gainesville, Florida 32608, USA
    Biochem Biophys Res Commun 291:722-6. 2002
    ..The latter may, in part, be explained by the failure of metformin to prevent GH-induced elevation of TNF in visceral fat...
  22. ncbi request reprint Neutralization of tumor necrosis factor reverses age-induced impairment of insulin responsiveness in skeletal muscle of Sprague-Dawley rats
    Stephen E Borst
    Department of Exercise and Sport Sciences, University of Florida, Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Center, Gainesville, FL, USA
    Metabolism 51:1061-4. 2002
    ..Muscle mass and visceral fat mass were unchanged. These data suggest that skeletal muscle pools of TNF may play an important role in the development of insulin resistance...
  23. pmc Influence of androgens on circulating adiponectin in male and female rodents
    Joshua F Yarrow
    Malcom Randall Veterans Affairs Medical Center, Gainesville, FL, USA
    PLoS ONE 7:e47315. 2012
    ....
  24. doi request reprint Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity
    Joshua F Yarrow
    Geriatric Research, Education and Clinical Center, VA Medical Center, Gainesville, FL 32608, United States
    Steroids 75:377-89. 2010
    ....
  25. ncbi request reprint Testosterone dose dependently prevents bone and muscle loss in rodents after spinal cord injury
    Joshua F Yarrow
    1 VA Medical Center, Research Service, VA Medical Center, Gainesville, Florida
    J Neurotrauma 31:834-45. 2014
    ..Testosterone-induced prostate enlargement, however, represents a potential barrier to the clinical implementation of high-dose TE as a means of preserving musculoskeletal tissue after SCI...
  26. doi request reprint Invalidation of a commercially available human 5α-dihydrotestosterone immunoassay
    Joshua F Yarrow
    VA Medical Center, Gainesville, FL 32608, United States Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, United States Electronic address
    Steroids 78:1220-5. 2013
    ..The cross-reactivity of testosterone is particularly concerning because testsoterone is present in 100-fold greater concentrations than is DHT within the circulation...
  27. pmc Growth hormone responses to acute resistance exercise with vascular restriction in young and old men
    Todd M Manini
    University of Florida, Department of Aging and Geriatric Research, Gainesville, USA
    Growth Horm IGF Res 22:167-72. 2012
    ..We hypothesized that low-load RE with vascular restriction would attenuate the known age-related reduction in GH response to RE...
  28. ncbi request reprint Neuroendocrine responses to an acute bout of eccentric-enhanced resistance exercise
    Joshua F Yarrow
    University of Florida, Department of Applied Physiology and Kinesiology, Center for Exercise Science, Gainesville, FL 32611 8206, USA
    Med Sci Sports Exerc 39:941-7. 2007
    ....
  29. doi request reprint Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF)
    Joshua F Yarrow
    VA Medical Center GRECC, Gainesville, FL 32608, United States
    Neurosci Lett 479:161-5. 2010
    ....
  30. pmc Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle
    Emanuele Marzetti
    Department of Aging and Geriatric Research, Institute on Aging, University of Florida, PO Box 100143, Gainesville, FL 32610 0143, USA
    Age (Dordr) 35:1061-75. 2013
    ..Muscle protection by enalapril administered late in life appears to be primarily mediated by mitigation of oxidative stress and pro-inflammatory signaling...
  31. doi request reprint Intracrine and myotrophic roles of 5α-reductase and androgens: a review
    Joshua F Yarrow
    VA Medical Center, Gainesville, FL 32608 1197, USA
    Med Sci Sports Exerc 44:818-26. 2012
    ..The intramuscular expression of these enzymes suggests that skeletal muscle is capable of synthesizing bioactive androgens, which could induce myotrophic effects via intracrine action...
  32. pmc Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization
    Jennifer E Stevens-Lapsley
    Dept of Physical Therapy, Univ of Florida, Gainesville, 32610, USA
    Am J Physiol Endocrinol Metab 299:E730-40. 2010
    ..Changes in IGFBP-5 mRNA expression during cast immobilization and reambulation paralleled those of IGF-I, whereas IGFBP-3 expression changed inversely to IGFBP-5...
  33. ncbi request reprint Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway
    Tossaporn Yimlamai
    Department of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL, USA
    J Appl Physiol 99:71-80. 2005
    ....
  34. ncbi request reprint Effects of resistance training on insulin-like growth factor and its binding proteins in men and women aged 60 to 85
    Stephen E Borst
    Department of Exercise and Sport Sciences, University of Florida, Gainesville, Florida, USA
    J Am Geriatr Soc 50:884-8. 2002
    ..Our goals were to determine whether RT produces a similar effect in the healthy older persons and to determine the effects of low- versus high-intensity RT on hormonal status...
  35. ncbi request reprint Growth hormone isoform responses to GABA ingestion at rest and after exercise
    Michael E Powers
    Division of Athletic Training, Shenendoah University, Winchester, VA 22601, USA
    Med Sci Sports Exerc 40:104-10. 2008
    ..Oral administration of the amino acid/inhibitory neurotransmitter gamma aminobutyric acid (GABA) reportedly elevates resting serum growth hormone (GH) concentrations...