Alexander D Borowsky

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A human breast cell model of preinvasive to invasive transition
    Aylin Rizki
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 68:1378-87. 2008
  2. pmc Establishment of clonal MIN-O transplant lines for molecular imaging via lentiviral transduction & in vitro culture
    David L Boucher
    Department of Biomedical Engineering, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e39350. 2012
  3. pmc Initiation of prostate cancer in mice by Tp53R270H: evidence for an alternative molecular progression
    Ruth L Vinall
    Department of Pharmaceutical and Biomedical Sciences, California Northstate University College of Pharmacy, Rancho Cordova, CA, USA
    Dis Model Mech 5:914-20. 2012
  4. pmc Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer
    Rachel L Dusek
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Center for Clinical Sciences Research Room 1255, 269 Campus Drive, Stanford, CA 94305, USA
    Breast Cancer Res 14:R65. 2012
  5. ncbi request reprint Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior
    Alexander D Borowsky
    Department of Medical Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
    Clin Exp Metastasis 22:47-59. 2005
  6. pmc Choosing a mouse model: experimental biology in context--the utility and limitations of mouse models of breast cancer
    Alexander D Borowsky
    Department of Pathology and Center for Comparative Medicine, University of California at Davis, Davis, California 95616, USA
    Cold Spring Harb Perspect Biol 3:a009670. 2011
  7. pmc Inflammation and atrophy precede prostatic neoplasia in a PhIP-induced rat model
    Alexander D Borowsky
    University of California and the Lawrence Livermore NationalLaboratory, USA
    Neoplasia 8:708-15. 2006
  8. pmc Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors
    Ellen Q Ingalla
    University of California Davis Cancer Center, Sacramento, California 95817, USA
    J Biol Chem 285:28691-7. 2010
  9. pmc Mammary carcinoma behavior is programmed in the precancer stem cell
    Patrizia Damonte
    Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, UC Davis, County Road 98 and Hutchison Drive, Davis, California 95616, USA
    Breast Cancer Res 10:R50. 2008
  10. ncbi request reprint Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes
    Jeannie E Maglione
    Department of Medicine, UCSD Cancer Center, School of Medicine, University of California San Diego, La Jolla, CA, USA
    Mol Cancer Ther 3:941-53. 2004

Research Grants

Collaborators

Detail Information

Publications59

  1. pmc A human breast cell model of preinvasive to invasive transition
    Aylin Rizki
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cancer Res 68:1378-87. 2008
    ..This model provides a new tool for dissection of mechanisms by which preinvasive breast cells could acquire invasiveness in a metaplastic context...
  2. pmc Establishment of clonal MIN-O transplant lines for molecular imaging via lentiviral transduction & in vitro culture
    David L Boucher
    Department of Biomedical Engineering, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e39350. 2012
    ..We also present the in vivo imaging and immunohistochemical analysis of serial transplantation of one such subline and detail the progressive multifocal loss of the transgene in successive generations...
  3. pmc Initiation of prostate cancer in mice by Tp53R270H: evidence for an alternative molecular progression
    Ruth L Vinall
    Department of Pharmaceutical and Biomedical Sciences, California Northstate University College of Pharmacy, Rancho Cordova, CA, USA
    Dis Model Mech 5:914-20. 2012
    ..Further characterization of this model, particularly in a setting of androgen deprivation, should allow further insight into the mechanisms by which the Tp53(R270H) mutation mediates CaP progression...
  4. pmc Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer
    Rachel L Dusek
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Center for Clinical Sciences Research Room 1255, 269 Campus Drive, Stanford, CA 94305, USA
    Breast Cancer Res 14:R65. 2012
    ..Given that p63 is essential for proper mammary gland development and that cell adhesion is fundamental for ensuring the proper architecture and function of the mammary epithelium, here we investigate Perp function in the mammary gland...
  5. ncbi request reprint Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior
    Alexander D Borowsky
    Department of Medical Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
    Clin Exp Metastasis 22:47-59. 2005
    ..Therefore, these two cell lines provide a stable, reproducible resource for the study of metastasis modulators, AKT molecular pathway interactions, and gene target and marker discovery...
  6. pmc Choosing a mouse model: experimental biology in context--the utility and limitations of mouse models of breast cancer
    Alexander D Borowsky
    Department of Pathology and Center for Comparative Medicine, University of California at Davis, Davis, California 95616, USA
    Cold Spring Harb Perspect Biol 3:a009670. 2011
    ..Overall, the many mouse models available are a rich resource for experimental biology with phenocopies of breast cancer subtypes, and a variety of practical advantages. The challenge is matching the model to the experimental question...
  7. pmc Inflammation and atrophy precede prostatic neoplasia in a PhIP-induced rat model
    Alexander D Borowsky
    University of California and the Lawrence Livermore NationalLaboratory, USA
    Neoplasia 8:708-15. 2006
    ..Overall, these findings suggest that the pathogenesis of prostatic neoplasia in the PhIP-treated rat prostate proceeds from inflammation to postinflammatory proliferative atrophy to PIN...
  8. pmc Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors
    Ellen Q Ingalla
    University of California Davis Cancer Center, Sacramento, California 95817, USA
    J Biol Chem 285:28691-7. 2010
    ..These observations indicate that mammary tumors use potent post-transcriptional mechanisms to suppress Nrdp1 protein levels and that protein destabilization may play a central role in Nrdp1 loss in tumors...
  9. pmc Mammary carcinoma behavior is programmed in the precancer stem cell
    Patrizia Damonte
    Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, UC Davis, County Road 98 and Hutchison Drive, Davis, California 95616, USA
    Breast Cancer Res 10:R50. 2008
    ..Transition to carcinoma has a consistent latency for each line, and three of the lines also exhibit pulmonary metastatic potential...
  10. ncbi request reprint Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes
    Jeannie E Maglione
    Department of Medicine, UCSD Cancer Center, School of Medicine, University of California San Diego, La Jolla, CA, USA
    Mol Cancer Ther 3:941-53. 2004
    ..These lines provide an opportunity to study the full range of events occurring secondary to PyV-mT expression in the mammary gland...
  11. ncbi request reprint Molecular characterization of the transition to malignancy in a genetically engineered mouse-based model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Davis, Sacramento, California 95817, USA
    Mol Cancer Res 2:453-63. 2004
    ..With consistent tumor latency and molecular profiles, this model provides an experimental platform that can be used to assess functional genomics and molecular pharmacology and to test promising chemoprevention strategies...
  12. pmc ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2
    Ekaterina V Kalashnikova
    Department of Biochemistry and Molecular Medicine, School of Medicine, and UC Davis Cancer Center Basic Sciences, University of California at Davis, Sacramento, California 95817, USA
    Cancer Res 70:9402-12. 2010
    ..Our results suggest that ANCCA may integrate multiple oncogenic programs in breast cancer, serving in particular as a prognostic marker and a therapeutic target for triple-negative cancers...
  13. ncbi request reprint Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Clin Cancer Res 12:2613-21. 2006
    ..Both of these models were derived from mammary lesions in Tg(MMTV-PyV-mT) mice...
  14. pmc Heterogeneity of mammary lesions represent molecular differences
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA
    BMC Cancer 6:275. 2006
    ..Each MIN-O line has distinguishable morphologies, metastatic potentials and estrogen dependencies...
  15. ncbi request reprint Preclinical imaging of mammary intraepithelial neoplasia with positron emission tomography
    Craig K Abbey
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    J Mammary Gland Biol Neoplasia 11:137-49. 2006
    ..We conclude with a brief survey of emerging approaches in small-animal PET imaging...
  16. pmc The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells
    Heather C Workman
    Division of Basic Sciences, UC Davis Cancer Center, 4645 2ndAvenue, Sacramento, California 95817, USA
    Breast Cancer Res 11:R70. 2009
    ....
  17. pmc Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ
    Ruria Namba
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA
    Breast Cancer Res 7:R881-9. 2005
    ..We studied the ovarian-hormone-responsiveness of one of the lines with a particular focus on the effects of two related SERMs, tamoxifen and ospemifene...
  18. ncbi request reprint Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth
    Lily Yen
    University of California Davis Cancer Center, Sacramento, CA 95817 2305, USA
    Cancer Res 66:11279-86. 2006
    ..Our observations suggest that Nrdp1-mediated ErbB3 degradation suppresses cellular growth and motility, and that Nrdp1 loss in breast tumors may promote tumor progression by augmenting ErbB2/ErbB3 signaling...
  19. pmc Molecular analysis of metastasis in a polyomavirus middle T mouse model: the role of osteopontin
    Katayoun Alavi Jessen
    Department of Pathology, University of California, Davis, School of Medicine, Sacramento, California, USA
    Breast Cancer Res 6:R157-69. 2004
    ..In order to study metastatic disease, we employed the use of two related polyomavirus middle T transgenic mouse tumor transplant models of mammary carcinoma (termed Met and Db) that display significant differences in metastatic potential...
  20. pmc Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer
    Jamie K Miller
    School of Medicine, Davis Cancer Center, University of California at Davis, Sacramento, California 95817, USA
    Cancer Res 68:8286-94. 2008
    ..Moreover, our observations point to the existence of a feed-forward regulatory loop in breast tumor cells where aberrant ErbB2 signaling suppresses LRIG1 protein levels, which in turn contributes to ErbB2 overexpression...
  21. pmc Longitudinal investigation of permeability and distribution of macromolecules in mouse malignant transformation using PET
    Cecilie B Rygh
    Department of Physiology and Membrane Biology, University of California Davis, California, USA
    Clin Cancer Res 17:550-9. 2011
    ....
  22. ncbi request reprint Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice
    Moon Seok Choi
    Transplant Research Institute, UC Davis Medical Center, Sacramento, CA 95817, USA
    Cell Transplant 17:899-909. 2008
    ..In conclusion, our study demonstrated that bioluminescent imaging appears to be a sensitive, noninvasive modality for serial monitoring of transplanted hepatic stem cells...
  23. pmc High-mannose glycans are elevated during breast cancer progression
    Maria Lorna A de Leoz
    Department of Chemistry, University of California Davis, Davis, CA 95616, USA
    Mol Cell Proteomics 10:M110.002717. 2011
    ..630 in both mouse and human sera in the presence of breast cancer, suggesting an incompletion of the glycosylation process that normally trims back Man(9) to produce complex and hybrid type oligosaccharides...
  24. pmc EMT tumorigenesis in the mouse mammary gland
    Patrizia Damonte
    Center for Comparative Medicine, University of California at Davis, Davis, CA 95616, USA
    Lab Invest 87:1218-26. 2007
    ..This suggests that potential EMT tumors are best designated EMT-phenotype tumors...
  25. pmc In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia
    Craig K Abbey
    Department of Biomedical Engineering, University of California, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:11438-43. 2004
    ..Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points...
  26. ncbi request reprint Validation: the new challenge for pathology
    Robert D Cardiff
    Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
    Toxicol Pathol 32:31-9. 2004
    ..The phenotypes can be placed into structural and functional clusters with shared characteristics leading to the concepts of Pathway Pathology: tumor phenotype reflects the genotype...
  27. pmc Aberrant activation of androgen receptor in a new neuropeptide-autocrine model of androgen-insensitive prostate cancer
    Joy C Yang
    Department of Urology and Biological Chemistry, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Cancer Res 69:151-60. 2009
    ..This xenograft model shows autocrine, neuropeptide- and Src kinase-mediated progression of androgen-independent CaP postcastration, and is potentially useful for testing novel therapeutic agents...
  28. pmc Quantitation of fixative-induced morphologic and antigenic variation in mouse and human breast cancers
    Robert D Cardiff
    Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Lab Invest 93:480-97. 2013
    ..The strong cross-linker fixatives, such as formalin, consistently ranked higher than weak cross-linker, coagulant and combination fixatives in both the morphometric and immunohistochemical parameters...
  29. doi request reprint Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex
    Zhijian Duan
    Cancer Center Basic Sciences, University of California at Davis, Sacramento, California 95817, USA
    Prostate 73:455-66. 2013
    ..However, how their expression is regulated in the tumors and whether they play a role in prostate development remains unclear...
  30. ncbi request reprint Mouse models of human cancers (Part 2)
    Jose J Galvez
    Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Ohio 45267 0529, USA
    Comp Med 54:13-5. 2004
  31. ncbi request reprint Mouse models of human cancers (part 3)
    Alexander D Borowsky
    Center for Comparative Medicine, University of California Davis, 95615, USA
    Comp Med 54:258-70. 2004
  32. ncbi request reprint Mouse models of prostate cancer
    Alexander D Borowsky
    Center for Comparative Medicine, Department of Medical Pathology, University of California Davis, 95616, USA
    Comp Med 53:253-6. 2003
  33. doi request reprint Precancer: sequentially acquired or predetermined?
    Robert D Cardiff
    University of California, Davis, CA 95616, USA
    Toxicol Pathol 38:171-9. 2010
    ..If correct, this model suggests that "progression" to malignancy is epigenetic. Further, future assessment of biological potential will involve identification and genetic analysis of the progenitor cell populations...
  34. doi request reprint Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer
    Elaine Y C Hsia
    Department of Biochemistry and Molecular Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Mol Cancer Res 8:183-93. 2010
    ....
  35. pmc Grade-dependent proteomics characterization of kidney cancer
    Bertrand Perroud
    Genome Center, Department of Internal Medicine, University of California, Davis, California 95616, USA
    Mol Cell Proteomics 8:971-85. 2009
    ....
  36. ncbi request reprint Cytosolic p21Waf1/Cip1 increases cell cycle transit in vascular smooth muscle cells
    Yao Dong
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Cell Signal 16:263-9. 2004
    ..Furthermore, compartmentalization of p21 may help explain the biphasic nature of p21 in a variety of cell types and may lead to therapeutic advances directed at modulating pathologic cell growth in vascular diseases and cancer...
  37. pmc An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R
    Masaaki Fujita
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, California 95817, USA
    J Biol Chem 288:19593-603. 2013
    ..Our results are consistent with a model in which ternary complex formation is critical for IGF signaling. ..
  38. pmc Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance
    Charles B Stephensen
    USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
    Immunology 121:484-98. 2007
    ..These differences were modest in magnitude and their impact on disease resistance is yet to be examined...
  39. ncbi request reprint An antisense oligodeoxynucleotide to p21(Waf1/Cip1) causes apoptosis in human breast cancer cells
    Yaping Fan
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, California 95616, USA
    Mol Cancer Ther 2:773-82. 2003
    ....
  40. ncbi request reprint Histopathology as a predictive biomarker: strengths and limitations
    Robert D Cardiff
    Department of Medical Pathology and Laboratory Medicine, University of California, Davis CA 95616, USA
    J Nutr 136:2673S-5S. 2006
  41. pmc Copper-doxorubicin as a nanoparticle cargo retains efficacy with minimal toxicity
    Azadeh Kheirolomoom
    Department of Biomedical Engineering, 451 East Health Sciences Drive, School of Medicine, University of California, Davis, Davis, California 95616, United States
    Mol Pharm 7:1948-58. 2010
    ..After the 28-day course of therapy, syngeneic tumors regressed to a premalignant phenotype of ∼(1 mm)(3) or could not be detected...
  42. pmc Initial characterization of a dedicated breast PET/CT scanner during human imaging
    Spencer L Bowen
    Department of Biomedical Engineering, UC Davis, Davis, California, USA
    J Nucl Med 50:1401-8. 2009
    ..We have constructed a dedicated breast PET/CT scanner capable of high-resolution functional and anatomic imaging. Here, we present an initial characterization of scanner performance during patient imaging...
  43. ncbi request reprint p21 is a prognostic marker for renal cell carcinoma: implications for novel therapeutic approaches
    Robert H Weiss
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, California 95616, USA
    J Urol 177:63-8; discussion 68-9. 2007
    ..The apoptosis and cell cycle regulatory protein, p21(waf1/cip1), has been investigated as a possible target in other cancers since it is involved in the repair and apoptotic response of normal and malignant cells to DNA damage...
  44. ncbi request reprint A serum glycomics approach to breast cancer biomarkers
    Crystal Kirmiz
    Department of Chemistry, University of California, Davis, California 95616, USA
    Mol Cell Proteomics 6:43-55. 2007
    ..quot;..
  45. pmc Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues
    Alexander D Borowsky
    Center for Comparative Medicine, University of California at Davis, Davis, CA 95616, USA
    J Lipid Res 53:1920-31. 2012
    ..This unique expression pattern suggests SPL has many undiscovered physiological functions apart from its role in immunity...
  46. ncbi request reprint Genetically engineering a mouse
    Alexander D Borowsky
    Center for Comparative Medicine, Department of Medical Pathology, University of California Davis, 95616, USA
    Comp Med 53:249-50. 2003
  47. pmc Assessment of carprofen and buprenorphine on recovery of mice after surgical removal of the mammary fat pad
    Trinka W Adamson
    Center for Laboratory Animal Science, University of California Davis, Davis, California, USA
    J Am Assoc Lab Anim Sci 49:610-6. 2010
    ..Care should be taken when using visual assessment scores to evaluate pain in mice, given that analgesics may have side effects that inadvertently elevate the score...
  48. ncbi request reprint Multiplexed ion beam imaging of human breast tumors
    Michael Angelo
    1 Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, California, USA 2 Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA
    Nat Med 20:436-42. 2014
    ..The resulting data suggest that MIBI can provide new insights into disease pathogenesis that will be valuable for basic research, drug discovery and clinical diagnostics. ..
  49. pmc A recombinant rhesus cytomegalovirus expressing enhanced green fluorescent protein retains the wild-type phenotype and pathogenicity in fetal macaques
    W L William Chang
    Center for Comparative Medicine and Department of Medical Pathology, University of California, Davis, California 95616, USA
    J Virol 76:9493-504. 2002
    ..The pattern of RhCMV infection in the central nervous system may offer an explanation for the severe developmental outcomes associated with congenital human CMV infection early in gestation...
  50. ncbi request reprint Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse
    Bojie Dai
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cancer Res 66:8058-64. 2006
    ....
  51. ncbi request reprint Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases
    Cory Abate-Shen
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Cancer Res 63:3886-90. 2003
    ..We conclude that Nkx3.1(+/-); Pten(+/-) mice recapitulate key features of advanced prostate cancer and represent a useful model for investigating associated molecular mechanisms and for evaluating therapeutic approaches...
  52. pmc A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis
    Hui Gao
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 101:17204-9. 2004
    ..Our findings suggest that p27(kip1) possesses dosage-sensitive positive as well as negative modulatory roles in prostate cancer progression...
  53. ncbi request reprint MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
    Catherine M Shachaf
    Division of Medical Oncology, Department of Medicine, Stanford University, California 94305, USA
    Nature 431:1112-7. 2004
    ....
  54. ncbi request reprint Mice expressing SV40 T antigen directed by the intestinal trefoil factor promoter develop tumors resembling human small cell carcinoma of the colon
    James R Gum
    Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cancer Res 2:504-13. 2004
    ..ITFTag tumors closely resemble human small cell carcinomas of the colon, suggesting the possibility that these tumors might be derived from the enteroendocrine cell lineage as well...
  55. ncbi request reprint Chromosome instability and tumor predisposition inversely correlate with BLM protein levels
    Lisa D McDaniel
    Department of Pathology, CY1 107, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8840, USA
    DNA Repair (Amst) 2:1387-404. 2003
    ....
  56. pmc A cautionary note as to the use of pBi-L and related luciferase/transgenic vectors in the study of thyroid endocrinology
    Ivan H Chan
    Thyroid 18:665-6. 2008
  57. ncbi request reprint Comparative pathology of nerve sheath tumors in mouse models and humans
    Anat O Stemmer-Rachamimov
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 64:3718-24. 2004
    ..A novel classification scheme for peripheral nerve sheath tumors in murine models was therefore devised...
  58. pmc Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome
    Claire Farrington-Rock
    Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, SSB 371, Los Angeles, CA 90048, USA
    Hum Mol Genet 17:631-41. 2008
    ..These findings suggest that spinal segmentation can occur normally in the absence of filamin B, but the protein is required for maintenance of intervertebral, carpal and sternal joints, and the joint fusion process commences antenatally...
  59. pmc Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
    Babak Oskouian
    Children s Hospital Oakland Research Institute Center for Cancer Research, Oakland, CA 94609 1673, USA
    Proc Natl Acad Sci U S A 103:17384-9. 2006
    ..Our findings suggest that genetic or epigenetic changes affecting intestinal S1P metabolism may correlate with and potentially contribute to carcinogenesis...

Research Grants2

  1. UCD Mouse Biology Program: Pathology Resources Training and Cancer Modeling
    Alexander Borowsky; Fiscal Year: 2007
    ..Developing the national pool of expertise in the combined area of human disease, mouse biology and genetics is the primary objective of this proposal. ..