Laura N Borodinsky
Affiliation: University of California
Belgacem Y, Borodinsky L. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A. 2015;112:4140-5 pubmed publisher
..The developmentally regulated intercalation of electrical activity in the Shh pathway may represent a paradigm for switching from canonical to noncanonical roles of developmental cues during neuronal differentiation and maturation. ..
Belgacem Y, Hamilton A, Shim S, Spencer K, Borodinsky L. The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. J Dev Biol. 2016;4: pubmed publisher
..Here, we review the variety of Shh functions in the developing nervous system and their consequences for neurodevelopmental diseases and neural regeneration, with particular emphasis on the signaling mechanisms underlying Shh action. ..
Borodinsky L, Belgacem Y. Crosstalk among electrical activity, trophic factors and morphogenetic proteins in the regulation of neurotransmitter phenotype specification. J Chem Neuroanat. 2016;73:3-8 pubmed publisher
Tu M, Levin J, Hamilton A, Borodinsky L. Calcium signaling in skeletal muscle development, maintenance and regeneration. Cell Calcium. 2016;59:91-7 pubmed publisher
Sequerra E, Goyal R, Castro P, Levin J, Borodinsky L. NMDA Receptor Signaling Is Important for Neural Tube Formation and for Preventing Antiepileptic Drug-Induced Neural Tube Defects. J Neurosci. 2018;38:4762-4773 pubmed publisher
..Understanding the mechanisms of neurotransmitter signaling during neural tube formation may contribute to the identification and development of antiepileptic drugs that are safer during pregnancy. ..
Balashova O, Visina O, Borodinsky L. Folate receptor 1 is necessary for neural plate cell apical constriction during Xenopus neural tube formation. Development. 2017;144:1518-1530 pubmed publisher
..Further studies in this organism could unveil novel cellular and molecular events mediated by folate and lead to new ways of preventing NTDs. ..