Larry C Borish

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization
    John W Steinke
    Carter Immunology Center, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA, USA
    J Allergy Clin Immunol 124:724-30.e4. 2009
  2. pmc Chronic sinusitis pathophysiology: the role of allergy
    Joshua L Kennedy
    Department of Medicine, Asthma and Allergic Disease Center, Carter Immunology Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Rhinol Allergy 27:367-71. 2013
  3. pmc Chronic rhinosinusitis and antibiotics: the good, the bad, and the ugly
    Joshua L Kennedy
    Department of Medicine, Asthma and Allergic Disease Center, Carter Immunology Center, University of Virginia Health System, Charlottesville, Virginia, USA
    Am J Rhinol Allergy 27:467-72. 2013
  4. pmc Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
    J W Steinke
    University of Virginia, Charlottesville, Virginia, USA
    Respir Res 2:66-70. 2001
  5. ncbi request reprint Maybe rhinitis, maybe sinusitis, maybe rhinitis and sinusitis, but certainly not rhinosinusitis!
    Larry Borish
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 116:1269-71. 2005
  6. ncbi request reprint Asthma: a syndrome composed of heterogeneous diseases
    Larry Borish
    Asthma and Allergic Disease Center, Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann Allergy Asthma Immunol 101:1-8; quiz 8-11, 50. 2008
  7. pmc Interleukin-33 in asthma: how big of a role does it play?
    Larry Borish
    Asthma and Allergic Disease Center, Box 801355, University of Virginia Health Systems, Charlottesville, VA 22908 1355, USA
    Curr Allergy Asthma Rep 11:7-11. 2011
  8. ncbi request reprint The role of leukotrienes in upper and lower airway inflammation and the implications for treatment
    Larry Borish
    Asthma and Allergic Disease Center, Bernie B Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville 22908 1355, USA
    Ann Allergy Asthma Immunol 88:16-22. 2002
  9. ncbi request reprint Fungi in chronic hyperplastic eosinophilic sinusitis: reasonable doubt
    Larry Borish
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA, USA
    Clin Rev Allergy Immunol 30:195-204. 2006
  10. doi request reprint Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathways
    Julie Negri
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, Department of Medicine, University of Virginia Health System, Charlottesville, VA
    J Allergy Clin Immunol 121:1232-7. 2008

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization
    John W Steinke
    Carter Immunology Center, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA, USA
    J Allergy Clin Immunol 124:724-30.e4. 2009
    ..Through an unknown mechanism, aspirin desensitization is an effective treatment...
  2. pmc Chronic sinusitis pathophysiology: the role of allergy
    Joshua L Kennedy
    Department of Medicine, Asthma and Allergic Disease Center, Carter Immunology Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Rhinol Allergy 27:367-71. 2013
    ..Aeroallergen sensitization in CHES occurs regularly, but the causality between allergen sensitivity, exposure, and disease is unclear...
  3. pmc Chronic rhinosinusitis and antibiotics: the good, the bad, and the ugly
    Joshua L Kennedy
    Department of Medicine, Asthma and Allergic Disease Center, Carter Immunology Center, University of Virginia Health System, Charlottesville, Virginia, USA
    Am J Rhinol Allergy 27:467-72. 2013
    ..CRS is a constellation of inflammatory diseases that typically involve either noneosinophilic or eosinophilic processes, distinct conditions that must be treated individually...
  4. pmc Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
    J W Steinke
    University of Virginia, Charlottesville, Virginia, USA
    Respir Res 2:66-70. 2001
    ..We report the results of initial clinical trials, which demonstrate clinical efficacy of this naturally occurring IL-4 antagonist as a therapeutic agent in asthma...
  5. ncbi request reprint Maybe rhinitis, maybe sinusitis, maybe rhinitis and sinusitis, but certainly not rhinosinusitis!
    Larry Borish
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 116:1269-71. 2005
  6. ncbi request reprint Asthma: a syndrome composed of heterogeneous diseases
    Larry Borish
    Asthma and Allergic Disease Center, Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann Allergy Asthma Immunol 101:1-8; quiz 8-11, 50. 2008
    ..To review the concept that asthma comprises distinct heterogeneous inflammatory disorders characterized by patients showing different phenotypes with distinct genetic components, environmental causes, and immunopathologic signa-..
  7. pmc Interleukin-33 in asthma: how big of a role does it play?
    Larry Borish
    Asthma and Allergic Disease Center, Box 801355, University of Virginia Health Systems, Charlottesville, VA 22908 1355, USA
    Curr Allergy Asthma Rep 11:7-11. 2011
    ..As such, IL-33 is an attractive candidate for therapeutic intervention with the goal of ameliorating disease. This review focuses on the role of IL-33 in promoting and maintaining the asthma phenotype...
  8. ncbi request reprint The role of leukotrienes in upper and lower airway inflammation and the implications for treatment
    Larry Borish
    Asthma and Allergic Disease Center, Bernie B Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville 22908 1355, USA
    Ann Allergy Asthma Immunol 88:16-22. 2002
    ..After reading this article, readers should have a greater understanding of the effects of the CysLTs on both upper and lower airways and their implications for treatment...
  9. ncbi request reprint Fungi in chronic hyperplastic eosinophilic sinusitis: reasonable doubt
    Larry Borish
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA, USA
    Clin Rev Allergy Immunol 30:195-204. 2006
    ....
  10. doi request reprint Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathways
    Julie Negri
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, Department of Medicine, University of Virginia Health System, Charlottesville, VA
    J Allergy Clin Immunol 121:1232-7. 2008
    ....
  11. pmc Concordant modulation of cysteinyl leukotriene receptor expression by IL-4 and IFN-gamma on peripheral immune cells
    S Brandon Early
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Respir Cell Mol Biol 36:715-20. 2007
    ..These results support the concept that cytokines increase expression of both receptors on lymphocytes and granulocytes, allowing these cells to be more responsive to secreted leukotrienes at sites of inflammation...
  12. doi request reprint Immunologic messenger molecules: cytokines, interferons, and chemokines
    Scott P Commins
    University of Virginia Health System, Carter Center for Immunology Research, Asthma and Allergic Disease Center, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 125:S53-72. 2010
    ..A discussion of chemokine function and their role in cell trafficking and disease follows...
  13. ncbi request reprint Leukotriene receptors in rhinitis and sinusitis
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, 22908 1355, USA
    Curr Allergy Asthma Rep 4:217-23. 2004
    ..Comprehensive inhibition of the proinflammatory activities of CysLTs might require either combination CysLT1 and CysLT2 receptor antagonists or inhibitors of the CysLT synthesis pathway...
  14. ncbi request reprint Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthma
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 111:342-9. 2003
    ..The frequent coexpression of these disorders and their shared pathophysiology suggests that these are similar disorders affecting the upper and lower airways...
  15. ncbi request reprint 2. Cytokines and chemokines
    Larry C Borish
    Beirne Carter Center for Immunology, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 111:S460-75. 2003
    ..The biology of chemokines are then reviewed, grouped by family...
  16. ncbi request reprint The role of allergy in chronic rhinosinusitis
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Box 801355, Charlottesville, VA 22908 1355, USA
    Immunol Allergy Clin North Am 24:45-57. 2004
  17. ncbi request reprint Perioperative anaphylaxis in a 44-year-old man
    Jeffrey A Culp
    Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA 22908, USA
    Allergy Asthma Proc 28:602-5. 2007
    ..Skin testing regimens for several commonly implicated drugs used for general anesthesia are available and are described...
  18. ncbi request reprint Hypoxia stimulates inflammatory and fibrotic responses from nasal-polyp derived fibroblasts
    S Brandon Early
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Laryngoscope 117:511-5. 2007
    ..The role of hypoxia in chronic sinusitis is unknown. We hypothesized that hypoxia induces production of mediators that recruit cells into the sinus tissue and are involved in remodeling of the nasal mucosa...
  19. ncbi request reprint Characterization of interleukin-4-stimulated nasal polyp fibroblasts
    John W Steinke
    Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Respir Cell Mol Biol 30:212-9. 2004
    ..The metabolic cascade involved in CysLT synthesis was not expressed in fibroblasts and could not be induced by IL-4 treatment...
  20. pmc Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polyps
    Spencer C Payne
    Department of Otolaryngology Head and Neck Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Am J Rhinol 22:568-81. 2008
    ....
  21. ncbi request reprint 3. Cytokines and chemokines
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 117:S441-5. 2006
    ..For this update, recent advances in our understanding of cytokines will be discussed, which includes the IL-10, IL-17, and IL-27 families...
  22. ncbi request reprint Dual action of TGF-beta1 on nasal-polyp derived fibroblasts
    Stewart C Little
    Department of Otolaryngology HNS, University of Virginia Health System, Charlottesville, VA 22908, USA
    Laryngoscope 118:320-4. 2008
    ..We wanted to determine the effect of stimulation with TGF-beta1 on nasal polyp-derived fibroblasts and assess the role this molecule would have in polyp formation and growth...
  23. ncbi request reprint Cysteinyl leukotrienes in chronic hyperplastic rhinosinusitis
    Pablo Arango
    Department of Otolaryngology, Division of Allergy Immunology, University of Virginia Health Sciences Center, Charlottesville, VA 22903, USA
    Otolaryngol Head Neck Surg 127:512-5. 2002
    ..Our study was designed to demonstrate that, similar to asthma, eosinophilic chronic rhinosinusitis is a disease characterized by activation and the expression of cysteinyl leukotrienes (LTs)...
  24. ncbi request reprint Chronic hyperplastic eosinophilic sinusitis as a predictor of aspirin-exacerbated respiratory disease
    Kimberly Mascia
    Department of Medicine, University of Virginia Health Systems, Charlottesville, Virginia 22908 1355, USA
    Ann Allergy Asthma Immunol 94:652-7. 2005
    ..Aspirin-exacerbated respiratory disease (AERD) is a disease of intense eosinophilic inflammation that can produce fibrosis, hyperplasia, and remodeling...
  25. ncbi request reprint Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by sp1
    John W Steinke
    Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 173:3215-22. 2004
    ..Individuals carrying the A allele of the IL-10 promoter may display increased synthesis of IL-10, resulting in suppressed immune responses and a modulation of their susceptibility to autoimmune, infectious, neoplastic, or atopic disease...
  26. pmc Differential interleukin-10 production stratified by -571 promoter polymorphism in purified human immune cells
    John W Steinke
    Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, 409 Lane Road, Room 5031, P O Box 801355, Charlottesville, VA 22908 1355, USA
    Cell Immunol 249:101-7. 2007
    ..Changes in IL-10 protein production were paralleled by similar changes in IL-10 mRNA production. These results demonstrate that changes in IL-10 production observed due to the -571 genotype depend on both cell type and stimulus...
  27. pmc Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose
    Scott P Commins
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA
    J Allergy Clin Immunol 123:426-33. 2009
    ..Recent work, however, has shown that IgE antibodies to galactose-alpha-1,3-galactose (alpha-gal), a carbohydrate commonly expressed on nonprimate mammalian proteins, are capable of eliciting serious, even fatal, reactions...
  28. ncbi request reprint Modulation of T-cell function by (R)- and (S)-isomers of albuterol: anti-inflammatory influences of (R)-isomers are negated in the presence of the (S)-isomer
    Dawn Baramki
    Asthma and Allergic Disease Center, Beirne Carter Center, Department of Medicine, University of Virginia Health System, Charlottesville 22908 1355, USA
    J Allergy Clin Immunol 109:449-54. 2002
    ..However, anti-inflammatory effects are not observed when beta(2)-adrenergic agonists are administered in vivo as racemates...
  29. pmc Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma
    Edward J Peters
    Asthma and Allergic Disease Center, Beirne Carter Center, University of Virginia, Charlottesville, Virginia, USA
    Ann Allergy Asthma Immunol 90:316-22. 2003
    ..The inappropriate closure of the vocal cords is characteristic of vocal cord dysfunction (VCD). These patients present with wheezing and frequently receive a misdiagnosis of asthma...
  30. doi request reprint Role of hypoxia in inflammatory upper airway disease
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Curr Opin Allergy Clin Immunol 8:16-20. 2008
    ..This hypoxia reflects occlusion of the sinus ostia and thereby failure of transepithelial oxygenation, nonvascularized exudates, and the tendency of inflammatory hyperplasia to exceed neovascularization...
  31. ncbi request reprint Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma
    Kimberly Mascia
    University of Virginia Health Systems, Charlottesville, USA
    J Allergy Clin Immunol 116:970-5. 2005
    ..We speculated that similar mechanisms could be acting in the lower airway and that these individuals would demonstrate more severe asthma and irreversible loss of lung function...
  32. ncbi request reprint Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells
    John W Steinke
    Allergy Division, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Mol Immunol 41:1145-53. 2004
    ..Together, these data provide the first analysis of regulatory modules necessary for GCET expression, a model for GC B cell-specific transcription...
  33. ncbi request reprint Allergic rhinitis: systemic inflammation and implications for management
    Larry Borish
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 112:1021-31. 2003
    ..Leukotriene modifiers have both systemic anti-inflammatory effects and an acceptable safety profile...
  34. doi request reprint The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29
    Scott Commins
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 121:1108-11. 2008
    ..However, its members mediate diverse activities, including immune suppression, enhanced antibacterial and antiviral immunity, antitumor activity, and promotion of self-tolerance in autoimmune diseases...
  35. ncbi request reprint 5. Genetics of hypersensitivity
    John W Steinke
    University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 111:S495-501. 2003
    ..It is to be hoped that they will also define new targets for the next generation of asthma and allergy therapeutic agents...
  36. ncbi request reprint Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis
    Alessandro de Alarcon
    Department of Otolaryngology Head and Neck Surgery, University of Virginia Health Sciences System, Charlottesville, Virginia 22908, USA
    Am J Rhinol 20:545-9. 2006
    ..The role of these polymorphisms was investigated in patients with sinusitis and polyps. We performed a prospective study of patients undergoing endoscopic sinus surgery at a university hospital between 1996 and 2004...
  37. ncbi request reprint Lack of a role for cross-reacting anti-thyroid antibodies in chronic idiopathic urticaria
    Jonathan D Mozena
    Asthma and Allergic Disease Center, Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA
    J Invest Dermatol 130:1860-5. 2010
    ..Epitopic cross-reactivity does not explain the increased prevalence of HT found in CIU patients. The frequent concurrence of HT and CIU likely reflects a genetic tendency toward autoimmune diseases...
  38. ncbi request reprint Genetics of allergic disease
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908 1355, USA
    Med Clin North Am 90:1-15. 2006
    ..The end result will be the ability to tailor a specific treatment regime for each patient and reduce the overall cost of health care related to allergies and asthma...
  39. pmc Evaluation of cytokines in nasal secretions after nasal antigen challenge: lack of influence of antihistamines
    Greg W Bensch
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Ann Allergy Asthma Immunol 88:457-62. 2002
    ..For this study we used filter paper as a matrix to collect nasal secretions in patients undergoing nasal antigen challenge...
  40. ncbi request reprint Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma
    Larry Borish
    University of Virginia, Charlottesville, Virginia, USA
    Ann Allergy Asthma Immunol 95:247-53. 2005
    ..Limited data are available on levels of IgE in large cohorts of patients with severe or difficult-to-treat asthma...
  41. doi request reprint 5. Genetics of allergic disease
    John W Steinke
    Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, PO Box 801355, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 121:S384-7; quiz S416. 2008
    ..This review will discuss the techniques used for genetic analysis of complex diseases, some of the important genes that have been replicated in multiple asthma studies, and the future of genetic studies in asthma...
  42. pmc Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: comparison with healthy subjects and patients with COPD
    Chengbo Wang
    Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    J Magn Reson Imaging 28:80-8. 2008
    ..To investigate short- and long-time-scale (3)He diffusion in asthma...
  43. ncbi request reprint Inhibition of effector T lymphocytes mediated through antagonism of IL-4
    Richard Enelow
    J Allergy Clin Immunol 113:560-2. 2004

Research Grants11

  1. RECOMBINANT HUMAN INTERLEUKIN 4 RECEPTOR IN ASTHMA
    Larry Borish; Fiscal Year: 2000
    ..We hypothesize that individuals who are genetically predisposed to either increased IL-4 production or IL-4 responsiveness will represent a cohort more likely to benefit from the IL-4 antagonists. ..
  2. Cysteinyl leukotrienes in chronic sinusitis and asthma
    Larry Borish; Fiscal Year: 2009
    ..Finally, aspirin desensitization is an effective treatment for AERD. Therefore specific aim #3 will investigate the role of IL-4 antagonism by aspirin as the therapeutic basis for the efficacy of this procedure ..
  3. Cysteinyl leukotrienes in chronic sinusitis and asthma
    Larry Borish; Fiscal Year: 2007
    ..Finally, aspirin desensitization is an effective treatment for AERD. Therefore specific aim #3 will investigate the role of IL-4 antagonism by aspirin as the therapeutic basis for the efficacy of this procedure ..
  4. Cysteinyl leukotrienes in chronic sinusitis and asthma
    Larry Borish; Fiscal Year: 2006
    ..Finally, aspirin desensitization is an effective treatment for AERD. Therefore specific aim #3 will investigate the role of IL-4 antagonism by aspirin as the therapeutic basis for the efficacy of this procedure ..
  5. RECOMBINANT HUMAN INTERLEUKIN-4 RECEPTOR IN ASTHMA
    Larry Borish; Fiscal Year: 2004
    ..We hypothesize that individuals who are genetically predisposed to either increased IL-4 production or IL-4 responsiveness will represent a cohort more likely to benefit from the IL-4 antagonists. ..
  6. RECOMBINANT HUMAN INTERLEUKIN-4 RECEPTOR IN ASTHMA
    Larry Borish; Fiscal Year: 2003
    ..We hypothesize that individuals who are genetically predisposed to either increased IL-4 production or IL-4 responsiveness will represent a cohort more likely to benefit from the IL-4 antagonists. ..
  7. RECOMBINANT HUMAN INTERLEUKIN-4 RECEPTOR IN ASTHMA
    Larry Borish; Fiscal Year: 2002
    ..We hypothesize that individuals who are genetically predisposed to either increased IL-4 production or IL-4 responsiveness will represent a cohort more likely to benefit from the IL-4 antagonists. ..
  8. RECOMBINANT HUMAN INTERLEUKIN-4 RECEPTOR IN ASTHMA
    Larry Borish; Fiscal Year: 2001
    ..We hypothesize that individuals who are genetically predisposed to either increased IL-4 production or IL-4 responsiveness will represent a cohort more likely to benefit from the IL-4 antagonists. ..
  9. Cysteinyl leukotrienes in chronic sinusitis and asthma
    Larry C Borish; Fiscal Year: 2010
    ..Finally, aspirin desensitization is an effective treatment for AERD. Therefore specific aim #3 will investigate the role of IL-4 antagonism by aspirin as the therapeutic basis for the efficacy of this procedure ..