Research Topics
Species | Larry C BorishSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitizationJohn W Steinke
Carter Immunology Center, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA, USA
J Allergy Clin Immunol 124:724-30.e4. 2009..Through an unknown mechanism, aspirin desensitization is an effective treatment...
Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonistsJ W Steinke
University of Virginia, Charlottesville, Virginia, USA
Respir Res 2:66-70. 2001..We report the results of initial clinical trials, which demonstrate clinical efficacy of this naturally occurring IL-4 antagonist as a therapeutic agent in asthma...
Fungi in chronic hyperplastic eosinophilic sinusitis: reasonable doubtLarry Borish
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA, USA
Clin Rev Allergy Immunol 30:195-204. 2006....- Maybe rhinitis, maybe sinusitis, maybe rhinitis and sinusitis, but certainly not rhinosinusitis!Larry Borish
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908-1355, USA
J Allergy Clin Immunol 116:1269-71. 2005 - Interleukin-33 in asthma: how big of a role does it play?Larry Borish
Asthma and Allergic Disease Center, Box 801355, University of Virginia Health Systems, Charlottesville, VA 22908 1355, USA
Curr Allergy Asthma Rep 11:7-11. 2011..As such, IL-33 is an attractive candidate for therapeutic intervention with the goal of ameliorating disease. This review focuses on the role of IL-33 in promoting and maintaining the asthma phenotype... - Asthma: a syndrome composed of heterogeneous diseasesLarry Borish
Asthma and Allergic Disease Center, Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, Virginia, USA
Ann Allergy Asthma Immunol 101:1-8; quiz 8-11, 50. 2008..To review the concept that asthma comprises distinct heterogeneous inflammatory disorders characterized by patients showing different phenotypes with distinct genetic components, environmental causes, and immunopathologic signa-.. - The role of leukotrienes in upper and lower airway inflammation and the implications for treatmentLarry Borish
Asthma and Allergic Disease Center, Bernie B Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville 22908 1355, USA
Ann Allergy Asthma Immunol 88:16-22. 2002..After reading this article, readers should have a greater understanding of the effects of the CysLTs on both upper and lower airways and their implications for treatment... - Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathwaysJulie Negri
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, Department of Medicine, University of Virginia Health System, Charlottesville, VA
J Allergy Clin Immunol 121:1232-7. 2008.... - Concordant modulation of cysteinyl leukotriene receptor expression by IL-4 and IFN-gamma on peripheral immune cellsS Brandon Early
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Respir Cell Mol Biol 36:715-20. 2007..These results support the concept that cytokines increase expression of both receptors on lymphocytes and granulocytes, allowing these cells to be more responsive to secreted leukotrienes at sites of inflammation... - Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthmaJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA
J Allergy Clin Immunol 111:342-9. 2003..The frequent coexpression of these disorders and their shared pathophysiology suggests that these are similar disorders affecting the upper and lower airways... - Immunologic messenger molecules: cytokines, interferons, and chemokinesScott P Commins
University of Virginia Health System, Carter Center for Immunology Research, Asthma and Allergic Disease Center, Charlottesville, VA 22908 1355, USA
J Allergy Clin Immunol 125:S53-72. 2010..A discussion of chemokine function and their role in cell trafficking and disease follows... - Leukotriene receptors in rhinitis and sinusitisJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, 22908-1355, USA
Curr Allergy Asthma Rep 4:217-23. 2004..Comprehensive inhibition of the proinflammatory activities of CysLTs might require either combination CysLT1 and CysLT2 receptor antagonists or inhibitors of the CysLT synthesis pathway... - 3. Cytokines and chemokinesJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908, USA
J Allergy Clin Immunol 117:S441-5. 2006..For this update, recent advances in our understanding of cytokines will be discussed, which includes the IL-10, IL-17, and IL-27 families... - Perioperative anaphylaxis in a 44-year-old manJeffrey A Culp
Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA 22908, USA
Allergy Asthma Proc 28:602-5. 2007..Skin testing regimens for several commonly implicated drugs used for general anesthesia are available and are described... - Dual action of TGF-beta1 on nasal-polyp derived fibroblastsStewart C Little
Department of Otolaryngology HNS, University of Virginia Health System, Charlottesville, VA 22908, USA
Laryngoscope 118:320-4. 2008..We wanted to determine the effect of stimulation with TGF-beta1 on nasal polyp-derived fibroblasts and assess the role this molecule would have in polyp formation and growth... - Differential interleukin-10 production stratified by -571 promoter polymorphism in purified human immune cellsJohn W Steinke
Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, 409 Lane Road, Room 5031, P O Box 801355, Charlottesville, VA 22908 1355, USA
Cell Immunol 249:101-7. 2007..Changes in IL-10 protein production were paralleled by similar changes in IL-10 mRNA production. These results demonstrate that changes in IL-10 production observed due to the -571 genotype depend on both cell type and stimulus... - Microarray analysis of distinct gene transcription profiles in non-eosinophilic chronic sinusitis with nasal polypsSpencer C Payne
Department of Otolaryngology Head and Neck Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Am J Rhinol 22:568-81. 2008.... - Hypoxia stimulates inflammatory and fibrotic responses from nasal-polyp derived fibroblastsS Brandon Early
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Laryngoscope 117:511-5. 2007..The role of hypoxia in chronic sinusitis is unknown. We hypothesized that hypoxia induces production of mediators that recruit cells into the sinus tissue and are involved in remodeling of the nasal mucosa... - Characterization of interleukin-4-stimulated nasal polyp fibroblastsJohn W Steinke
Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Respir Cell Mol Biol 30:212-9. 2004..The metabolic cascade involved in CysLT synthesis was not expressed in fibroblasts and could not be induced by IL-4 treatment... - Cysteinyl leukotrienes in chronic hyperplastic rhinosinusitisPablo Arango
Department of Otolaryngology, Division of Allergy/Immunology, University of Virginia Health Sciences Center, Charlottesville, VA 22903, USA
Otolaryngol Head Neck Surg 127:512-5. 2002..LT expression occurs in patients who demonstrate few or no mucosal eosinophils, which indicates that cell lines other than eosinophils may be responsible for LT production in chronic rhinosinusitis... - Chronic hyperplastic eosinophilic sinusitis as a predictor of aspirin-exacerbated respiratory diseaseKimberly Mascia
Department of Medicine, University of Virginia Health Systems, Charlottesville, Virginia 22908-1355, USA
Ann Allergy Asthma Immunol 94:652-7. 2005..CONCLUSIONS: AERD can be distinguished from ATA by the extent of hyperplasia on CT scan and the presence of nasal polyps. We hypothesize that AERD represents a remodeling process that affects both the upper and lower airways... - Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by sp1John W Steinke
Asthma and Allergic Diseases Center, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 173:3215-22. 2004..Individuals carrying the A allele of the IL-10 promoter may display increased synthesis of IL-10, resulting in suppressed immune responses and a modulation of their susceptibility to autoimmune, infectious, neoplastic, or atopic disease... - The role of allergy in chronic rhinosinusitisJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Box 801355, Charlottesville, VA 22908-1355, USA
Immunol Allergy Clin North Am 24:45-57. 2004 - Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthmaKimberly Mascia
University of Virginia Health Systems, Charlottesville, USA
J Allergy Clin Immunol 116:970-5. 2005..001). CONCLUSIONS: These data suggest that aspirin sensitivity is associated with increased asthma severity and possible remodeling of both the upper and lower airways... - Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthmaEdward J Peters
Asthma and Allergic Disease Center, Beirne Carter Center, University of Virginia, Charlottesville, Virginia, USA
Ann Allergy Asthma Immunol 90:316-22. 2003..Clinical symptom scores are not predictive of presence or extent of sinus disease in most cases... - Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactoseScott P Commins
Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA
J Allergy Clin Immunol 123:426-33. 2009..Recent work, however, has shown that IgE antibodies to galactose-alpha-1,3-galactose (alpha-gal), a carbohydrate commonly expressed on nonprimate mammalian proteins, are capable of eliciting serious, even fatal, reactions... - Modulation of T-cell function by (R)- and (S)-isomers of albuterol: anti-inflammatory influences of (R)-isomers are negated in the presence of the (S)-isomerDawn Baramki
Asthma and Allergic Disease Center, Beirne Carter Center, Department of Medicine, University of Virginia Health System, Charlottesville 22908-1355, USA
J Allergy Clin Immunol 109:449-54. 2002..The presence of excess (S)-albuterol resulted in proinflammatory influences. We hypothesize that the (S)-isomer functions as an inverse agonist to switch the function of the beta(2)-adrenergic receptor... - Role of hypoxia in inflammatory upper airway diseaseJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Curr Opin Allergy Clin Immunol 8:16-20. 2008..This hypoxia reflects occlusion of the sinus ostia and thereby failure of transepithelial oxygenation, nonvascularized exudates, and the tendency of inflammatory hyperplasia to exceed neovascularization... - Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cellsJohn W Steinke
Allergy Division, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
Mol Immunol 41:1145-53. 2004..Together, these data provide the first analysis of regulatory modules necessary for GCET expression, a model for GC B cell-specific transcription... - 2. Cytokines and chemokinesLarry C Borish
Beirne Carter Center for Immunology, Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, VA 22908-1355, USA
J Allergy Clin Immunol 111:S460-75. 2003..The biology of chemokines are then reviewed, grouped by family... - Lack of a role for cross-reacting anti-thyroid antibodies in chronic idiopathic urticariaJonathan D Mozena
Asthma and Allergic Disease Center, Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA
J Invest Dermatol 130:1860-5. 2010..Epitopic cross-reactivity does not explain the increased prevalence of HT found in CIU patients. The frequent concurrence of HT and CIU likely reflects a genetic tendency toward autoimmune diseases... - Genetics of allergic diseaseJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, Charlottesville, VA 22908-1355, USA
Med Clin North Am 90:1-15. 2006..The end result will be the ability to tailor a specific treatment regime for each patient and reduce the overall cost of health care related to allergies and asthma... - Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitisAlessandro de Alarcon
Department of Otolaryngology Head and Neck Surgery, University of Virginia Health Sciences System, Charlottesville, Virginia 22908, USA
Am J Rhinol 20:545-9. 2006..The role of these polymorphisms was investigated in patients with sinusitis and polyps. We performed a prospective study of patients undergoing endoscopic sinus surgery at a university hospital between 1996 and 2004... - Allergic rhinitis: systemic inflammation and implications for managementLarry Borish
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System Charlottesville, VA 22908, USA
J Allergy Clin Immunol 112:1021-31. 2003..Leukotriene modifiers have both systemic anti-inflammatory effects and an acceptable safety profile... - The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29Scott Commins
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA 22908, USA
J Allergy Clin Immunol 121:1108-11. 2008..However, its members mediate diverse activities, including immune suppression, enhanced antibacterial and antiviral immunity, antitumor activity, and promotion of self-tolerance in autoimmune diseases... - 5. Genetics of hypersensitivityJohn W Steinke
University of Virginia Health System, Charlottesville, VA 22908-1355, USA
J Allergy Clin Immunol 111:S495-501. 2003..It is to be hoped that they will also define new targets for the next generation of asthma and allergy therapeutic agents... - Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthmaLarry Borish
University of Virginia, Charlottesville, Virginia, USA
Ann Allergy Asthma Immunol 95:247-53. 2005..In addition, IgE levels are associated with asthma severity among younger patients... - 5. Genetics of allergic diseaseJohn W Steinke
Asthma and Allergic Disease Center, Beirne Carter Center for Immunology Research, University of Virginia Health Systems, PO Box 801355, Charlottesville, VA 22908 1355, USA
J Allergy Clin Immunol 121:S384-7; quiz S416. 2008..This review will discuss the techniques used for genetic analysis of complex diseases, some of the important genes that have been replicated in multiple asthma studies, and the future of genetic studies in asthma... - Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: comparison with healthy subjects and patients with COPDChengbo Wang
Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
J Magn Reson Imaging 28:80-8. 2008..To investigate short- and long-time-scale (3)He diffusion in asthma... - Evaluation of cytokines in nasal secretions after nasal antigen challenge: lack of influence of antihistaminesGreg W Bensch
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Ann Allergy Asthma Immunol 88:457-62. 2002..Symptoms of allergic rhinitis using this type of antigen challenge did not differ from treatment with fexofenadine versus placebo... - Inhibition of effector T lymphocytes mediated through antagonism of IL-4Richard Enelow
J Allergy Clin Immunol 113:560-2. 2004
Research Grants
- Cysteinyl leukotrienes in chronic sinusitis and asthmaLarry Borish; Fiscal Year: 2007..Finally, aspirin desensitization is an effective treatment for AERD. Therefore specific aim #3 will investigate the role of IL-4 antagonism by aspirin as the therapeutic basis for the efficacy of this procedure ..
- RECOMBINANT HUMAN INTERLEUKIN-4 RECEPTOR IN ASTHMALarry Borish; Fiscal Year: 2004..We hypothesize that individuals who are genetically predisposed to either increased IL-4 production or IL-4 responsiveness will represent a cohort more likely to benefit from the IL-4 antagonists. ..
- Cysteinyl leukotrienes in chronic sinusitis and asthmaLarry C Borish; Fiscal Year: 2010..Finally, aspirin desensitization is an effective treatment for AERD. Therefore specific aim #3 will investigate the role of IL-4 antagonism by aspirin as the therapeutic basis for the efficacy of this procedure ..