Stephen A Boppart

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi Optical probes and techniques for molecular contrast enhancement in coherence imaging
    Stephen A Boppart
    University of Illinois at Urbana Champaign, Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, College of Engineering, Urbana, Illinois 61801, USA
    J Biomed Opt 10:41208. 2005
  2. ncbi Advances in contrast enhancement for optical coherence tomography
    Stephen A Boppart
    Dept of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Conf Proc IEEE Eng Med Biol Soc 1:121-4. 2006
  3. ncbi Optical coherence tomography: feasibility for basic research and image-guided surgery of breast cancer
    Stephen A Boppart
    Department of Electrical and Computer Engineering, Bioengineering Program, Beckman Institute for Advanced Science and Technology, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Breast Cancer Res Treat 84:85-97. 2004
  4. ncbi Optical coherence tomography: technology and applications for neuroimaging
    Stephen A Boppart
    Department of Electrical and Computer Engineering, Bioengineering Program, Beckman Institute for Advanced Science and Technology, College of Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Psychophysiology 40:529-41. 2003
  5. ncbi Autocorrelation artifacts in optical coherence tomography and interferometric synthetic aperture microscopy
    Brynmor J Davis
    Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Opt Lett 32:1441-3. 2007
  6. ncbi Inverse scattering for frequency-scanned full-field optical coherence tomography
    Daniel L Marks
    Beckman Institute of Advanced Science and Technology, 405 North Mathews, Urbana, Illinois 61801, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1034-41. 2007
  7. ncbi Anomalous bending effect in photonic crystal fibers
    Haohua Tu
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Opt Express 16:5617-22. 2008
  8. ncbi Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials
    Vasilica Crecea
    Department of Physics, University of Illinois at Urbana Champaign, 1110 W Green St, Urbana, IL 61801, USA
    Opt Express 17:23114-22. 2009
  9. ncbi Dynamic spectral-domain optical coherence elastography for tissue characterization
    Xing Liang
    Department of Electrical and Computer Engineering, Urbana, IL 61801, USA
    Opt Express 18:14183-90. 2010
  10. ncbi Molecular histopathology by spectrally reconstructed nonlinear interferometric vibrational imaging
    Praveen D Chowdary
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cancer Res 70:9562-9. 2010

Research Grants

  1. Nonlinear Interferometric Vibrational Imaging of Cancer
    Stephen Boppart; Fiscal Year: 2007
  2. Magnetomotive Optical Molecular Imaging Probes (RMI)
    Stephen Boppart; Fiscal Year: 2007

Collaborators

Detail Information

Publications79

  1. ncbi Optical probes and techniques for molecular contrast enhancement in coherence imaging
    Stephen A Boppart
    University of Illinois at Urbana Champaign, Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, College of Engineering, Urbana, Illinois 61801, USA
    J Biomed Opt 10:41208. 2005
    ..Probes and techniques designed for coherent molecular imaging are likely to improve the detection and diagnostic capabilities of OCT...
  2. ncbi Advances in contrast enhancement for optical coherence tomography
    Stephen A Boppart
    Dept of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Conf Proc IEEE Eng Med Biol Soc 1:121-4. 2006
    ..This paper and presentation will discuss novel OCT contrast enhancing methods designed to selectively identify tissues of interest...
  3. ncbi Optical coherence tomography: feasibility for basic research and image-guided surgery of breast cancer
    Stephen A Boppart
    Department of Electrical and Computer Engineering, Bioengineering Program, Beckman Institute for Advanced Science and Technology, College of Medicine, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Breast Cancer Res Treat 84:85-97. 2004
    ..These results illustrate the potential of OCT for a wide range of basic research studies and for intra-operative image-guidance to identify foci of tumor cells within surgical margins during the surgical treatment of breast cancer...
  4. ncbi Optical coherence tomography: technology and applications for neuroimaging
    Stephen A Boppart
    Department of Electrical and Computer Engineering, Bioengineering Program, Beckman Institute for Advanced Science and Technology, College of Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Psychophysiology 40:529-41. 2003
    ..This technology offers a potential investigative tool for addressing many of the present challenges in neuroimaging...
  5. ncbi Autocorrelation artifacts in optical coherence tomography and interferometric synthetic aperture microscopy
    Brynmor J Davis
    Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Opt Lett 32:1441-3. 2007
    ..It is shown that this focusing of the image also produces a defocusing effect in autocorrelation artifacts resulting from Fourier-domain data collection. This effect is verified experimentally and through simulation...
  6. ncbi Inverse scattering for frequency-scanned full-field optical coherence tomography
    Daniel L Marks
    Beckman Institute of Advanced Science and Technology, 405 North Mathews, Urbana, Illinois 61801, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1034-41. 2007
    ....
  7. ncbi Anomalous bending effect in photonic crystal fibers
    Haohua Tu
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Opt Express 16:5617-22. 2008
    ..Bending near the fiber entrance dissipates the propagating seed of this leaky mode, preventing the leaky mode amplification and therefore enhancing the transmission of these pulses...
  8. ncbi Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials
    Vasilica Crecea
    Department of Physics, University of Illinois at Urbana Champaign, 1110 W Green St, Urbana, IL 61801, USA
    Opt Express 17:23114-22. 2009
    ..This real-time non-destructive technique constitutes a novel way of probing the natural frequencies of viscoelastic materials in which magnetic nanoparticles can be introduced...
  9. ncbi Dynamic spectral-domain optical coherence elastography for tissue characterization
    Xing Liang
    Department of Electrical and Computer Engineering, Urbana, IL 61801, USA
    Opt Express 18:14183-90. 2010
    ..With high resolution, high acquisition speed, and the ability to characterize the mechanical properties of tissue, this OCE technique has potential use in non-destructive volumetric imaging and clinical applications...
  10. ncbi Molecular histopathology by spectrally reconstructed nonlinear interferometric vibrational imaging
    Praveen D Chowdary
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cancer Res 70:9562-9. 2010
    ..By optimizing optical sources and beam delivery, this technique can potentially enable real-time point-of-care optical molecular imaging and diagnosis...
  11. ncbi Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents
    Renu John
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA
    Mol Imaging Biol 14:17-24. 2012
    ..The development, characterization, and use of multifunctional multimodal microspheres are described for targeted contrast and therapeutic applications...
  12. ncbi Inverse scattering for high-resolution interferometric microscopy
    Tyler S Ralston
    Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Opt Lett 31:3585-7. 2006
    ..Simulations show that the computed structure outside of the focal plane exhibits spatially invariant resolution on par with the resolution achieved at the focal plane...
  13. ncbi Inverse scattering for optical coherence tomography
    Tyler S Ralston
    Beckman Institute for Advanced Science Technology, Department of Electrical and Computer Engineering, University of Illnois at Urbana Champaign, 61801, USA
    J Opt Soc Am A Opt Image Sci Vis 23:1027-37. 2006
    ..Spatially invariant resolution is verified with numerical simulations and indicates an improvement of the high-resolution cross-sectional imaging capabilities of OCT...
  14. ncbi High-spectral-resolution coherent anti-Stokes Raman scattering with interferometrically detected broadband chirped pulses
    Gareth W Jones
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana--Champaign, 61801, USA
    Opt Lett 31:1543-5. 2006
    ..With the temporally resolved anti-Stokes signal, we can remove the chirp of the anti-Stokes pulse and restore high spectral resolution while also rejecting nonresonant scattering...
  15. ncbi Speckle reduction by I-divergence regularization in optical coherence tomography
    Daniel L Marks
    Beckman Institute of Advanced Science and Technology, 405 N. Mathews, Urbana, Illinois 61801, USA
    J Opt Soc Am A Opt Image Sci Vis 22:2366-71. 2005
    ..This method is demonstrated on a test image and on an OCT image of a Xenopus laevis tadpole...
  16. ncbi Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy
    Brynmor J Davis
    Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, USA
    J Opt Soc Am A Opt Image Sci Vis 24:2527-42. 2007
    ..Furthermore, the model presented is suitable for the quantitative study of polarimetric coherent microscopy systems operating within the first Born approximation...
  17. ncbi Inverse scattering for rotationally scanned optical coherence tomography
    Daniel L Marks
    Beckman Institute of Advanced Science and Technology, Urbana, Illinois 61801, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2433-9. 2006
    ..This solution provides quantitatively meaningful reconstructions while also extending the volume of the sample that is resolvable by the instrument...
  18. ncbi Intraoperative evaluation of breast tumor margins with optical coherence tomography
    Freddy T Nguyen
    Departments of Chemistry, College of Medicine, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Illinois 61801, USA
    Cancer Res 69:8790-6. 2009
    ..These results show the potential of OCT as a real-time method for intraoperative margin assessment in breast-conserving surgeries...
  19. ncbi In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes
    Renu John
    Department of Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 107:8085-90. 2010
    ..These engineered magnetic nanoprobes have multifunctional capabilities enabling them to be used as dynamic contrast agents in MM-OCT and MRI...
  20. ncbi Scalar generalized nonlinear Schrödinger equation-quantified continuum generation in an all-normal dispersion photonic crystal fiber for broadband coherent optical sources
    Haohua Tu
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Opt Express 18:27872-84. 2010
    ..We also identify the nonlinear polarization effect that limits the bandwidth of these continuum pulses, and therefore report the path toward a series of attractive alternative broadband coherent optical sources...
  21. ncbi Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a tunable broad bandwidth source for optical coherence tomography
    Haohua Tu
    Biophotonics Imaging Laboratory, Bechman Institute for Advanced Science and Technology, University of Illinois at UrbanChampaign, Urbana Illinois 61801, USA
    Opt Lett 32:2037-9. 2007
    ..The performance deterioration due to the formation of other waveguides can be reversed by overwriting them with this particular waveguide...
  22. ncbi Spectroscopic optical coherence elastography
    Steven G Adie
    Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, 405 N Mathews Avenue, Urbana, IL 61801, USA
    Opt Express 18:25519-34. 2010
    ..Spectroscopic optical coherence elastography (S-OCE) provides a high-resolution imaging capability for the detection of tissue pathologies that are characterized by a frequency-dependent viscoelastic response...
  23. ncbi Acoustomotive optical coherence elastography for measuring material mechanical properties
    Xing Liang
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 North Mathews, Urbana, Illinois 61801, USA
    Opt Lett 34:2894-6. 2009
    ..Quantitative measurement, microscale resolution, and remote excitation are the main features of AM-OCE, which make the technique promising for measuring biomechanical properties...
  24. ncbi High-resolution three-dimensional imaging of biofilm development using optical coherence tomography
    Chuanwu Xi
    University of Illinois at Urbana-Champaign, Department of Civil and Environmental Engineering, Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, 61801, USA
    J Biomed Opt 11:34001. 2006
    ..Based on the imaging capabilities of OCT and the biofilm imaging data obtained, OCT has potential to be used as a non-invasive, label-free, real-time, in-situ and/or in-vivo imaging modality for biofilm characterization...
  25. ncbi Three-dimensional optical coherence tomography of the embryonic murine cardiovascular system
    Wei Luo
    University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, Urbana, Illinois 61801, USA
    J Biomed Opt 11:021014. 2006
    ....
  26. ncbi Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues
    Amy L Oldenburg
    Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Opt Express 16:11525-39. 2008
    ..We demonstrate biological feasibility by imaging topically applied MNPs during their diffusion into an excised rat tumor over a 2 hour time period...
  27. ncbi Cross-validation of interferometric synthetic aperture microscopy and optical coherence tomography
    Tyler S Ralston
    Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
    Opt Lett 35:1683-5. 2010
    ..The width of the ISAM point-spread function is seen to be independent of depth, in contrast to OCT...
  28. ncbi High-speed processing architecture for spectral-domain optical coherence microscopy
    Robin G Chelliyil
    University of Illinois at Urbana Champaign, Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, Biophotonics Imaging Laboratory, Urbana, Illinois 61801, USA
    J Biomed Opt 13:044013. 2008
    ..This new realization has been shown to reduce the processing time to obtain the en face OCM images by a factor of 30...
  29. ncbi Spectroscopic spectral-domain optical coherence microscopy
    Chengyang Xu
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
    Opt Lett 31:1079-81. 2006
    ..Simultaneous acquisition of multiphoton microscopy images is used to validate tissue structure and localization of nuclei within individual cells...
  30. ncbi Deconvolution methods for mitigation of transverse blurring in optical coherence tomography
    Tyler S Ralston
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    IEEE Trans Image Process 14:1254-64. 2005
    ..Implementation of this method in sparse scattering specimens, such as engineered tissues, has the potential to improve cellular detection and categorization...
  31. ncbi Group refractive index reconstruction with broadband interferometric confocal microscopy
    Daniel L Marks
    Beckman Institute of Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA
    J Opt Soc Am A Opt Image Sci Vis 25:1156-64. 2008
    ..Included are a physical framework defining the forward problem, linear solutions to the inverse problem, and simulated images of biologically relevant phantoms...
  32. ncbi Real-time interferometric synthetic aperture microscopy
    Tyler S Ralston
    Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, 405 North Mathews Ave, Urbana, IL 61801, USA
    Opt Express 16:2555-69. 2008
    ..This system provides quantitatively meaningful structural information from previously indistinguishable scattering intensities and provides proof of feasibility for future real-time ISAM systems...
  33. ncbi Plastinated tissue samples as three-dimensional models for optical instrument characterization
    Daniel L Marks
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 N Mathews Ave, Urbana, IL 61801, USA
    Opt Express 16:16272-83. 2008
    ..We detail our plastination procedures and show examples of imaging several plastinated tissues from a pre-clinical rat model using optical coherence tomography...
  34. ncbi Optical micro-scale mapping of dynamic biomechanical tissue properties
    Xing Liang
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Opt Express 16:11052-65. 2008
    ..08%. Spatial micro-scale mapping of elastic moduli of tissue offers the potential for basic science and clinical investigations into the role biomechanics play in health and disease...
  35. ncbi Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography
    Adeel Ahmad
    Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Opt Express 17:8125-36. 2009
    ..This technique could enable the acquisition of images during manual OCT needle-guided biopsy or catheter-based imaging, and for assembly of large field-of-view images with hand-held probes during intraoperative in vivo OCT imaging...
  36. ncbi Imaging cellular responses to mechanical stimuli within three-dimensional tissue constructs
    Wei Tan
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinoisat Urbana Champaign, Illinois 61801, USA
    Microsc Res Tech 70:361-71. 2007
    ..The microscopy technique presented here reveals unique complementary data on the structure and function of cells and their adhesions and interactions with the surrounding microenvironment...
  37. ncbi Needle-based refractive index measurement using low-coherence interferometry
    Adam M Zysk
    Biophotonics Imaging Laboratory, Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Opt Lett 32:385-7. 2007
    ..The device could be used to exploit the refractive index variations of tissue for medical and biological diagnostics accessible by needle insertion...
  38. ncbi Ultraviolet-visible non-supercontinuum ultrafast source enabled by switching single silicon strand-like photonic crystal fibers
    Haohua Tu
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Opt Express 17:17983-8. 2009
    ....
  39. ncbi Imaging engineered tissues using structural and functional optical coherence tomography
    Xing Liang
    Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
    J Biophotonics 2:643-55. 2009
    ..From these results, OCT demonstrates great promise for imaging and visualizing engineered tissues, and the complex cellular dynamics that directly affect their practical and clinical use...
  40. ncbi Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin
    Youbo Zhao
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Biophotonics 5:437-48. 2012
    ....
  41. ncbi Nonlinear polarization dynamics in a weakly birefringent all-normal dispersion photonic crystal fiber: toward a practical coherent fiber supercontinuum laser
    Haohua Tu
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Opt Express 20:1113-28. 2012
    ..We therefore propose the fabrication of polarization-maintaining DFDD-ANDi fibers to avoid these adverse effects in pursuing a practical coherent fiber SC laser...
  42. ncbi Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography
    Amy L Oldenburg
    Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, IL 61801, USA
    Phys Med Biol 55:1189-201. 2010
    ..Using this new technique, named magnetomotive resonant acoustic spectroscopy (MRAS), we monitored the relative stiffening of an excised rat liver during a chemical fixation process...
  43. ncbi Numerical analysis of gradient index lens-based optical coherence tomography imaging probes
    Woonggyu Jung
    University of Illinois, Beckman Institute for Advanced Science and Technology, Urbana, IL 61801, USA
    J Biomed Opt 15:066027. 2010
    ..Numerical results show that the adjustment of the maximum beam diameter and focusing angle at the end of the GRIN lens surface is very important for determining the optical performance parameters of the probe...
  44. ncbi Sonification of optical coherence tomography data and images
    Adeel Ahmad
    Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, Urbana, IL 61801, USA
    Opt Express 18:9934-44. 2010
    ..Results obtained from parameter-mapped sonification of human adipose and tumor tissues are presented, indicating that audio feedback of OCT data may be useful for the interpretation of OCT images...
  45. ncbi Detecting intrinsic scattering changes correlated to neuron action potentials using optical coherence imaging
    Benedikt W Graf
    Department of Electrical and Computer Engineering, Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology University of Illinois at Urbana Champaign405 N Mathews Avenue, Urbana, IL 61801, USA
    Opt Express 17:13447-57. 2009
    ..This study demonstrates the first use of OCT and OCM to detect functionally-correlated optical scattering changes in single neurons...
  46. ncbi Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy
    Benedikt W Graf
    University of Illinois at Urbana Champaign, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, Biophotonics Imaging Laboratory, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
    J Biomed Opt 14:034019. 2009
    ..Images of unstained in vivo human skin are also presented. This source extends the feasibility of this integrated imaging modality and will facilitate new investigations in in vivo microscopy, tissue engineering, and cell biology...
  47. ncbi Measuring the scattering parameters of tissues from quantitative phase imaging of thin slices
    Huafeng Ding
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Opt Lett 36:2281-3. 2011
    ..Using tissue path-length maps that contain nanoscale information about the tissue, the scattering mean free path l(s) and anisotropy factor g were measured in a spatially resolved manner...
  48. ncbi Imaging and analysis of three-dimensional cell culture models
    Benedikt W Graf
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Methods Mol Biol 591:211-27. 2010
    ..Using these techniques, dynamic changes to cells in 3D microenvironments can be non-destructively assessed repeatedly over time...
  49. ncbi Computational methods for analysis of human breast tumor tissue in optical coherence tomography images
    Adam M Zysk
    Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 N. Mathews Ave, Urbana, Illinois 61801, USA
    J Biomed Opt 11:054015. 2006
    ..Derived from preliminary OCT data, these methods are aimed at the development of automated diagnostic tools that will aid in the translation of this technology into the clinical environment...
  50. ncbi Optical coherence elastography of engineered and developing tissue
    Han-Jo Ko
    Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
    Tissue Eng 12:63-73. 2006
    ..By anatomically mapping the regional variation stiffness with micron resolution, it may be possible to provide new insight into the complex by which engineered and natural tissues develop complex structures...
  51. ncbi Evaluation of microfluidic biosensor development using microscopic analysis of molecular beacon hybridization kinetics
    Chuanwu Xi
    Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, Urbana, IL 61801, USA
    Biomed Microdevices 7:7-12. 2005
    ....
  52. ncbi Optical coherence tomography: a review of clinical development from bench to bedside
    Adam M Zysk
    University of Illinois at Urbana Champaign, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, Biophotonics Imaging Laboratory, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
    J Biomed Opt 12:051403. 2007
    ..This work presents a brief history of OCT development, reviews current clinical applications, discusses some clinical translation challenges, and reviews laboratory developments poised for future clinical application...
  53. ncbi Fast-Fourier-domain delay line for in vivo optical coherence tomography with a polygonal scanner
    Amy L Oldenburg
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews, Urbana, Illinois 61801, USA
    Appl Opt 42:4606-11. 2003
    ..6% linearity in group delay over 2 mm, and bandwidth support exceeding 150 nm. Images are obtained in an animal model (Xenopus laevis), and limitations due to phase-delay nonlinearity and polygon asymmetry are discussed...
  54. ncbi Noninvasive in vivo optical detection of biofilm in the human middle ear
    Cac T Nguyen
    Beckman Institute for Advanced Science and Technology and Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 109:9529-34. 2012
    ....
  55. ncbi Molecularly sensitive optical coherence tomography
    Jeremy S Bredfeldt
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
    Opt Lett 30:495-7. 2005
    ..CARS can be generated and interferometrically measured over at least 600 microm of the depth of field of a low-numerical-aperture objective...
  56. ncbi Engineered microsphere contrast agents for optical coherence tomography
    Tin Man Lee
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    Opt Lett 28:1546-8. 2003
    ..We characterize the optical properties of gold-, melanin-, and carbon-shelled contrast agents and demonstrate enhancement of optical coherence tomography imaging after intravenous injection of such an agent into a mouse...
  57. ncbi Imaging magnetically labeled cells with magnetomotive optical coherence tomography
    Amy L Oldenburg
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, USA
    Opt Lett 30:747-9. 2005
    ..Magnetomotive contrast is demonstrated in bulk three-dimensional cell scaffolds containing macrophages labeled with microparticles of iron oxide, demonstrating magnetic-specific contrast over a dynamic range of 30 dB...
  58. ncbi Magnetomotive molecular nanoprobes
    Renu John
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 North Mathews Avenue, Urbana, IL 61801, USA
    Curr Med Chem 18:2103-14. 2011
    ..The iron-oxide nanoparticles also exhibit negative T2 contrast in MRI, and modulations can produce ultrasound imaging contrast for multimodal imaging applications...
  59. ncbi Clinical feasibility of microscopically-guided breast needle biopsy using a fiber-optic probe with computer-aided detection
    Adam M Zysk
    Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign IL 61820 5711, USA
    Technol Cancer Res Treat 8:315-21. 2009
    ..Integration of this probe into current practices offers the potential to reduce nondiagnostic sampling rates by directly evaluating in situ microscopic tissue properties in real-time, before removal...
  60. ncbi Fourier transform light scattering of inhomogeneous and dynamic structures
    Huafeng Ding
    Quantitative Light Imaging Laboratory, Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Phys Rev Lett 101:238102. 2008
    ....
  61. ncbi Multimodal biomedical imaging with asymmetric single-walled carbon nanotube/iron oxide nanoparticle complexes
    Jong Hyun Choi
    Department of Chemical and Biomolecular Engineering, Medical Scholars Program, College of Medicine, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Nano Lett 7:861-7. 2007
    ....
  62. ncbi Optical frequency up-conversion by supercontinuum-free widely-tunable fiber-optic Cherenkov radiation
    Haohua Tu
    Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Opt Express 17:9858-72. 2009
    ..Appropriate selection of fiber parameters and pumping conditions efficiently suppresses the supercontinuum generation typically associated with Cherenkov radiation...
  63. ncbi Partially coherent illumination in full-field interferometric synthetic aperture microscopy
    Daniel L Marks
    Beckman Institute for Advanced Science and Technology and the Department of Electrical and ComputerEngineering, University of Illinois at Urbana Champaign, 405 North Mathews, Urbana, Illinois 61801, USA
    J Opt Soc Am A Opt Image Sci Vis 26:376-86. 2009
    ..Partial spatial coherence of the source is shown to have the advantage of mitigating multiple-scattering effects that can otherwise produce significant artifacts in full-field coherent imaging...
  64. ncbi Autofocus algorithm for dispersion correction in optical coherence tomography
    Daniel L Marks
    Beckman Institute of Advanced Science and Technology, 405 North Mathews, Urbana, Illinois 61801, USA
    Appl Opt 42:3038-46. 2003
    ..This autofocus algorithm can be used in conjunction with a high-speed, digital-signal-processor-based OCT acquisition system for rapid image correction...
  65. ncbi Comparative performance analysis of time-frequency distributions for spectroscopic optical coherence tomography
    Chenyang Xu
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 North Mathews, Urbana, Illinois 61801, USA
    Appl Opt 44:1813-22. 2005
    ..Cohen's class TFDs generate the most compact time-frequency (TF) analysis, while linear TFDs offer the most reliable TF analysis. In both cases, if some prior information is known, model-based TF analysis can improve the performance...
  66. ncbi Adaptive spectral apodization for sidelobe reduction in optical coherence tomography images
    Daniel Marks
    University of Illinois at Urbana Champaign, Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, 405 North Mathews, Urbana, Illinois 61801, USA
    J Biomed Opt 9:1281-7. 2004
    ..In this work, a sidelobe supression method is proposed and demonstrated to achieve low sidelobes even with highly nonuniform, non-Gaussian spectra...
  67. ncbi Real-time digital signal processing-based optical coherence tomography and Doppler optical coherence tomography
    Alexander W Schaefer
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    IEEE Trans Biomed Eng 51:186-90. 2004
    ..This acquisition system is readily configurable for a wide range of real-time signal processing and image processing applications in OCT...
  68. ncbi Structural and functional optical imaging of three-dimensional engineered tissue development
    Wei Tan
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
    Tissue Eng 10:1747-56. 2004
    ..These findings demonstrate the potential for optical coherence tomography in applications in cell and tissue biology, tissue engineering, and drug discovery...
  69. ncbi Molecular identification by generating coherence between molecular normal modes using stimulated Raman scattering
    Daniel L Marks
    Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Opt Lett 34:1756-8. 2009
    ..We investigate how target and confounder molecules can be distinguished by pulses that drive many vibrations coherently, which has applications in coherent Raman microspectroscopy...
  70. ncbi Functional optical coherence tomography for detecting neural activity through scattering changes
    Mariya Lazebnik
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    Opt Lett 28:1218-20. 2003
    ..Motion-mode OCT images of nerve fibers showed transient scattering changes from spontaneous action potentials. These results demonstrate that OCT is sensitive to the optical changes in electrically active nerve fibers...
  71. ncbi Near-infrared dyes as contrast-enhancing agents for spectroscopic optical coherence tomography
    Chenyang Xu
    Department of Electrical and Computer Engineering, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana--Champaign, Urbana, Illinois 61801, USA
    Opt Lett 29:1647-9. 2004
    ..We introduce and demonstrate the use of NIR dyes as contrast agents for SOCT. Contrast-enhanced images are compared with fluorescence microscopy, demonstrating a link between SOCT and fluorescence imaging...
  72. ncbi Optical properties of tissues quantified by Fourier-transform light scattering
    Huafeng Ding
    Quantitative Light Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Opt Lett 34:1372-4. 2009
    ..This "bottom up" approach to measuring tissue scattering parameters allows for predicting the wave transport phenomena within the organ of interest at a multitude of scales-from organelle to organ level...
  73. ncbi Biomechanical properties of in vivo human skin from dynamic optical coherence elastography
    Xing Liang
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    IEEE Trans Biomed Eng 57:953-9. 2010
    ....
  74. ncbi Nonlinear interferometric vibrational imaging
    Daniel L Marks
    Beckman Institute for Advanced Science and Technology, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 405 North Mathews, Urbana, Illinois 61801, USA
    Phys Rev Lett 92:123905. 2004
    ..This could be useful for identifying the three-dimensional spatial distribution of molecular species in tissue...
  75. ncbi Projected index computed tomography
    Adam M Zysk
    Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    Opt Lett 28:701-3. 2003
    ..The resultant PICT images are free of the spatial distortion that is inherent in standard optical cross-sectional images and correspond well to the manufactured dimensions of specific samples...
  76. ncbi Lymphatic biodistribution of polylactide nanoparticles
    Eric J Chaney
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Mol Imaging 9:153-62. 2010
    ..This technique has the potential for providing optical contrast and drug delivery through the lymphatic circulation for the treatment of metastatic cancer...
  77. ncbi Comment on "In vivo cancer diagnosis with optical spectroscopy and acoustically induced blood stasis using a murine Mca35 model," [Med. Phys. 33, 1623-1633 (2006)]
    Adam M Zysk
    Med Phys 34:1130. 2007
  78. ncbi Optical biopsy of lymph node morphology using optical coherence tomography
    Wei Luo
    University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, 405 N. Mathews Ave, Urbana, IL 61801, USA
    Technol Cancer Res Treat 4:539-48. 2005
    ..The results illustrate the potential for OCT to visualize detailed lymph node structures on the scale of micrometastases and the potential for the detection of metastatic nodal disease intraoperatively...
  79. ncbi Structural and functional imaging of 3D microfluidic mixers using optical coherence tomography
    Chuanwu Xi
    Department of Civil and Environmental Engineering, Beckman Institute for Advanced Science and Technology, College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 101:7516-21. 2004
    ..Mixing patterns in the vortex mixer were compared with light-microscopy and OCT image analysis. These results demonstrate that OCT can significantly improve the characterization of 3D microfluidic device structure and function...

Research Grants4

  1. Nonlinear Interferometric Vibrational Imaging of Cancer
    Stephen Boppart; Fiscal Year: 2007
    ..This research will establish NIVI as a unique in vivo nonlinear optical molecular imaging technique for distinguishing and spatially mapping the distribution of molecules associated with cancer. ..
  2. Magnetomotive Optical Molecular Imaging Probes (RMI)
    Stephen Boppart; Fiscal Year: 2007
    ..Conversely, we expect that the capability afforded by MMOCT to screen for efficacy and specificity will drive further development of more effective probes. ..