Frank Booth


Affiliation: University of Missouri
Country: USA


  1. Ruegsegger G, Toedebusch R, Braselton J, Roberts C, Booth F. Reduced metabolic disease risk profile by voluntary wheel running accompanying juvenile Western diet in rats bred for high and low voluntary exercise. Physiol Behav. 2015;152:47-55 pubmed publisher
    ..Furthermore, high physical activity in HVR may offset the deleterious effects of a WD on adiposity despite greater energy intake in this group. ..
  2. Grigsby K, Ruegsegger G, Childs T, Booth F. Overexpression of Protein Kinase Inhibitor Alpha Reverses Rat Low Voluntary Running Behavior. Mol Neurobiol. 2018;: pubmed publisher
    ..Importantly, there were divergent molecular responses to protein kinase inhibitor alpha overexpression in low voluntary runners compared to wild-type rats. ..
  3. Booth F, Laye M. Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery. J Physiol. 2009;587:5527-39 pubmed publisher
    ..Additionally, the scientific criteria that the authors demand to be met to legitimately use the terms 'exercise pill' and 'exercise mimetic' are presented. ..
  4. Booth F, Ruegsegger G, Toedebusch R, Yan Z. Endurance Exercise and the Regulation of Skeletal Muscle Metabolism. Prog Mol Biol Transl Sci. 2015;135:129-51 pubmed publisher
    ..Endurance athletes possess enlarged arteries, which may also exhibit decreased wall thickness. VEGF is required for endurance training-induced increases in capillary-muscle fiber ratio and capillary density. ..
  5. Toedebusch R, Ruegsegger G, Braselton J, Heese A, Hofheins J, Childs T, et al. AMPK agonist AICAR delays the initial decline in lifetime-apex V̇o2 peak, while voluntary wheel running fails to delay its initial decline in female rats. Physiol Genomics. 2016;48:101-15 pubmed publisher
    ..Contrary to our primary hypothesis, wheel running was not sufficient to delay the chronological age of lifetime-apex V̇o2 peak decline, whereas AICAR delayed it 1 wk. ..
  6. Booth F, Laye M, Roberts M. Lifetime sedentary living accelerates some aspects of secondary aging. J Appl Physiol (1985). 2011;111:1497-504 pubmed publisher
    ..In summary, physical inactivity plays a major role in the secondary aging of many essential physiological functions, and this aging can be prevented through a lifetime of physical activity. ..
  7. Booth F, Roberts C, Laye M. Lack of exercise is a major cause of chronic diseases. Compr Physiol. 2012;2:1143-211 pubmed publisher
    ..In addition, physical activity primarily prevents, or delays, chronic diseases, implying that chronic disease need not be an inevitable outcome during life. ..
  8. Ruegsegger G, Speichinger K, Manier J, Younger K, Childs T, Booth F. Hypothalamic Npy mRNA is correlated with increased wheel running and decreased body fat in calorie-restricted rats. Neurosci Lett. 2016;618:83-88 pubmed publisher
    ..These data suggest that below a 'threshold' fat content, body fat may drive activity levels, potentially through hypothalamic Npy action. ..
  9. Ruegsegger G, Brown J, Kovarik M, Miller D, Booth F. Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running. Neuroscience. 2016;339:525-537 pubmed publisher

More Information


  1. Ruegsegger G, Toedebusch R, Braselton J, Childs T, Booth F. Left ventricle transcriptomic analysis reveals connective tissue accumulation associates with initial age-dependent decline in V?o2peak from its lifetime apex. Physiol Genomics. 2017;49:53-66 pubmed publisher
  2. Booth F, Ruegsegger G, Olver T. Exercise Has a Bone to Pick with Skeletal Muscle. Cell Metab. 2016;23:961-962 pubmed publisher
    ..2016) report that osteocalcin improves endurance exercise performance by enhancing myofiber fuel uptake and utilization, while osteocalcin supplementation reverses the age-induced decline in endurance exercise performance. ..
  3. Ruegsegger G, Grigsby K, Kelty T, Zidon T, Childs T, Vieira Potter V, et al. Maternal Western diet age-specifically alters female offspring voluntary physical activity and dopamine- and leptin-related gene expression. FASEB J. 2017;31:5371-5383 pubmed publisher
    ..E., Vieira-Potter, V. J., Klinkebiel, D. L., Matheny, M., Scarpace, P. J., Booth, F. W. Maternal Western diet age-specifically alters female offspring voluntary physical activity and dopamine- and leptin-related gene expression. ..