Research Topics
Species | John BooneSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Evaluation of x-ray scatter properties in a dedicated cone-beam breast CT scannerAlexander L C Kwan
Department of Radiology, U. C. Davis Medical Center, X-ray Imaging Laboratory, 4701 X Street, Sacramento, California 95817, USA
Med Phys 32:2967-75. 2005....- The trouble with CTD100John M Boone
Department of Radiology, University of California Davis Medical Center, Ellison Building, 4860 Y Street, Suite 3100, Sacramento, California 95817, USA
Med Phys 34:1364-71. 2007..However, these data illustrate that the efficiency of the CTDI100 measurement even with 10 mm beam widths is low and, consequently, dose computations which are derived from this metric may not be as accurate as desirable... 
Method for evaluating bow tie filter angle-dependent attenuation in CT: theory and simulation resultsJohn M Boone
Department of Radiology, UC Davis Medical Center, University of California, Davis, 4860 Y Street, Suite 3100, Sacramento, California 95817, USA
Med Phys 37:40-8. 2010..A simple method for characterizing the bow tie filter attenuation profile in CT scanners would therefore be very useful. The theory behind such a method is proposed...- Dose reduction in pediatric CT: a rational approachJohn M Boone
Department of Radiology, University of California Davis Medical Center, Research Imaging Center, 4701 X St, Sacramento, CA 95817, USA
Radiology 228:352-60. 2003..To determine size-dependent technique factors for pediatric computed tomography (CT) by using physically measured objective data... - Automated recognition of lateral from PA chest radiographs: saving seconds in a PACS environmentJohn M Boone
Department of Radiology, University of California Davis Medical Center, Sacramento, CA 95817, USA
J Digit Imaging 16:345-9. 2003..The accumulated time saved by correctly positioning the lateral and PA chest images on the work station monitors in accordance with each radiologist's hanging protocols was estimated to be about 1 week of radiologist time per year... - A comprehensive analysis of DgN(CT) coefficients for pendant-geometry cone-beam breast computed tomographyJ M Boone
Department of Radiology, U C Davis Medical Center, 4701 X Street, X ray Imaging Laboratory Sacramento, California 95817, USA
Med Phys 31:226-35. 2004..78 for an 18 cm 50% glandular breast. The results of this investigation should be useful for those interested computing the glandular breast dose for geometries relevant to dedicated breast CT... - Small-animal X-ray dose from micro-CTJohn M Boone
Department of Radiology, UC Davis Medical Center, 4701 X Street, X ray Imaging Laboratory Sacramento, CA 95817, USA
Mol Imaging 3:149-58. 2004..80, 0.63, 0.52, and 0.44 mGy/mGy for mouse diameters of 10, 20, 30, and 40 mm, respectively. A number of tables and figures are provided for dose estimation over a range of mouse imaging geometries... - What parameters are most accurate in predicting appropriate technique factors for CT scanning?John M Boone
Department of Radiology, University of California Davis Medical Center, Research Imaging Center, 4701 X St, Sacramento, CA 95817, USA
Radiology 236:377-8. 2005 - Technique factors and their relationship to radiation dose in pendant geometry breast CTJohn M Boone
Department of Radiology, University of California Davis Medical Center, Sacramento, California 95817, USA
Med Phys 32:3767-76. 2005..Tables are provided for both air kerma at the isocenter and mAs for 0%, 50%, and 100% glandular breasts. Other issues that impact breast CT technique factors are also discussed... - Breast CT: potential for breast cancer screening and diagnosisJohn M Boone
University of California, Davis, Radiology Research, UC Davis Medical Center, Sacramento, CA 95817, USA
Future Oncol 2:351-6. 2006..The radiation dose levels needed to produce excellent image quality are equal to two-view mammography. Further study of breast CT is needed to better understand its potential role in breast cancer screening and diagnosis... - Computed tomography for imaging the breastJohn M Boone
Department of Radiology, UC Davis Medical Center, University of California, Davis, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USA
J Mammary Gland Biol Neoplasia 11:103-11. 2006..While a thorough scientific investigation based upon observer performance studies is in progress, initial breast CT images do appear promising and it is likely that breast CT will play some role in breast cancer imaging... - Radiological interpretation 2020: toward quantitative image assessmentJohn M Boone
University of California, Davis, UC Davis Medical Center, 4860 Y Street, Ellison Building Suite 3100, Sacramento, California 95817, USA
Med Phys 34:4173-9. 2007..Most importantly, quantitative metrics need to be developed which have genuine impact on patient diagnosis and welfare, and only then will QI techniques become integrated into the clinical environment... - Dose spread functions in computed tomography: a Monte Carlo studyJohn M Boone
Department of Radiology, University of California, Davis Medical Center 4860 Y Street, Suite 3100 Ellison Building, Sacramento, California 95817, USA
Med Phys 36:4547-54. 2009..This study was conducted to provide a better understanding of the radiation dose distributions in CT... - Development and Monte Carlo analysis of antiscatter grids for mammographyJohn M Boone
Department of Radiology, U C Davis Medical Center, Research Imaging Center, 4701 X Street, Sacramento, CA 95817, USA
Technol Cancer Res Treat 1:441-7. 2002.... - Scatter/primary in mammography: comprehensive resultsJ M Boone
Department of Radiology, University of California, Davis, Sacramento 95817, USA
Med Phys 27:2408-16. 2000..3960980055927, and c = 8.85064260299289, the equation SPR= [a + b x (diameter in cm)--(-1.5) + c x (thickness in cm) --(-0.5)]-- -1 produces SPR data from 2 to 8 cm and from 3 to 30 cm breast diameters with an average error of about 1%... - Glandular breast dose for monoenergetic and high-energy X-ray beams: Monte Carlo assessmentJ M Boone
Department of Radiology, University of California, Davis, Medical Center, Sacramento 95817, USA
Radiology 213:23-37. 1999..To extend the utility of normalized glandular dose (DgN) calculations to higher x-ray energies (up to 120 keV) and to provide the tools for investigators to calculate DgN values for arbitrary mammographic and x-ray spectra... - Monte Carlo assessment of computed tomography dose to tissue adjacent to the scanned volumeJ M Boone
Department of Radiology, University of California, Davis, UC Davis Medical Center, Sacramento 95817, USA
Med Phys 27:2393-407. 2000..The tables should be useful for medical physicists and radiologists in the estimation of dose to sites beyond the edge of the CT scanned volume... - Monte Carlo validation in diagnostic radiological imagingJ M Boone
Department of Radiology, University of California, Davis, Sacramento 95817, USA
Med Phys 27:1294-304. 2000..We conclude that for research applications in diagnostic radiology, the SIERRA Monte Carlo code demonstrates accuracy and precision to well within acceptable levels... - Molybdenum, rhodium, and tungsten anode spectral models using interpolating polynomials with application to mammographyJ M Boone
Department of Radiology, University of California, Davis, UC Davis Medical Center, Sacramento 95817, USA
Med Phys 24:1863-74. 1997..A short C subroutine which uses the polynomial coefficients and generates x-ray spectra based on the proposed model is available on the World Wide Web at http:/(/)www.aip.org/epaps/epaps.html... - Determination of the presampled MTF in computed tomographyJ M Boone
Department of Radiology, University of California, Davis, UC Davis Medical Center, Sacramento 95817, USA
Med Phys 28:356-60. 2001..It is likely that the proposed technique would be useful for all tomographic imaging systems, including single photon emission computed tomography, positron emission tomography, magnetic resonance imaging and ultrasound scanners... - Scatter/primary in mammography: Monte Carlo validationJ M Boone
Department of Radiology, University of California, Davis, Sacramento 95817, USA
Med Phys 27:1818-31. 2000..Limitations of the beam stop method were also discussed. The results suggest that the SIERRA Monte Carlo routines produce accurate SPR calculations and may be useful for a more comprehensive study of scatter in mammography... - Dedicated breast CT: radiation dose and image quality evaluationJ M Boone
Department of Radiology, X ray Imaging Laboratory, University of California, Davis Medical Center, 4701 X St, Sacramento, CA 95817, USA
Radiology 221:657-67. 2001..To evaluate the feasibility of breast computed tomography (CT) in terms of radiation dose and image quality... - Grid and slot scan scatter reduction in mammography: comparison by using Monte Carlo techniquesJohn M Boone
Department of Radiology, University of California, Davis, 4701 X St, Research Imaging Laboratory, UC Davis Medical Center, Sacramento, CA 95817, USA
Radiology 222:519-27. 2002..To evaluate a comprehensive array of scatter cleanup techniques in mammography by using a consistent methodology... - Normalized glandular dose (DgN) coefficients for arbitrary X-ray spectra in mammography: computer-fit values of Monte Carlo derived dataJohn M Boone
Department of Radiology, University of California, Davis, Sacramento 95817, USA
Med Phys 29:869-75. 2002..All fits resulted in r2 values of 0.9999 or better. The computer fit equations, along with easy to use spectral modeling routines, are available electronically on the web... - Determining sensitivity of mammography from screening data, cancer incidence, and receiver-operating characteristic curve parametersJohn M Boone
Department of Radiology, University of California, Davis, UC Davis Medical Center, Sacramento 95817, USA
Med Decis Making 22:228-37. 2002.... - Mammography spectrum measurement using an x-ray diffraction deviceJ M Boone
Department of Radiology, University of California, Davis, UC Davis Medical Center, Sacramento 95817, USA
Phys Med Biol 43:2569-82. 1998..Additional utility of the device for accurately determining the attenuation characteristics of various normal and abnormal breast tissues and phantom substitutes is anticipated... - Overview of patient dosimetry in diagnostic radiology in the USA for the past 50 yearsWalter Huda
Department of Radiology, Medical University of South Carolina, Charleston, South Carolina 29425 3230, USA
Med Phys 35:5713-28. 2008..An overview is provided of doses received by pediatric patients undergoing CT examinations, as well as methods, and results, of studies performed to assess the radiation absorbed by the conceptus of pregnant patients... - Noise power properties of a cone-beam CT system for breast cancer detectionKai Yang
Department of Radiology, University of California, Davis Medical Center, Sacramento, California 95817, USA
Med Phys 35:5317-27. 2008..Quantitative results from this noise power analysis provide guidance for the bCT system operation, optimization, and data reconstruction... - Computer modeling of the spatial resolution properties of a dedicated breast CT systemKai Yang
Department of Radiology, University of California, Davis Medical Center, 4860 Y Street, Suite 3100 Ellison Building, Sacramento, California 95817, USA
Med Phys 34:2059-69. 2007..9 mm from the isocenter. The results elucidate the intrinsic spatial resolution properties of the prototype breast CT system, and suggest ways in which spatial resolution can be improved with system modification... - Contrast-enhanced dedicated breast CT: initial clinical experienceNicolas D Prionas
Department of Radiology, University of California Davis Medical Center, Sacramento, CA 95817, USA
Radiology 256:714-23. 2010..To quantify contrast material enhancement of breast lesions scanned with dedicated breast computed tomography (CT) and to compare their conspicuity with that at unenhanced breast CT and mammography... - The effect of skin thickness determined using breast CT on mammographic dosimetryShih Ying Huang
Department of Biomedical Engineering, University of California, Davis, California 95616, USA
Med Phys 35:1199-206. 2008..g., 6-cm 50% glandular breast, 28 kVp Mo-Mo spectrum). The thinner skin dimensions found in this study suggest that the current DgN values used for mammographic dosimetry lead to a slight underestimate in glandular dose... - A geometric calibration method for cone beam CT systemsKai Yang
Department of Radiology, University of California, Davis Medical Center, 4701 X Street, Sacramento, California 95817, USA
Med Phys 33:1695-706. 2006..The reconstructed tomographic images demonstrated that the proposed method is robust and easy to implement with high precision... - Anniversary paper: History and status of CAD and quantitative image analysis: the role of Medical Physics and AAPMMaryellen L Giger
Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
Med Phys 35:5799-820. 2008..A historical review of CAD and a discussion of challenges for the future are presented here, along with the extension to quantitative image analysis... - PET characteristics of a dedicated breast PET/CT scanner prototypeYibao Wu
Department of Biomedical Engineering, University of California, Davis, Genome and Biomedical Sciences, CA, USA
Phys Med Biol 54:4273-87. 2009..7% and 2.8%, respectively. The impact of the increased reconstructed spatial resolution compared to typical whole-body PET scanners is currently being assessed in a clinical trial... - Volume assessment accuracy in computed tomography: a phantom studyNicolas D Prionas
Department of Radiology, University of California Davis Medical Center, Sacramento, CA, USA
J Appl Clin Med Phys 11:3037. 2010..The results of this investigation provide guidance for CT protocol development and may guide the development of more advanced techniques to promote quantitatively accurate CT volumetric analysis of tumors... - Initial characterization of a dedicated breast PET/CT scanner during human imagingSpencer L Bowen
Department of Biomedical Engineering, UC Davis, Davis, California, USA
J Nucl Med 50:1401-8. 2009..We have constructed a dedicated breast PET/CT scanner capable of high-resolution functional and anatomic imaging. Here, we present an initial characterization of scanner performance during patient imaging... - Characterizing anatomical variability in breast CT imagesKathrine G Metheany
University of California Davis Medical Center, Sacramento, California 95817, USA
Med Phys 35:4685-94. 2008..Exponents from the segmented bCT images (average value: 2.06) were systematically slightly higher than bCT images, with substantial correlation between the two (r=0.84)... - Noise variance analysis using a flat panel x-ray detector: a method for additive noise assessment with application to breast CT applicationsKai Yang
Department of Radiology, University of California, Davis Medical Center, 4860 Y Street, Suite 3100 Ellison Building, Sacramento, California 95817, USA
Med Phys 37:3527-37. 2010..A simplified linear model approach was proposed to accurately model the response of a flat panel detector used for breast CT (bCT)... - Dedicated breast computed tomography: the optimal cross-sectional imaging solution?Karen K Lindfors
Department of Radiology, University of California, Davis School of Medicine, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USA
Radiol Clin North Am 48:1043-54. 2010..With a slightly altered design, the DBCT platform may also be useful for external-beam radiation with image guidance... - An X-Ray computed tomography/positron emission tomography system designed specifically for breast imagingJohn M Boone
Department of Radiology Engineering University of California, Davis UC Davis Medical Center 4860 Y Street, ACC Suite 3100 Sacramento, CA 95817, USA
Technol Cancer Res Treat 9:29-44. 2010..This system will have several copies fabricated so that several breast CT scanners can be used in a multi-institutional clinical trial to better understand the role that this technology can bring to breast imaging... - Evaluation of the spatial resolution characteristics of a cone-beam breast CT scannerAlexander L C Kwan
Department of Radiology, U C Davis Medical Center, X ray Imaging Laboratory, 4701 X Street, Sacramento, California 95817, USA
Med Phys 34:275-81. 2007..5 mm(-1)), and tend to be very constant throughout the coronal plane direction. The results suggest that an increase in the MTF for the prototype breast CT system is possible by optimizing various scanning and reconstruction parameters... - X-ray imaging physics for nuclear medicine technologists. Part 2: X-ray interactions and image formationJ Anthony Seibert
Department of Radiology, University of California Davis, Sacramento, California 95817, USA
J Nucl Med Technol 33:3-18. 2005..In this article, the principles of x-ray interactions and image formation are discussed, in preparation for a general review of CT (part 3) and a more detailed investigation of PET/CT scanners in part 4... - Computed tomography use in a tertiary care university hospitalJohn M Boone
University of California Davis Medical Center, Sacramento, California 95817, USA
J Am Coll Radiol 5:132-8. 2008..This increased use has implications for health policy and radiation risk assessment. The purpose of this study was to evaluate trends in CT use... - Dedicated breast CT: initial clinical experienceKaren K Lindfors
Department of Radiology, University of California, Davis Medical Center, Suite 3100, 4860 Y St, Sacramento, CA 95817, USA
Radiology 246:725-33. 2008..To prospectively and intraindividually compare dedicated breast computed tomographic (CT) images with screen-film mammograms... - Cone beam CT dosimetry: a unified and self-consistent approach including all scan modalities--with or without phantom motionRobert L Dixon
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27160, USA
Med Phys 37:2703-18. 2010..Likewise, the pencil chamber has limited utility in this domain (even one of extended length)... - A comparison of x-ray detectors for mouse CT imagingAndrew L Goertzen
Department of Biomedical Engineering, University of California, Davis, Davis, CA, USA
Phys Med Biol 49:5251-65. 2004..Despite the higher DQE of the a-Se detector, the reconstructed CT images acquired with the a-Si detector had lower noise levels, likely due to the blurring effects from the phosphor screen... - An equivalent relative utility metric for evaluating screening mammographyCraig K Abbey
Department of Biomedical Engineering, University of California, Davis, CA, USA
Med Decis Making 30:113-22. 2010..As examples of application of ERU, they reanalyze 2 recently published reports using recall and detection rates in screening mammography... - Monte Carlo evaluation of CTD(infinity) in infinitely long cylinders of water, polyethylene and PMMA with diameters from 10 mm to 500 mmHong Zhou
Department of Radiology, University of California, Davis, Sacramento, California 95817, USA
Med Phys 35:2424-31. 2008..A freely available spreadsheet was developed to allow the computation of radiation dose as a function of object diameter (10-500 mm), composition (water, polyethylene, PMMA), and beam energy (10-140 keV, 40-140 kVp)... - An improved method for flat-field correction of flat panel x-ray detectorAlexander L C Kwan
Department of Radiology, U. C. Davis Medical Center, X-ray Imaging Laboratory, 4701 X Street, Sacramento, California 95817, USA
Med Phys 33:391-3. 2006..76 for the fixed correction method to 4.13 for the variable flat-field correction method with a fourth-order polynomial fit for the 60 kVp spectrum, and from 16.42 to 3.97 for the 95 kVp spectrum... - Classification of breast computed tomography dataThomas R Nelson
Department of Radiology, University of California, San Diego, La Jolla, California 92037 0610, USA
Med Phys 35:1078-86. 2008..For most individuals the composition is better characterized as being a 70% (fat)-30% (gland) composition than a 50% (fat)-50% (gland) composition... - Pulmonary embolism in pregnant patients: fetal radiation dose with helical CTHelen T Winer-Muram
Department of Radiology, Indiana University School of Medicine, 550 N University Blvd, Indianapolis, IN 46202, USA
Radiology 224:487-92. 2002.... - Determination of height, weight, body mass index, and body surface area with a single abdominal CT imageEstella M Geraghty
Department of Radiology, University of California Davis Medical Center, 4701 X St, Sacramento, CA 95817-2205, USA
Radiology 228:857-63. 2003..93). For BMI and BSA, r was greater than 0.893 and greater than 0.895, respectively. In this study, predictive equations for height, weight, BMI, and BSA were generated... - Quality control for digital mammography: part II. Recommendations from the ACRIN DMIST trialMartin J Yaffe
Imaging Research Program, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
Med Phys 33:737-52. 2006.... - Multidetector CT: opportunities, challenges, and concerns associated with scanners with 64 or more detector rowsJohn M Boone
Radiology 241:334-7. 2006 - Radiation dose reduction for augmentation mammographyRalph L Smathers
Mammography Specialists Medical Group, Inc, 14651 S Bascom Ave, Suite 210, Los Gatos, CA 95032, USA
AJR Am J Roentgenol 188:1414-21. 2007..Patients who undergo cosmetic augmentation have larger and denser breasts and receive higher radiation doses during mammography than women without implants. In this study we evaluated the dose increase and techniques for dose reduction... - Dedicated breast computed tomography: volume image denoising via a partial-diffusion equation based techniqueJessie Q Xia
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Med Phys 35:1950-8. 2008..The denoised images had appealing visual characteristics with much lower noise levels and improved tissue textures while maintaining sharpness of the original reconstructed volume... - Simulation of mechanical compression of breast tissueAlbert L Kellner
Department of Electrical and Computer Engineering, University of California at San Diego, La Jolla, CA 92093 0407, USA
IEEE Trans Biomed Eng 54:1885-91. 2007..Analysis times are sufficiently short to be used in the clinical setting for data comparison. The methods presented here provide a high quality method for simulating mechanical compression of breast data...
Research Grants
- Breast CT scanner for earlier cancer detectionJohn Boone; Fiscal Year: 2009..At the end of this program of research and discovery, breast CT will likely be shown to be a key clinical tool for the diagnosis and treatment of breast cancer. ..
- Breast CT scanner for earlier cancer detectionJohn Boone; Fiscal Year: 2006..that particularly warrant screening using breast CT. The Phase II trial will shed more light on this issue. ..
- Hybrid Nuclear/X-ray Projection System for Mouse ImagingJohn Boone; Fiscal Year: 2005..abstract_text> ..
- Feasibility of CT in high risk breast cancer patientsJohn Boone; Fiscal Year: 2003..The results of this investigation should provide a clear understanding of the potential of breast CT as a tool to reduce breast cancer mortality in the population of women with dire risk of breast cancer. ..
- Breast CT scanner for earlier cancer detectionJohn M Boone; Fiscal Year: 2010..At the end of this program of research and discovery, breast CT will likely be shown to be a key clinical tool for the diagnosis and treatment of breast cancer. ..