D J Bonthius


Affiliation: University of Iowa
Country: USA


  1. request reprint
    Bonthius D, Karacay B. Meningitis and encephalitis in children. An update. Neurol Clin. 2002;20:1013-38, vi-vii pubmed
    ..Although much progress has been made toward understanding, treating, and preventing these important infections, much remains to be learned. ..
  2. Winters Z, Karacay B, Bousquet S, Bonthius D. Importance of genetics in fetal alcohol effects: null mutation of the nNOS gene worsens alcohol-induced cerebellar neuronal losses and behavioral deficits. Neurotoxicology. 2015;46:60-72 pubmed publisher
    ..Thus, homozygous mutation of the nNOS gene increases vulnerability to alcohol-induced cerebellar dysfunction and neuronal loss. nNOS is the first gene identified whose mutation worsens alcohol-induced cerebellar behavioral deficits. ..
  3. Bonthius D, Karacay B. Alexander Disease: A Novel Mutation in GFAP Leading to Epilepsia Partialis Continua. J Child Neurol. 2016;31:869-72 pubmed publisher
    ..Whether and how the E312 K mutation produces pathologic changes and clinical signs that are unique from other Alexander disease-inducing mutations in GFAP remain to be determined. ..
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    Bonthius D, McKim R, Koele L, Harb H, Karacay B, Mahoney J, et al. Use of frozen sections to determine neuronal number in the murine hippocampus and neocortex using the optical disector and optical fractionator. Brain Res Brain Res Protoc. 2004;14:45-57 pubmed
    ..These advantages include expansion of the size of tissue blocks that can be processed, reduction in expended time and costs, and ability to quantify multiple brain regions from a single set of sections. ..
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    Klein H, Rabe G, Karacay B, Bonthius D. T-Cells Underlie Some but Not All of the Cerebellar Pathology in a Neonatal Rat Model of Congenital Lymphocytic Choriomeningitis Virus Infection. J Neuropathol Exp Neurol. 2016;: pubmed
    ..Cerebellar hypoplasia from LCMV occurs even in the absence of T-lymphocytes and is likely due to the viral infection itself. ..
  6. Bonthius D, Stanek N, Grose C. Subacute sclerosing panencephalitis, a measles complication, in an internationally adopted child. Emerg Infect Dis. 2000;6:377-81 pubmed
    ..The boy had most likely contracted wild-type measles in Thailand. Measles complications are a risk in international adoptions...
  7. Bonthius D, Mahoney J, Buchmeier M, Karacay B, Taggard D. Critical role for glial cells in the propagation and spread of lymphocytic choriomeningitis virus in the developing rat brain. J Virol. 2002;76:6618-35 pubmed
    ..Thus, LCMV infects four specific brain regions in the developing brain by spreading from glial cells to neurons and then induces substantially different pathological changes with diverse time courses in each of the four infected regions...
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    Bonthius D, Tzouras G, Karacay B, Mahoney J, Hutton A, McKim R, et al. Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing mice. Brain Res Dev Brain Res. 2002;138:45-59 pubmed
    ..Because NO upregulates intracellular cGMP, which can activate cGMP-dependent protein kinase (PKG), we hypothesize that the NO-cGMP-PKG pathway has a neuroprotective role against alcohol toxicity within the developing brain. ..
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    Bonthius D, Wright R, Tseng B, Barton L, Marco E, Karacay B, et al. Congenital lymphocytic choriomeningitis virus infection: spectrum of disease. Ann Neurol. 2007;62:347-55 pubmed
    ..We examined the spectrum of clinical presentations, neuroimaging findings, and clinical outcomes of children with congenital LCMV infection...

More Information


  1. Bonthius D, Perlman S. Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat. PLoS Pathog. 2007;3:e149 pubmed
  2. Bonthius D. Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult. Semin Pediatr Neurol. 2012;19:89-95 pubmed publisher
    ..The possibility of LCMV infection should be considered in all babies with evidence of congenital infection, especially those with prominent neurologic signs, such as microencephaly, periventricular calcifications, and hydrocephalus. ..