Research Topics
Species | D J BonthiusSummaryAffiliation: University of Iowa Country: USA Publications
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Publications
Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adultDaniel J Bonthius
Department of Pediatrics, Division of Child Neurology, University of Iowa College of Medicine, Iowa City 52242, USA
Semin Pediatr Neurol 19:89-95. 2012..The possibility of LCMV infection should be considered in all babies with evidence of congenital infection, especially those with prominent neurologic signs, such as microencephaly, periventricular calcifications, and hydrocephalus...
Pathology of the insular cortex in Alzheimer disease depends on cortical architectureDaniel J Bonthius
Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Neuropathol Exp Neurol 64:910-22. 2005..Thus, the insula is often involved in AD, and some of the behavioral abnormalities in AD may reflect insular pathology...- Severe alcohol-induced neuronal deficits in the hippocampus and neocortex of neonatal mice genetically deficient for neuronal nitric oxide synthase (nNOS)Daniel J Bonthius
Neuroscience Program, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
J Comp Neurol 499:290-305. 2006.... 
Proceedings of the 2006 annual meeting of the Fetal Alcohol Spectrum Disorders Study GroupDaniel J Bonthius
Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, USA
Alcohol 40:61-5. 2006....- Congenital lymphocytic choriomeningitis virus infection: spectrum of diseaseDaniel J Bonthius
Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Ann Neurol 62:347-55. 2007..We examined the spectrum of clinical presentations, neuroimaging findings, and clinical outcomes of children with congenital LCMV infection... - Lymphocytic choriomeningitis virus infection of the developing brain: critical role of host ageDaniel J Bonthius
Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Ann Neurol 62:356-74. 2007..We hypothesize that the variability in neuropathology and outcome is due to differences in the gestational timing of LCMV infection... 
Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal ratDaniel J Bonthius
Department of Pediatrics, Neurology, and Anatomy at the Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
PLoS Pathog 3:e149. 2007....- The protective effect of neuronal nitric oxide synthase (nNOS) against alcohol toxicity depends upon the NO-cGMP-PKG pathway and NF-kappaBDaniel J Bonthius
Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, IA, USA
Neurotoxicology 29:1080-91. 2008..Thus, nNOS protects developing neurons against alcohol toxicity by activating the NO-cGMP-PKG-NF-kappaB pathway and is crucial for the acquisition of maturation-dependent alcohol resistance... - Nitric oxide utilizes NF-kappaB to signal its neuroprotective effect against alcohol toxicityDaniel J Bonthius
Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Neuropharmacology 56:716-31. 2009..Thus, NF-kappaB plays a critical role in the acquisition of alcohol resistance by maturing neurons and is a key downstream effector through which the NO-cGMP-PKG pathway signals its neuroprotective effects against alcohol... - Ataxia and the cerebellumDaniel J Bonthius
Child Neurology Training Program, Department of Pediatrics, University of Iowa Hospital, Iowa City, IA 52242, USA
Semin Pediatr Neurol 18:69-71. 2011..It is critically important for child neurologists to recognize ataxia and to master its differential diagnosis because many of the diseases that induce ataxia in children are treatable and may require urgent attention... - Use of frozen sections to determine neuronal number in the murine hippocampus and neocortex using the optical disector and optical fractionatorDaniel J Bonthius
Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
Brain Res Brain Res Protoc 14:45-57. 2004..These advantages include expansion of the size of tissue blocks that can be processed, reduction in expended time and costs, and ability to quantify multiple brain regions from a single set of sections... - Subacute sclerosing panencephalitis, a measles complication, in an internationally adopted childD J Bonthius
Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
Emerg Infect Dis 6:377-81. 2000..The boy had most likely contracted wild-type measles in Thailand. Measles complications are a risk in international adoptions... - Reduced seizure threshold and hippocampal cell loss in rats exposed to alcohol during the brain growth spurtD J Bonthius
Department of Pediatrics, University of Iowa, Iowa City 52242, USA
Alcohol Clin Exp Res 25:70-82. 2001..We examined the effect of alcohol exposure during development on the seizure threshold and examined the relationship between alteration of seizure threshold and alcohol-induced neuronal loss from the hippocampus... - Alcohol exposure during the brain growth spurt promotes hippocampal seizures, rapid kindling, and spreading depressionD J Bonthius
Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
Alcohol Clin Exp Res 25:734-45. 2001..This study tests the hypothesis that developmental alcohol exposure facilitates epileptic activity and promotes kindling within hippocampal circuitry... - Critical role for glial cells in the propagation and spread of lymphocytic choriomeningitis virus in the developing rat brainDaniel J Bonthius
Department of Pediatrics, Division of Child Neurology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
J Virol 76:6618-35. 2002..Thus, LCMV infects four specific brain regions in the developing brain by spreading from glial cells to neurons and then induces substantially different pathological changes with diverse time courses in each of the four infected regions... - Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing miceDaniel J Bonthius
Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Brain Res Dev Brain Res 138:45-59. 2002..Because NO upregulates intracellular cGMP, which can activate cGMP-dependent protein kinase (PKG), we hypothesize that the NO-cGMP-PKG pathway has a neuroprotective role against alcohol toxicity within the developing brain... - Meningitis and encephalitis in children. An updateDaniel J Bonthius
Departments of Pediatrics, Neurology, and Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, IA, USA
Neurol Clin 20:1013-38, vi-vii. 2002..Although much progress has been made toward understanding, treating, and preventing these important infections, much remains to be learned... - The NO-cGMP-PKG pathway plays an essential role in the acquisition of ethanol resistance by cerebellar granule neuronsDaniel J Bonthius
Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Neurotoxicol Teratol 26:47-57. 2004..Thus, the developmental stage-dependent alcohol resistance acquired by CGN cultures depends on a functional NO-cGMP-PKG pathway... - A single exposure to alcohol during brain development induces microencephaly and neuronal losses in genetically susceptible mice, but not in wild type miceHannah Klein de Licona
Neuroscience Graduate Program, University of Iowa College of Medicine, Iowa City, IA, United States
Neurotoxicology 30:459-70. 2009..Since the genes that confer alcohol resistance and vulnerability in developing humans are unknown, any particular human fetus is potentially vulnerable. Thus, women should be counseled to consume no alcohol during pregnancy... - FGF-2, NGF and IGF-1, but not BDNF, utilize a nitric oxide pathway to signal neurotrophic and neuroprotective effects against alcohol toxicity in cerebellar granule cell culturesDaniel J Bonthius
Department of Pediatrics, College of Medicine University of Iowa, Iowa City, IA, USA
Brain Res Dev Brain Res 140:15-28. 2003..While FGF-2, NGF and IGF-1 all signal their survival-promoting effects through the NO-cGMP-PKG pathway, BDNF does not rely upon this pathway for signal transduction in CGC cultures... - Stimulation of the cAMP pathway protects cultured cerebellar granule neurons against alcohol-induced cell death by activating the neuronal nitric oxide synthase (nNOS) geneBahri Karacay
Division of Child Neurology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Brain Res 1143:34-45. 2007..These results indicate that the neuroprotective effect of the cAMP pathway is mediated, in part, by the pathway's downstream target, the nNOS gene... - Maturation-dependent alcohol resistance in the developing mouse: cerebellar neuronal loss and gene expression during alcohol-vulnerable and -resistant periodsBahri Karacay
Division of Child Neurology, Department of Pediatrics, 200 Hawkins Dr, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Alcohol Clin Exp Res 32:1439-50. 2008..We determined if maturation-dependent alcohol resistance occurs in mice and compared patterns of gene expression during the alcohol resistant and sensitive periods... - Inhibition of the NF-kappaB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cellsBahri Karacay
Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
Cancer Gene Ther 11:681-90. 2004..Thus, concurrent inhibition of the NF-kappaB pathway and the induction of TRAIL-mediated apoptosis may become a useful approach for the treatment of neuroblastoma... - Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channelsLinda W Dickerson
Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
Brain Res 958:227-50. 2002..The increase in GABA(A) receptor density may represent a compensatory response either to chronic excessive excitatory stimuli or reduced inhibitory input from local GABAergic interneurons within the dentate gyrus... - VIP receptor 1 (VPAC1) promoter targets the expression of a reporter gene to cerebellum and adrenal medulla in transgenic miceBahri Karacay
Division of Hematology Oncology, Department of Pediatrics, University of Iowa Hospitals and Clinics, 200 Hawkins Drive 2526 JCP, Iowa City, IA 52242, USA
Regul Pept 116:1-12. 2003..Along with our previous findings, these results suggest that VPAC1 may play a functional role in development of both cerebellum and adrenal medulla...
Research Grants
- NEUROTERATOGENIC MECHANISM OF LCM VIRUS INFECTIONDaniel Bonthius; Fiscal Year: 2005..The importance of a-DG in influencing the tropism and infectivity of LCMV will be examined by blocking alpha-DG with an antibody prior to exposure of brain slices to LCMV. ..
- Viral vector-based RNAi therapy for Alexander DiseaseDaniel Bonthius; Fiscal Year: 2007..Alexander Disease is a progressive and devastating pediatric brain disease. The disease is due to an abnormal gene. This research aims to develop a form of gene therapy to prevent and reverse the brain dysfunction of Alexander Disease. ..