J L Bonkowsky
Affiliation: University of Utah
Bonkowsky J, Son J. Hypoxia and connectivity in the developing vertebrate nervous system. Dis Model Mech. 2018;11: pubmed publisher
..In addition, this Review explores the current gaps in knowledge, and suggests important areas for future studies. ..
Bonkowsky J, Filloux F, Byington C. Herpes simplex virus central nervous system relapse during treatment of infantile spasms with corticotropin. Pediatrics. 2006;117:e1045-8 pubmed
..Corticotropin should be relatively contraindicated for use when a patient has a history of HSV infection, or intravenous acyclovir should be administered concurrently. ..
Richards J, Korgenski E, Srivastava R, Bonkowsky J. Costs of the diagnostic odyssey in children with inherited leukodystrophies. Neurology. 2015;85:1167-70 pubmed publisher
..Our results suggest that diagnostic testing is a relatively modest contributor to the overall health care costs in patients with leukodystrophy, and offer insights into the diagnostic odyssey of children with neurologic impairment. ..
Bonkowsky J, Guenther E, Filloux F, Srivastava R. Death, child abuse, and adverse neurological outcome of infants after an apparent life-threatening event. Pediatrics. 2008;122:125-31 pubmed publisher
..Neurological evaluation during hospitalization for a first apparent life-threatening event is of low yield, but close follow-up is essential. ..
Bonkowsky J, Chien C. Molecular cloning and developmental expression of foxP2 in zebrafish. Dev Dyn. 2005;234:740-6 pubmed
..Thus, in addition to specific roles in language development, foxP2 likely has a more general conserved role in nervous system development. ..
Xing L, Quist T, Stevenson T, Dahlem T, Bonkowsky J. Rapid and efficient zebrafish genotyping using PCR with high-resolution melt analysis. J Vis Exp. 2014;:e51138 pubmed publisher
..This approach is rapid, sensitive, and inexpensive, with lower risk of contamination artifacts. Genotyping by PCR with HRMA can be used for embryos or adult fish, including in high-throughput screening protocols. ..
Milash B, Gao J, Stevenson T, Son J, Dahl T, Bonkowsky J. Temporal Dysynchrony in brain connectivity gene expression following hypoxia. BMC Genomics. 2016;17:334 pubmed publisher
..The observed dysynchrony of gene expression could impair the development of normal CNS connectivity maps. ..
Bonkowsky J, Wang X, Fujimoto E, Lee J, Chien C, Dorsky R. Domain-specific regulation of foxP2 CNS expression by lef1. BMC Dev Biol. 2008;8:103 pubmed publisher
..The foxP2 enhancers we identified will allow dissection of foxP2's role during CNS development. ..
Bonkowsky J, Nelson C, Kingston J, Filloux F, Mundorff M, Srivastava R. The burden of inherited leukodystrophies in children. Neurology. 2010;75:718-25 pubmed publisher
..Overall population incidence is higher than generally appreciated (1 in 7,663 live births). Most leukodystrophies remain undiagnosed, but a logical algorithm based on prevalence could aid testing. ..