Herbert L Bonkovsky

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis
    Stephen J Polyak
    Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Virol J 2:41. 2005
  2. pmc Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis
    Herbert L Bonkovsky
    Liver Biliary Pancreatic Center and the Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
    J Hepatol 46:420-31. 2007
  3. ncbi request reprint Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C
    Herbert L Bonkovsky
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 131:1440-51. 2006
  4. ncbi request reprint Iron as a co-morbid factor in nonhemochromatotic liver disease
    Herbert L Bonkovsky
    University of Connecticut Health Center, MC 1111, 263 Farmington Avenue, Farmington, CT 06030 1111, USA
    Alcohol 30:137-44. 2003
  5. pmc Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C
    Richard W Lambrecht
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 140:1490-500.e3. 2011
  6. pmc Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 133:1166-74. 2007
  7. ncbi request reprint HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells
    Tahereh Ghaziani
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1111, USA
    J Hepatol 45:5-12. 2006
  8. ncbi request reprint Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    FASEB J 20:2651-3. 2006
  9. ncbi request reprint Identification of key elements that are responsible for heme-mediated induction of the avian heme oxygenase-1 gene
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Biochim Biophys Acta 1679:87-94. 2004
  10. pmc A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma
    Barham K Abu Dayyeh
    Gastrointestinal Unit, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 141:141-9. 2011

Research Grants

  1. REGULATION OF HEPATIC HEME METABOLISM
    HERBERT BONKOVSKY; Fiscal Year: 2007

Detail Information

Publications60

  1. pmc Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis
    Stephen J Polyak
    Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Virol J 2:41. 2005
    ..QS diversity and complexity were quantified using heteroduplex mobility assays (HMA)...
  2. pmc Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis
    Herbert L Bonkovsky
    Liver Biliary Pancreatic Center and the Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
    J Hepatol 46:420-31. 2007
    ..This study assessed HRQOL and sexual health in patients with advanced fibrosis or cirrhosis in the HALT-C Trial...
  3. ncbi request reprint Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C
    Herbert L Bonkovsky
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 131:1440-51. 2006
    ....
  4. ncbi request reprint Iron as a co-morbid factor in nonhemochromatotic liver disease
    Herbert L Bonkovsky
    University of Connecticut Health Center, MC 1111, 263 Farmington Avenue, Farmington, CT 06030 1111, USA
    Alcohol 30:137-44. 2003
    ..Iron loading has also been described after portosystemic shunts and in end-stage liver disease...
  5. pmc Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C
    Richard W Lambrecht
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 140:1490-500.e3. 2011
    ..Our aim was to assess the relationship of iron and HFE genetic variations to progression and outcomes in the HALT-C Trial and whether PegIFN therapy influenced iron variables...
  6. pmc Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 133:1166-74. 2007
    ..This study was to assess whether a specific miR-122 antagomir down-regulates HCV protein replication and up-regulates HO-1...
  7. ncbi request reprint HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells
    Tahereh Ghaziani
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1111, USA
    J Hepatol 45:5-12. 2006
    ..Other recent work has implicated Bach1, a heme binding protein that represses gene expression, in the regulation of HO-1 gene expression...
  8. ncbi request reprint Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    FASEB J 20:2651-3. 2006
    ..Because CoPP, unlike heme, is neither a prooxidant nor a substrate for HO-1, it might be considered as a potential therapeutic agent in situations where up-regulation of HO-1 is desired...
  9. ncbi request reprint Identification of key elements that are responsible for heme-mediated induction of the avian heme oxygenase-1 gene
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Biochim Biophys Acta 1679:87-94. 2004
    ..1Luc or pcHO7.1-4.6Luc as templates. Single and multiple mutations of HeREs and MPRE significantly abrogated the heme- and CoPP-dependent up-regulation of reporter gene expression in transient or stable transfection experiments...
  10. pmc A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma
    Barham K Abu Dayyeh
    Gastrointestinal Unit, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 141:141-9. 2011
    ..We tested associations between demographic, clinical, and genetic data and development of HCC, and developed a simple predictive model in a cohort of patients with chronic hepatitis C and advanced fibrosis...
  11. pmc Effects of silymarin on hepatitis C virus and haem oxygenase-1 gene expression in human hepatoma cells
    Vania Bonifaz
    Department of Microbial Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Liver Int 29:366-73. 2009
    ..HCV infection is associated with increased hepatic oxidative stress, and one of the antioxidant enzymes that protect cells against this stress is haem oxygenase-1 (HO-1)...
  12. ncbi request reprint Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS
    Ying Shan
    Department of Medicine and Pharmacology, the General Clinical Research Center of the University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 279:51769-74. 2004
    ..Exogenous heme produces additional up-regulation, beyond that produced by Bach-1 siRNAs, suggesting that heme does not act solely through its effects on Bach-1...
  13. pmc A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-alpha treatment
    Amira Pierucci-Lagha
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Psychosomatics 51:137-48. 2010
    ..Interferon-alpha (IFN-alpha) treatment frequently induces depression, potentially leading to early dose reductions or a shorter duration of treatment, which can adversely affect outcomes, including quality of life...
  14. pmc Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH
    Sridevi Kolluri
    Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biochem J 392:173-80. 2005
    ....
  15. doi request reprint Efficacy and safety of peginterferon alfa-2a/ribavirin in methadone maintenance patients: randomized comparison of direct observed therapy and self-administration
    Herbert L Bonkovsky
    University of Connecticut Health Center, Farmington, Connecticut, USA
    Am J Gastroenterol 103:2757-65. 2008
    ..We assessed the safety, tolerability, and efficacy of peginterferon alfa-2a/ribavirin treatment in methadone maintenance patients previously untreated for CHC...
  16. pmc Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 102:669-76. 2008
    ..These data suggest that the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S1P...
  17. ncbi request reprint Drug-induced liver injury associated with statins
    Mark W Russo
    Department of Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
    Semin Liver Dis 29:412-22. 2009
    ..Multiple retrospective studies as well as a large prospective randomized controlled trial demonstrate that statins can safely be given to hyperlipidemic patients with compensated chronic liver disease...
  18. ncbi request reprint Iron in nonhemochromatotic liver disorders
    Vamsee Alla
    Department of Medicine and The Liver Biliary Pancreatic Center, The University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Semin Liver Dis 25:461-72. 2005
    ..In this article we review selected nonhemochromatotic disorders in which iron can play an important comorbid role...
  19. ncbi request reprint Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Clin Infect Dis 40:834-41. 2005
    ..In the present study, the association of hepatitis C virus (HCV) infection with serum measurements of iron status was assessed in the US population...
  20. ncbi request reprint Liver transplantation for erythropoietic protoporphyria liver disease
    Brendan M McGuire
    Department of Medicine, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294 0005, USA
    Liver Transpl 11:1590-6. 2005
    ..In conclusion, the 5-year patient survival rate in patients transplanted for EPP liver disease is good, but the recurrence of EPP liver disease appears to diminish long term graft and patient survival...
  21. pmc Liver injury from tumor necrosis factor-α antagonists: analysis of thirty-four cases
    Marwan Ghabril
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Clin Gastroenterol Hepatol 11:558-564.e3. 2013
    ..Tumor necrosis factor (TNF)-α antagonists have been associated with drug-induced liver injury (DILI). We reviewed cases of DILI in the United States to identify those associated with use of TNF-α antagonists...
  22. ncbi request reprint Genetic aspects of porphyria cutanea tarda
    Richard W Lambrecht
    Department of Pharmacology, and The Liver Biliary Pancreatic Center, University of Connecticut Health Center, Farmington, Connecticut 06030 1119, USA
    Semin Liver Dis 27:99-108. 2007
    ....
  23. ncbi request reprint Serum measures of iron status and HFE gene mutations in patients with hepatitis B virus infection
    Tahereh Ghaziani
    Department of Medicine, University of Connecticut Health Center, Farmington, USA
    Hepatol Res 37:172-8. 2007
    ..Carriage of HFE mutations is not associated with the presence of chronic HBV infection or values of serum iron measures in this population, although HFE H63D is associated with more advanced hepatic fibrosis...
  24. doi request reprint Case records of the Massachusetts General Hospital. Case 20-2008. A 57-year-old woman with abdominal pain and weakness after gastric bypass surgery
    Herbert L Bonkovsky
    Department of Medicine, University of Connecticut Health Center, Farmington, USA
    N Engl J Med 358:2813-25. 2008
  25. pmc DNA methylation patterns in alcoholics and family controls
    Manish Thapar
    Manish Thapar, Herbert L Bonkovsky, Department of Medicine, The University of Connecticut Health Center, Farmington, CT 06030, United States
    World J Gastrointest Oncol 4:138-44. 2012
    ..To assess whether DNA methylation patterns in chronic alcoholics are different from non-alcoholic sibling controls...
  26. pmc Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States
    Naga Chalasani
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Gastroenterology 135:1924-34, 1934.e1-4. 2008
    ..This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled...
  27. ncbi request reprint Autoimmune hepatitis triggered by statins
    Vamsee Alla
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Gastroenterol 40:757-61. 2006
    ..3 similar previously reported cases are reviewed. We conclude that the 3 cases reported here and 3 similar previously reported cases, indicate that severe, ongoing AIH on rare occasions can be triggered by statins...
  28. ncbi request reprint Management of nonalcoholic steatohepatitis: an analytic review
    Sanjay Agrawal
    Department of Medicine, The Liver Biliary Pancreatic Center of the University of Massachusetts Medical School, Worchester, USA
    J Clin Gastroenterol 35:253-61. 2002
    ..In this review, we summarize the extant literature on the management of NASH and discuss the potential future therapies and prophylactic recommendations in patients with NASH...
  29. pmc Vascular endothelial growth factor increases heme oxygenase-1 protein expression in the chick embryo chorioallantoic membrane
    Mercedes Fernandez
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Br J Pharmacol 139:634-40. 2003
    ..Our findings also suggest that HO-1 activity is necessary for VEGF-induced angiogenesis in CAMs...
  30. ncbi request reprint Hepatic porphyrias: diagnosis and management
    Annie T Chemmanur
    Office of Clinical Research, Liver Biliary Pancreatic Center, University of Connecticut Health Center, Farmington, CT 06030, USA
    Clin Liver Dis 8:807-38, viii. 2004
    ..Thus, the porphyrias can best be understood after reviewing the chemical properties of porphyrins and heme and the control of their biosynthesis...
  31. ncbi request reprint Fatal air and bile embolism after percutaneous liver biopsy and ERCP
    Junaid Siddiqui
    Department of Medicine Gastroenterology Hepatology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Gastrointest Endosc 61:153-7. 2005
  32. ncbi request reprint Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins
    Ying Shan
    Department of Medicine, and the The Liver Biliary Pancreatic Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Arch Biochem Biophys 399:159-66. 2002
    ..We conclude that the chick HO-1 promoter region contains a unique sequence that subserves up-regulation of the gene by metalloporphyrins and propose the name "metalloporphyrin-responsive element" for this sequence...
  33. ncbi request reprint Phlebotomy improves therapeutic response to interferon in patients with chronic hepatitis C: a meta-analysis of six prospective randomized controlled trials
    Tusar K Desai
    William Beaumont Hospital, Royal Oak, MI, USA
    Dig Dis Sci 53:815-22. 2008
    ..Phlebotomy improves the SVR in response to IFN treatment in patients with CHC. Confirmation of this will require RCT with detailed pre-treatment iron studies and appropriately powered to demonstrate a statistically significant benefit...
  34. doi request reprint Blunted cytopenias and weight loss: new correlates of virologic null response to re-treatment of chronic hepatitis C
    Karen L Lindsay
    Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Clin Gastroenterol Hepatol 6:234-41. 2008
    ..Although viral kinetic profiles in treatment responders shed light on the mechanism of action of interferon and ribavirin, minimal information is available to explain why some patients experience little or no virologic suppression...
  35. ncbi request reprint Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial
    Leonard B Seeff
    Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 47:605-12. 2008
    ..Because its use among these HALT-C participants was self-motivated and uncontrolled, however, only a well-designed prospective study can determine whether silymarin provides benefit to persons with chronic hepatitis C...
  36. ncbi request reprint Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C
    Robert J Fontana
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Hepatology 47:789-98. 2008
    ..79). Multivariate analysis demonstrated that the serum fibrosis markers correlated substantially better with Ishak fibrosis scores than with the log hepatic collagen content (AUROC 0.84 versus 0.72)...
  37. ncbi request reprint Hereditary hemochromatosis: time for targeted screening
    Pradyumna D Phatak
    Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    Ann Intern Med 149:270-2. 2008
    ..In this article, the authors draw attention again to hereditary hemochromatosis as a cause of preventable organ dysfunction and propose targeted case finding for Caucasian men of Northern European ancestry...
  38. pmc Zinc mesoporphyrin induces rapid and marked degradation of the transcription factor Bach1 and up-regulates HO-1
    Weihong Hou
    The Liver Biliary Pancreatic Center, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Biochim Biophys Acta 1779:195-203. 2008
    ..Our results indicate that ZnMP up-regulates HO-1 gene expression by markedly increasing Bach1 protein degradation in a proteasome-dependent manner...
  39. ncbi request reprint Hepatic steatosis in hepatitis C: comparison of diabetic and nondiabetic patients in the hepatitis C antiviral long-term treatment against cirrhosis trial
    Anna S F Lok
    Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0362, USA
    Clin Gastroenterol Hepatol 5:245-54. 2007
    ....
  40. ncbi request reprint Evolution of the intrahepatic T cell repertoire during chronic hepatitis C virus infection
    Vicki M Giuggio
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Viral Immunol 18:179-89. 2005
    ..Detailed analysis using TCRBJ-primed run-off reactions revealed that the intrahepatic TCR repertoires were not stable within an individual, although some TCR clonotypes were maintained for at least 45 months...
  41. ncbi request reprint Hemochromatosis mutations in Iranians with hepatitis B virus infection
    Hossein Sendi
    Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Clin Infect Dis 40:e19-21. 2005
    ..We found that the major C282Y mutation was significantly more frequent in subjects infected with hepatitis B virus (4%) than in 194 control subjects (0%, P=.02; Fisher's exact test)...
  42. ncbi request reprint Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University, Richmond, 23298, USA
    Gastroenterology 126:1015-23; discussion 947. 2004
    ..This study evaluated the effectiveness of this treatment in patients who were nonresponders to previous interferon-based therapy...
  43. ncbi request reprint Iron as a comorbid factor in chronic viral hepatitis
    Herbert L Bonkovsky
    Am J Gastroenterol 97:1-4. 2002
  44. ncbi request reprint Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C
    Herbert L Bonkovsky
    Liver Biliary Pancreatic Center, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Hepatol 37:848-54. 2002
    ..The aim of this study was to assess the role of hepatic iron, HFE and TfR1 variations on development and progression of chronic hepatitis C infection...
  45. ncbi request reprint Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT-C cohort
    Anna S F Lok
    Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI 48210, USA
    Hepatology 42:282-92. 2005
    ..In conclusion, a model based on standard laboratory test results can be used to predict histological cirrhosis with a high degree of accuracy in 50% of patients with CHC...
  46. ncbi request reprint No role of the -2518 promoter polymorphism of monocyte chemotactic protein-1 in chronic hepatitis C
    Herbert L Bonkovsky
    Gastroenterology 129:1361-2. 2005
  47. ncbi request reprint Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C
    Chihiro Morishima
    Department of Laboratory Medicine and Pediatrics, University of Washington, Seattle, USA
    J Infect Dis 193:931-40. 2006
    ..Thus, in patients with advanced hepatic fibrosis due to HCV infection, pretreatment HCV-specific immune responses and increased QS variability appear to hinder viral clearance by pegylated IFN- alpha 2a and ribavirin combination therapy...
  48. ncbi request reprint HCV RNA detection by TMA during the hepatitis C antiviral long-term treatment against cirrhosis (Halt-C) trial
    Chihiro Morishima
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98104, USA
    Hepatology 44:360-7. 2006
    ..In patients with negative PCR results during treatment, a single positive TMA test did not exclude SVR, although persistently positive tests did...
  49. ncbi request reprint Impact of disease severity on outcome of antiviral therapy for chronic hepatitis C: Lessons from the HALT-C trial
    Gregory T Everson
    Section of Hepatology, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, CO, USA
    Hepatology 44:1675-84. 2006
    ..In conclusion, disease severity is a major independent determinant of rate of SVR in patients with advanced chronic hepatitis C. New strategies are needed to optimize antiviral therapy in these "difficult-to-cure" patients...
  50. ncbi request reprint Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C
    Mitchell L Shiffman
    Hepatology Section, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA
    Gastroenterology 132:103-12. 2007
    ..However, prior studies did not assess the impact of reducing the dose of peginterferon independent of ribavirin or differentiate between dose reduction or interrupting or prematurely discontinuing treatment...
  51. ncbi request reprint Intestinal expression of genes involved in iron absorption in humans
    Andreas Rolfs
    Membrane Biology Program and Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 282:G598-607. 2002
    ..The lack of appropriate downregulation of apical and basolateral iron transporters in duodenum likely leads to excessive iron absorption in persons with HHC...
  52. ncbi request reprint Evolution of the HALT-C Trial: pegylated interferon as maintenance therapy for chronic hepatitis C in previous interferon nonresponders
    William M Lee
    Control Clin Trials 25:472-92. 2004
    ..The protocol changes enhanced enrollment while upholding the original goals of the study and its integrity...
  53. ncbi request reprint Hemochromatosis and porphyria
    Richard W Lambrecht
    Department of Medicine and Biochemistry, The Liver Biliary Pancreatic Center, University of Massachusetts Medical School, Worcester 01605 2324, USA
    Semin Gastrointest Dis 13:109-19. 2002
    ..After the diagnosis, the patient underwent an aggressive series of therapeutic phlebotomies to reduce iron levels, and gradually the cutaneous manifestations of porphyria cutanea tarda improved...
  54. ncbi request reprint Optimal management of nonalcoholic fatty liver/steatohepatitis
    Herbert L Bonkovsky
    J Clin Gastroenterol 36:193-5. 2003
  55. ncbi request reprint Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C
    Alan Lee Rothman
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Hepatology 41:617-25. 2005
    ....
  56. ncbi request reprint Marked hyperbilirubinemia associated with the heme oxygenase-1 gene promoter microsatellite polymorphism in a boy with autoimmune hemolytic anemia
    Stephan Immenschuh
    Institute of Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
    Pediatrics 119:e764-7. 2007
    ..Because bilirubin production plays a critical role during the neonatal period, the HO-1 promoter polymorphism may be an important genetic factor for the clinical outcome of neonatal hyperbilirubinemia...
  57. ncbi request reprint Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol
    Jianyu Zheng
    Liver Biliary Pancreatic Center, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    FEBS Lett 582:1829-34. 2008
    ..These results provide novel insights into the effects of chronic ethanol consumption on hepatic heme biosynthesis and porphyrias...
  58. ncbi request reprint Hepatotoxicity due to extracts of Chinese green tea (Camellia sinensis): a growing concern
    Adnan Javaid
    J Hepatol 45:334-5; author reply 335-6. 2006
  59. ncbi request reprint Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial
    Adrian M Di Bisceglie
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Avenue, St Louis, MO 63110, USA
    J Hepatol 43:434-41. 2005
    ..We assessed serum AFP among patients with chronic hepatitis C and advanced fibrosis to establish predictors of AFP elevations and changes with antiviral therapy...
  60. ncbi request reprint Benefits of chronic plasmapheresis and intravenous heme-albumin in erythropoietic protoporphyria after orthotopic liver transplantation
    Khoa D Do
    The Department of Medicine, The University of Massachusetts Medical School, and University of Massachusetts Memorial Health Care, Worcester, MA 01655, USA
    Transplantation 73:469-72. 2002
    ..We conclude that plasmapheresis and heme-albumin are of benefit in EPP complicated by hepatotoxicity before and after liver transplantation...

Research Grants1

  1. REGULATION OF HEPATIC HEME METABOLISM
    HERBERT BONKOVSKY; Fiscal Year: 2007
    ..the molecular mechanisms that mediate heme regulation of ALAS-1 and HO-1 are similar in avian, human, and murine hepatocytes in culture or in intact organisms. ..