H L Bonkovsky

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis
    H L Bonkovsky
    Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    J Hepatol 31:421-9. 1999
  2. ncbi request reprint Hepatic iron concentration: noninvasive estimation by means of MR imaging techniques
    H L Bonkovsky
    Dept of Medicine, University of Massachusetts Medical School, Worcester, USA
    Radiology 212:227-34. 1999
  3. ncbi request reprint Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins
    E E Cable
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    Eur J Biochem 240:112-7. 1996
  4. ncbi request reprint Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases
    K K Elbirt
    Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Worcester, Massachusetts 01655, USA
    J Biol Chem 273:8922-31. 1998
  5. ncbi request reprint Effects of antidepressants and benzodiazepine-type anxiolytic agents on hepatic porphyrin accumulation in primary cultures of chick embryo liver cells
    R W Lambrecht
    Department of Medicine, UMass Memorial Health Care, Worcester, MA 01655 0317, USA
    J Pharmacol Exp Ther 291:1150-5. 1999
  6. ncbi request reprint Effects of selected antihypertensives and analgesics on hepatic porphyrin accumulation: implications for clinical porphyria
    R W Lambrecht
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Biochem Pharmacol 58:887-96. 1999
  7. ncbi request reprint Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC)
    S Kolluri
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Biochim Biophys Acta 1472:658-67. 1999
  8. ncbi request reprint Utility of hepatic iron index in American patients with hereditary hemochromatosis: a multicenter study
    K V Kowdley
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Gastroenterology 113:1270-7. 1997
  9. ncbi request reprint Induction of heme oxygenase-1 by phenylarsine oxide. Studies in cultured primary liver cells
    O S Gildemeister
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Mol Cell Biochem 226:17-26. 2001
  10. ncbi request reprint Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: role in modulating mesenteric vascular reactivity
    M Fernandez
    Division of Digestive Disease and Nutrition and The Liver, Biliary, Pancreatic Center, UMass Memorial Health Care, Worcester, MA 01655, USA
    J Hepatol 34:812-7. 2001

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis
    H L Bonkovsky
    Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    J Hepatol 31:421-9. 1999
    ..The aim of this study was to determine whether there is an association of NASH and mutations in the HFE gene associated with hereditary hemochromatosis (HHC)...
  2. ncbi request reprint Hepatic iron concentration: noninvasive estimation by means of MR imaging techniques
    H L Bonkovsky
    Dept of Medicine, University of Massachusetts Medical School, Worcester, USA
    Radiology 212:227-34. 1999
    ..To identify a magnetic resonance (MR) imaging method sufficiently sensitive and specific in the estimation of hepatic iron content to obviate liver biopsy...
  3. ncbi request reprint Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins
    E E Cable
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    Eur J Biochem 240:112-7. 1996
    ....
  4. ncbi request reprint Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases
    K K Elbirt
    Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Worcester, Massachusetts 01655, USA
    J Biol Chem 273:8922-31. 1998
    ..We conclude that the MAP kinases ERK and p38 are involved in the induction of heme oxygenase-1, and that at least one AP-1 element (located -1576 base pairs upstream of the transcription start site) is involved in this response...
  5. ncbi request reprint Effects of antidepressants and benzodiazepine-type anxiolytic agents on hepatic porphyrin accumulation in primary cultures of chick embryo liver cells
    R W Lambrecht
    Department of Medicine, UMass Memorial Health Care, Worcester, MA 01655 0317, USA
    J Pharmacol Exp Ther 291:1150-5. 1999
    ..Among the latter, low doses of lorazepam and oxazepam may be safer than those of diazepam, midazolam, and triazolam...
  6. ncbi request reprint Effects of selected antihypertensives and analgesics on hepatic porphyrin accumulation: implications for clinical porphyria
    R W Lambrecht
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Biochem Pharmacol 58:887-96. 1999
    ....
  7. ncbi request reprint Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC)
    S Kolluri
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Biochim Biophys Acta 1472:658-67. 1999
    ..Similarly, heme repressed ALA synthase mRNA levels in both cell types and ALA synthase activities in LMH cells. We conclude that LMH cells are a useful model for the study of hepatic heme biosynthesis and regulation of ALA synthase...
  8. ncbi request reprint Utility of hepatic iron index in American patients with hereditary hemochromatosis: a multicenter study
    K V Kowdley
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Gastroenterology 113:1270-7. 1997
    ..There are limited data on the diagnostic use of the hepatic iron index in patients with HHC in the United States. This study evaluated the hepatic iron index in the diagnosis of HHC in a multicenter U.S. study...
  9. ncbi request reprint Induction of heme oxygenase-1 by phenylarsine oxide. Studies in cultured primary liver cells
    O S Gildemeister
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Mol Cell Biochem 226:17-26. 2001
    ..Our results are consistent with the proposition that induction of HO-1 by PAO involves inhibition of specific PTP(s), and that the mechanisms of induction of HO-1 by PAO and by heme may share some common pathways...
  10. ncbi request reprint Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: role in modulating mesenteric vascular reactivity
    M Fernandez
    Division of Digestive Disease and Nutrition and The Liver, Biliary, Pancreatic Center, UMass Memorial Health Care, Worcester, MA 01655, USA
    J Hepatol 34:812-7. 2001
    ....
  11. pmc Porphyrin loading of lipofuscin granules in inflamed striated muscle
    C R Kiefer
    Department of Hospital Laboratories Clinical Pathology, University of Massachusetts Medical Center, Worcester, USA
    Am J Pathol 153:703-8. 1998
    ....
  12. ncbi request reprint Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells
    T H Lu
    Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    Gene 207:177-86. 1998
    ..In addition, such binding was increased by cobalt or sodium arsenite treatment...