Lynda Bonewald

Summary

Affiliation: University of Missouri-Kansas City
Country: USA

Publications

  1. pmc Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop
    Lynda F Bonewald
    Department of Oral and Craniofacial Science, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Bone Miner Res 28:1857-65. 2013
  2. pmc The osteocyte: an endocrine cell ... and more
    Sarah L Dallas
    PhD, Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri Kansas City, 650 East 25th Street, Kansas City, Missouri 64108
    Endocr Rev 34:658-90. 2013
  3. pmc FGF23 production by osteocytes
    Lynda F Bonewald
    School of Dentistry, University of Missouri, 650 East 25th Street, Kansas City, MO, 64108 2784, USA
    Pediatr Nephrol 28:563-8. 2013
  4. ncbi request reprint Generation and function of osteocyte dendritic processes
    L F Bonewald
    University of Missouri at Kansas City, Kansas City, MO 64108 2784, USA
    J Musculoskelet Neuronal Interact 5:321-4. 2005
  5. pmc The amazing osteocyte
    Lynda F Bonewald
    Department of Oral Biology, University of Missouri Kansas City, Kansas City, MO 64108 2784, USA
    J Bone Miner Res 26:229-38. 2011
  6. ncbi request reprint Osteocyte biology: its implications for osteoporosis
    L F Bonewald
    Department of Oral Biology, University of Missouri at Kansas City School of Dentistry, Kansas City, MO 64108 2784, USA
    J Musculoskelet Neuronal Interact 4:101-4. 2004
  7. ncbi request reprint Summary--Osteocytes and mechanotransduction
    L F Bonewald
    University of Missouri at Kansas City, Kansas City, MO 64108 2784, USA
    J Musculoskelet Neuronal Interact 5:333-4. 2005
  8. ncbi request reprint von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation
    L F Bonewald
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 7877, USA
    Calcif Tissue Int 72:537-47. 2003
  9. pmc Osteocytes as multifunctional cells
    L Bonewald
    University of Missouri at Kansas City School of Dentistry, Kansas City, MO 64108 2716, USA
    J Musculoskelet Neuronal Interact 6:331-3. 2006
  10. ncbi request reprint Osteocyte messages from a bony tomb
    Lynda F Bonewald
    Department of Oral Biology, University of Missouri at Kansas City School of Dentistry, 650 East 25th Street, Kansas City, MO 64108, USA
    Cell Metab 5:410-1. 2007

Research Grants

  1. 5 LIPOXYGENASE IN BONE
    Lynda Bonewald; Fiscal Year: 2001

Detail Information

Publications51

  1. pmc Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop
    Lynda F Bonewald
    Department of Oral and Craniofacial Science, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Bone Miner Res 28:1857-65. 2013
    ..The ultimate goal of the meeting was to generate a better understanding of how these two tissues integrate and crosstalk in both health and disease to stimulate new therapeutic strategies to enhance and maintain musculoskeletal health. ..
  2. pmc The osteocyte: an endocrine cell ... and more
    Sarah L Dallas
    PhD, Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri Kansas City, 650 East 25th Street, Kansas City, Missouri 64108
    Endocr Rev 34:658-90. 2013
    ..As we continue to search for new therapeutics, in addition to the osteoclast and the osteoblast, the osteocyte should be considered in new strategies to prevent and treat bone disease. ..
  3. pmc FGF23 production by osteocytes
    Lynda F Bonewald
    School of Dentistry, University of Missouri, 650 East 25th Street, Kansas City, MO, 64108 2784, USA
    Pediatr Nephrol 28:563-8. 2013
    ..In this review we discuss FGF23 expression in osteocytes and the potential means to regulate expression and function of this protein at the osteocyte level...
  4. ncbi request reprint Generation and function of osteocyte dendritic processes
    L F Bonewald
    University of Missouri at Kansas City, Kansas City, MO 64108 2784, USA
    J Musculoskelet Neuronal Interact 5:321-4. 2005
  5. pmc The amazing osteocyte
    Lynda F Bonewald
    Department of Oral Biology, University of Missouri Kansas City, Kansas City, MO 64108 2784, USA
    J Bone Miner Res 26:229-38. 2011
    ..Therefore, healthy, viable osteocytes are necessary for proper functionality of bone and other organs...
  6. ncbi request reprint Osteocyte biology: its implications for osteoporosis
    L F Bonewald
    Department of Oral Biology, University of Missouri at Kansas City School of Dentistry, Kansas City, MO 64108 2784, USA
    J Musculoskelet Neuronal Interact 4:101-4. 2004
    ....
  7. ncbi request reprint Summary--Osteocytes and mechanotransduction
    L F Bonewald
    University of Missouri at Kansas City, Kansas City, MO 64108 2784, USA
    J Musculoskelet Neuronal Interact 5:333-4. 2005
  8. ncbi request reprint von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation
    L F Bonewald
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 7877, USA
    Calcif Tissue Int 72:537-47. 2003
    ....
  9. pmc Osteocytes as multifunctional cells
    L Bonewald
    University of Missouri at Kansas City School of Dentistry, Kansas City, MO 64108 2716, USA
    J Musculoskelet Neuronal Interact 6:331-3. 2006
  10. ncbi request reprint Osteocyte messages from a bony tomb
    Lynda F Bonewald
    Department of Oral Biology, University of Missouri at Kansas City School of Dentistry, 650 East 25th Street, Kansas City, MO 64108, USA
    Cell Metab 5:410-1. 2007
    ....
  11. ncbi request reprint Osteocytes as dynamic multifunctional cells
    Lynda F Bonewald
    University of Missouri, School of Dentistry, Kansas City, MO 64108, USA
    Ann N Y Acad Sci 1116:281-90. 2007
    ..A novel function now attributed to osteocytes includes regulation of phosphate metabolism. Therefore, in addition to osteoblasts and osteoclasts, osteocytes are also important for bone health...
  12. pmc Osteocytes, mechanosensing and Wnt signaling
    Lynda F Bonewald
    University of Missouri, Kansas City School of Dentistry, Department of Oral Biology, 650 East 25th Street, Kansas City, MO 64108, USA
    Bone 42:606-15. 2008
    ..The study of osteocyte biology is becoming an intense area of research interest and this review will examine some of the recent findings that are reshaping our understanding of bone/bone cell biology...
  13. pmc Prostaglandin E2: from clinical applications to its potential role in bone- muscle crosstalk and myogenic differentiation
    Chenglin Mo
    University of Missouri Kansas City, Muscle Biology Research Group MUBIG, School of Nursing, Kansas City, MO, 64108, USA
    Recent Pat Biotechnol 6:223-9. 2012
    ....
  14. pmc DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix
    S E Harris
    University of Texas Health Science Center at San Antonio, TX 78229, USA
    J Musculoskelet Neuronal Interact 7:313-5. 2007
  15. pmc Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice
    Zhousheng Xiao
    Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38165, USA
    FASEB J 25:2418-32. 2011
    ..These data indicate that polycystin-1 is essential for the anabolic response to skeletal loading in osteoblasts/osteocytes...
  16. ncbi request reprint Use of the transgenic approach to determine the role of DMP1 in phosphate regulation
    Y Lu
    Oral Biology, UMKC, Kansas City, MO, USA
    J Musculoskelet Neuronal Interact 7:309. 2007
  17. ncbi request reprint Osteoblast-mediated mineral deposition in culture is dependent on surface microtopography
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Calcif Tissue Int 71:519-29. 2002
    ..This demonstrates that interactions between growth factor or hormone and surface microtopography can modulate bone cell differentiation and mineralization...
  18. doi request reprint Bisphosphonate-related osteonecrosis of the jaw: model and diagnosis with cone beam computerized tomography
    C Barragan-Adjemian
    Special Patient Care Clinic, University of Missouri Kansas City, Kansas City, MO 64108 2784, USA
    Cells Tissues Organs 189:284-8. 2009
    ..We propose that CBCT can potentially identify and follow the progression of both pre- and postclinical lesions in ONJ patients, allowing better diagnosis and assessment of disease status...
  19. ncbi request reprint DMP1 is essential for osteocyte formation and function
    H F Rios
    University of Missouri at Kansas City, Kansas City, MO, USA
    J Musculoskelet Neuronal Interact 5:325-7. 2005
  20. pmc Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets
    L Ye
    Oral Biology, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Dent Res 87:624-9. 2008
    ..We propose that defective alveolar bone and cementum may account for the periodontal breakdown and increased susceptibility to bacterial infection in Dmp1 null mice...
  21. ncbi request reprint Preferential production of latent transforming growth factor beta-2 by primary prostatic epithelial cells and its activation by prostate-specific antigen
    S L Dallas
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Cell Physiol 202:361-70. 2005
    ..PSA-mediated activation of latent TGFbeta2 may be an important mechanism for autocrine TGFbeta regulation in the prostate and may potentially contribute to the formation of osteoblastic lesions in bone metastatic prostate cancer...
  22. pmc Mechanism by which MLO-A5 late osteoblasts/early osteocytes mineralize in culture: similarities with mineralization of lamellar bone
    C Barragan-Adjemian
    Department of Oral Biology, University of Missouri at Kansas City, 650 East 25th Street, Kansas City, MO 64108 2784, USA
    Calcif Tissue Int 79:340-53. 2006
    ..As the cellular process narrows in diameter, these mineralized structures become associated with and initiate collagen-mediated mineralization...
  23. pmc Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression
    Zhousheng Xiao
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 281:30884-95. 2006
    ..These findings are consistent with a possible functional role of cilia and PC1 in anabolic signaling in osteoblasts/osteocytes...
  24. pmc Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice
    H F Rios
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Periodontol 79:1480-90. 2008
    ..Cementum, alveolar bone, and the PDL of periostin-null mice dramatically deteriorate following tooth eruption. The purpose of this study was to determine the role of periostin in maintaining the functional integrity of the periodontium...
  25. pmc Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein
    S L Dallas
    Department of Medicine, University of Texas Health Science Center, San Antonio 78284 7877, USA
    J Cell Biol 131:539-49. 1995
    ....
  26. pmc Glucocorticoid dose determines osteocyte cell fate
    Junjing Jia
    Department of Medicine, University of California at Davis Medical Center, Sacramento, California 95817, USA
    FASEB J 25:3366-76. 2011
    ..These data suggest that autophagy may provide a mechanism for osteocytes to survive the stress after GC exposure and provide further insight into how GCs alter bone cell fate...
  27. ncbi request reprint Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO-Y4 osteocyte-like cells and ROS 17/2.8 osteoblast-like cells
    C H Lohmann
    Department of Orthopaedics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Orthop Res 21:326-34. 2003
    ..8 cells and terminally differentiated osteocyte-like MLO-Y4 cells, respond to PEMF with changes in local factor production and reduced Cx43, suggesting decreased gap junctional signaling...
  28. ncbi request reprint In vitro and in vivo study on osteocyte-specific mechanical signaling pathways
    W Yang
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Musculoskelet Neuronal Interact 4:386-7. 2004
  29. ncbi request reprint DMP1-targeted Cre expression in odontoblasts and osteocytes
    Y Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Dent Res 86:320-5. 2007
    ..Results showed that odontoblasts and osteocytes were specifically targeted, suggesting that this animal model will be useful for the preferential study of gene functions in both types of cells...
  30. doi request reprint Evaluation of bone regeneration, angiogenesis, and hydroxyapatite conversion in critical-sized rat calvarial defects implanted with bioactive glass scaffolds
    Lianxiang Bi
    Department of Oral Biology, UMKC School of Dentistry, University of Missouri Kansas City, Kansas City, Missouri 64108 2784, USA
    J Biomed Mater Res A 100:3267-75. 2012
    ..The 1393B3 glass provided greater bone formation and may be more promising for bone defect repair due to its capacity to be molded into scaffolds. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A 100A:3267-3275, 2012...
  31. ncbi request reprint MLO-Y4 osteocyte-like cells support osteoclast formation and activation
    S Zhao
    Department of Medicine, University of Texas Health Science Center, San Antonio, USA
    J Bone Miner Res 17:2068-79. 2002
    ..These studies suggest that both RANKL and OPG may play a role in osteocyte signaling, OPG and M-CSF as soluble factors and RANKL as a surface molecule that is functional in osteocytes or along their exposed dendritic processes...
  32. ncbi request reprint Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo
    S L Dallas
    Department of Medicine, University of Texas Health Science Center at San Antonio, USA
    J Bone Miner Res 15:68-81. 2000
    ..LTBP1 may therefore be a candidate gene for Marfan-related connective tissue disorders in which linkage to fibrillins has been excluded...
  33. ncbi request reprint Composition of the extracellular matrix of the peritoneum
    C A Witz
    Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Soc Gynecol Investig 8:299-304. 2001
    ..To localize the extracellular matrix proteins collagen I, collagen IV, fibronectin, and laminin in the peritoneal membrane...
  34. ncbi request reprint PGE(2) is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain
    B Cheng
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
    Endocrinology 142:3464-73. 2001
    ..Hence, PGE(2) is an essential mediator between mechanical strain and gap junctions in osteocyte-like cells...
  35. pmc Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading
    Arlene J Siller-Jackson
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 283:26374-82. 2008
    ....
  36. ncbi request reprint Proteolysis of latent transforming growth factor-beta (TGF-beta )-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix
    Sarah L Dallas
    Department of Medicine, Division of Endocrinology and Metabolism, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Biol Chem 277:21352-60. 2002
    ....
  37. pmc Tissue strain amplification at the osteocyte lacuna: a microstructural finite element analysis
    Amber Rath Bonivtch
    Mechanical and Materials Engineering Division, Southwest Research Institute, 6220 Culebra Road, San Antonio, TX, USA
    J Biomech 40:2199-206. 2007
    ..A decrease in the perilacunar tissue modulus amplifies the perilacunar tissue strain and canaliculi deformation while an increase in the local perilacunar tissue modulus attenuates this effect...
  38. ncbi request reprint CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4
    Seema S Ahuja
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Endocrinology 144:1761-9. 2003
    ..Because osteocyte cell death appears to result in bone loss, these studies have important implications for the treatment of bone loss due to glucocorticoid excess and/or to osteoporosis in general...
  39. ncbi request reprint Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor
    Priscilla P Cherian
    Department of Biochemistry and Radiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:43146-56. 2003
    ..These data support the hypothesis that the EP2 receptor, cAMP, and PKA are critical components of the signaling cascade between mechanical strain and gap junction-mediated communication between osteocytes...
  40. ncbi request reprint Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo
    Wuchen Yang
    Department of Periodontics and Cellular and Structural Biology, University of Texas, San Antonio, Texas 78229, USA
    J Biol Chem 280:20680-90. 2005
    ..Thus, the 8-kb region of the DMP1 gene is a target for mechanotransduction in osteocytes, and its cis-regulatory activity may be correlated to local strain in bone...
  41. pmc Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin
    Priscilla P Cherian
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Mol Biol Cell 16:3100-6. 2005
    ....
  42. pmc Osteocyte lacunae tissue strain in cortical bone
    Daniel P Nicolella
    Mechanical and Materials Engineering Division, Southwest Research Institute, San Antonio, TX, USA
    J Biomech 39:1735-43. 2006
    ..1 to 3.8, which is consistent with analytical and numerical estimates. This information should lead to a better understanding of how bone cells are affected by whole bone functional loading...
  43. pmc Measurement of microstructural strain in cortical bone
    Daniel P Nicolella
    Mechanical and Materials Engineering Division, Southwest Research Institute, San Antonio, TX 78238, USA
    Eur J Morphol 42:23-9. 2005
    ..This information may lead to a better understanding of how bone cells are affected by whole bone functional loading...
  44. pmc Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice
    Nancy E Lane
    Department of Medicine, University of California at Davis, Sacramento, California 95817, USA
    J Bone Miner Res 21:466-76. 2006
    ..These microstructural changes in combination with the macrostructural changes could amplify the bone fragility in this metabolic bone disease...
  45. pmc E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation
    Keqin Zhang
    Department of Oral Biology, School of Dentistry, University of Missouri at Kansas City, 630 East 25th Street, Kansas City, MO 64108 2784, USA
    Mol Cell Biol 26:4539-52. 2006
    ..These data suggest that osteocytes may be able to extend their cellular processes after embedment in mineralized matrix and have implications for osteocytic modification of their microenvironment...
  46. ncbi request reprint Erk pathways negatively regulate matrix mineralization
    Shin jiro Kono
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    Bone 40:68-74. 2007
    ..These results suggest that the Erk pathway is a negative regulator of the matrix mineralization both in vitro and in vivo...
  47. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
    ..Our findings suggest a bone-renal axis that is central to guiding proper mineral metabolism...
  48. ncbi request reprint Evidence for distinct membrane receptors for 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) in osteoblasts
    Barbara D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Steroids 67:235-46. 2002
    ..These results demonstrate that response to 1 alpha,25-(OH)(2)D(3) and 24R,25-(OH)(2)D(3) depends on osteoblast maturation state and suggest that specific and distinct membrane receptors are involved...
  49. ncbi request reprint Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo
    Jelica Gluhak-Heinrich
    Department of Orthodontics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Bone Miner Res 18:807-17. 2003
    ..These results support the hypothesis that osteocytes alter their matrix microenvironment in response to mechanical loading...
  50. pmc Generation of a conditional null allele for Dmp1 in mouse
    Jian Q Feng
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75246, USA
    Genesis 46:87-91. 2008
    ..These homozygous Cre-recombined null mice display an identical phenotype to conventional null mice. This animal model will be useful to reveal distinct roles of DMP1 in different tissues at different ages...
  51. ncbi request reprint Nitric oxide and prostaglandin E2 production in response to ultra-high molecular weight polyethylene particles depends on osteoblast maturation state
    Christoph H Lohmann
    University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    J Bone Joint Surg Am 84:411-9. 2002
    ..We tested the hypothesis that the state of cell maturation plays a role in the response of osteogenic cells to ultra-high molecular weight polyethylene particles...

Research Grants3

  1. 5 LIPOXYGENASE IN BONE
    Lynda Bonewald; Fiscal Year: 2001
    ..Hence, these studies may also have profound implications for the increasing number of asthmatic patients who are currently being treated with steroids and 5LO inhibitors. ..