Stephen Bondy

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration
    Stephen C Bondy
    Environmental Toxicology Program, Center for Occupational and Environmental Health, Department of Medicine, University of California, Irvine, CA 92697 1825, USA Electronic address
    Toxicology 315:1-7. 2014
  2. ncbi request reprint Melatonin decreases levels of S100β and NFΚB, increases levels of synaptophysin in a rat model of Alzheimer's disease
    Zhou Jun
    Department of Medicine, University of California, Irvine, CA 92697 1825, USA
    Curr Aging Sci 6:142-9. 2013
  3. ncbi request reprint Exposure of mice to tobacco smoke attenuates the toxic effect of methamphetamine on dopamine systems
    S C Bondy
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697 1820, USA
    Toxicol Lett 118:43-6. 2000
  4. pmc Melatonin alters age-related changes in transcription factors and kinase activation
    Stephen C Bondy
    Division of Occupational and Environmental Health, Department of Medicine, University of California, Irvine, CA 92697 1825, USA
    Neurochem Res 35:2035-42. 2010
  5. pmc The neurotoxicity of environmental aluminum is still an issue
    Stephen C Bondy
    Program in Environmental Toxicology, Division Occupational and Environmental Health, Department of Medicine, University of California, Irvine, CA 92697 1825, USA
    Neurotoxicology 31:575-81. 2010
  6. ncbi request reprint Dietary modulation of age-related changes in cerebral pro-oxidant status
    Stephen C Bondy
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California Irvine, Irvine, CA 92697 1820, USA
    Neurochem Int 40:123-30. 2002
  7. pmc Nanoparticles and colloids as contributing factors in neurodegenerative disease
    Stephen C Bondy
    Division of Occupational and Environmental Health, Department of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Int J Environ Res Public Health 8:2200-11. 2011
  8. ncbi request reprint Melatonin and the aging brain
    Stephen C Bondy
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697 1825, USA
    Neurochem Int 50:571-80. 2007
  9. ncbi request reprint Developmental neurotoxicology
    Stephen C Bondy
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine, Irvine, California 92967 1820, USA
    J Neurosci Res 81:605-12. 2005
  10. ncbi request reprint Aluminum but not iron treatment induces pro-oxidant events in the rat brain
    S C Bondy
    Department of Community and Environmental Medicine, University of California, Irvine 92697 1820, USA
    Mol Chem Neuropathol 34:219-32. 1998

Collaborators

Detail Information

Publications41

  1. doi request reprint Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration
    Stephen C Bondy
    Environmental Toxicology Program, Center for Occupational and Environmental Health, Department of Medicine, University of California, Irvine, CA 92697 1825, USA Electronic address
    Toxicology 315:1-7. 2014
    ..Evidence is outlined supporting the concept of aluminum's involvement in hastening brain aging. This acceleration would then inevitably lead to increased incidence of specific age-related neurological diseases...
  2. ncbi request reprint Melatonin decreases levels of S100β and NFΚB, increases levels of synaptophysin in a rat model of Alzheimer's disease
    Zhou Jun
    Department of Medicine, University of California, Irvine, CA 92697 1825, USA
    Curr Aging Sci 6:142-9. 2013
    ..However, melatonin administration had no effect on the reduced level of synaptophysin in Aβ-treated mice. Overall, these findings suggest that melatonin may exert a potentially beneficial effect upon the progression of AD. ..
  3. ncbi request reprint Exposure of mice to tobacco smoke attenuates the toxic effect of methamphetamine on dopamine systems
    S C Bondy
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697 1820, USA
    Toxicol Lett 118:43-6. 2000
    ..Results suggest a specific protective effect of inhaled tobacco smoke upon the effects of methamphetamine upon dopaminergic circuitry...
  4. pmc Melatonin alters age-related changes in transcription factors and kinase activation
    Stephen C Bondy
    Division of Occupational and Environmental Health, Department of Medicine, University of California, Irvine, CA 92697 1825, USA
    Neurochem Res 35:2035-42. 2010
    ..The potentially beneficial nature of melatonin for the preservation of brain function with aging was suggested by the finding that an age-related decline in cortical synaptophysin levels was prevented by dietary melatonin...
  5. pmc The neurotoxicity of environmental aluminum is still an issue
    Stephen C Bondy
    Program in Environmental Toxicology, Division Occupational and Environmental Health, Department of Medicine, University of California, Irvine, CA 92697 1825, USA
    Neurotoxicology 31:575-81. 2010
    ..These are not attributable to obvious exogenous stimuli and may reflect the lifespan history of the organism's immune responses. It is possible that aluminum salts can act as a subtle promoter of such apparently unprovoked responses...
  6. ncbi request reprint Dietary modulation of age-related changes in cerebral pro-oxidant status
    Stephen C Bondy
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California Irvine, Irvine, CA 92697 1820, USA
    Neurochem Int 40:123-30. 2002
    ..While no diet altered motor activity or improved recall of older animals, lipoic acid or tocopherol treatment adversely affected place recall familiarity...
  7. pmc Nanoparticles and colloids as contributing factors in neurodegenerative disease
    Stephen C Bondy
    Division of Occupational and Environmental Health, Department of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Int J Environ Res Public Health 8:2200-11. 2011
    ..In addition with their induction by inflammatory events, these may be further heightened by the presence of redox active transition metals to the large surface area afforded by nanoparticles and amphipathic micelles...
  8. ncbi request reprint Melatonin and the aging brain
    Stephen C Bondy
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697 1825, USA
    Neurochem Int 50:571-80. 2007
    ..Melatonin has potential utility both in slowing normal brain aging and in treatment of neurodegenerative conditions. This is reinforced by the low cost of melatonin and its very low toxic hazard...
  9. ncbi request reprint Developmental neurotoxicology
    Stephen C Bondy
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine, Irvine, California 92967 1820, USA
    J Neurosci Res 81:605-12. 2005
    ..The rate of brain aging may be influenced by events taking place in embryogenesis, following a prolonged asymptomatic period. The potential for appearance of adverse effects after prolonged latent periods is underscored...
  10. ncbi request reprint Aluminum but not iron treatment induces pro-oxidant events in the rat brain
    S C Bondy
    Department of Community and Environmental Medicine, University of California, Irvine 92697 1820, USA
    Mol Chem Neuropathol 34:219-32. 1998
    ..These changes are tissue-specific and appear to be independent of any promotion of pro-oxidant status induced by exogenous Fe...
  11. ncbi request reprint Retardation of brain aging by chronic treatment with melatonin
    S C Bondy
    Department of Community and Environmental Medicine, University of California, Irvine, 92697 1825, USA
    Ann N Y Acad Sci 1035:197-215. 2004
    ..This report summarizes the progress made in this area...
  12. ncbi request reprint Effects of age and dietary antioxidants on cerebral electron transport chain activity
    E H Sharman
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, Irvine, CA 92697-1825, USA
    Neurobiol Aging 22:629-34. 2001
    ..NADH-ubiquinone oxidoreductase (Complex I) and ubiquinol:ferricytochrome-c oxidoreductase (Complex III) activities remained unchanged...
  13. ncbi request reprint Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine
    Edward H Sharman
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California Irvine, Irvine, CA 92697 1825, USA
    Brain Res 957:223-30. 2002
    ..These findings suggest that dietary supplementation cannot merely arrest but indeed reverse some age-related increases in markers of oxidative and inflammatory events occurring with the cortex...
  14. pmc Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways
    M T Kleinman
    Department of Community and Environmental Medicine, University of California Irvine, Irvine, CA 92697, USA
    Toxicol Lett 178:127-30. 2008
    ..This suggests that the signaling pathway by which these transcription factors are activated involves the activation of JNK...
  15. ncbi request reprint Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain
    A Campbell
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, Irvine, California 92697, USA
    J Neurosci Res 75:565-72. 2004
    ....
  16. ncbi request reprint Aluminum as a toxicant
    A Becaria
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, Irvine, CA 92697 1820, USA
    Toxicol Ind Health 18:309-20. 2002
    ..This review encompasses the general toxicology of aluminum with emphasis on the potential mechanisms by which it may accelerate the progression of chronic age-related neurodegenerative disorders...
  17. ncbi request reprint The chemistry of transition metals in relation to their potential role in neurodegenerative processes
    D Hamai
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine 92697 1820, USA
    Curr Top Med Chem 1:541-51. 2001
    ....
  18. ncbi request reprint Modulation of oxidative events by multivalent manganese complexes in brain tissue
    D Hamai
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine, Irvine, CA 92697 1825, USA
    Free Radic Biol Med 31:763-8. 2001
    ..Such findings of the potent effects of trace amounts of trivalent cations upon Mn2+-related free radical generation offer resolution of earlier disparate findings concerning the oxidative character of manganese...
  19. ncbi request reprint Mechanisms by which metals promote events connected to neurodegenerative diseases
    A Campbell
    Department of Community and Environmental Medicine, University of California, Irvine, Irvine, CA 92697 1825, USA
    Brain Res Bull 55:125-32. 2001
    ..This review addresses mechanisms by which endogenous or environmental factors, through interaction with redox active metals, may initiate a common cascade of events terminating in neurodegeneration...
  20. ncbi request reprint Aluminum-induced oxidative events in cell lines: glioma are more responsive than neuroblastoma
    A Campbell
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California Irvine, 92697 1825, USA
    Free Radic Biol Med 26:1166-71. 1999
    ..Thus, it is possible that the cerebral target following an acute exposure to aluminum may be glial rather than neuronal...
  21. ncbi request reprint Elevation of cerebral proteases after systemic administration of aluminum
    S Guo-Ross
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine 92697 1825, USA
    Neurochem Int 33:277-82. 1998
    ..Since aluminum is suspected as a possible factor in the pathogenesis of Alzheimer's disease and other neurological diseases, it is speculated that changed levels in proteolytic enzymes may relate to the neurotoxicity of aluminum...
  22. ncbi request reprint Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain
    A Campbell
    Department of Community and Environmental Medicine, University of California, Irvine, CA 92697 1825, USA
    Neurotoxicology 26:133-40. 2005
    ..These data indicate that components of inhaled particulate matter may trigger a proinflammatory response in nervous tissue that could contribute to the pathophysiology of neurodegenerative diseases...
  23. ncbi request reprint Chronic exposure to low levels of aluminum alters cerebral cell signaling in response to acute MPTP administration
    H Li
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine, California 92697 1825, USA
    Toxicol Ind Health 23:515-24. 2007
    ..However, no interaction in alteration of monoamine levels was found between Al and MPTP...
  24. ncbi request reprint Differential toxicity of aluminum salts in human cell lines of neural origin: implications for neurodegeneration
    A Campbell
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine 92697-1820, USA
    Neurotoxicology 22:63-71. 2001
    ..It is possible that the principal neurotoxic target of the metal is glial and when these cells are in a compromised state, this may secondarily impact the neuronal population and thus eventually lead to neurodegeneration...
  25. ncbi request reprint Reduced basal levels and enhanced LPS response of IL-6 mRNA in aged mice
    K Sharman
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697-1825, USA
    J Gerontol A Biol Sci Med Sci 56:B520-3. 2001
    ..These data indicate that the aging process may predispose animals to an exaggerated and potentially harmful inflammatory response...
  26. ncbi request reprint Changes in synaptosomal pH and rates of oxygen radical formation induced by chlordecone
    S C Bondy
    Department of Community and Environmental Medicine, University of California, Irvine 92717
    Mol Chem Neuropathol 13:95-106. 1990
    ..The elevation of cytosolic pH, and depression of oxygen radical formation by chlordecone, may result from both the attenuation of respiratory metabolism and an impaired capacity of the plasma membrane to maintain ionic gradients...
  27. ncbi request reprint GM1 ganglioside enhances synaptosomal resistance to chemically induced damage
    S C Bondy
    Department of Community and Environmental Medicine, University of California, Irvine 92717
    Neurosci Lett 84:229-33. 1988
    ..These data may underlie the known effect of gangliosides in enhancing neuronal regeneration after lesion induction...
  28. ncbi request reprint Melatonin causes gene expression in aged animals to respond to inflammatory stimuli in a manner differing from that of young animals
    Edward H Sharman
    Center for Occupational and Environmental Health, Community and Environmental Medicine, University of California, Irvine, CA, USA
    Curr Aging Sci 1:152-8. 2008
    ..This difference with aging suggests that key immune processes are markedly altered by aging. It is likely that the ability of the immune system to mount a defense is impaired in older animals...
  29. ncbi request reprint Oxidative basis of manganese neurotoxicity
    Diem HaMai
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine 92697 1825, USA
    Ann N Y Acad Sci 1012:129-41. 2004
    ..This review focuses on studies that evaluate the redox chemistry of manganese during the neurodegenerative process and its molecular consequences...
  30. ncbi request reprint Pro-inflammatory effects of aluminum in human glioblastoma cells
    Arezoo Campbell
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California Irvine, Irvine, CA 92697 1820, USA
    Brain Res 933:60-5. 2002
    ..This may reflect the ability of the cells to discern different stress factors and thus orchestrate an innate immune response profile distinct to each immunogen...
  31. ncbi request reprint Dietary melatonin selectively reverses age-related changes in cortical cytokine mRNA levels, and their responses to an inflammatory stimulus
    Kaizhi G Sharman
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine 92697 1825, USA
    Neurobiol Aging 23:633-8. 2002
    ..Dietary melatonin had no effect on the responses of TNF-alpha mRNA to LPS but attenuated the reaction of splenic IL-6 mRNA, thus bringing the response closer to that of the younger mice...
  32. ncbi request reprint Aluminum and copper interact in the promotion of oxidative but not inflammatory events: implications for Alzheimer's disease
    Angelica Becaria
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California Irvine, 92697 1820, USA
    J Alzheimers Dis 5:31-8. 2003
    ..Thus the ability of aluminum to promote inflammatory processes does not depend on an increase ROS production induced by interaction with transition metals...
  33. ncbi request reprint Pro- or anti-oxidant manganese: a suggested mechanism for reconciliation
    Diem HaMai
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health, University of California, Irvine, CA 92692 1820, USA
    Neurochem Int 44:223-9. 2004
    ....
  34. ncbi request reprint Age-related changes in murine CNS mRNA gene expression are modulated by dietary melatonin
    Edward H Sharman
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697, USA
    J Pineal Res 36:165-70. 2004
    ..The restoration of a more youthful gene profile to brains of aged animals by melatonin, to a large extent, involves reversal of age-induced elevation of basal inflammatory parameters...
  35. pmc Effects of melatonin and age on gene expression in mouse CNS using microarray analysis
    Edward H Sharman
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697 1825, USA
    Neurochem Int 50:336-44. 2007
    ..This suggests that melatonin treatment may influence the inflammatory responses of old animals, driving them to resemble more closely those occurring in young animals...
  36. ncbi request reprint Decreased expression of inflammation-related genes following inhalation exposure to manganese
    Diem HaMai
    Department of Community and Environmental Medicine, University of California, Irvine, CA 92697 1825, USA
    Neurotoxicology 27:395-401. 2006
    ..This suggests that prior exposure to Mn may have attenuated the effects of inhalation exposure to Mn in adulthood, in which the expression of inflammation-related genes were suppressed...
  37. ncbi request reprint Parallel changes in gene expression in aged human and mouse cortex
    Edward H Sharman
    Center for Occupational and Environmental Health, Department of Community and Environmental Medicine, University of California, 19772 Jamboree, Irvine, CA 92697 1825, USA
    Neurosci Lett 390:4-8. 2005
    ..This parallel serves to validate the use of mouse strains to study general age-related genetic events associated with aging...
  38. ncbi request reprint Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex
    Debomoy K Lahiri
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Pineal Res 36:224-31. 2004
    ..Thus, melatonin supplementation may retard neurodegenerative changes associated with brain aging. Depletion of melatonin in the brain of aging mice may in part account for this adverse change...
  39. ncbi request reprint Age-related changes in serum melatonin in mice: higher levels of combined melatonin and 6-hydroxymelatonin sulfate in the cerebral cortex than serum, heart, liver and kidney tissues
    Debomoy K Lahiri
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Pineal Res 36:217-23. 2004
    ..Thus, any age-related decline of tissue melatonin can be reversed by supplementation with dietary melatonin...
  40. ncbi request reprint Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain
    Angelica Becaria
    Department of Community and Environmental Medicine, Center for Occupational and Environmental Health Sciences, University of California, Irvine, Irvine, CA 92697 1825, USA
    J Neuroimmunol 176:16-23. 2006
    ..Results suggest that although Al or Cu may independently initiate inflammatory or oxidative events, they may function cooperatively to increase APP levels...
  41. ncbi request reprint Potential occupational risks for neurodegenerative diseases
    Robert M Park
    Education and Information Division, National Institute for Occupational Safety and Health, MS C 15, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Am J Ind Med 48:63-77. 2005
    ..Associations between occupations and neurodegenerative diseases (NDD) may be discernable in death certificate data...

Research Grants24

  1. NEURODEGENERATION AND MITOCHONDRIAL DYSFUNCTION IN AGING
    Stephen Bondy; Fiscal Year: 2003
    ..The identification and protection of such common targets will help in the development of agents that can reduce the incidence of neurodegenerative disorders. ..
  2. Deceleration of Brain Senescence by Dietary Melatonin
    Stephen Bondy; Fiscal Year: 2004
    ..The principal goal of this study is to contribute to the development of a rational nutritional strategy for delaying progression of brain aging. ..
  3. ALUMINUM/IRON INTERACTIONS IN NEURODEGENERATIVE DISEASE
    Stephen Bondy; Fiscal Year: 2005
    ..Together, these five objectives delineate a research strategy that will allow resolution of the seemingly contradictory evidence relating aluminum to neurological degeneration. ..
  4. FREE RADICALS IN MENTAL HEALTH & NEUROBIOLOGY
    Stephen Bondy; Fiscal Year: 2005
    ..The long-term support of this series of annual meetings will permit better planning for meeting organizers, attendees, students, and publishers. ..
  5. Neurodegenration and Mitochnodrial Dysfunction in Aging
    Stephen Bondy; Fiscal Year: 2007
    ..This is also likely to be relevant to slowing the onset of, and reducing the incidence of, several neurodegenerative diseases where age is a major co-factor. ..
  6. ALUMINUM INDUCED INTERACTIONS AND NEUROLOGICAL DISEASE
    Stephen Bondy; Fiscal Year: 2000
    ..This will involve dietary supplementation with antioxidant vitamins or the use of selective chelators. Results will illuminate the role that aluminum may play in potentiation of age-related neurological diseases. ..