MARK BONDI

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Do neuropsychological tests detect preclinical Alzheimer's disease: individual-test versus cognitive-discrepancy score analyses
    Mark W Jacobson
    Department of Veterans Affairs Medical Center, San Diego, California 92161, USA
    Neuropsychology 16:132-9. 2002
  2. ncbi request reprint Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease: verbal versus design fluency
    Wes S Houston
    University of Iowa, Department of Neurology, Division of Cognitive Neuroscience, Iowa City, Iowa 52242 1053, USA
    J Int Neuropsychol Soc 11:863-70. 2005
  3. ncbi request reprint Verbal learning and memory in alcohol abusers and polysubstance abusers with concurrent alcohol abuse
    M W Bondi
    California State University San Marcos, San Diego Veterans Affairs Medical Center
    J Int Neuropsychol Soc 4:319-28. 1998
  4. pmc Neuropsychological deficits associated with Alzheimer's disease in the very-old: discrepancies in raw vs. standardized scores
    Mark W Bondi
    VA San Diego Healthcare System, San Diego, California 92161, USA
    J Int Neuropsychol Soc 9:783-95. 2003
  5. pmc Neuropsychological contributions to the early identification of Alzheimer's disease
    Mark W Bondi
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neuropsychol Rev 18:73-90. 2008
  6. ncbi request reprint Genetic and brain imaging contributions to neuropsychological functioning in preclinical dementia
    Mark W Bondi
    Psychology Service, VA San Diego Healthcare System, San Diego, California 92161, USA
    J Int Neuropsychol Soc 8:915-7. 2002
  7. ncbi request reprint Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease
    Mark W Bondi
    Psychology Service, Veterans Affairs San Diego Healthcare System and Department of Psychiatry, University of California 92161, USA
    Neuropsychology 16:335-43. 2002
  8. ncbi request reprint Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease
    M W Bondi
    San Diego Veterans Affairs Medical Center and Department of Psychiatry and School of Medicine, University of California, 92161, USA
    Psychol Aging 14:295-303. 1999
  9. pmc fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    Mark W Bondi
    University of California San Diego and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Neurology 64:501-8. 2005
  10. pmc APOE genotype is associated with left-handedness and visuospatial skills in children
    Cinnamon S Bloss
    SDSU UCSD Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA 92120 4913, USA
    Neurobiol Aging 31:787-95. 2010

Detail Information

Publications50

  1. ncbi request reprint Do neuropsychological tests detect preclinical Alzheimer's disease: individual-test versus cognitive-discrepancy score analyses
    Mark W Jacobson
    Department of Veterans Affairs Medical Center, San Diego, California 92161, USA
    Neuropsychology 16:132-9. 2002
    ..The PCAD group also had a higher frequency of asymmetric cognitive profiles relative to a normative group...
  2. ncbi request reprint Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease: verbal versus design fluency
    Wes S Houston
    University of Iowa, Department of Neurology, Division of Cognitive Neuroscience, Iowa City, Iowa 52242 1053, USA
    J Int Neuropsychol Soc 11:863-70. 2005
    ..e., fluency plus switching) may serve as a useful preclinical marker of AD...
  3. ncbi request reprint Verbal learning and memory in alcohol abusers and polysubstance abusers with concurrent alcohol abuse
    M W Bondi
    California State University San Marcos, San Diego Veterans Affairs Medical Center
    J Int Neuropsychol Soc 4:319-28. 1998
    ..It is concluded that the combined use of alcohol and drugs, cocaine in particular, may compound memory difficulties beyond what is typically observed in alcoholic individuals...
  4. pmc Neuropsychological deficits associated with Alzheimer's disease in the very-old: discrepancies in raw vs. standardized scores
    Mark W Bondi
    VA San Diego Healthcare System, San Diego, California 92161, USA
    J Int Neuropsychol Soc 9:783-95. 2003
    ..These data suggest that the profile of neuropsychological deficits associated with AD in the Very-Old lacks the disproportionate saliency of episodic memory and executive function deficits typical of the Young-Old...
  5. pmc Neuropsychological contributions to the early identification of Alzheimer's disease
    Mark W Bondi
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Neuropsychol Rev 18:73-90. 2008
    ..Finally, we provide a critical examination of the clinical concept of Mild Cognitive Impairment and offer suggestions for an increased focus on the impact of cerebrovascular disease (CVD) and CVD risk during the prodromal period of AD...
  6. ncbi request reprint Genetic and brain imaging contributions to neuropsychological functioning in preclinical dementia
    Mark W Bondi
    Psychology Service, VA San Diego Healthcare System, San Diego, California 92161, USA
    J Int Neuropsychol Soc 8:915-7. 2002
  7. ncbi request reprint Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease
    Mark W Bondi
    Psychology Service, Veterans Affairs San Diego Healthcare System and Department of Psychiatry, University of California 92161, USA
    Neuropsychology 16:335-43. 2002
    ..Results of clinicopathologic correlations in an autopsy-confirmed AD subgroup further suggest the invocation of a broad network of integrated cortical regions and executive and language processes underlying successful SCWT performance...
  8. ncbi request reprint Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease
    M W Bondi
    San Diego Veterans Affairs Medical Center and Department of Psychiatry and School of Medicine, University of California, 92161, USA
    Psychol Aging 14:295-303. 1999
    ..Results support the importance of specific episodic memory changes and possession of the ApoE-epsilon4 allele in the preclinical detection of AD...
  9. pmc fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease
    Mark W Bondi
    University of California San Diego and VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Neurology 64:501-8. 2005
    ..The relationship between APOE genotype and blood oxygenation level dependent (BOLD) brain response was examined during a picture-encoding task in nondemented older adults...
  10. pmc APOE genotype is associated with left-handedness and visuospatial skills in children
    Cinnamon S Bloss
    SDSU UCSD Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA 92120 4913, USA
    Neurobiol Aging 31:787-95. 2010
    ..Results may be consistent with the theory of antagonistic pleiotropy, which suggests that APOE may have different protective effects at different developmental stages...
  11. pmc Differential age effects on cerebral blood flow and BOLD response to encoding: associations with cognition and stroke risk
    Katherine J Bangen
    San Diego State University University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120 4913, USA
    Neurobiol Aging 30:1276-87. 2009
    ..Stroke risk was associated with both CBF and BOLD response. Results suggest that aging effects on CBF and BOLD responses to encoding are dissociable and that cerebrovascular alterations contribute to findings of age-related differences...
  12. pmc Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults
    Amy J Jak
    Veteran s Medical Research Foundation, San Diego, CA 92161, USA
    Dement Geriatr Cogn Disord 23:382-9. 2007
    ..Because of conflicting findings across studies, we sought to better determine the relationship between apolipoprotein E (APOE) genotype, hippocampal volume, and cognitive performance in nondemented older adults...
  13. pmc Complex activities of daily living vary by mild cognitive impairment subtype
    Katherine J Bangen
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California San Diego, San Diego, California, USA
    J Int Neuropsychol Soc 16:630-9. 2010
    ..Results further suggest performance-based IADL assessment may have utility in distinguishing MCI subtypes...
  14. pmc Profile of hippocampal volumes and stroke risk varies by neuropsychological definition of mild cognitive impairment
    Amy J Jak
    Research Service, VA San Diego Healthcare System, San Diego, CA 92161, USA
    J Int Neuropsychol Soc 15:890-7. 2009
    ....
  15. ncbi request reprint Deficits in inhibition and flexibility are associated with the APOE-E4 allele in nondemented older adults
    Spencer R Wetter
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    J Clin Exp Neuropsychol 27:943-52. 2005
    ..The association between these subtle executive-function deficits and the overall cognitive functioning of at-risk individuals provides further evidence of their utility as a possible preclinical marker of AD...
  16. pmc Cognitive discrepancies versus APOE genotype as predictors of cognitive decline in normal-functioning elderly individuals: a longitudinal study
    Eric M Fine
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 16:366-74. 2008
    ....
  17. pmc Comparison of the traditional recall-based versus a new list-based method for computing semantic clustering on the California Verbal Learning Test: evidence from Alzheimer's disease
    Dean C Delis
    Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Clin Neuropsychol 24:70-9. 2010
    ..Logistic regression and score distribution analyses indicated that the new list-based method enhances the detection of differences in semantic-clustering ability between the groups...
  18. pmc Use of functional magnetic resonance imaging in the early identification of Alzheimer's disease
    Christina E Wierenga
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Neuropsychol Rev 17:127-43. 2007
    ....
  19. ncbi request reprint Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease
    Laura Mickes
    Department of Psychology, University of California, San Diego, CA 92093 0109, USA
    Neuropsychology 21:696-705. 2007
    ....
  20. pmc APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study
    Lisa Delano-Wood
    VA San Diego Healthcare System, San Diego, CA 92161, USA
    Int J Geriatr Psychiatry 23:632-6. 2008
    ..The association between the APOE epsilon4 allele and depression was investigated in a retrospective study of 323 AD patients...
  21. pmc Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Clin Neuropsychol 25:724-33. 2010
    ....
  22. pmc Increased functional brain response during word retrieval in cognitively intact older adults at genetic risk for Alzheimer's disease
    Christina E Wierenga
    Department of Psychiatry, Veterans Affairs San Diego Healthcare System, School of Medicine, University of California, San Diego, CA 92161, USA
    Neuroimage 51:1222-33. 2010
    ..Findings are discussed in the context of possible compensatory mechanisms invoked to maintain performance in those at genetic risk for AD...
  23. pmc Neuropsychological assessment of dementia
    David P Salmon
    Department of Neurosciences, University of California, San Diego, California 92093, USA
    Annu Rev Psychol 60:257-82. 2009
    ....
  24. pmc Heterogeneity in mild cognitive impairment: differences in neuropsychological profile and associated white matter lesion pathology
    Lisa Delano-Wood
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92161, USA
    J Int Neuropsychol Soc 15:906-14. 2009
    ..Overall, findings suggest different underlying pathologies within MCI and contribute to our understanding of MCI subtypes...
  25. pmc The emergence of cognitive discrepancies in preclinical Alzheimer's disease: a six-year case study
    Mark W Jacobson
    Veterans Affairs San Diego Healthcare System, Department 151B, 3350 La Jolla Village Dr, San Diego, CA 92151, USA
    Neurocase 15:278-93. 2009
    ..The present case provides intriguing evidence that cognitive-discrepancy measures could improve our ability to detect subtle changes in cognition at the earliest, preclinical stages of AD...
  26. pmc Brain substrates of learning and retention in mild cognitive impairment diagnosis and progression to Alzheimer's disease
    Yu Ling Chang
    Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Drive Suite C101, La Jolla, CA 92037, USA
    Neuropsychologia 48:1237-47. 2010
    ..Overall, our results highlight the importance of including learning measures in addition to retention measures when making a diagnosis of MCI and for predicting clinical outcome...
  27. pmc Quantification of five neuropsychological approaches to defining mild cognitive impairment
    Amy J Jak
    VA San Diego Healthcare System, San Diego, CA 92161, USA
    Am J Geriatr Psychiatry 17:368-75. 2009
    ....
  28. ncbi request reprint Recall discriminability: utility of a new CVLT-II measure in the differential diagnosis of dementia
    Dean C Delis
    Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    J Int Neuropsychol Soc 11:708-15. 2005
    ..Implications of these results for clinical practice and theories of memory disorder in dementia are discussed...
  29. pmc Asymmetry in auditory and spatial attention span in normal elderly genetically at risk for Alzheimer's disease
    Mark W Jacobson
    Department of Veterans Affairs Medical Center, San Diego, CA 92161, USA
    J Clin Exp Neuropsychol 27:240-53. 2005
    ....
  30. ncbi request reprint Identification of Alzheimer disease risk by functional magnetic resonance imaging
    Adam S Fleisher
    Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA
    Arch Neurol 62:1881-8. 2005
    ..Functional magnetic resonance imaging plays a promising role in the preclinical characterization of Alzheimer disease (AD) for use in early diagnosis and in preventive drug trials...
  31. ncbi request reprint Asymmetries in global-local processing ability in elderly people with the apolipoprotein e-epsilon4 allele
    Mark W Jacobson
    Veterans Affairs San Diego Healthcare System, Research Service, and University of California, San Diego School of Medicine, Department of Psychiatry, CA 92161, USA
    Neuropsychology 19:822-9. 2005
    ..These findings build on previous studies identifying subgroups of elderly people at greater risk for AD who often demonstrate increased cognitive asymmetries relative to groups without significant risk factors...
  32. pmc Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response
    S Duke Han
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92093 0603, United States
    Neurobiol Aging 28:238-47. 2007
    ....
  33. pmc Identifying the "source" of recognition memory deficits in patients with Huntington's disease or Alzheimer's disease: evidence from the CVLT-II
    Eric M Fine
    Psychology Service 116B Delis Lab, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Clin Exp Neuropsychol 30:463-70. 2008
    ..Implications of these findings on the differentiation of the memory disorders associated with HD and AD are discussed...
  34. ncbi request reprint The myth of testing construct validity using factor analysis or correlations with normal or mixed clinical populations: lessons from memory assessment
    Dean C Delis
    Psychology Service, Department of Veterans Affairs Medical Center, San Diego, California 92161, USA
    J Int Neuropsychol Soc 9:936-46. 2003
    ..Implications of these findings for research and clinical practice are discussed...
  35. pmc Neuropsychological and neuroimaging changes in preclinical Alzheimer's disease
    Elizabeth W Twamley
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Int Neuropsychol Soc 12:707-35. 2006
    ..The preclinical indicators of AD reflect early compromise of generalized brain integrity and temporal lobe functioning in particular...
  36. ncbi request reprint Are late-onset schizophrenia spectrum disorders neurodegenerative conditions? Annual rates of change on two dementia measures
    Barton W Palmer
    Department of Psychiatry, University of California, San Diego, USA
    J Neuropsychiatry Clin Neurosci 15:45-52. 2003
    ..Cognitive changes among LOSD patients were similar to those in EOSD patients and NCs, whereas the AD groups had greater declines. Results support viewing LOSDs as static encephalopathies...
  37. pmc Altered brain response for semantic knowledge in Alzheimer's disease
    Christina E Wierenga
    Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Neuropsychologia 49:392-404. 2011
    ....
  38. pmc Decreased cognition in children with risk factors for Alzheimer's disease
    Cinnamon S Bloss
    San Diego State University and University of California, San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    Biol Psychiatry 64:904-6. 2008
    ....
  39. ncbi request reprint Eyeblink classical conditioning to auditory and olfactory stimuli: performance among older adults with and without the apolipoprotein E epsilon 4 allele
    Anna Bacon Moore
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120 4913, USA
    Neuropsychology 19:437-45. 2005
    ..Both groups acquired the CR to an auditory CS at the same rate. Results support olfactory compromise in the earliest stages of the AD disease process. ((c) 2005 APA, all rights reserved)...
  40. pmc Contributions of neuropsychology and neuroimaging to understanding clinical subtypes of mild cognitive impairment
    Amy J Jak
    Department of Psychiatry, School of Medicine, University of California, San Diego 92093, USA
    Int Rev Neurobiol 84:81-103. 2009
    ..Finally, the review comments on select methodological issues involved in studying this heterogeneous population, and future directions to continue to improve our understanding of MCI and its clinical subtypes are offered...
  41. pmc Stroke risk modifies regional white matter differences in mild cognitive impairment
    Lisa Delano-Wood
    Department of Psychiatry, University of California, San Diego School of Medicine, CA, USA
    Neurobiol Aging 31:1721-31. 2010
    ..Findings demonstrate a relationship between increased vascular burden and white matter changes, and they support the possibility that posterior white matter pathology may contribute to the development of MCI-related cognitive changes...
  42. pmc Cerebral blood flow and BOLD responses to a memory encoding task: a comparison between healthy young and elderly adults
    Khaled Restom
    Center for Functional Magnetic Resonance Imaging and Department of Radiology, University of California San Diego, La Jolla, CA 92093 0677, USA
    Neuroimage 37:430-9. 2007
    ..The percent CBF and BOLD responses are consistent with an age-related increase in the cerebral metabolic rate of oxygen metabolism (CMRO(2)) response to memory encoding...
  43. pmc A technique for the deidentification of structural brain MR images
    Amanda Bischoff-Grethe
    Laboratory of Cognitive Imaging, Department of Psychiatry, University of California, San Diego, La Jolla, USA
    Hum Brain Mapp 28:892-903. 2007
    ..Analyses support this algorithm as a viable method to allow data sharing with minimal data alteration within large-scale multisite projects...
  44. pmc Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: effects of diagnosis, bias correction, and slice location
    Christine Fennema-Notestine
    Laboratory of Cognitive Imaging, Department of Psychiatry, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, California 92093, USA
    Hum Brain Mapp 27:99-113. 2006
    ..The results of this study may direct users towards a method appropriate to their T1-weighted datasets and improve the efficiency of processing for large, multisite neuroimaging studies...
  45. pmc Associations between stroke risk and cognition in normal aging and Alzheimer's disease with and without depression
    Katherine J Bangen
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    Int J Geriatr Psychiatry 25:175-82. 2010
    ..However, few studies have described the relations among stroke risk, cognition, and APOE genotype in AD, and the findings have been equivocal...
  46. ncbi request reprint Heterogeneity in verbal memory: a marker of preclinical Alzheimer's disease?
    Spencer R Wetter
    Veterans Affairs San Diego Healthcare System, California, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:503-15. 2006
    ..Implications of these findings for the detection of a preclinical phase of AD are discussed...
  47. pmc Decline in verbal memory during preclinical Alzheimer's disease: examination of the effect of APOE genotype
    Kelly L Lange
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, USA
    J Int Neuropsychol Soc 8:943-55. 2002
    ..The presence of an APOE-epsilon4 allele, however, did have a differential effect on the sensitivity of the 2 types of memory tests for tracking progression and made an independent contribution to the prediction of conversion to AD...
  48. ncbi request reprint Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation
    Tara T Lineweaver
    Department of Psychology, Butler University, Indianapolis, Indiana 46208, USA
    J Int Neuropsychol Soc 11:30-9. 2005
    ....
  49. doi request reprint Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis
    S Duke Han
    Department of Psychology, Loyola University Chicago, Chicago, IL, USA
    Alzheimers Dement 4:251-4. 2008
    ....
  50. pmc Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism?
    S Duke Han
    Department of Psychology, Loyola University Chicago, Chicago, Illinois, USA
    J Neurol Neurosurg Psychiatry 78:1103-8. 2007
    ....

Research Grants10

  1. Neuroimaging and Risk Factor Correlates in Aging and MCI
    MARK BONDI; Fiscal Year: 2007
    ..If successful, our ability to preclinically detect and monitor Alzheimer's disease will have far-reaching implications for early treatment. ..
  2. Cognitive Abilities of At-Risk Elderly for Dementia
    MARK BONDI; Fiscal Year: 2005
    ..Furthermore, an improved understanding of the brain mechanisms associated with the earliest cognitive changes in at-risk groups will advance our ability to target those who stand to benefit most from early pharmacologic intervention. ..
  3. Cognitive Abilities of At-Risk Elderly for Dementia
    Mark W Bondi; Fiscal Year: 2010
    ..e., those aged 80 and above) and on genetic susceptibility (e.g., apolipoprotein E). Critical examination of another risk factor for progression to AD, Mild Cognitive Impairment, will also represent a new aim for this project. ..