RICHARD AGUSTIN BOND

Summary

Affiliation: University of Houston
Country: USA

Publications

  1. ncbi request reprint Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant?
    Sergio Parra
    Department of Pharmaceutical and Pharmacological Sciences, University of Houston, 4800 Calhoun Room 521E, Bldg S and R 2, TX 77204 5037, USA
    Curr Opin Pharmacol 7:146-50. 2007
  2. pmc β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model
    Vaidehi J Thanawala
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204 5037, USA
    Am J Respir Cell Mol Biol 48:220-9. 2013
  3. pmc For the love of paradox: from neurobiology to pharmacology
    Richard A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204 5037, USA
    Behav Pharmacol 22:385-9. 2011
  4. ncbi request reprint Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?
    Richard A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 521 Science and Research Building 2, Houston, TX 77204 5037, USA
    Pharmacol Ther 115:360-74. 2007
  5. ncbi request reprint A proposal for a national program reporting beneficial drug responses, analogous to the existing program to detect adverse drug responses
    Richard A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 521E, Houston, TX 77204 5037, USA
    Med Hypotheses 66:10-3. 2006
  6. ncbi request reprint Is paradoxical pharmacology a strategy worth pursuing?
    R A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 4800 Calhoun, Houston, TX 77204 5515, USA
    Trends Pharmacol Sci 22:273-6. 2001
  7. ncbi request reprint Can intellectualism stifle scientific discovery?
    Richard A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204 5037, USA
    Nat Rev Drug Discov 1:825-9. 2002
  8. pmc Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma
    Zsuzsanna Callaerts-Vegh
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 521 Science and Research Building 2, Houston, TX 77204 5037, USA
    Proc Natl Acad Sci U S A 101:4948-53. 2004
  9. pmc beta-Adrenoceptor inverse agonists in asthma
    Burton F Dickey
    Department of Pulmonary Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Opin Pharmacol 10:254-9. 2010
  10. ncbi request reprint Chronic infusion of beta-adrenoceptor antagonist and inverse agonists decreases elevated protein kinase A activity in transgenic mice with cardiac-specific overexpression of human beta 2-adrenoceptor
    Xiushi Liu
    University of Houston, Department of Pharmacological and Pharmaceutical Sciences, Texas 77204 5037, USA
    J Cardiovasc Pharmacol 40:448-55. 2002

Research Grants

Collaborators

  • N A Hanania
  • Clive Page
  • D Spina
  • DAVID BRIAN CORRY
  • Long P Nguyen
  • Burton F Dickey
  • Brian J Knoll
  • Sergio Parra
  • Zsuzsanna Callaerts-Vegh
  • Kenda L J Evans
  • Michael J Tuvim
  • Rui Lin
  • Vaidehi J Thanawala
  • Julia K L Walker
  • Ozozoma Omoluabi
  • Heather Giles
  • Felix R Shardonofsky
  • Rui Ping Xiao
  • Xiushi Liu
  • Nour Al-Sawalha
  • Gloria S Forkuo
  • Thomas W Lowder
  • Jason L Eriksen
  • Zoulikha Azzegagh
  • Noor B Dudekula
  • Samuel B Ho
  • Hui Peng
  • Felix Shardonofsky
  • Camille Ehre
  • Zoulikha Ammar-Aouchiche
  • Mehmet Kesimer
  • Joanna M Frieske
  • Cecilia Clement
  • Patrick F K Callaerts
  • Noornabi Dudekula
  • Donald Cuba
  • Donald L Cuba
  • Gregory L Shipley
  • Hunaid A Gurji
  • Edward G Lakatta
  • Sheng Jun Zhang
  • C William Balke
  • Peter J A Davies
  • Heping Cheng
  • Pavel Avdonin
  • Khalid Chakir
  • Weizhong Zhu

Detail Information

Publications18

  1. ncbi request reprint Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant?
    Sergio Parra
    Department of Pharmaceutical and Pharmacological Sciences, University of Houston, 4800 Calhoun Room 521E, Bldg S and R 2, TX 77204 5037, USA
    Curr Opin Pharmacol 7:146-50. 2007
    ..Although there are diseases of spontaneous constitutively active receptors, which in theory would be better suited for inverse agonist treatment, this work is still a long way from being realised...
  2. pmc β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model
    Vaidehi J Thanawala
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204 5037, USA
    Am J Respir Cell Mol Biol 48:220-9. 2013
    ..These data further support the hypothesis that chronic asthma management may be better served by treatment with certain "β-blockers."..
  3. pmc For the love of paradox: from neurobiology to pharmacology
    Richard A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204 5037, USA
    Behav Pharmacol 22:385-9. 2011
    ..Although Francis Colpaert used this knowledge to lead a drug discovery project for an analgesic compound that initially produced hyperalgesia, we focused on examples outside the central nervous system...
  4. ncbi request reprint Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?
    Richard A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 521 Science and Research Building 2, Houston, TX 77204 5037, USA
    Pharmacol Ther 115:360-74. 2007
    ..This begs the question of whether a similar paradigm shift is applicable in the treatment of asthma and whether under certain circumstances the long-term use of certain beta blockers may be useful in the treatment of this disease...
  5. ncbi request reprint A proposal for a national program reporting beneficial drug responses, analogous to the existing program to detect adverse drug responses
    Richard A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 521E, Houston, TX 77204 5037, USA
    Med Hypotheses 66:10-3. 2006
    ..It is time to create the largest stage ever for serendipity to appear in biomedical research. After all, her previous appearances have marked some of science's most amazing discoveries...
  6. ncbi request reprint Is paradoxical pharmacology a strategy worth pursuing?
    R A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 4800 Calhoun, Houston, TX 77204 5515, USA
    Trends Pharmacol Sci 22:273-6. 2001
    ....
  7. ncbi request reprint Can intellectualism stifle scientific discovery?
    Richard A Bond
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204 5037, USA
    Nat Rev Drug Discov 1:825-9. 2002
  8. pmc Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma
    Zsuzsanna Callaerts-Vegh
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 521 Science and Research Building 2, Houston, TX 77204 5037, USA
    Proc Natl Acad Sci U S A 101:4948-53. 2004
    ..These results suggest that beta-AR agonists and beta-blockers with inverse agonist properties may exert reciprocating effects on cellular signaling dependent on duration of administration...
  9. pmc beta-Adrenoceptor inverse agonists in asthma
    Burton F Dickey
    Department of Pulmonary Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Opin Pharmacol 10:254-9. 2010
    ..Both lung parenchymal and hematopoietic cells appear to be involved in mediating the beneficial effects of beta-AR inverse agonists...
  10. ncbi request reprint Chronic infusion of beta-adrenoceptor antagonist and inverse agonists decreases elevated protein kinase A activity in transgenic mice with cardiac-specific overexpression of human beta 2-adrenoceptor
    Xiushi Liu
    University of Houston, Department of Pharmacological and Pharmaceutical Sciences, Texas 77204 5037, USA
    J Cardiovasc Pharmacol 40:448-55. 2002
    ....
  11. pmc Clinical implications of the intrinsic efficacy of beta-adrenoceptor drugs in asthma: full, partial and inverse agonism
    Nicola A Hanania
    Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Pulm Med 16:1-5. 2010
    ..We review the role of beta2-AR agonist intrinsic efficacy in asthma treatment focusing on recent literature...
  12. pmc Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model
    Long P Nguyen
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, 4800 Calhoun, Houston, TX 77204 5037, USA
    Am J Respir Cell Mol Biol 38:256-62. 2008
    ..Similar to heart failure, our results provide a second disease model in which beta-blockers producing an acutely detrimental effect may provide a therapeutically beneficial effect with chronic administration...
  13. pmc The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot study
    Nicola A Hanania
    Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
    Pulm Pharmacol Ther 21:134-41. 2008
    ..Our findings warrant further testing in future larger trials...
  14. pmc Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model
    Rui Lin
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA
    Pulm Pharmacol Ther 21:115-24. 2008
    ..We have previously reported that chronic treatment with certain 'beta-blockers' reduces airway hyperresponsiveness (AHR) to methacholine in a murine model of asthma...
  15. pmc Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model
    Long P Nguyen
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Science and Research Building 2, Houston, TX 77204, USA
    Proc Natl Acad Sci U S A 106:2435-40. 2009
    ....
  16. ncbi request reprint Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma
    Kenda L J Evans
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Texas 77030, USA
    J Appl Physiol 94:245-52. 2003
    ..These mechanisms amplify the pulmonary mechanical responses to constrictor stimuli at physiological breathing rates and have important roles in the pathophysiology of human asthma...
  17. pmc Effects of different beta adrenoceptor ligands in mice with permanent occlusion of the left anterior descending coronary artery
    Zsuzsanna Callaerts-Vegh
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA
    Br J Pharmacol 138:1505-16. 2003
    ..We hypothesise that these beneficial effects of the drug may be because of the negative efficacy at the beta2AR, combined with beta1AR antagonism...
  18. ncbi request reprint Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts
    Rui Ping Xiao
    The Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Circulation 108:1633-9. 2003
    ....

Research Grants3

  1. Mechanisms of beta-blocker induced improvements in asthma
    Richard Bond; Fiscal Year: 2009
    ..Using a murine antigen driven 3=(n' 0 moo +L' 0p., >_E Off' :.(n ECM (II :.. O-0 o-- (Q' 6C' 0-: ..
  2. Mechanisms of beta-blocker induced improvements in asthma
    RICHARD AGUSTIN BOND; Fiscal Year: 2010
    ..Using a murine antigen driven 3=(n' 0 moo +L' 0p., >_E Off' :.(n ECM (II :.. O-0 o-- (Q' 6C' 0-: ..