Research Topics
| RICHARD AGUSTIN BONDSummaryAffiliation: University of Houston Country: USA Publications
Research Grants
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Detail Information
Publications
Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant?Sergio Parra
Department of Pharmaceutical and Pharmacological Sciences, University of Houston, 4800 Calhoun Room 521E, Bldg S and R 2, TX 77204 5037, USA
Curr Opin Pharmacol 7:146-50. 2007..Although there are diseases of spontaneous constitutively active receptors, which in theory would be better suited for inverse agonist treatment, this work is still a long way from being realised...
β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine modelVaidehi J Thanawala
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204 5037, USA
Am J Respir Cell Mol Biol 48:220-9. 2013..These data further support the hypothesis that chronic asthma management may be better served by treatment with certain "β-blockers."..
For the love of paradox: from neurobiology to pharmacologyRichard A Bond
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204 5037, USA
Behav Pharmacol 22:385-9. 2011..Although Francis Colpaert used this knowledge to lead a drug discovery project for an analgesic compound that initially produced hyperalgesia, we focused on examples outside the central nervous system...- Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?Richard A Bond
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 521 Science and Research Building 2, Houston, TX 77204 5037, USA
Pharmacol Ther 115:360-74. 2007..This begs the question of whether a similar paradigm shift is applicable in the treatment of asthma and whether under certain circumstances the long-term use of certain beta blockers may be useful in the treatment of this disease... - A proposal for a national program reporting beneficial drug responses, analogous to the existing program to detect adverse drug responsesRichard A Bond
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 521E, Houston, TX 77204 5037, USA
Med Hypotheses 66:10-3. 2006..It is time to create the largest stage ever for serendipity to appear in biomedical research. After all, her previous appearances have marked some of science's most amazing discoveries... - Is paradoxical pharmacology a strategy worth pursuing?R A Bond
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 4800 Calhoun, Houston, TX 77204 5515, USA
Trends Pharmacol Sci 22:273-6. 2001.... - Can intellectualism stifle scientific discovery?Richard A Bond
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204 5037, USA
Nat Rev Drug Discov 1:825-9. 2002 - Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthmaZsuzsanna Callaerts-Vegh
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 521 Science and Research Building 2, Houston, TX 77204-5037, USA
Proc Natl Acad Sci U S A 101:4948-53. 2004..These results suggest that beta-AR agonists and beta-blockers with inverse agonist properties may exert reciprocating effects on cellular signaling dependent on duration of administration... - beta-Adrenoceptor inverse agonists in asthmaBurton F Dickey
Department of Pulmonary Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Curr Opin Pharmacol 10:254-9. 2010..Both lung parenchymal and hematopoietic cells appear to be involved in mediating the beneficial effects of beta-AR inverse agonists... - Chronic infusion of beta-adrenoceptor antagonist and inverse agonists decreases elevated protein kinase A activity in transgenic mice with cardiac-specific overexpression of human beta 2-adrenoceptorXiushi Liu
University of Houston, Department of Pharmacological and Pharmaceutical Sciences, Texas 77204-5037, USA
J Cardiovasc Pharmacol 40:448-55. 2002.... - Clinical implications of the intrinsic efficacy of beta-adrenoceptor drugs in asthma: full, partial and inverse agonismNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Curr Opin Pulm Med 16:1-5. 2010..We review the role of beta2-AR agonist intrinsic efficacy in asthma treatment focusing on recent literature... - Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma modelLong P Nguyen
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, 4800 Calhoun, Houston, TX 77204 5037, USA
Am J Respir Cell Mol Biol 38:256-62. 2008..Similar to heart failure, our results provide a second disease model in which beta-blockers producing an acutely detrimental effect may provide a therapeutically beneficial effect with chronic administration... - The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot studyNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
Pulm Pharmacol Ther 21:134-41. 2008..Our findings warrant further testing in future larger trials... - Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma modelRui Lin
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA
Pulm Pharmacol Ther 21:115-24. 2008..We have previously reported that chronic treatment with certain 'beta-blockers' reduces airway hyperresponsiveness (AHR) to methacholine in a murine model of asthma... - Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine modelLong P Nguyen
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Science and Research Building 2, Houston, TX 77204, USA
Proc Natl Acad Sci U S A 106:2435-40. 2009.... - Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthmaKenda L J Evans
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Texas 77030, USA
J Appl Physiol 94:245-52. 2003..These mechanisms amplify the pulmonary mechanical responses to constrictor stimuli at physiological breathing rates and have important roles in the pathophysiology of human asthma... - Effects of different beta adrenoceptor ligands in mice with permanent occlusion of the left anterior descending coronary arteryZsuzsanna Callaerts-Vegh
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA
Br J Pharmacol 138:1505-16. 2003..We hypothesise that these beneficial effects of the drug may be because of the negative efficacy at the beta2AR, combined with beta1AR antagonism... - Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat heartsRui Ping Xiao
The Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Circulation 108:1633-9. 2003....
Research Grants
- Mechanisms of beta-blocker induced improvements in asthmaRichard Bond; Fiscal Year: 2009..Using a murine antigen driven 3=(n' 0 moo +L' 0p., >_E Off' :.(n ECM (II :.. O-0 o-- (Q' 6C' 0-: ..
- Mechanisms of beta-blocker induced improvements in asthmaRICHARD AGUSTIN BOND; Fiscal Year: 2010..Using a murine antigen driven 3=(n' 0 moo +L' 0p., >_E Off' :.(n ECM (II :.. O-0 o-- (Q' 6C' 0-: ..