Antonello Bonci

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system
    Antonello Bonci
    Howard J Weinberger Chair in Addiction Research, Ernest Gallo Clinic and Research Center, University of California, San Francisco, USA
    Neuropharmacology 56:107-11. 2009
  2. ncbi request reprint Ion channels and intracellular signaling proteins as potential targets for novel therapeutics for addictive and depressive disorders
    Antonello Bonci
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, CA 94110, USA
    Pharmacol Ther 108:65-75. 2005
  3. ncbi request reprint The dopamine D2 receptor: new surprises from an old friend
    Antonello Bonci
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    Neuron 47:335-8. 2005
  4. ncbi request reprint Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    Neuron 49:589-601. 2006
  5. doi request reprint Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake
    Taban Seif
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, San Francisco, California, USA
    Nat Neurosci 16:1094-100. 2013
  6. pmc Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence
    F Woodward Hopf
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, San Francisco, CA 94608, USA
    Neuron 65:682-94. 2010
  7. pmc Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons
    Garret D Stuber
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    Science 321:1690-2. 2008
  8. pmc Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate
    Garret D Stuber
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 30:8229-33. 2010
  9. pmc Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons
    Junghyun Hahn
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 29:6535-44. 2009
  10. ncbi request reprint Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area
    Federica Sarti
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, San Francisco, CA 94608, USA
    Eur J Neurosci 26:749-56. 2007

Collaborators

Detail Information

Publications59

  1. doi request reprint Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system
    Antonello Bonci
    Howard J Weinberger Chair in Addiction Research, Ernest Gallo Clinic and Research Center, University of California, San Francisco, USA
    Neuropharmacology 56:107-11. 2009
    ..Taken together, the results from the studies reviewed here shed new light on the mechanistic role of plasticity at glutamatergic synapses in the VTA in mediating addictive, as well as stress-dependent behaviors...
  2. ncbi request reprint Ion channels and intracellular signaling proteins as potential targets for novel therapeutics for addictive and depressive disorders
    Antonello Bonci
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, CA 94110, USA
    Pharmacol Ther 108:65-75. 2005
    ....
  3. ncbi request reprint The dopamine D2 receptor: new surprises from an old friend
    Antonello Bonci
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    Neuron 47:335-8. 2005
    ....
  4. ncbi request reprint Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    Neuron 49:589-601. 2006
    ..These results provide in vitro and in vivo evidence for a critical role of orexin signaling in the VTA in neural plasticity relevant to addiction...
  5. doi request reprint Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake
    Taban Seif
    Ernest Gallo Clinic and Research Center, University of California at San Francisco, San Francisco, California, USA
    Nat Neurosci 16:1094-100. 2013
    ..Our results identify a mechanism by which hyperpolarization-active NMDA receptors under mPFC- and insula-to-NAcore inputs sustain aversion-resistant alcohol intake. ..
  6. pmc Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence
    F Woodward Hopf
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, San Francisco, CA 94608, USA
    Neuron 65:682-94. 2010
    ..Thus, decreased NAcb core SK currents and increased excitability represents a critical mechanism that facilitates motivation to seek alcohol after abstinence...
  7. pmc Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons
    Garret D Stuber
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    Science 321:1690-2. 2008
    ..Thus, enhanced synaptic strength onto dopamine neurons may act to facilitate the transformation of neutral environmental stimuli to salient reward-predictive cues...
  8. pmc Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate
    Garret D Stuber
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 30:8229-33. 2010
    ..Thus, the unique ability of NAc-projecting dopamine neurons to synchronously activate both dopamine and glutamate receptors may have crucial implications for the ability to respond to motivationally significant stimuli...
  9. pmc Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons
    Junghyun Hahn
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 29:6535-44. 2009
    ....
  10. ncbi request reprint Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area
    Federica Sarti
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, San Francisco, CA 94608, USA
    Eur J Neurosci 26:749-56. 2007
    ..Taken together, our data provide evidence that increased spine density and synaptic plasticity are coexpressed within the same VTA neuronal population and that only type I neurons are structurally and synaptically modified by cocaine...
  11. pmc Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area
    Anuradha Madhavan
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 30:14029-35. 2010
    ..Thus, a paradoxical bidirectionality in μ-receptor-mediated control of GABA transmission following chronic morphine treatment is a critical mechanism that determines the expression of opioid reward in the VTA...
  12. ncbi request reprint Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro
    F Woodward Hopf
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Department of Neurology, Emeryville, CA 94608, USA
    J Neurophysiol 98:2297-310. 2007
    ....
  13. pmc Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area
    Emanuela Argilli
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:9092-100. 2008
    ....
  14. pmc The melanin-concentrating hormone system modulates cocaine reward
    Shinjae Chung
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:6772-7. 2009
    ..Thus, the MCH system has an important modulatory role in cocaine reward and reinforcement by potentiating the dopaminergic system in the NAcSh, which may provide a new rationale for treating cocaine addiction...
  15. pmc Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area
    Anuradha Madhavan
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California 94608, USA
    J Neurosci 33:12329-36. 2013
    ..Together these data suggest that functional loss of D2 receptors is a critical mechanism mediating cocaine-induced glutamate plasticity in VTA neurons. ..
  16. pmc Endocytosis promotes rapid dopaminergic signaling
    SARAH J KOTOWSKI
    Department of Psychiatry and Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94158, USA
    Neuron 71:278-90. 2011
    ..Together, these results suggest a previously unanticipated role of endocytosis, and the early endocytic pathway, in supporting rapid dopaminergic neurotransmission...
  17. pmc Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats
    F Woodward Hopf
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    Biol Psychiatry 69:618-24. 2011
    ..Thus, positive SK modulators such as chlorzoxazone (CZX), a US Food and Drug Administration-approved centrally acting myorelaxant, might enhance SK function and decrease neuronal activity, resulting in reduced alcohol intake...
  18. pmc Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats
    Jemma K Richards
    Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 199:109-17. 2008
    ..In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking...
  19. pmc Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure
    MATTHEW J WANAT
    Neuroscience Graduate Program, University of California San Francisco, San Francisco, California, USA
    Biol Psychiatry 65:646-53. 2009
    ....
  20. pmc Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma
    M Scott Bowers
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Proc Natl Acad Sci U S A 105:12533-8. 2008
    ..AGS3 up-regulation during abstinence may be a key determinant of the transition from social consumption to compulsion-like seeking during relapse...
  21. pmc Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA
    Billy T Chen
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    Neuron 59:288-97. 2008
    ..Such persistent synaptic potentiation in VTA DA neurons may represent a fundamental cellular phenomenon driving pathological drug-seeking behavior...
  22. pmc micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal
    Anuradha Madhavan
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 30:3276-86. 2010
    ..5 microl), directly tying enhanced cAMP-driven GABA release to naloxone-precipitated morphine withdrawal in the VTA...
  23. ncbi request reprint Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors
    Yuichiro Inoue
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    J Pharmacol Exp Ther 322:23-9. 2007
    ....
  24. doi request reprint Neuroplastic alterations in the limbic system following cocaine or alcohol exposure
    Garret D Stuber
    Department of Neurology, University of California, San Francisco, CA, USA
    Curr Top Behav Neurosci 3:3-27. 2010
    ..Synaptic insertion of AMPARs by drugs of abuse can be long lasting, depending on the route of administration, number of drug exposures, or whether the drugs are received passively or self-administered...
  25. pmc Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function
    Luna Abdallah
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 29:8156-65. 2009
    ..We conclude that 5-HT(2C)Rs regulate nigrostriatal dopaminergic activity and function both at SNc dopaminergic neurons and at a locus downstream of the DSt...
  26. ncbi request reprint Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons
    Elyssa B Margolis
    Ernest Gallo Clinic and Research Center, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    J Neurophysiol 93:3086-93. 2005
    ..These findings show that MOP-R and KOP-R agonists regulate excitatory input onto each VTA cell type...
  27. pmc Voluntary ethanol intake enhances excitatory synaptic strength in the ventral tegmental area
    Garret D Stuber
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
    Alcohol Clin Exp Res 32:1714-20. 2008
    ..Here, we examined whether voluntary ethanol intake altered VTA AMPAR function...
  28. pmc The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum
    F Woodward Hopf
    Ernest Gallo Clinic and Research Center, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
    Eur J Neurosci 31:1946-59. 2010
    ..Thus, these data demonstrate that SKs are potent modulators of action potential generation and LTD in the dorsal striatum, and could represent a fundamental cellular mechanism through which habits are regulated...
  29. pmc Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA
    Kimberly A Kempadoo
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 33:7618-26. 2013
    ..The striking behavioral and electrophysiological effects of NT and glutamate highlight the LH to VTA pathway as an important component of reward...
  30. pmc Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    J Neurosci 29:11215-25. 2009
    ....
  31. pmc Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity
    David Kapfhamer
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 30:8830-40. 2010
    ..These data support a previously uncharacterized mechanism by which PP2A/GSK3beta signaling regulates M-type potassium channel activity in the mPFC to modulate sensorimotor gating...
  32. pmc The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration
    Subhashini Srinivasan
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America
    PLoS ONE 7:e44726. 2012
    ..The results demonstrate that orexin/hypocretin receptors in distinct brain regions regulate ethanol and sucrose mediated behaviors...
  33. pmc Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse
    Billy T Chen
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    Ann N Y Acad Sci 1187:129-39. 2010
    ..In particular, we will focus our discussion on recent studies showing changes in AMPA receptor function as a common molecular target of addictive drugs, and the possible behavioral consequences of such neuroadaptations...
  34. ncbi request reprint Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats
    M Scott Bowers
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 195:397-406. 2007
    ..Acamprosate (calcium acetylhomotaurinate) is a glutamatergic neuromodulator used for the treatment of alcoholism, but its potential efficacy in the treatment of psychostimulant addiction has not been explored...
  35. ncbi request reprint Brief ischemia causes long-term depression in midbrain dopamine neurons
    Vineeta Singh
    Department of Neurology, University of California, San Francisco, Ernest Gallo Clinic and Research Center, Emeryville, CA 94608, USA
    Eur J Neurosci 26:1489-99. 2007
    ....
  36. doi request reprint Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area
    Dennis R Sparta
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California
    Alcohol Clin Exp Res 37:1680-7. 2013
    ....
  37. doi request reprint Transient stimulation of distinct subpopulations of striatal neurons mimics changes in action value
    Lung Hao Tai
    Ernest Gallo Clinic and Research Center, Emeryville, California, USA
    Nat Neurosci 15:1281-9. 2012
    ..Together, our data suggest that striatal activity is involved in goal-directed action selection...
  38. pmc Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration
    FREDERIC WOODWARD HOPF
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
    Alcohol Clin Exp Res 34:1565-73. 2010
    ..However, given the time required to model compulsive alcohol seeking in previous studies, there is considerable interest in developing more efficient and quantitative rodent models of aversion-resistant alcohol self-administration...
  39. ncbi request reprint Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 24:7482-90. 2004
    ..Furthermore, chronic cocaine exposure disrupts the normal, presumably adaptive relationship between synaptic enhancement in the VTA and behavior...
  40. ncbi request reprint Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons
    F Woodward Hopf
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 25:985-9. 2005
    ..Thus, aPKCs appear to mediate dopaminergic enhancement of spike firing in the NAcb shell, and may therefore play a critical role in NAcb- and dopamine-dependent goal-directed behaviors...
  41. pmc Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning
    Kay M Tye
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    Nature 453:1253-7. 2008
    ..These findings provide evidence of a connection between LA synaptic plasticity and cue-reward learning, potentially representing a key mechanism underlying goal-directed behaviour...
  42. ncbi request reprint Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens
    Miquel Martin
    Ernest Gallo Clinic and Research Center, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
    Nat Neurosci 9:868-9. 2006
    ....
  43. ncbi request reprint Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras
    Neesha Suvarna
    Ernest Gallo Research Center, Emeryville, California 94608, USA
    J Biol Chem 280:31450-9. 2005
    ..Our results suggest that addictive drugs such as ethanol alter NMDAR trafficking and subunit composition. This may be an important mechanism by which ethanol exerts its effects on NMDARs to produce alcohol-induced aberrant plasticity...
  44. doi request reprint The SK channel as a novel target for treating alcohol use disorders
    Frederic W Hopf
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, USA
    Channels (Austin) 5:289-92. 2011
    ....
  45. pmc Methylphenidate facilitates learning-induced amygdala plasticity
    Kay M Tye
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California, USA
    Nat Neurosci 13:475-81. 2010
    ..These findings reveal critical and distinct roles for dopamine receptor subtypes in mediating methylphenidate-induced enhancements of neural transmission and learning performance...
  46. ncbi request reprint The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference
    Doo Sup Choi
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California, 94608, USA
    Nat Neurosci 7:855-61. 2004
    ..Our results indicate that ENT1 has a physiological role in ethanol-mediated behaviors and suggest that decreased A(1) adenosine receptor function promotes alcohol consumption...
  47. ncbi request reprint Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons
    Mark A Ungless
    Ernest Gallo Clinic and Research Center and Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    Neuron 39:401-7. 2003
    ..These results provide evidence of the first specific roles for CRF-R2 and CRF-BP in the modulation of neuronal activity and suggest that NMDARs in the VTA may be a target for both drugs of abuse and stress...
  48. doi request reprint Effects of stress and aversion on dopamine neurons: implications for addiction
    Mark A Ungless
    Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Neurosci Biobehav Rev 35:151-6. 2010
    ..Finally, we examine how the effects of stress and cocaine interact and how these cellular mechanisms in ventral tegmental area dopamine neurons may be engaged in stress-induced relapse...
  49. ncbi request reprint Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure
    Miriam Melis
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California 94110, USA
    J Neurosci 22:2074-82. 2002
    ....
  50. pmc The α5 subunit regulates the expression and function of α4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area
    Susmita Chatterjee
    Ernest Gallo Clinic and Research Center at the University of California, San Francisco, Emeryville, California, USA
    PLoS ONE 8:e68300. 2013
    ..Together, the data suggest that the α5 subunit is critical for controlling the expression and functional role of a population of α4*-containing nAChRs in the VTA. ..
  51. pmc Dopamine responsiveness is regulated by targeted sorting of D2 receptors
    Selena E Bartlett
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94608, USA
    Proc Natl Acad Sci U S A 102:11521-6. 2005
    ..Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors...
  52. ncbi request reprint Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons
    Elyssa B Margolis
    Joint University of California San Francisco University of California, Berkeley Bioengineering Graduate Group, San Francisco, California 94143 0775, USA
    J Neurosci 23:9981-6. 2003
    ..These results provide a cellular mechanism for the opposing behavioral effects of KOR and MOR agonists and shed light on how KORs might regulate the motivational effects of both natural rewards and addictive drugs...
  53. pmc Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens
    Jonathan P Britt
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuron 76:790-803. 2012
    ..Finally, direct optical activation of medium spiny neurons proved to be capable of supporting self-stimulation, demonstrating that behavioral reinforcement is an explicit consequence of strong excitatory drive to the NAc...
  54. ncbi request reprint A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans
    Andrew G Davies
    Ernest Gallo Clinic and Research Center, Department of Neurology, Program in Neuroscience, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
    Cell 115:655-66. 2003
    ..elegans. BK channel activation may explain a variety of behavioral responses to ethanol in invertebrate and vertebrate systems...
  55. ncbi request reprint Cooperative activation of dopamine D1 and D2 receptors increases spike firing of nucleus accumbens neurons via G-protein betagamma subunits
    F Woodward Hopf
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 23:5079-87. 2003
    ..These results provide evidence for a novel cellular mechanism through which cooperative action of D1 and D2 receptors in the nucleus accumbens could mediate dopamine-dependent behaviors...
  56. ncbi request reprint The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction?
    Antonello Bonci
    Ernest Gallo Clinic and Research Center and Department of Neurology, University of California, San Francisco, CA 94110, USA
    Trends Pharmacol Sci 24:172-7. 2003
    ..Therefore, we suggest that both the modulation of dopamine release in the extracellular space and transient or enduring changes in the firing of dopamine-containing neurons could be associated with important features of drugs of abuse...
  57. pmc NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1
    Rami Yaka
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94110 3518, USA
    Proc Natl Acad Sci U S A 99:5710-5. 2002
    ..Therefore, RACK1 is a regulator of NMDA receptor function and may play a role in synaptic plasticity, addiction, learning, and memory...
  58. ncbi request reprint Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons
    Daniel Saal
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 37:577-82. 2003
    ....
  59. ncbi request reprint Synaptic plasticity and drug addiction
    Susan Jones
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Curr Opin Pharmacol 5:20-5. 2005
    ..We hypothesize that drug-induced synaptic plasticity might play a role in reward-related learning and addiction by modifying the fine tuning of dopaminergic cell firing...