Research Topics
Genomes and Genes
| Antonello BonciSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The dopamine D2 receptor: new surprises from an old friendAntonello Bonci
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
Neuron 47:335-8. 2005....- Ion channels and intracellular signaling proteins as potential targets for novel therapeutics for addictive and depressive disordersAntonello Bonci
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, CA 94110, USA
Pharmacol Ther 108:65-75. 2005.... 
Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic systemAntonello Bonci
Howard J Weinberger Chair in Addiction Research, Ernest Gallo Clinic and Research Center, University of California, San Francisco, USA
Neuropharmacology 56:107-11. 2009..Taken together, the results from the studies reviewed here shed new light on the mechanistic role of plasticity at glutamatergic synapses in the VTA in mediating addictive, as well as stress-dependent behaviors...- Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaineStephanie L Borgland
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
Neuron 49:589-601. 2006..These results provide in vitro and in vivo evidence for a critical role of orexin signaling in the VTA in neural plasticity relevant to addiction... 
Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinenceF Woodward Hopf
Ernest Gallo Clinic and Research Center, University of California, San Francisco, San Francisco, CA 94608, USA
Neuron 65:682-94. 2010..Thus, decreased NAcb core SK currents and increased excitability represents a critical mechanism that facilitates motivation to seek alcohol after abstinence...- Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neuronsGarret D Stuber
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
Science 321:1690-2. 2008..Thus, enhanced synaptic strength onto dopamine neurons may act to facilitate the transformation of neutral environmental stimuli to salient reward-predictive cues... - Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamateGarret D Stuber
Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 30:8229-33. 2010..Thus, the unique ability of NAc-projecting dopamine neurons to synchronously activate both dopamine and glutamate receptors may have crucial implications for the ability to respond to motivationally significant stimuli... - Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neuronsJunghyun Hahn
Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
J Neurosci 29:6535-44. 2009.... - Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental areaFederica Sarti
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, San Francisco, CA 94608, USA
Eur J Neurosci 26:749-56. 2007..Taken together, our data provide evidence that increased spine density and synaptic plasticity are coexpressed within the same VTA neuronal population and that only type I neurons are structurally and synaptically modified by cocaine... - Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental areaAnuradha Madhavan
Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 30:14029-35. 2010..Thus, a paradoxical bidirectionality in μ-receptor-mediated control of GABA transmission following chronic morphine treatment is a critical mechanism that determines the expression of opioid reward in the VTA... - Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitroF Woodward Hopf
Ernest Gallo Clinic and Research Center, University of California San Francisco, Department of Neurology, Emeryville, CA 94608, USA
J Neurophysiol 98:2297-310. 2007.... - Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental areaEmanuela Argilli
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 28:9092-100. 2008.... - The melanin-concentrating hormone system modulates cocaine rewardShinjae Chung
Department of Pharmacology, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 106:6772-7. 2009..Thus, the MCH system has an important modulatory role in cocaine reward and reinforcement by potentiating the dopaminergic system in the NAcSh, which may provide a new rationale for treating cocaine addiction... - Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in ratsF Woodward Hopf
Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
Biol Psychiatry 69:618-24. 2011..Thus, positive SK modulators such as chlorzoxazone (CZX), a US Food and Drug Administration-approved centrally acting myorelaxant, might enhance SK function and decrease neuronal activity, resulting in reduced alcohol intake... - Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans ratsJemma K Richards
Ernest Gallo Clinic and Research Center, University of California San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 199:109-17. 2008..In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking... - Endocytosis promotes rapid dopaminergic signalingSARAH J KOTOWSKI
Department of Psychiatry and Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94158, USA
Neuron 71:278-90. 2011..Together, these results suggest a previously unanticipated role of endocytosis, and the early endocytic pathway, in supporting rapid dopaminergic neurotransmission... - Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposureMATTHEW J WANAT
Neuroscience Graduate Program, University of California San Francisco, San Francisco, California, USA
Biol Psychiatry 65:646-53. 2009.... - Nucleus accumbens AGS3 expression drives ethanol seeking through G betagammaM Scott Bowers
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Proc Natl Acad Sci U S A 105:12533-8. 2008..AGS3 up-regulation during abstinence may be a key determinant of the transition from social consumption to compulsion-like seeking during relapse... - Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTABilly T Chen
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
Neuron 59:288-97. 2008..Such persistent synaptic potentiation in VTA DA neurons may represent a fundamental cellular phenomenon driving pathological drug-seeking behavior... - micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawalAnuradha Madhavan
Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
J Neurosci 30:3276-86. 2010..5 microl), directly tying enhanced cAMP-driven GABA release to naloxone-precipitated morphine withdrawal in the VTA... - Voluntary ethanol intake enhances excitatory synaptic strength in the ventral tegmental areaGarret D Stuber
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, California 94608, USA
Alcohol Clin Exp Res 32:1714-20. 2008..Here, we examined whether voluntary ethanol intake altered VTA AMPAR function... - The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatumF Woodward Hopf
Ernest Gallo Clinic and Research Center, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
Eur J Neurosci 31:1946-59. 2010..Thus, these data demonstrate that SKs are potent modulators of action potential generation and LTD in the dorsal striatum, and could represent a fundamental cellular mechanism through which habits are regulated... - Neuroplastic alterations in the limbic system following cocaine or alcohol exposureGarret D Stuber
Department of Neurology, University of California, San Francisco, CA, USA
Curr Top Behav Neurosci 3:3-27. 2010..Synaptic insertion of AMPARs by drugs of abuse can be long lasting, depending on the route of administration, number of drug exposures, or whether the drugs are received passively or self-administered... - Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway functionLuna Abdallah
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158, USA
J Neurosci 29:8156-65. 2009..We conclude that 5-HT(2C)Rs regulate nigrostriatal dopaminergic activity and function both at SNc dopaminergic neurons and at a locus downstream of the DSt... - Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptorsYuichiro Inoue
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
J Pharmacol Exp Ther 322:23-9. 2007.... - Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neuronsElyssa B Margolis
Ernest Gallo Clinic and Research Center, 5858 Horton St, Suite 200, Emeryville, CA 94608, USA
J Neurophysiol 93:3086-93. 2005..These findings show that MOP-R and KOP-R agonists regulate excitatory input onto each VTA cell type... - Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcersStephanie L Borgland
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
J Neurosci 29:11215-25. 2009.... - Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activityDavid Kapfhamer
Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
J Neurosci 30:8830-40. 2010..These data support a previously uncharacterized mechanism by which PP2A/GSK3beta signaling regulates M-type potassium channel activity in the mPFC to modulate sensorimotor gating... - The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administrationSubhashini Srinivasan
Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California, United States of America
PLoS ONE 7:e44726. 2012..The results demonstrate that orexin/hypocretin receptors in distinct brain regions regulate ethanol and sucrose mediated behaviors... - Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuseBilly T Chen
Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
Ann N Y Acad Sci 1187:129-39. 2010..In particular, we will focus our discussion on recent studies showing changes in AMPA receptor function as a common molecular target of addictive drugs, and the possible behavioral consequences of such neuroadaptations... - Brief ischemia causes long-term depression in midbrain dopamine neuronsVineeta Singh
Department of Neurology, University of California, San Francisco, Ernest Gallo Clinic and Research Center, Emeryville, CA 94608, USA
Eur J Neurosci 26:1489-99. 2007.... - Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in ratsM Scott Bowers
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 195:397-406. 2007..Acamprosate (calcium acetylhomotaurinate) is a glutamatergic neuromodulator used for the treatment of alcoholism, but its potential efficacy in the treatment of psychostimulant addiction has not been explored... - Transient stimulation of distinct subpopulations of striatal neurons mimics changes in action valueLung Hao Tai
Ernest Gallo Clinic and Research Center, Emeryville, California, USA
Nat Neurosci 15:1281-9. 2012..Together, our data suggest that striatal activity is involved in goal-directed action selection... - Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual ratsStephanie L Borgland
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 24:7482-90. 2004..Furthermore, chronic cocaine exposure disrupts the normal, presumably adaptive relationship between synaptic enhancement in the VTA and behavior... - Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neuronsF Woodward Hopf
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 25:985-9. 2005..Thus, aPKCs appear to mediate dopaminergic enhancement of spike firing in the NAcb shell, and may therefore play a critical role in NAcb- and dopamine-dependent goal-directed behaviors... - Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administrationFREDERIC WOODWARD HOPF
Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA
Alcohol Clin Exp Res 34:1565-73. 2010..However, given the time required to model compulsive alcohol seeking in previous studies, there is considerable interest in developing more efficient and quantitative rodent models of aversion-resistant alcohol self-administration... - Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learningKay M Tye
Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
Nature 453:1253-7. 2008..These findings provide evidence of a connection between LA synaptic plasticity and cue-reward learning, potentially representing a key mechanism underlying goal-directed behaviour... - Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-RasNeesha Suvarna
Ernest Gallo Research Center, Emeryville, California 94608, USA
J Biol Chem 280:31450-9. 2005..Our results suggest that addictive drugs such as ethanol alter NMDAR trafficking and subunit composition. This may be an important mechanism by which ethanol exerts its effects on NMDARs to produce alcohol-induced aberrant plasticity... - Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbensMiquel Martin
Ernest Gallo Clinic and Research Center, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
Nat Neurosci 9:868-9. 2006.... - Methylphenidate facilitates learning-induced amygdala plasticityKay M Tye
Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California, USA
Nat Neurosci 13:475-81. 2010..These findings reveal critical and distinct roles for dopamine receptor subtypes in mediating methylphenidate-induced enhancements of neural transmission and learning performance... - The SK channel as a novel target for treating alcohol use disordersFrederic W Hopf
Ernest Gallo Clinic and Research Center, University of California, San Francisco, USA
Channels (Austin) 5:289-92. 2011.... - The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preferenceDoo Sup Choi
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California, 94608, USA
Nat Neurosci 7:855-61. 2004..Our results indicate that ENT1 has a physiological role in ethanol-mediated behaviors and suggest that decreased A(1) adenosine receptor function promotes alcohol consumption... - Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neuronsMark A Ungless
Ernest Gallo Clinic and Research Center and Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
Neuron 39:401-7. 2003..These results provide evidence of the first specific roles for CRF-R2 and CRF-BP in the modulation of neuronal activity and suggest that NMDARs in the VTA may be a target for both drugs of abuse and stress... - Effects of stress and aversion on dopamine neurons: implications for addictionMark A Ungless
Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Neurosci Biobehav Rev 35:151-6. 2010..Finally, we examine how the effects of stress and cocaine interact and how these cellular mechanisms in ventral tegmental area dopamine neurons may be engaged in stress-induced relapse... - Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposureMiriam Melis
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California 94110, USA
J Neurosci 22:2074-82. 2002.... - Dopamine responsiveness is regulated by targeted sorting of D2 receptorsSelena E Bartlett
Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94608, USA
Proc Natl Acad Sci U S A 102:11521-6. 2005..Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors... - Kappa-opioid agonists directly inhibit midbrain dopaminergic neuronsElyssa B Margolis
Joint University of California San Francisco University of California, Berkeley Bioengineering Graduate Group, San Francisco, California 94143 0775, USA
J Neurosci 23:9981-6. 2003..These results provide a cellular mechanism for the opposing behavioral effects of KOR and MOR agonists and shed light on how KORs might regulate the motivational effects of both natural rewards and addictive drugs... - Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbensJonathan P Britt
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neuron 76:790-803. 2012..Finally, direct optical activation of medium spiny neurons proved to be capable of supporting self-stimulation, demonstrating that behavioral reinforcement is an explicit consequence of strong excitatory drive to the NAc... - A central role of the BK potassium channel in behavioral responses to ethanol in C. elegansAndrew G Davies
Ernest Gallo Clinic and Research Center, Department of Neurology, Program in Neuroscience, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, CA 94608, USA
Cell 115:655-66. 2003..elegans. BK channel activation may explain a variety of behavioral responses to ethanol in invertebrate and vertebrate systems... - Cooperative activation of dopamine D1 and D2 receptors increases spike firing of nucleus accumbens neurons via G-protein betagamma subunitsF Woodward Hopf
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
J Neurosci 23:5079-87. 2003..These results provide evidence for a novel cellular mechanism through which cooperative action of D1 and D2 receptors in the nucleus accumbens could mediate dopamine-dependent behaviors... - The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction?Antonello Bonci
Ernest Gallo Clinic and Research Center and Department of Neurology, University of California, San Francisco, CA 94110, USA
Trends Pharmacol Sci 24:172-7. 2003..Therefore, we suggest that both the modulation of dopamine release in the extracellular space and transient or enduring changes in the firing of dopamine-containing neurons could be associated with important features of drugs of abuse... - NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1Rami Yaka
Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA 94110 3518, USA
Proc Natl Acad Sci U S A 99:5710-5. 2002..Therefore, RACK1 is a regulator of NMDA receptor function and may play a role in synaptic plasticity, addiction, learning, and memory... - Synaptic plasticity and drug addictionSusan Jones
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Curr Opin Pharmacol 5:20-5. 2005..We hypothesize that drug-induced synaptic plasticity might play a role in reward-related learning and addiction by modifying the fine tuning of dopaminergic cell firing... - Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neuronsDaniel Saal
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
Neuron 37:577-82. 2003....