Research Topics
| JUDY BOLTONSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
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Publications
Potential mechanisms of estrogen quinone carcinogenesisJudy L Bolton
Department of Medicinal Chemisry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612 7231, USA
Chem Res Toxicol 21:93-101. 2008....
Quinoids formed from estrogens and antiestrogensJudy L Bolton
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612-7231, USA
Methods Enzymol 378:110-23. 2004- Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductaseBirgit M Dietz
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, USA
Chem Res Toxicol 18:1296-305. 2005..This suggests that XH induces QR by covalently modifying the Keap1 protein. Therefore, XH and hops dietary supplements might function as chemopreventive agents, through induction of detoxification enzymes such as QR... 
Estrogenic activity of the equine estrogen metabolite, 4-methoxyequileninMinsun Chang
Department of Medicinal Chemistry and Pharmacology, College of Pharmacy, University of Illinois, Chicago, IL, USA
Adv Exp Med Biol 617:601-7. 2008..Methylation of 4-OHEN may not represent a detoxification pathway, since 4-MeOEN is a full estrogen agonist with nanomolar potency...- Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principlesJoanna E Burdette
Department of Medicinal Chemistry and Pharmacognosy and UIC/NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Agric Food Chem 50:7022-8. 2002..These data suggest that black cohosh can protect against cellular DNA damage caused by reactive oxygen species by acting as antioxidants... - Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulatorHong Liu
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612-7231, USA
Chem Res Toxicol 19:779-87. 2006.... - Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formationHong Liu
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, USA
Chem Res Toxicol 18:162-73. 2005..In microsomal incubations of 4'-F-DMA in the presence of GSH, no GSH adducts were detected. These data suggest that 4'-F-DMA might be a promising SERM with similar activity to DMA and raloxifene and less toxicity... - Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methidesJu Liu
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, USA
Chem Res Toxicol 18:174-82. 2005..Acolbifene could also induce DNA damage in the S30 breast cancer cell line. These data imply that the classical electrophilic acolbifene quinone methide might contribute to the potential toxicity of acolbifene... - High-content screening and mechanism-based evaluation of estrogenic botanical extractsCassia R Overk
UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Comb Chem High Throughput Screen 11:283-93. 2008..In addition, possible explanations for the conflicts in the literature over the estrogenicity of Cimicifuga racemosa (black cohosh) are suggested... - Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense)Cassia R Overk
Department of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, M/C 781, University of Illinois, 833 South Wood Street, Chicago, Illinois 60612, USA
J Agric Food Chem 53:6246-53. 2005..9 microg/mL, respectively, in the alkaline phosphatase induction assay. On the basis of these data, hops and red clover could be attractive for the development as herbal dietary supplements to alleviate menopause-associated symptoms... - Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the NucleusZhican Wang
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois, Chicago, Illinois 60612 7231, USA
J Biol Chem 284:8633-42. 2009..The Trojan horse mechanism may be of general importance beyond estrogen genotoxins... - Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolitesXuemei Liu
Department of Medicinal Chemistry and Pharmacognosy (M/C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illnois 60612, USA
Chem Res Toxicol 16:832-7. 2003..However, catechols induced more DNA damage at nontoxic doses in breast cancer cells, which implies that o-quinones formed from catechols could contribute to genotoxicity in vivo, which is ER-dependent... - Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobioticsBolan Yu
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 60612, USA
Bioconjug Chem 20:728-41. 2009..For study of the protein targets of electrophilic metabolites formed by in situ oxidative bioactivation, the COATag is both sensitive and specific and does not appear to suffer from poor cell permeability... - Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1Guowen Liu
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 South Wood Street, Chicago, Illinois 60612-7231, USA
Anal Chem 77:6407-14. 2005..Therefore, this new mass spectrometric screening assay was demonstrated to facilitate the discovery of chemoprevention agents in complex natural product mixtures... - The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical useNorman R Farnsworth
University of Illinois at Chicago National Institutes of Health Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
Am J Clin Nutr 87:504S-8S. 2008..We conclude that this type of research can only be successful with the use of a multidisciplinary approach... - Medical potential of plants used by the Q'eqchi Maya of Livingston, Guatemala for the treatment of women's health complaintsJoanna Michel
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA
J Ethnopharmacol 114:92-101. 2007.... - Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanismsBolan Yu
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
Mol Cancer Ther 6:2418-28. 2007..The correlation of SERM structure with antioxidant activity and NQO1 induction also suggests that oxidative bioactivation of SERMs may be modulated to enhance chemopreventive activity... - Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cellsMinsun Chang
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Endocrinology 148:4793-802. 2007..Methylation of 4-OHEN may not represent a detoxification pathway because 4-MeOEN is a full, potent estrogen agonist... - Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinonesLinning Yu
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, USA
Chem Res Toxicol 17:879-88. 2004..These results suggest that raloxifene could be metabolized to electrophilic and redox active quinoids, which have the potential to cause toxicity in vivo... - Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trialStacie E Geller
Department of Obstetrics and Gynecology, Center for Research on Women and Gender, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Menopause 16:1156-66. 2009..The aim of this study was to evaluate the safety and efficacy of black cohosh and red clover compared with placebo for the relief of menopausal vasomotor symptoms... - Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alphaXuemei Liu
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, The University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
Chem Res Toxicol 15:512-9. 2002..These data suggest that the mechanism of DNA damage induced by equine estrogen metabolites could involve oxidative stress and that the estrogen receptor may play a role in this process... - Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1Birgit M Dietz
Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, Chicago, Illinois 60612 7231, USA
Chem Res Toxicol 21:1939-48. 2008..These observations suggest that A. sinensis dietary supplements standardized to ligustilide have potential as chemopreventive agents through induction of detoxification enzymes... - Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cellsZhican Wang
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
Chem Res Toxicol 22:1129-36. 2009..In conclusion, this newly developed LC-MS/MS method allows detection and relative quantification of 4-OHEN-DNA adducts in human breast cancer cells, which could be adapted for adduct detection in human samples... - Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogensJudy L Bolton
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612 7231, USA
Toxicology 177:55-65. 2002..The focus of this review is the role of quinoids, quinoid radicals, and phenoxyl radicals in the biological effects of estrogens and antiestrogens... - Altered apoptotic response in MCF 10A cells treated with the equine estrogen metabolite, 4-hydroxyequileninYan Li
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612 7231, USA
Toxicol Lett 154:225-33. 2004..These data indicate that long-term low-level equine estrogen metabolite exposure could induce DNA damage and initiate cells to become resistant to apoptosis... - The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extractNancy L Booth
UIC/NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA
J Altern Complement Med 12:133-9. 2006..This is the first report to thoroughly summarize the chemistry and biology of all major peaks observed in the HPLC-UV chromatogram of a clinical red clover dietary supplement... - Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cellsKuan Wei Peng
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
ACS Chem Biol 4:1039-49. 2009..The novel conjugation of quinone warheads to an ER-targeting SERM gives ER-dependent, enhanced apoptosis in mammary cancer cells of potential application in cancer therapy... - Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptorJoanna E Burdette
Department of Medicinal Chemistry and Pharmacognosy and UIC/NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, IL 60612, USA
J Agric Food Chem 51:5661-70. 2003..This study identifies other possible biological targets of black cohosh that could account for reported biological effects... - Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expressionMuriel Cuendet
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA
Mutat Res 550:109-21. 2004..Moreover, we showed the involvement of other genes important in cell transformation and oxidative stress, strengthening the hypothesis that this mechanism plays a considerable role in 4-OHEN-induced anchorage-independent growth... - Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferaseJiaqin Yao
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, 60612, USA
Chem Res Toxicol 16:668-75. 2003..These data suggest that inhibition of COMT methylation by 4-OHEN might reduce endogenous catechol estrogen clearance in vivo and further enhance toxicity... - In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringeninCassia R Overk
UIC NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences PCRPS, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, M C 781, Chicago, IL 60612, USA
Chem Biol Interact 176:30-9. 2008..lupulus and T. pratense extracts do not have an effect on the rat uterus, 8-PN at equivalent doses to those previously used in humans did have an effect, and may therefore have a deleterious effect in women... - Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifeneHong Liu
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M C 781, Chicago, Illinois 60612 7231, USA
Chem Res Toxicol 20:1676-84. 2007..The protein modification could be enhanced by the addition of H2O2 and decreased by the addition of NADPH, suggesting that unlike liver metabolism the formation of quinoids in the uterus could be mediated by uterine peroxidases... - Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferaseR Esala P Chandrasena
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
Chem Res Toxicol 21:1324-9. 2008..These results indicate that a key role for NQO1 and GST in direct detoxification of 4-hydroxy-estrogen quinones is problematic... - Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinityZhihui Qin
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
J Med Chem 50:2682-92. 2007..An efficient synthetic procedure is reported yielding benzothiophene SERMs wherein redox activity and ER affinity are modulated... - Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptorsYongkai Sun
Department of Medical Chemistry and Pharmacognosy, The University of Illinois College of Pharmacy, Chicago, Illinois 60612, USA
J Am Soc Mass Spectrom 16:271-9. 2005..Several characteristic recyclization pathways during tandem mass spectrometry were identified, which might be useful for distinguishing related estrogens... - Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley ratsJoanna E Burdette
Department of Medicinal Chemistry and Pharmacognosy and UIC/National Institutes of Health Center for Botanical and Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
J Nutr 132:27-30. 2002..Neither antiestrogenic nor additive estrogenic properties were observed in any of the tissues studied. These data suggest that red clover extract is weakly estrogenic in the ovariectomized rat model... - Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle studyJu Liu
Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612, USA
Chem Res Toxicol 18:1485-96. 2005..The identification of modified proteins is important for defining pathways that might lead alternatively to either cytotoxicity or cytoprotection... - Characterization of two new variants of human catechol O-methyltransferase in vitroYan Li
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612 7231, USA
Cancer Lett 230:81-9. 2005..Our data indicate that the Ala22Ser polymorphism might also be of functional significance and might play a role in susceptibility to estrogen-associated cancers... - Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activityNancy L Booth
UIC/NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, College of Pharmacy, University of Illinois at Chicago, M/C877, 833 South Wood Street, Chicago, Illinois 60612, USA
J Agric Food Chem 54:1277-82. 2006.... - Identification of novel electrophilic metabolites of piper methysticum Forst (Kava)Benjamin M Johnson
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612-7231, USA
Chem Res Toxicol 16:733-40. 2003..g., because of a drug interaction, genetic difference in enzyme expression, etc.) or if conjugation pathways become saturated... - Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1Jiaqin Yao
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
Chem Res Toxicol 15:935-42. 2002..These data suggest that GST P1-1 may be a preferred protein target for equine catechol estrogens in vivo... - Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen speciesVioleta Toader
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 Wood Street, Chicago, Illinois 60612-7231, USA
Chem Res Toxicol 16:1264-76. 2003..The ready autoxidation of raloxifene, observed in the presence of NO, is the first such observation on the reactivity of SERMs and is potentially a general phenomenon of significance to SERM chemical toxicology... - Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equileninXuemei Liu
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street M C 877, Chicago, Illinois 60612 7231, USA
Chem Res Toxicol 16:741-9. 2003..These data suggest that the 4-fluoroequilenin derivatives have promise as alternatives to traditional estrogen replacement therapy due to their similar estrogenic properties with less overall toxicity... - Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulatorsZhihui Qin
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Drug Metab Dispos 37:161-9. 2009..The predicted extensive metabolism of DMA was confirmed in vivo and compared with the relatively stable arzoxifene and F-DMA... - Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferaseYan Li
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
Chem Res Toxicol 17:512-20. 2004.... - In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituentSHARLA L POWELL
Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, M C 781, University of Illinois at Chicago, Chicago, Illinois 60612 7231, USA
J Agric Food Chem 56:11718-26. 2008..These data suggest N(omega)-methylserotonin may be responsible for the serotonergic activity of black cohosh... - Response of human mammary epithelial cells to DNA damage induced by 4-hydroxyequilenin: Lack of p53-mediated G1 arrestMuriel Cuendet
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA
Chem Biol Interact 161:271-8. 2006..However, 4-OHEN did not induce a G1 checkpoint and cells with damaged DNA accumulated in the S phase. This S phase delay could be beneficial for the survival of the damaged cells which could contribute to the carcinogenic process... - Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extractsTanja Gödecke
UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy and PCRPS, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Phytochem Anal 20:120-33. 2009..The discovery of strongly basic alkaloids, cimipronidines, from the active extract partition and evaluation of previously employed work-up procedures has led to the hypothesis of strong acid/base association in the extract... - Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometryYoung Geun Shin
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood St, Chicago, IL 60612-7231, USA
Comb Chem High Throughput Screen 5:59-64. 2002..This approach might be particularly useful for the ranking of a directed library of drug leads with respect to metabolic stability and then the selection of lead compounds for further drug development... - Estrogens and congeners from spent hops (Humulus lupulus)Lucas R Chadwick
UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Nat Prod 67:2024-32. 2004..The principle estrogen 8-prenylnaringenin (15) from hops is an artifact formed along with its positional isomer 6-prenylnaringenin (16) through the spontaneous isomerization of the pro-estrogenic chalcone DMX (7)... - Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensisShixin Deng
UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
J Nat Prod 69:536-41. 2006..Biosynthetic pathways for dimeric phthalides 3 and 4 are proposed. Compounds 5, 7, 11, 12, 15, and imperatorin exhibited affinity toward 5-HT(7) receptors in a competitive binding assay... - Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifeneCassia R Overk
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612, USA
ChemMedChem 2:1520-6. 2007..The in vitro studies were extended to the juvenile rat model, in which the desired antiestrogenic profile and putative cardiovascular benefits of SERMs were observed... - Botanical dietary supplements gone badBirgit Dietz
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
Chem Res Toxicol 20:586-90. 2007 - Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferaseYan Li
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood St, Chicago, IL 60612 7231, USA
Chem Biol Interact 152:151-63. 2005....
Research Grants
- CARCINOGENIC METABOLITES FORMED FROM ANTIESTROGENSJUDY BOLTON; Fiscal Year: 2006..abstract_text> ..
- CARCINOGENIC METABOLITES FORMED FROM ANTIESTROGENSJUDY BOLTON; Fiscal Year: 2007..1 2- 2 Description, ..
- Role of electrophilic/redox active quinoids in estrogen carcinogenesisJUDY BOLTON; Fiscal Year: 2007..These data will be correlated with the DNA damage experiments described in Aim 1 and the protein targets identified in Aim 2 in order to give an overall picture of the involvement of ERs in estrogen carcinogenesis. ..
- Carcinogenic Metabolites Formed from AntiestrogenJudy L Bolton; Fiscal Year: 2010..It is the focus of this proposal to investigate these potentially carcinogenic reactive compounds in an effort to provide crucial information leading to the development of the "perfect" SERM. ..
- Biotransformation of Estrogens to Carcinogenic QuinoidsJUDY BOLTON; Fiscal Year: 2005..These data will determine the role of quinoids in the carcinogenic effects of estrogens and provide a basis for the development of estrogen replacement drugs devoid of carcinogenic activity. ..
- CARCINOGENIC METABOLITES FORMED FROM ANTIESTROGENSJUDY BOLTON; Fiscal Year: 2002..These studies will greatly assist in the design of estrogen antagonists that maintain beneficial properties without generating genotoxic metabolites. ..
- CARCINOGENIC METABOLITES FORMED FROM ANTIESTROGENSJUDY BOLTON; Fiscal Year: 2003....
- Role of electrophilic/redox active quinoids in estrogen carcinogenesisJudy L Bolton; Fiscal Year: 2010..These data will be correlated with the DNA damage experiments described in Aim 1 and the protein targets identified in Aim 2 in order to give an overall picture of the involvement of ERs in estrogen carcinogenesis. ..