D C Bolser

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Older-generation antihistamines and cough due to upper airway cough syndrome (UACS): efficacy and mechanism
    Donald C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610 0144, USA
    Lung 186:S74-7. 2008
  2. ncbi request reprint Inspiratory and expiratory patterns of the pectoralis major muscle during pulmonary defensive reflexes
    D C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville, Florida 32612, USA
    J Appl Physiol 85:1786-92. 1998
  3. pmc Codeine and cough: an ineffective gold standard
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    Curr Opin Allergy Clin Immunol 7:32-6. 2007
  4. pmc Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Respir Physiol Neurobiol 152:255-65. 2006
  5. pmc Current and future centrally acting antitussives
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Respir Physiol Neurobiol 152:349-55. 2006
  6. pmc Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines
    Donald C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610 0144, USA
    Chest 129:238S-249S. 2006
  7. pmc Experimental models and mechanisms of enhanced coughing
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, P O Box 100144, Gainesville, FL 32610 0144, USA
    Pulm Pharmacol Ther 17:383-8. 2004
  8. ncbi request reprint Functional organization of the central cough generation mechanism
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0144, USA
    Pulm Pharmacol Ther 15:221-5. 2002
  9. ncbi request reprint Responses of the anterolateral abdominal muscles during cough and expiratory threshold loading in the cat
    D C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville, Florida 32612, USA
    J Appl Physiol 88:1207-14. 2000
  10. ncbi request reprint Influence of central antitussive drugs on the cough motor pattern
    D C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32606, USA
    J Appl Physiol 86:1017-24. 1999

Detail Information

Publications37

  1. pmc Older-generation antihistamines and cough due to upper airway cough syndrome (UACS): efficacy and mechanism
    Donald C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610 0144, USA
    Lung 186:S74-7. 2008
    ..Additional studies should be performed to document the activity of these drugs in double-blind placebo-controlled trials...
  2. ncbi request reprint Inspiratory and expiratory patterns of the pectoralis major muscle during pulmonary defensive reflexes
    D C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville, Florida 32612, USA
    J Appl Physiol 85:1786-92. 1998
    ..We conclude that, in contrast to the diaphragm or rectus abdominis muscles, the pectoralis major is active during both inspiratory and expiratory pulmonary defensive reflexes...
  3. pmc Codeine and cough: an ineffective gold standard
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    Curr Opin Allergy Clin Immunol 7:32-6. 2007
    ..Cough is one of the most common reasons why patients visit physicians. The opioid codeine has been a mainstay in the treatment of cough for decades and this drug is widely regarded as the 'gold standard' cough suppressant...
  4. pmc Neurogenesis of cough, other airway defensive behaviors and breathing: A holarchical system?
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Respir Physiol Neurobiol 152:255-65. 2006
    ..As such, co-expression of multiple rhythmic behaviors such as cough and swallow can occur without compromising airway defense...
  5. pmc Current and future centrally acting antitussives
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Respir Physiol Neurobiol 152:349-55. 2006
    ..Resolution of these issues in the human will be a challenging process, but one which will lay the foundation for the development of more effective cough suppressants...
  6. pmc Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines
    Donald C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610 0144, USA
    Chest 129:238S-249S. 2006
    ..The intent of this type of therapy is to reduce the frequency and/or intensity of coughing on a short-term basis...
  7. pmc Experimental models and mechanisms of enhanced coughing
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, P O Box 100144, Gainesville, FL 32610 0144, USA
    Pulm Pharmacol Ther 17:383-8. 2004
    ..Furthermore, we present a modified model of the neurogenesis of cough that takes into account peripheral and central plasticity induced by mediators of inflammation...
  8. ncbi request reprint Functional organization of the central cough generation mechanism
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0144, USA
    Pulm Pharmacol Ther 15:221-5. 2002
    ....
  9. ncbi request reprint Responses of the anterolateral abdominal muscles during cough and expiratory threshold loading in the cat
    D C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville, Florida 32612, USA
    J Appl Physiol 88:1207-14. 2000
    ..These results suggest that, unlike their behavior during expiratory loading, the anterolateral abdominal muscles act as a unit during cough...
  10. ncbi request reprint Influence of central antitussive drugs on the cough motor pattern
    D C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32606, USA
    J Appl Physiol 86:1017-24. 1999
    ..CTtot and inspiratory motor drive are relatively insensitive to the effects of these drugs. CTtot can be controlled independently from cough number...
  11. ncbi request reprint Volume-timing relationships during cough and resistive loading in the cat
    D C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville 32612, USA
    J Appl Physiol 89:785-90. 2000
    ..These results support separate ventilatory pattern regulation during cough that does not include modulation of phase durations by pulmonary volume-related feedback...
  12. ncbi request reprint Antitussive action of nociceptin in the cat
    D C Bolser
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610 0144, USA
    Eur J Pharmacol 430:107-11. 2001
    ..1 mg x kg(-1), i.v.). We conclude that intravenous nociceptin inhibits cough in the cat...
  13. pmc The effect of codeine on the Urge-to-Cough response to inhaled capsaicin
    P W Davenport
    Department of Physiological Sciences, University of Florida, P O Box 100144, HSC, Gainesville, FL 32610, USA
    Pulm Pharmacol Ther 20:338-46. 2007
    ..The response of subjects to inhalation of capsaicin consisted of both a sensory component leading to perception of an Urge-to-Cough and motor cough behavior...
  14. pmc Respiratory recovery following high cervical hemisection
    M S Sandhu
    Department of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Respir Physiol Neurobiol 169:94-101. 2009
    ..1+/-0.19ms lag from zero on the abscissa. These data are consistent with prolonged conduction time to IL (vs. CL) PhrMNs and the possibility of polysynaptic inputs to IL PhrMNs after chronic C2HS...
  15. ncbi request reprint Altered respiratory motor drive after spinal cord injury: supraspinal and bilateral effects of a unilateral lesion
    F J Golder
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 21:8680-9. 2001
    ..Some of these effects may be modulated by serotonin-containing neurons...
  16. pmc Capsaicin exposure elicits complex airway defensive motor patterns in normal humans in a concentration-dependent manner
    A Vovk
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Pulm Pharmacol Ther 20:423-32. 2007
    ....
  17. pmc Microinjection of codeine into the region of the caudal ventral respiratory column suppresses cough in anesthetized cats
    Ivan Poliacek
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA
    J Appl Physiol 108:858-65. 2010
    ..01). These results suggest that 1) codeine can act within the cVRC to suppress cough and 2) expiratory premotoneurons within the cVRC are relatively insensitive to this opioid...
  18. ncbi request reprint Respiratory motor recovery after unilateral spinal cord injury: eliminating crossed phrenic activity decreases tidal volume and increases contralateral respiratory motor output
    Francis J Golder
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 23:2494-501. 2003
    ..Moreover, by preventing ipsilateral phrenic motor recovery in rats with unilateral SCI, segmental and supraspinal changes could be induced in contralateral respiratory motor output beyond that seen with SCI alone...
  19. pmc Influence of microinjections of D,L-homocysteic acid into the Botzinger complex area on the cough reflex in the cat
    I Poliacek
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA
    J Physiol Pharmacol 59:585-96. 2008
    ..The results support predominantly inhibitory effects of neurons in the region of the Bötzinger complex on cough abdominal activity and cough number...
  20. pmc Urge to cough with voluntary suppression following mechanical pharyngeal stimulation
    K W Hegland
    Department of Physiological Sciences, University of Florida, Gainesville, Florida 32608, USA
    Bratisl Lek Listy 112:109-14. 2011
    ..The goal of this project was to determine if mechanical stimulation to the posterolateral oropharynx would elicit the urge-to-cough and/or cough...
  21. ncbi request reprint Cervical spinal cord injury alters the pattern of breathing in anesthetized rats
    F J Golder
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    J Appl Physiol 91:2451-8. 2001
    ..In conclusion, C(2) hemisection alters the pattern of breathing at 1 and 2 mo postinjury via vagal mechanisms...
  22. pmc Poster discussion: summary. Fifth International Cough Symposium
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0144, USA
    Pulm Pharmacol Ther 22:163-5. 2009
    ..At the Fifth International Cough Symposium 16 posters were presented and, as well as discussions at the poster sites, were considered in a formal symposium session. Here they are divided into groups and we summarize the discussions...
  23. pmc The urge-to-cough and cough motor response modulation by the central effects of nicotine
    Paul W Davenport
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA
    Pulm Pharmacol Ther 22:82-9. 2009
    ....
  24. pmc Recovery of airway protective behaviors after spinal cord injury
    Donald C Bolser
    Dept of Physiological Sciences, College of Veterinary Medicine, University of Florida, United States
    Respir Physiol Neurobiol 169:150-6. 2009
    ..These mechanisms may contribute to functional resiliency of the cough reflex that has been observed following chronic spinal cord injury in the cat...
  25. pmc Cervical prephrenic interneurons in the normal and lesioned spinal cord of the adult rat
    Michael A Lane
    Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Comp Neurol 511:692-709. 2008
    ..Their connectivity and relative stability after cervical hemisection raise speculation for potentially diverse roles in modulating phrenic function normally and postinjury...
  26. ncbi request reprint Gray matter repair in the cervical spinal cord
    Paul J Reier
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Box 100244, Gainesville, FL 32610 0244, USA
    Prog Brain Res 137:49-70. 2002
  27. pmc Pharmacologic management of cough
    Donald C Bolser
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0144, USA
    Otolaryngol Clin North Am 43:147-55, xi. 2010
    ..No pharmacologic treatments ae available for dystussia, but scientists and clinicians with experience in studying chronic cough are well qualified to develop methodologies to address the problem of impaired cough...
  28. pmc Modest spontaneous recovery of ventilation following chronic high cervical hemisection in rats
    D D Fuller
    University of Florida, College of Health and Health Professions, Department of Physical Therapy, 100 Newell Drive, Gainesville, FL 32610, USA
    Exp Neurol 211:97-106. 2008
    ..2-week post-injury. We conclude that recovery of ventilation deficits occurs over 2-12-week post-C2HS; however, intrinsic neuroplasticity remains insufficient to concurrently restore a normal level of ipsilateral phrenic output...
  29. pmc Augmented breath phase volume and timing relationships in the anesthetized rat
    Francis J Golder
    Department of Physiological Sciences, University of Florida, Gainesville, FL, USA
    Neurosci Lett 373:89-93. 2005
    ..These data support the hypothesis that multiple respiratory behaviors occur following dynamic reconfiguration of the respiratory neural network...
  30. pmc Expiratory muscle strength training in persons with multiple sclerosis having mild to moderate disability: effect on maximal expiratory pressure, pulmonary function, and maximal voluntary cough
    Toni Chiara
    Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, FL 32608, USA
    Arch Phys Med Rehabil 87:468-73. 2006
    ..To determine the effect of expiratory muscle strength training (EMST) on maximal expiratory strength, pulmonary function, and maximal voluntary cough in persons with multiple sclerosis (MS) having mild to moderate disability...
  31. pmc Cough following low thoracic hemisection in the cat
    Stephanie C Jefferson
    Brain Rehabilitation and Research Center, Malcom Randall VA Medical Center, Gainesville, FL 32608, USA
    Exp Neurol 222:165-70. 2010
    ....
  32. pmc Microinjection of DLH into the region of the caudal ventral respiratory column in the cat: evidence for an endogenous cough-suppressant mechanism
    Ivan Poliacek
    Dept of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0144, USA
    J Appl Physiol 102:1014-21. 2007
    ..These results suggest that an endogenous cough suppressant neuronal network in the region of the cVRC may exist, and this network may be involved in the control of cough reflex excitability...
  33. pmc Brainstem circuitry of tracheal-bronchial cough: c-fos study in anesthetized cats
    Jan Jakus
    Department of Medical Biophysics, Comenius University Bratislava, Jessenius Faculty of Medicine, Mala Hora 4, 03754 Martin, Slovakia
    Respir Physiol Neurobiol 160:289-300. 2008
    ..02). Results of this study suggest a large medullary - pontine - mesencephalic neuronal circuit involved in the control of the tracheal-bronchial cough in cats...
  34. pmc Brainstem regions involved in the expiration reflex. A c-fos study in anesthetized cats
    Ivan Poliacek
    Department of Medical Biophysics, Comenius University Bratislava, Jessenius Faculty of Medicine, Mala Hora 4, 03754, Martin, Slovakia
    Brain Res 1184:168-77. 2007
    ..The FLI related to the expulsive behavior ER differs from that induced by laryngeal stimulation and laryngeal adductor responses, particularly in ventrolateral medulla and mesencephalon...
  35. ncbi request reprint Antitussive effect of nociceptin/orphanin FQ in experimental cough models
    Robbie L McLeod
    Department of Allergy, Schering Plough Research Institute, Kenilworth, NJ, 07033 0539, USA
    Pulm Pharmacol Ther 15:213-6. 2002
    ..Presently, we discuss preclinical findings showing that activation of the 'opioid-like' receptor (NOP(1)) inhibits cough in the guinea pig and cat...
  36. ncbi request reprint Summary: animal models for cough
    Maria G Belvisi
    Respiratory Pharmacology Group, Cardiothoracic Surgery, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Pulm Pharmacol Ther 15:249-50. 2002
  37. pmc Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines
    Richard S Irwin
    University of Massachusetts Medical School, Room S6 842, 55 Lake Ave North, Worcester, MA 01655, USA
    Chest 129:1S-23S. 2006