R Bolli

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8692-7. 2005
  2. pmc Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction
    Buddhadeb Dawn
    Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    Stem Cells 26:1646-55. 2008
  3. doi request reprint Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy
    Roberto Bolli
    Division of Cardiovascular Medicine and Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Circulation 128:122-31. 2013
  4. pmc Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance
    Atul R Chugh
    Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA
    Circulation 126:S54-64. 2012
  5. pmc Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning
    Roberto Bolli
    Division of Cardiology, University of Louisville, 550 South Jackson St, KY 40202, USA
    Cardiovasc Res 55:506-19. 2002
  6. pmc Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
    Roberto Bolli
    Divisions of Cardiovascular Medicine, University of Louisville, Louisville, KY 40202, USA
    Lancet 378:1847-57. 2011
  7. ncbi request reprint The late phase of preconditioning
    R Bolli
    Division of Cardiology, University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    Circ Res 87:972-83. 2000
  8. ncbi request reprint The role of sodium-hydrogen ion exchange in patients undergoing coronary artery bypass grafting
    Roberto Bolli
    Division of Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    J Card Surg 18:21-6. 2003
  9. pmc Preconditioning: a paradigm shift in the biology of myocardial ischemia
    Roberto Bolli
    Division of Cardiology, Univ of Louisville, 550 S Jackson St, ACB, 3rd Floor, Louisville, KY 40292, USA
    Am J Physiol Heart Circ Physiol 292:H19-27. 2007
  10. ncbi request reprint Why myocardial stunning is clinically important
    R Bolli
    Division of Cardiology, University of Louisville, Kentucky 40292, USA
    Basic Res Cardiol 93:169-72. 1998

Research Grants

  1. Hematopoietic Stem Cell Therapy for Myocardial Regeneration
    Roberto Bolli; Fiscal Year: 2007
  2. Mechanisms of Cardioprotection
    Roberto Bolli; Fiscal Year: 2007
  3. OXYGEN RADICALS AND CARDIAC ADAPTATIONS TO ISCHEMIA
    Roberto Bolli; Fiscal Year: 2007
  4. MOLECULAR BASIS OF PRECONDITIONING
    Roberto Bolli; Fiscal Year: 2003
  5. OXYGEN RADICALS AND POSTISCHEMIC DYSFUNCTION
    Roberto Bolli; Fiscal Year: 2002

Detail Information

Publications111 found, 100 shown here

  1. pmc Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8692-7. 2005
    ..The loss of functionally competent CSCs in chronic ischemic cardiomyopathy may underlie the progressive functional deterioration and the onset of terminal failure...
  2. pmc Transplantation of bone marrow-derived very small embryonic-like stem cells attenuates left ventricular dysfunction and remodeling after myocardial infarction
    Buddhadeb Dawn
    Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    Stem Cells 26:1646-55. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  3. doi request reprint Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy
    Roberto Bolli
    Division of Cardiovascular Medicine and Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Circulation 128:122-31. 2013
    ..The present study was undertaken to determine whether intracoronary CSCs are beneficial in a porcine model of chronic ischemic cardiomyopathy...
  4. pmc Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance
    Atul R Chugh
    Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA
    Circulation 126:S54-64. 2012
    ..In the present study, we report the surgical aspects and interim cardiac magnetic resonance (CMR) results...
  5. pmc Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning
    Roberto Bolli
    Division of Cardiology, University of Louisville, 550 South Jackson St, KY 40202, USA
    Cardiovasc Res 55:506-19. 2002
    ....
  6. pmc Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
    Roberto Bolli
    Divisions of Cardiovascular Medicine, University of Louisville, Louisville, KY 40202, USA
    Lancet 378:1847-57. 2011
    ..We undertook a phase 1 trial (Stem Cell Infusion in Patients with Ischemic cardiOmyopathy [SCIPIO]) of autologous CSCs for the treatment of heart failure resulting from ischaemic heart disease...
  7. ncbi request reprint The late phase of preconditioning
    R Bolli
    Division of Cardiology, University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    Circ Res 87:972-83. 2000
    ..The purpose of this review is to summarize current information regarding the pathophysiology and mechanism of late PC...
  8. ncbi request reprint The role of sodium-hydrogen ion exchange in patients undergoing coronary artery bypass grafting
    Roberto Bolli
    Division of Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    J Card Surg 18:21-6. 2003
    ....
  9. pmc Preconditioning: a paradigm shift in the biology of myocardial ischemia
    Roberto Bolli
    Division of Cardiology, Univ of Louisville, 550 S Jackson St, ACB, 3rd Floor, Louisville, KY 40292, USA
    Am J Physiol Heart Circ Physiol 292:H19-27. 2007
    ....
  10. ncbi request reprint Why myocardial stunning is clinically important
    R Bolli
    Division of Cardiology, University of Louisville, Kentucky 40292, USA
    Basic Res Cardiol 93:169-72. 1998
    ..This may turn out to be the major clinical importance of myocardial stunning...
  11. pmc The late phase of preconditioning and its natural clinical application--gene therapy
    Roberto Bolli
    Division of Cardiology, University of Louisville, 550 S Jackson Street, ACB, Louisville, KY 40292, USA
    Heart Fail Rev 12:189-99. 2007
    ....
  12. ncbi request reprint Role of the JAK-STAT pathway in protection against myocardial ischemia/reperfusion injury
    Roberto Bolli
    Experimental Research Laboratory, Division of Cardiology, University of Louisville, Louisville, KY 40292, USA
    Trends Cardiovasc Med 13:72-9. 2003
    ..The present review focuses on this novel cardioprotective role of JAK-STAT signaling and on its potential exploitation for developing therapeutic strategies aimed at limiting ischemia/reperfusion injury...
  13. ncbi request reprint Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning
    P Ping
    Experimental Research Laboratory, Division of Cardiology, and the Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40202, USA
    Circ Res 84:587-604. 1999
    ....
  14. ncbi request reprint Targeted deletion of the A3 adenosine receptor confers resistance to myocardial ischemic injury and does not prevent early preconditioning
    Y Guo
    Division of Cardiology, University of Louisville and Jewish Heart and Lung Institute, Louisville, Kentucky 40202, USA
    J Mol Cell Cardiol 33:825-30. 2001
    ....
  15. ncbi request reprint PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits
    P Ping
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville, Kentucky 40202, USA
    Am J Physiol 276:H1468-81. 1999
    ..The results are compatible with the hypothesis that p44 and p42 MAPKs may play a role in myocardial adaptations to ischemic stress...
  16. ncbi request reprint Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits
    P Ping
    Experimental Research Laboratory, Division of Cardiology and the Department of Physiology and Biophysics, University of Louisville and Jewish Hospital Heart and Lung Institute, KY 40202, USA
    Circ Res 85:542-50. 1999
    ....
  17. ncbi request reprint Protein kinase C epsilon-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling
    T M Vondriska
    Department of Physiology, Division of Cardiology, University of Louisville, Louisville, KY, USA
    Circ Res 88:1306-13. 2001
    ....
  18. ncbi request reprint Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide
    R Bolli
    Experimental Research Laboratory, University of Louisville, KY 40292, USA
    Circ Res 81:42-52. 1997
    ....
  19. ncbi request reprint Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity
    P Ping
    Department of Physiology and Biophysics, University of Louisville, KY 40202, USA
    Circ Res 81:404-14. 1997
    ..The results are consistent with the concept that the epsilon and eta isozymes play an important role in the genesis of ischemic PC in the conscious rabbit...
  20. pmc Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarction
    Q Li
    Cardiology Research Laboratory, Division of Cardiology, University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville, KY, USA
    Circulation 103:1893-8. 2001
    ..01 group II versus group I). CONCLUSIONS: Direct gene transfer of the cDNA encoding membrane-bound Ec-SOD affords powerful cardioprotection, providing proof of principle for the effectiveness of antioxidant gene therapy against MI...
  21. ncbi request reprint PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression
    J M Pass
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    Am J Physiol Heart Circ Physiol 280:H946-55. 2001
    ..Our observations demonstrate that RACK expression is dynamically regulated by PKCepsilon and suggest that differential patterns of PKCepsilon-RACK interactions may be important determinants of PKCepsilon-dependent cardiac phenotypes...
  22. ncbi request reprint Cyclooxygenase-2 does not mediate late preconditioning induced by activation of adenosine A1 or A3 receptors
    E Kodani
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and Jewish Heart and Lung Institute, Louisville, Kentucky 40292, USA
    Am J Physiol Heart Circ Physiol 281:H959-68. 2001
    ..9 +/- 3.7% (n = 9)]. Taken together, these results demonstrate that, in contrast to ischemia-induced late PC, the mechanisms of adenosine A1 or A3 receptor-induced late PC is independent of COX-2...
  23. ncbi request reprint Protection of IB-MECA against myocardial stunning in conscious rabbits is not mediated by the A1 adenosine receptor
    E Kodani
    Division of Cardiology, University of Louisville, and Jewish Heart and Lung Institute, KY 40292, USA
    Basic Res Cardiol 96:487-96. 2001
    ....
  24. ncbi request reprint Delayed preconditioning-mimetic action of nitroglycerin in patients undergoing coronary angioplasty
    M A Leesar
    Division of Cardiology, University of Louisville, and Jewish Hospital Heart and Lung Institute, Louisville, KY, USA
    Circulation 103:2935-41. 2001
    ..The results suggest that prophylactic administration of nitrates could be a novel approach to the protection of the ischemic myocardium in patients...
  25. pmc IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2
    Buddhadeb Dawn
    Institute of Molecular Cardiology, Division of Cardiology, University of Louisville, Louisville, KY 40292, USA
    Cardiovasc Res 64:61-71. 2004
    ..We sought to determine whether interleukin (IL)-6 modulates myocardial infarction or the late phase of preconditioning (PC)...
  26. ncbi request reprint Nitroglycerin induces late preconditioning against myocardial infarction in conscious rabbits despite development of nitrate tolerance
    M Hill
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville, KY, USA
    Circulation 104:694-9. 2001
    ..These findings reveal a new action of nitrates and support novel applications of these drugs for protecting the ischemic myocardium in patients...
  27. pmc An essential role of the JAK-STAT pathway in ischemic preconditioning
    Y T Xuan
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    Proc Natl Acad Sci U S A 98:9050-5. 2001
    ..The results reveal a signaling mechanism that underlies the transcriptional up-regulation of the cardiac iNOS gene and the adaptation of the heart to ischemic stress...
  28. pmc Mechanism of cyclooxygenase-2 upregulation in late preconditioning
    Yu Ting Xuan
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    J Mol Cell Cardiol 35:525-37. 2003
    ..To our knowledge, this is the first evidence that myocardial COX-2 is upregulated via a JAK1/2-STAT1/3 pathway...
  29. ncbi request reprint Cardiac stem cell therapy for myocardial regeneration. A clinical perspective
    B Dawn
    Institute of Molecular Cardiology, Division of Cardiology, University of Louisville, Louisville, KY 40292, USA
    Minerva Cardioangiol 53:549-64. 2005
    ....
  30. ncbi request reprint Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection
    P Ping
    Department of Physiology, Division of Cardiology, University of Louisville, KY, USA
    Circ Res 88:59-62. 2001
    ..The results suggest heretofore-unrecognized functions of PKCepsilon and provide an integrated framework for the understanding of PKCepsilon-dependent signaling architecture and cardioprotection...
  31. ncbi request reprint Effect of aspirin on late preconditioning against myocardial stunning in conscious rabbits
    Ken Shinmura
    Experimental Research Laboratory, Division of Cardiology, University of Louisville, and the Jewish Hospital Heart and Lung Institute, Kentucky 40292, USA
    J Am Coll Cardiol 41:1183-94. 2003
    ..The goal of this study was to investigate the effect of three different doses of acetylsalicylic acid (aspirin) (ASA) on the late phase of ischemic preconditioning (PC) against myocardial stunning...
  32. pmc Delayed adaptation of the heart to stress: late preconditioning
    Adam B Stein
    Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Stroke 35:2676-9. 2004
    ..The purpose of this review is to summarize the mechanisms that underlie the late phase of ischemic PC...
  33. ncbi request reprint Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection
    Christopher P Baines
    Department of Physiology, University of Louisville, and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40202, USA
    Circ Res 90:390-7. 2002
    ..Furthermore, formation of mitochondrial PKCepsilon-ERK modules appears to play a role in PKCepsilon-mediated cardioprotection, in part by the phosphorylation and inactivation of Bad...
  34. ncbi request reprint Inducible nitric oxide synthase modulates cyclooxygenase-2 activity in the heart of conscious rabbits during the late phase of ischemic preconditioning
    Ken Shinmura
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    Circ Res 90:602-8. 2002
    ..NO-mediated activation of COX-2 may be a heretofore unrecognized mechanism by which NO exerts its salubrious effects in the late phase of PC...
  35. ncbi request reprint A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms
    H Takano
    Division of Cardiology, University of Louisville and Jewish Heart and Lung Institute, Louisville, KY, USA
    Circ Res 88:520-8. 2001
    ..However, A(1)AR-induced late PC uses an NOS-dependent pathway whereas A(3)AR-induced late PC is mediated by an NOS-independent pathway...
  36. pmc Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and delta1-opioid receptor agonists is mediated by iNOS
    Yiru Guo
    Institute of Molecular Cardiology, Univ of Louisville, Louisville, KY, USA
    Am J Physiol Heart Circ Physiol 289:H2251-7. 2005
    ....
  37. pmc Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition
    Matthew B West
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
    Circulation 118:1970-8. 2008
    ..In addition, it remains unclear whether sustained elevation of iNOS in myocytes provides chronic protection against ischemia/reperfusion injury...
  38. pmc Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning
    Yu Ting Xuan
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circulation 112:1971-8. 2005
    ....
  39. pmc Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function
    Buddhadeb Dawn
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circ Res 98:1098-105. 2006
    ....
  40. ncbi request reprint Role of nitric oxide in myocardial preconditioning
    Buddhadeb Dawn
    Experimental Research Laboratory, Division of Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    Ann N Y Acad Sci 962:18-41. 2002
    ..The purpose of this review is to summarize the current evidence in support of this critical role played by NO in ischemic PC...
  41. pmc Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction
    Magda Kucia
    Stem Cell Biology Program, University of Louisville, Louisville, Ken 40202, USA
    Circ Res 95:1191-9. 2004
    ..The present findings provide a novel paradigm that could reconcile current controversies and a rationale for investigating the use of BM-derived cardiac progenitors for myocardial regeneration...
  42. ncbi request reprint Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1
    J M Pass
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Heart Circ Physiol 281:H2500-10. 2001
    ....
  43. ncbi request reprint Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research
    R Bolli
    Division of Cardiology, University of Louisville and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    J Mol Cell Cardiol 33:1897-918. 2001
    ..The time has come to translate this enormous body of experimental evidence into clinically useful therapies by harnessing the cytoprotective properties of NO...
  44. ncbi request reprint Causative role of oxyradicals in myocardial stunning: a proven hypothesis. A brief review of the evidence demonstrating a major role of reactive oxygen species in several forms of postischemic dysfunction
    R Bolli
    Division of Cardiology, University of Louisville, Kentucky 40292, USA
    Basic Res Cardiol 93:156-62. 1998
    ..The major challenge for future studies will be to identify the specific molecular targets of ROS-mediated damage and to decipher the pathways whereby ROS and calcium interact in the genesis of myocardial stunning...
  45. pmc Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function
    Buddhadeb Dawn
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Proc Natl Acad Sci U S A 102:3766-71. 2005
    ..The results establish CSCs as candidates for cardiac regeneration and support an approach in which the heart's own stem cells could be collected, expanded, and stored for subsequent therapeutic repair...
  46. pmc Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment
    Buddhadeb Dawn
    Division of Cardiology, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Basic Res Cardiol 100:494-503. 2005
    ..The purpose of this review is to critically examine the available evidence regarding the ability of adult BMCs to regenerate non-hematopoietic tissues and their utility in therapeutic cardiac regeneration...
  47. ncbi request reprint The ubiquitous role of nitric oxide in cardioprotection
    Steven P Jones
    Department of Medicine, Institute of Molecular Cardiology, University of Louisville, 570 S Preston Street, Baxter I 119, Louisville, KY 40292, USA
    J Mol Cell Cardiol 40:16-23. 2006
    ....
  48. pmc The beneficial effects of postinfarct cytokine combination therapy are sustained during long-term follow-up
    Santosh K Sanganalmath
    Institute of Molecular Cardiology, University of Louisville, Division of Cardiovascular Medicine, 550 S Jackson St, ACB, 3rd Floor, Louisville, KY 40292, USA
    J Mol Cell Cardiol 47:528-35. 2009
    ..To our knowledge, this is the first long-term study of cytokines in postinfarction LV remodeling. The results reveal heretofore unknown differential actions of cytokines and have important translational implications...
  49. pmc Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart
    Guangwu Wang
    Division of Cardiovascular Medicine, Institute of Molecular Cardiology, Department of Medicine, University of Louisville, ACB, Third Floor, 550 S Jackson St, Louisville, KY 40202, USA
    Circulation 121:1912-25. 2010
    ..However, its pathophysiological role in cardiac remodeling and chronic heart failure (HF) is unknown. We hypothesized that induction of HO-1 in HF alleviates pathological remodeling...
  50. pmc Hepatocyte growth factor/Met gene transfer in cardiac stem cells--potential for cardiac repair
    Rosalinda Madonna
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
    Basic Res Cardiol 105:443-52. 2010
    ..Here, we discuss the possible application of HGF/Met gene therapy to enhance the ability of CSCs to promote myocardial regeneration...
  51. pmc Cardiac progenitor cells and bone marrow-derived very small embryonic-like stem cells for cardiac repair after myocardial infarction
    Xian Liang Tang
    Division of Cardiovascular Medicine and Institute of Molecular Cardiology, University of Louisville, KY 40292, USA
    Circ J 74:390-404. 2010
    ..This report summarizes the current data from those studies and discusses the potential implication of these cells in developing clinically-relevant stem cell-based therapeutic strategies for cardiac regeneration...
  52. pmc Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction
    Xian Liang Tang
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circulation 121:293-305. 2010
    ..Therefore, we sought to determine whether CPCs are beneficial in the more clinically relevant setting of an old MI (scar)...
  53. pmc Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase C epsilon p44/42 mitogen-activated protein kinase pSer-signal transducers and activators of transcription1/3 pathway
    Yu Ting Xuan
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circulation 116:535-44. 2007
    ..The role of endothelial nitric oxide synthase (eNOS) in ischemic preconditioning (PC) and cardioprotection is poorly understood. We addressed this issue using a genetic, rather than pharmacological, approach...
  54. pmc Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis
    Xiaofeng Hu
    Institute of Molecular Cardiology, Division of Cardiology, University of Louisville, Louisville, KY 40202, USA
    Circulation 116:654-63. 2007
    ..However, the role of the SDF-1alpha-CXCR4 axis in modulating myocardial ischemia/reperfusion injury is unknown...
  55. pmc Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-kappaB dependent pathway
    Qianhong Li
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
    Circulation 116:1577-84. 2007
    ..Accordingly, we used genetically engineered mice to test the hypothesis that the cardioprotection afforded by iNOS gene transfer is mediated by COX-2 upregulation via a nuclear factor (NF)-kappaB-dependent pathway...
  56. ncbi request reprint Tumor necrosis factor-alpha does not modulate ischemia/reperfusion injury in naïve myocardium but is essential for the development of late preconditioning
    Buddhadeb Dawn
    Experimental Research Laboratory, Division of Cardiology, University of Louisville, and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    J Mol Cell Cardiol 37:51-61. 2004
    ....
  57. pmc Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection
    Peipei Ping
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky, USA
    J Clin Invest 109:499-507. 2002
    ..Thus, PKCepsilon-Lck modules may serve as novel therapeutic targets for the prevention of ischemic injury...
  58. ncbi request reprint Nitric oxide (NO) induces nitration of protein kinase Cepsilon (PKCepsilon ), facilitating PKCepsilon translocation via enhanced PKCepsilon -RACK2 interactions: a novel mechanism of no-triggered activation of PKCepsilon
    Zarema Balafanova
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 277:15021-7. 2002
    ..These findings offer a plausible novel mechanism by which NO activates the PKC signaling pathway...
  59. ncbi request reprint Delta-opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits
    Eitaro Kodani
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and Jewish Heart and Lung Institute, Louisville, KY 40292, USA
    Am J Physiol Heart Circ Physiol 283:H1943-57. 2002
    ..These results demonstrate that activation of delta-opioid receptors induces late PC against both stunning and infarction via a COX-2-dependent mechanism...
  60. pmc Gene therapy with inducible nitric oxide synthase protects against myocardial infarction via a cyclooxygenase-2-dependent mechanism
    Qianhong Li
    Division of Cardiology, University of Louisville, The Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    Circ Res 92:741-8. 2003
    ..We propose that iNOS and COX-2 form a stress-responsive functional module that mitigates ischemia/reperfusion injury...
  61. ncbi request reprint Use of fractional flow reserve versus stress perfusion scintigraphy after unstable angina. Effect on duration of hospitalization, cost, procedural characteristics, and clinical outcome
    Massoud A Leesar
    Division of Cardiology, University of Louisville and Jewish Hospital Heart and Lung Institute, Kentucky 40292, USA
    J Am Coll Cardiol 41:1115-21. 2003
    ..The present study sought to determine the value of fractional flow reserve (FFR) compared with stress perfusion scintigraphy (SPS) in patients with recent unstable angina/non-ST-segment elevation myocardial infarction (UA/NSTEMI)...
  62. ncbi request reprint Role of Src protein tyrosine kinases in late preconditioning against myocardial infarction
    Buddhadeb Dawn
    Experimental Research Laboratory, Division of Cardiology, University of Louisville, Louisville, KY 40292, USA
    Am J Physiol Heart Circ Physiol 283:H549-56. 2002
    ..Taken together with previous studies in the setting of stunning, these findings reveal heretofore unrecognized differences in the roles of Src PTKs in late PC against stunning versus late PC against infarction...
  63. pmc Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria
    Christopher P Baines
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA
    Circ Res 92:873-80. 2003
    ..This in turn inhibits the pathological function of the pore and contributes to PKCepsilon-induced cardioprotection...
  64. ncbi request reprint Cardiac-specific abrogation of NF- kappa B activation in mice by transdominant expression of a mutant I kappa B alpha
    B Dawn
    Division of Cardiology, University of Louisville, and the Jewish Hospital Heart and Lung Institute, Louisville, KY 40292, USA
    J Mol Cell Cardiol 33:161-73. 2001
    ....
  65. pmc The cardioprotection of the late phase of ischemic preconditioning is enhanced by postconditioning via a COX-2-mediated mechanism in conscious rats
    Hiroshi Sato
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Heart Circ Physiol 293:H2557-64. 2007
    ..In conclusion, the combination of late PC and postconditioning produces additive protection, likely due to a postconditioning-induced enhancement of COX-2 activity...
  66. ncbi request reprint Role of cyclic guanosine monophosphate in late preconditioning in conscious rabbits
    Eitaro Kodani
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and the Jewish Heart and Lung Institute, Louisville, KY 40292, USA
    Circulation 105:3046-52. 2002
    ..The objective of this study was to investigate the role of sGC in late PC in conscious rabbits using the selective sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ)...
  67. ncbi request reprint Nonelectrocardiographic evidence that both ischemic preconditioning and adenosine preconditioning exist in humans
    Massoud A Leesar
    Division of Cardiology, University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville, Kentucky 40292, USA
    J Am Coll Cardiol 42:437-45. 2003
    ..The objective of this study was to use electrocardiogram (ECG)-independent parameters to determine whether preconditioning (PC) exists in humans during percutaneous transluminal coronary angioplasty (PTCA)...
  68. pmc Gene therapy with iNOS provides long-term protection against myocardial infarction without adverse functional consequences
    Qianhong Li
    Institute of Molecular Cardiology, Univ of Louisville, Louisville, KY, USA
    Am J Physiol Heart Circ Physiol 290:H584-9. 2006
    ....
  69. ncbi request reprint Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning
    Ken Shinmura
    Experimental Research Laboratory, Division of Cardiology, University of Louisville and Jewish Hospital Heart and Lung Institute, Louisville, KY, USA
    Circ Res 91:240-6. 2002
    ..Furthermore, the data suggest that myocardial ischemia/reperfusion injury is due in part to the generation of lipid peroxidation products and that late PC diminishes this source of injury by upregulating AR...
  70. pmc Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction
    Ewa K Zuba-Surma
    Stem Cell Institute, University of Louisville, Louisville, KY 40202, USA
    J Mol Cell Cardiol 44:865-73. 2008
    ..This is the first demonstration that Oct-4+ pluripotent stem cells (VSELs) are mobilized from the BM into the PB after acute MI. This phenomenon may have pathophysiological and therapeutic implications for repair of infarcted myocardium...
  71. pmc Hypercholesterolemia blunts NO donor-induced late preconditioning against myocardial infarction in conscious rabbits
    Xian Liang Tang
    Division of Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    Basic Res Cardiol 99:395-403. 2004
    ....
  72. ncbi request reprint Cardioprotection during the final stage of the late phase of ischemic preconditioning is mediated by neuronal NO synthase in concert with cyclooxygenase-2
    Yang Wang
    Institute of Molecular Cardiology, University of Louisville and the Jewish Hospital Heart and Lung Institute, Louisville, KY, USA
    Circ Res 95:84-91. 2004
    ..These data identify, for the first time, a cardioprotective role of nNOS and demonstrate, surprisingly, that the mechanism of late PC differs at 72 hours (nNOS) versus 24 hours (iNOS)...
  73. pmc Endothelial nitric oxide synthase is not necessary for the early phase of ischemic preconditioning in the mouse
    Yiru Guo
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    J Mol Cell Cardiol 44:496-501. 2008
    ..Early PC is not eNOS-dependent, at least in this species...
  74. pmc The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene
    Y Guo
    Experimental Research Laboratory, Division of Cardiology, University of Louisville, Louisville, KY 40292, USA
    Proc Natl Acad Sci U S A 96:11507-12. 1999
    ..Thus, this study identifies a specific protein that mediates late PC in vivo...
  75. ncbi request reprint Protein tyrosine kinase signaling is necessary for NO donor-induced late preconditioning against myocardial stunning
    Xian Liang Tang
    Experimental Research Laboratory, Division of Cardiology, University of Louisville, and Jewish Hospital Heart and Lung Institute, Louisville, Kentucky 40292, USA
    Am J Physiol Heart Circ Physiol 284:H1441-8. 2003
    ..We conclude that a PTK-dependent signaling mechanism is necessary for the development of NO donor-induced late PC against myocardial stunning in conscious rabbits...
  76. doi request reprint Fms-related tyrosine kinase 3 expression discriminates hematopoietic stem cells subpopulations with differing engraftment-potential: identifying the most potent combination
    Yiming Huang
    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY 40202 1760, USA
    Transplantation 85:1175-84. 2008
    ..FL significantly mobilized c-Kit(hi) and c-Kit(lo) Sca-1(+)Lin(-) cells into peripheral blood (PB). Here, we evaluated the influence of Flt3 expression on long-term repopulating ability of HSC subpopulations...
  77. pmc The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning
    Michael P Flaherty
    Division of Cardiovascular Medicine and the Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    J Mol Cell Cardiol 45:735-41. 2008
    ....
  78. ncbi request reprint Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis
    Ahmed Abdel-Latif
    Division of Cardiology, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Arch Intern Med 167:989-97. 2007
    ..However, the effects of BMC transplantation in patients with ischemic heart disease remains unclear...
  79. pmc Granulocyte colony-stimulating factor therapy for cardiac repair after acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials
    Ahmed Abdel-Latif
    Division of Cardiology and Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Am Heart J 156:216-226.e9. 2008
    ..The effect of G-CSF therapy on left ventricular (LV) function and structure in these patients remains unclear...
  80. ncbi request reprint Pretreatment with intracoronary enalaprilat protects human myocardium during percutaneous coronary angioplasty
    Massoud A Leesar
    Division of Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    J Am Coll Cardiol 49:1607-10. 2007
    ..We tested the hypothesis that enalaprilat induces preconditioning (PC)-mimetic actions in patients with stable coronary artery disease...
  81. pmc Nicorandil induces late preconditioning against myocardial infarction in conscious rabbits
    Xian Liang Tang
    Institute of Moleculat Cardiology, University of Louisville, Louisville, KY 40292, USA
    Am J Physiol Heart Circ Physiol 286:H1273-80. 2004
    ..We conclude that nicorandil induces delayed cardioprotection against myocardial infarction similar to that afforded by the late phase of ischemic PC, possibly by upregulating COX-2 and Bcl-2...
  82. ncbi request reprint Sca-1 expression is associated with decreased cardiomyogenic differentiation potential of skeletal muscle-derived adult primitive cells
    Ewa K Zuba-Surma
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    J Mol Cell Cardiol 41:650-60. 2006
    ....
  83. doi request reprint Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells
    Michael P Flaherty
    Division of Cardiology, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circulation 117:2241-52. 2008
    ..In addition, the role of Wnt signaling in cardiomyogenic differentiation of adult cells is unclear...
  84. pmc Gene transfer of inducible nitric oxide synthase affords cardioprotection by upregulating heme oxygenase-1 via a nuclear factor-{kappa}B-dependent pathway
    Qianhong Li
    Division of Cardiology, University of Louisville, Louisville, KY 40292, USA
    Circulation 120:1222-30. 2009
    ..Although inducible nitric oxide synthase (iNOS) is known to impart powerful protection against myocardial infarction, the mechanism for this salubrious action remains unclear...
  85. ncbi request reprint Foreword--focused issue on cardiac repair by stem cells
    Roberto Bolli
    Louisville, KY, USA
    Basic Res Cardiol 100:469-70. 2005
  86. pmc Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo
    Yiru Guo
    Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky 40292, USA
    Am J Physiol Heart Circ Physiol 286:H1649-53. 2004
    ..8% (n = 14), P < 0.05]. CORM-3 did not increase carboxyhemoglobin levels in the blood. These results suggest that a novel class of drugs, CO-releasing molecules, can be useful to limit myocardial ischemia-reperfusion injury in vivo...
  87. pmc Hypercholesterolemia abrogates late preconditioning via a tetrahydrobiopterin-dependent mechanism in conscious rabbits
    Xian Liang Tang
    Institute of Molecular Cardiology, University of Louisville, The Jewish Hospital Heart and Lung Institute, Louisville, KY, USA
    Circulation 112:2149-56. 2005
    ..The goal of this study was to determine whether the infarct-sparing effect of late PC is affected by hypercholesterolemia and, if so, whether a tetrahydrobiopterin (BH4)-dependent mechanism is responsible for the loss of late PC...
  88. pmc Chronic AMD3100 antagonism of SDF-1alpha-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction
    Shujing Dai
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    J Mol Cell Cardiol 49:587-97. 2010
    ....
  89. ncbi request reprint Oxidant species trigger late preconditioning against myocardial stunning in conscious rabbits
    Xian Liang Tang
    Experimental Research Laboratory, Division of Cardiology, University of Louisville, Louisville, KY 40292, USA
    Am J Physiol Heart Circ Physiol 282:H281-91. 2002
    ..In addition, the finding that exogenous ROS (CuOOH) reproduced the phenotype of late PC indicates that ROS are not only necessary but also sufficient to trigger this defensive adaptation of the heart to stress...
  90. pmc Cell therapy for ischaemic heart disease: focus on the role of resident cardiac stem cells
    S A J Chamuleau
    Institute of Molecular Cardiology, University of Louisville, KY, USA, Department of Cardiology, Academic Medical Center, University of Amsterdam, Interuniversity Cardiology Institute of The Netherlands and Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neth Heart J 17:199-207. 2009
    ..This review will discuss current views regarding the feasibility of cardiac repair, and focus on the potential role of the resident cardiac stem and progenitor cells. (Neth Heart J 2009;17:199-207.)...
  91. pmc Cardioprotection by postconditioning in conscious rats is limited to coronary occlusions <45 min
    Xian Liang Tang
    Division of Cardiology, Univ of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 291:H2308-17. 2006
    ..However, all studies reported to date have been conducted in open-chest animal models. We sought to determine whether postconditioning occurs in conscious animals and whether it protects against severe myocardial injury...
  92. doi request reprint Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection
    Guang Wu Wang
    Department of Physiology and the Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Mol Cell Cardiol 44:1016-22. 2008
    ..Consumption of an aldehyde-rich diet could exacerbate cardiac IR injury and block NO donor-induced cardioprotection via mechanisms that disrupt PKCepsilon signaling...
  93. ncbi request reprint Expression of activated PKC epsilon (PKC epsilon) protects the ischemic heart, without attenuating ischemic H(+) production
    Heather R Cross
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Mol Cell Cardiol 34:361-7. 2002
    ..Protection occurred in the PKC epsilon hearts without attenuation of ischemic H(+) production, implying that, at least in this ischemic model, reduced acidification during ischemia is not necessary for cardioprotection...
  94. pmc Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function
    Marcello Rota
    Department of Anesthesia and Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:107-16. 2008
    ..These forms of treatments could be repeated over time to reduce progressively tissue scarring and expand the working myocardium...
  95. pmc Gene dosage-dependent effects of cardiac-specific overexpression of the A3 adenosine receptor
    Richard G Black
    Department of Pharmacology and Toxicology and the Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Circ Res 91:165-72. 2002
    ....
  96. ncbi request reprint Bmx, a member of the Tec family of nonreceptor tyrosine kinases, is a novel participant in pharmacological cardioprotection
    Jun Zhang
    Department of Physiology, Cardiovascular Research Laboratories, Suite 1619 MRL Bldg, 675 Charles E Young Dr, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 287:H2364-6. 2004
    ..These findings indicate that a novel type of PKC-tyrosine kinase module (involving Bmx) is formed in the heart and may be involved in pharmacological cardioprotection by NO donors...
  97. ncbi request reprint Bone marrow cells for cardiac regeneration: the quest for the protagonist continues
    Buddhadeb Dawn
    Cardiovasc Res 65:293-5. 2005
  98. ncbi request reprint Gender and aging do not impair opioid-induced late preconditioning in rats
    Ken Shinmura
    Division of Geriatric Medicine, Dept of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku Tokyo 160 8582, Japan
    Basic Res Cardiol 99:46-55. 2004
    ..In conclusion, BW373U86-induced late preconditioning can be observed in aged and female hearts. A COX-2-dependent increase in PGI(2) production is essential for BW373U86-induced late PC in both sexes and in both young and old rats...
  99. ncbi request reprint Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia
    Faisal M Syed
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Circ Res 96:1103-9. 2005
    ....
  100. ncbi request reprint Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study
    Steven W Boyce
    Washington Hospital Center, 106 Irving Street NW, Suite 316, South Tower, Washington, DC 20010, USA
    J Thorac Cardiovasc Surg 126:420-7. 2003
    ..To evaluate the effects of cariporide on all-cause mortality or myocardial infarction at 36 days in patients at risk of myocardial necrosis after coronary artery bypass graft surgery...
  101. ncbi request reprint Molecular genetic advances in cardiovascular medicine: focus on the myocyte
    Piero Anversa
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Vosburgh Pavilion Room 302A, Valhalla, NY 10595, USA
    Circulation 109:2832-8. 2004

Research Grants23

  1. Hematopoietic Stem Cell Therapy for Myocardial Regeneration
    Roberto Bolli; Fiscal Year: 2007
    ..The results may eventually lead to the development of novel therapeutic strategies in patients with ischemic heart disease. ..
  2. Mechanisms of Cardioprotection
    Roberto Bolli; Fiscal Year: 2007
    ....
  3. OXYGEN RADICALS AND CARDIAC ADAPTATIONS TO ISCHEMIA
    Roberto Bolli; Fiscal Year: 2007
    ..Elucidation of the mechanism of exercise PC may have important therapeutic implications. ..
  4. MOLECULAR BASIS OF PRECONDITIONING
    Roberto Bolli; Fiscal Year: 2003
    ..this project should produce important new insights into the molecular mechanisms that underlie COX-2-dependent cytoprotection, late PC, and the role of COX-2 in cardiac pathophysiology in general. ..
  5. OXYGEN RADICALS AND POSTISCHEMIC DYSFUNCTION
    Roberto Bolli; Fiscal Year: 2002
    ..Elucidation of the mechanism of late PC should facilitate the development of drugs that duplicate its powerful cardioprotective effects. ..