C R Boland
Affiliation: University of California
- A rat virus visits the clinic: translating basic discoveries into clinical medicine in the 21st centuryC R Boland
Department of Medicine and Comprehensive Cancer Center, University of California San Diego, La Jolla, CA, USA
Gut 52:8-9. 2003
- A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancerC R Boland
University of California, San Diego, La Jolla 92093 0688, USA
Cancer Res 58:5248-57. 1998..f) The spectrum of microsatellite alterations in noncolonic tumors was reviewed, and it was concluded that the above recommendations apply only to colorectal neoplasms. (g) A research agenda was recommended...
- How many mutations does it take to make a tumor?C R Boland
Department of Medicine, University of California, San Diego, CA 92093 0688, USA
Proc Natl Acad Sci U S A 96:14675-7. 1999
- Molecular genetics of hereditary nonpolyposis colorectal cancerC R Boland
Department of Medicine, University of California at San Diego, California 92037, USA
Ann N Y Acad Sci 910:50-9; discussion 59-61. 2000..Certain pathological features have been identified that suggest that colon cancers have developed in the setting of defective DNA MMR...
- Antisense inhibition of hMLH1 is not sufficient for loss of DNA mismatch repair function in the HCT116+chromosome 3 cell lineD P Chauhan
Department of Medicine and Cancer Center, The University of California San Diego, La Jolla 92093 0688, USA
Clin Cancer Res 6:3827-31. 2000..Alternatively, Chr3 may contain a second hMLH1 homologue that might overlap with the function of hMLH1...
- Mismatch repair proficiency and in vitro response to 5-fluorouracilJ M Carethers
Department of Medicine, University of California, USA
Gastroenterology 117:123-31. 1999..Because defects in the MMR system can confer tolerance to acquired DNA damage and, by inference, the toxic effects of certain chemotherapeutic agents, we investigated the effect of 5-fluorouracil (5-FU) on colon cancer cell lines...
- Oxidative stress increases frameshift mutations in human colorectal cancer cellsC Gasche
Department of Medicine and Cancer Center, University of California at San Diego, La Jolla, California 92093-0688, USA
Cancer Res 61:7444-8. 2001..These data indicate that oxidative stress is a potential mutagen leading to accumulation of frameshift mutations and may contribute to MSI in the setting of chronic inflammation...
- Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissuesL Ricciardiello
Department of Medicine, University of California, San Diego, La Jolla, California 92093-0688, USA
J Virol 75:1996-2001. 2001..This strain may be involved in the development of chromosomal instability...
- Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndromeJ M Carethers
Department of Medicine, Cancer Center, University of California, San Diego 92093 0688, USA
Cancer Res 58:2724-6. 1998..Thus, other mechanisms besides mutation of PTEN must have occurred to cause BRRS in these patients. We speculate that BRRS and juvenile polyposis syndrome may have a heterogeneous etiology to cause their syndromes...
- Germline characterization of early-aged onset of hereditary non-polyposis colorectal cancerS C Huang
Division of Gastroenterology and Nutrition, Department of Pediatrics, University of California, San Diego, California, USA
J Pediatr 138:629-35. 2001..Adolescent colorectal cancer is unusual in HNPCC families. We speculated that some DNA mismatch repair germline mutations might be associated with early onset of disease...
- Genetic pathways in the evolution of morphologically distinct colorectal neoplasmsM Yashiro
Department of Medicine, University of California, San Diego, La Jolla 92093-0688, USA
Cancer Res 61:2676-83. 2001..There may be more than one genetic avenue for colorectal cancer formation, and this correlates with the morphological characteristics...
- Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancerJ M Carethers
Department of Medicine, University of California, San Diego, USA
Gastroenterology 114:1188-95. 1998..e., Dukes' B2) colorectal cancer. Our aim was to assess whether the DCC gene locus was responsible...
- JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tractL Ricciardiello
Department of Medicine and Cancer Center, University of California San Diego, and San Diego Veteran Affairs Medical Center, La Jolla, California 92093 0688, USA
Gastroenterology 119:1228-35. 2000..The mode of transmission of this virus is unclear, and we hypothesized that the gastrointestinal (GI) tract may be a reservoir for the virus...
- Steady-state regulation of the human DNA mismatch repair systemD K Chang
Department of Medicine and Cancer Center, University of California, San Diego, California 92093, USA
J Biol Chem 275:18424-31. 2000..A balanced up-regulation of all of the components was seen after viral transformation in a fibroblast model. Quantitative changes of the MMR components are a potential mechanism to modify the DNA MMR capabilities of a cell...
- Infection, inflammation, and gastrointestinal cancerC R Boland
Division of Gastroenterology, Department of Medicine, Baylor University Medical Center, Dallas, TX 75246, USA
Gut 54:1321-31. 2005
- Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cellsA Goel
Division of Gastroenterology, Department of Medicine, The University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0688, USA
Cancer Lett 172:111-8. 2001..These data suggest that a non-toxic concentration of curcumin has a significant effect on the in vitro growth of HT-29 cells, specifically inhibits COX-2 expression, and may have value as a safe chemopreventive agent for colon cancer...
- JC virus: a biomarker for colorectal cancer?F F Shadan
Department of Medicine and Comprehensive Cancer Center, UCSD, School of Medicine, La Jolla, California, USA
Med Hypotheses 59:667-9. 2002....
- Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancerK Krishnan
Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University and Medical Service, James H. Quillen Veterans Affairs Medical Center, Johnson City, Tennessee 37604, USA
Cancer Epidemiol Biomarkers Prev 10:447-53. 2001..Colorectal mucosal prostaglandin concentration may be used as a "drug-effect surrogate biomarker," that is, a surrogate to assess sufficient delivery and tissue effect of a chemopreventive agent...
- Conversion of diploidy to haploidyH Yan
Howard Hughes Medical Institute, The Oncology Center, Department of Mathematical Sciences, The Johns Hopkins University, Baltimore, Maryland 21231, USA
Nature 403:723-4. 2000
- The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC)--results of an international collaborative studyW Muller
Institute of Pathology, Heinrich Heine University, Dusseldorf, Germany
Fam Cancer 1:87-92. 2001..This study demonstrates the potential utility of immunohistochemistry in detecting HNPCC probands and identifies key technical components for successful staining...