Research Topics
Genomes and GenesSpecies | Gregory P BoivinSummaryAffiliation: University of Cincinnati Country: USA Publications
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Detail Information
Publications
Effects of mechanical stimulation on the biomechanics and histology of stem cell-collagen sponge constructs for rabbit patellar tendon repairNatalia Juncosa-Melvin
Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221-0048, USA
Tissue Eng 12:2291-300. 2006..This study shows that mechanical stimulation of stem cell-collagen sponge constructs can significantly improve tendon repair biomechanics up to and well beyond the functional limits of in vivo loading...
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancerSergio Kaiser
Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Genome Biol 8:R131. 2007..5-18.5...- Pathology of mouse models of intestinal cancer: consensus report and recommendationsGregory P Boivin
Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
Gastroenterology 124:762-77. 2003 - Mechanical stimulation of tendon tissue engineered constructs: effects on construct stiffness, repair biomechanics, and their correlationJason T Shearn
Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Mail Location 0048, Cincinnati, OH 45221 0048, USA
J Biomech Eng 129:848-54. 2007..56) as were their linear moduli (r=0.68). Such in vitro predictors of in vivo outcome hold the potential to speed the development of tissue engineered products by reducing the time and costs of in vivo studies... - The effect of autologous mesenchymal stem cells on the biomechanics and histology of gel-collagen sponge constructs used for rabbit patellar tendon repairNatalia Juncosa-Melvin
Department of Biomedical Engineering, University of Cincinnati, Ohio, USA
Tissue Eng 12:369-79. 2006..This study shows that introducing autogenous mesenchymal stem cells into a gel-collagen sponge composite significantly improves tendon repair compared to the use of a gel-sponge composite alone in the range of in vivo loading... - Effects of cell-to-collagen ratio in mesenchymal stem cell-seeded implants on tendon repair biomechanics and histologyNatalia Juncosa-Melvin
Noyes Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, OH 45221, USA
Tissue Eng 11:448-57. 2005..Current repairs achieved higher maximum forces than in previous studies and without ectopic bone, but will need to achieve sufficient stiffness as well to be effective in the in vivo range of loading... - Modeling variation in tumors in vivoJames R Stringer
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267 0524, USA
Proc Natl Acad Sci U S A 102:2408-13. 2005..Although genetic instability appeared to have occurred in most tumors, large clusters were much more common than expected based on instability alone... - Characterization of in vivo Achilles tendon forces in rabbits during treadmill locomotion at varying speeds and inclinationsJohn R West
Noyes-Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221-0041, USA
J Biomech 37:1647-53. 2004..Force patterns can also serve as input data for mechanical stimulation of tissue-engineered constructs in culture. Such approaches are expected to help accelerate tendon repair after injury... - Repair of patellar tendon injuries using a cell-collagen compositeHani A Awad
Noyes-Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, P.O. Box 210048, OH 45221-0048, USA
J Orthop Res 21:420-31. 2003.... - In vivo forces used to develop design parameters for tissue engineered implants for rabbit patellar tendon repairNatalia Juncosa
Noyes-Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, P.O. Box 210048, Cincinnati, OH 45221-0048, USA
J Biomech 36:483-8. 2003..001). Such design criteria should be useful in mechanically stimulating cell-gel constructs for tendon repair... - Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulationDavid L Butler
Department of Biomedical Engineering, 840 Engineering Research Center, Colleges of Engineering and Medicine, University of Cincinnati, 2901 Woodside Drive, Cincinnati, Ohio 45221 0048, USA
J Orthop Res 26:1-9. 2008..Our contributions in the area of tendon functional tissue engineering have the potential to create functional load-bearing repairs that will revolutionize surgical reconstruction after tendon and ligament injury... - Effects of cell-to-collagen ratio in stem cell-seeded constructs for Achilles tendon repairNatalia Juncosa-Melvin
Noyes Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Ohio 45221-0048, USA
Tissue Eng 12:681-9. 2006.... - Wnt/beta-catenin signaling is required for development of the exocrine pancreasJames M Wells
Department of Developmental Biology, Cincinnati Children s Hospital Research 45267, Cincinnati, OH 45267, USA
BMC Dev Biol 7:4. 2007..A Pdx1-cre mouse line was used to delete a floxed beta-catenin allele specifically in the developing pancreas, and embryonic pancreata were studied by immunohistochemistry and microarray analysis... - Precancer in mice: animal models used to understand, prevent, and treat human precancersRobert D Cardiff
The UCD Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
Toxicol Pathol 34:699-707. 2006..These studies suggest that genetically engineered mice are very useful preclinical models for chemoprevention and therapy... - Self-antigen recognition by TGF beta1-deficient T cells causes their activation and systemic inflammationRamireddy Bommireddy
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Lab Invest 86:1008-19. 2006..Thus, TGFbeta1 is required for the prevention of autoimmune disease through its ability to control the activation of autoreactive T cells to self-Ag... - RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesisChristopher N Mayhew
Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, Ohio 45267 0521, USA
Gastroenterology 133:976-84. 2007..We investigated the impact of RB loss on carcinogen-induced liver tumorigenesis... - Effect of age on collagen fibril diameter in rabbit patellar tendon repairAngela M Sklenka
Department of Pathology, Quantitative Analysis/Operations Management, University of Cincinnati, Cincinnati, Ohio, USA
Comp Med 56:8-11. 2006..This study found that collagen fibril diameter was not altered with increasing age in the healing rabbit patellar tendon... - Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendationsRalph H Hruban
Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Cancer Res 66:95-106. 2006.... - Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient miceRamireddy Bommireddy
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Cell Immunol 232:96-104. 2004..However, though TGFbeta1-deficient B cells are hyperresponsive to stimulation, alone they are not sufficient to cause inflammation... - Cardiac-specific blockade of NF-kappaB in cardiac pathophysiology: differences between acute and chronic stimuli in vivoMaria Brown
Dept. of Pharmacology and Cell Biophysics, 231 Albert Sabin Way, ML0575, Univ. of Cincinnati, Cincinnati, OH 45267-0575, USA
Am J Physiol Heart Circ Physiol 289:H466-76. 2005.... - Mouse Models of Intestinal CancerGregory P Boivin
Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Center, Ohio 45267-5029, USA
Comp Med 54:15-8. 2004 - The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn miceAmy E Moseley
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA
J Biol Chem 278:5317-24. 2003..These data demonstrate that the Na,K-ATPase alpha2 isoform could be important in the modulation of neuronal activity in the neonate... - Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient miceSandra J Engle
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
Cancer Res 62:6362-6. 2002..This animal model should provide insight into the protective role of TGF-beta1 in early stages of ulcerative colitis-associated human colon cancer... - Enhanced tumor formation in mice heterozygous for Blm mutationKathleen Heppner Goss
Department of Department of Molecular Genetics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
Science 297:2051-3. 2002..These observations indicate that Blm is a modifier of tumor formation in the mouse and that Blm haploinsufficiency is associated with tumor predisposition, a finding with important implications for cancer risk in humans...
Research Grants
- Cancer Center Tumor Phenotyping CoreGregory Boivin; Fiscal Year: 2006..Expansion of personnel and availability of supply dollars will allow this core to serve numerous investigators in the cancer community. ..