Gregory P Boivin

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Effects of mechanical stimulation on the biomechanics and histology of stem cell-collagen sponge constructs for rabbit patellar tendon repair
    Natalia Juncosa-Melvin
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng 12:2291-300. 2006
  2. ncbi Pathology of mouse models of intestinal cancer: consensus report and recommendations
    Gregory P Boivin
    Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Gastroenterology 124:762-77. 2003
  3. ncbi TGF-beta 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes
    Ramireddy Bommireddy
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 170:4612-22. 2003
  4. doi The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons
    David L Butler
    Department of Biomedical Engineering, Colleges of Engineering and Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Protoc 5:849-63. 2010
  5. pmc Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Cell Immunol 232:96-104. 2004
  6. pmc Self-antigen recognition by TGF beta1-deficient T cells causes their activation and systemic inflammation
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Lab Invest 86:1008-19. 2006
  7. doi Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors
    David L Myer
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Mutat Res 714:1-10. 2011
  8. pmc TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Immunol 170:3645-52. 2003
  9. pmc The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis
    Yunxia Fan
    Department of Environmental Health, University of Cincinnati Medical Center, College of Medicine, Cincinnati, Ohio 45267 0056, USA
    Cancer Res 70:212-20. 2010
  10. ncbi Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice
    Sandra J Engle
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Cancer Res 62:6362-6. 2002

Research Grants

  1. Cancer Center Tumor Phenotyping Core
    Gregory Boivin; Fiscal Year: 2006

Collaborators

Detail Information

Publications36

  1. ncbi Effects of mechanical stimulation on the biomechanics and histology of stem cell-collagen sponge constructs for rabbit patellar tendon repair
    Natalia Juncosa-Melvin
    Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    Tissue Eng 12:2291-300. 2006
    ..This study shows that mechanical stimulation of stem cell-collagen sponge constructs can significantly improve tendon repair biomechanics up to and well beyond the functional limits of in vivo loading...
  2. ncbi Pathology of mouse models of intestinal cancer: consensus report and recommendations
    Gregory P Boivin
    Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio 45267, USA
    Gastroenterology 124:762-77. 2003
  3. ncbi TGF-beta 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes
    Ramireddy Bommireddy
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 170:4612-22. 2003
    ..Together, these results demonstrate that the ex vivo proliferative hyporesponsiveness of Tgfb1(-/-) splenic lymphocytes is due to prior in vivo activation of T cells resulting from deregulated intracellular Ca(2+) levels...
  4. doi The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons
    David L Butler
    Department of Biomedical Engineering, Colleges of Engineering and Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Protoc 5:849-63. 2010
    ..The in vivo portion, from TEC implantation to limb harvest, takes 84 d. One complete loop around the tissue engineering road map, as presented here, takes 138 d to complete...
  5. pmc Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Cell Immunol 232:96-104. 2004
    ..However, though TGFbeta1-deficient B cells are hyperresponsive to stimulation, alone they are not sufficient to cause inflammation...
  6. pmc Self-antigen recognition by TGF beta1-deficient T cells causes their activation and systemic inflammation
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Lab Invest 86:1008-19. 2006
    ..Thus, TGFbeta1 is required for the prevention of autoimmune disease through its ability to control the activation of autoreactive T cells to self-Ag...
  7. doi Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors
    David L Myer
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Mutat Res 714:1-10. 2011
    ..However, neither this compromised DNA damage checkpoint nor reduced susceptibility to proteasome-mediated degradation after DNA damage translated into a significant increase in tumor incidence in the Plk3-deficient mice...
  8. pmc TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Immunol 170:3645-52. 2003
    ..Consequently, TGFbeta1 prevents autoimmune disease through a Ca(2+) regulatory pathway that maintains the activation threshold above that inducible by self-MHC-TCR interactions...
  9. pmc The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis
    Yunxia Fan
    Department of Environmental Health, University of Cincinnati Medical Center, College of Medicine, Cincinnati, Ohio 45267 0056, USA
    Cancer Res 70:212-20. 2010
    ..These data support the concept that in its basal state in the absence of a xenobiotic ligand, the Ahr gene functions as a tumor suppressor gene, and that its silencing may be associated with cancer progression...
  10. ncbi Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice
    Sandra J Engle
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Cancer Res 62:6362-6. 2002
    ..This animal model should provide insight into the protective role of TGF-beta1 in early stages of ulcerative colitis-associated human colon cancer...
  11. pmc Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias
    El Mustapha Bahassi
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 106:17111-6. 2009
    ....
  12. pmc An ACE inhibitor reduces Th2 cytokines and TGF-beta1 and TGF-beta2 isoforms in murine lupus nephritis
    Deijanira Alves De Albuquerque
    Department of Internal Medicine, University of Cincinnati College of Medicine, Veterans Administration Medical Center and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45267 0563, USA
    Kidney Int 65:846-59. 2004
    ..Here, we examine the effects of treatment with captopril on lupus nephritis and discuss the potential mechanism(s) by which this agent exerts its renoprotective effects...
  13. ncbi Mouse Models of Intestinal Cancer
    Gregory P Boivin
    Department of Pathology and Laboratory Medicine, University of Cincinnati and Cincinnati Veterans Affairs Center, Ohio 45267 5029, USA
    Comp Med 54:15-8. 2004
  14. ncbi RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis
    Christopher N Mayhew
    Department of Cell and Cancer Biology, University of Cincinnati, Cincinnati, Ohio 45267 0521, USA
    Gastroenterology 133:976-84. 2007
    ..We investigated the impact of RB loss on carcinogen-induced liver tumorigenesis...
  15. ncbi Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility
    Vikram Prasad
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Cancer Res 65:8655-61. 2005
    ..These findings show that SERCA2 haploinsufficiency predisposes mice to tumor development via a novel mode of cancer susceptibility involving a global change in the tumorigenic potential of keratinized epithelium in Atp2a2+/- mice...
  16. pmc Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Sergio Kaiser
    Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Genome Biol 8:R131. 2007
    ..5-18.5...
  17. pmc Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex
    Jitesh D Kawedia
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    Proc Natl Acad Sci U S A 104:3621-6. 2007
    ..These findings reveal the existence of a gender-influenced molecular mechanism involving AQP5 that allows transcellular and paracellular routes of water transport to act in conjunction...
  18. doi Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days
    Patrick Tso
    Department of Pathology, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237 0507, USA
    Food Chem Toxicol 50:1911-9. 2012
    ..We conclude that HGSO is biologically equivalent to borage oil and provides a safe alternative source of GLA in the diet...
  19. pmc Wnt/beta-catenin signaling is required for development of the exocrine pancreas
    James M Wells
    Department of Developmental Biology, Cincinnati Children s Hospital Research 45267, Cincinnati, OH 45267, USA
    BMC Dev Biol 7:4. 2007
    ..A Pdx1-cre mouse line was used to delete a floxed beta-catenin allele specifically in the developing pancreas, and embryonic pancreata were studied by immunohistochemistry and microarray analysis...
  20. pmc Daily exercise training protects against albuminuria and angiotensin converting enzyme 2 shedding in db/db diabetic mice
    Hari K Somineni
    Departments of Pharmacology and Toxicology Pathology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio 45435, USA Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    J Endocrinol 221:235-51. 2014
    ..Urinary ACE2 could serve as a prognostic tool for the progression of kidney damage and its attenuation by exercise may partially contribute to its renal protection. ..
  21. ncbi Enhanced tumor formation in mice heterozygous for Blm mutation
    Kathleen Heppner Goss
    Department of Department of Molecular Genetics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Science 297:2051-3. 2002
    ..These observations indicate that Blm is a modifier of tumor formation in the mouse and that Blm haploinsufficiency is associated with tumor predisposition, a finding with important implications for cancer risk in humans...
  22. ncbi Pituitary tumorigenesis in prolactin gene-disrupted mice
    Martha E Cruz-Soto
    Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Endocrinology 143:4429-36. 2002
    ....
  23. ncbi Mechanical stimulation of tendon tissue engineered constructs: effects on construct stiffness, repair biomechanics, and their correlation
    Jason T Shearn
    Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Mail Location 0048, Cincinnati, OH 45221 0048, USA
    J Biomech Eng 129:848-54. 2007
    ..56) as were their linear moduli (r=0.68). Such in vitro predictors of in vivo outcome hold the potential to speed the development of tissue engineered products by reducing the time and costs of in vivo studies...
  24. ncbi Cardiac-specific blockade of NF-kappaB in cardiac pathophysiology: differences between acute and chronic stimuli in vivo
    Maria Brown
    Dept of Pharmacology and Cell Biophysics, 231 Albert Sabin Way, ML0575, Univ of Cincinnati, Cincinnati, OH 45267 0575, USA
    Am J Physiol Heart Circ Physiol 289:H466-76. 2005
    ....
  25. ncbi The effect of autologous mesenchymal stem cells on the biomechanics and histology of gel-collagen sponge constructs used for rabbit patellar tendon repair
    Natalia Juncosa-Melvin
    Department of Biomedical Engineering, University of Cincinnati, Ohio, USA
    Tissue Eng 12:369-79. 2006
    ..This study shows that introducing autogenous mesenchymal stem cells into a gel-collagen sponge composite significantly improves tendon repair compared to the use of a gel-sponge composite alone in the range of in vivo loading...
  26. ncbi In vivo forces used to develop design parameters for tissue engineered implants for rabbit patellar tendon repair
    Natalia Juncosa
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, P O Box 210048, Cincinnati, OH 45221 0048, USA
    J Biomech 36:483-8. 2003
    ..001). Such design criteria should be useful in mechanically stimulating cell-gel constructs for tendon repair...
  27. ncbi Repair of patellar tendon injuries using a cell-collagen composite
    Hani A Awad
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, 2901 Campus Drive, P O Box 210048, OH 45221 0048, USA
    J Orthop Res 21:420-31. 2003
    ....
  28. ncbi Characterization of in vivo Achilles tendon forces in rabbits during treadmill locomotion at varying speeds and inclinations
    John R West
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221 0041, USA
    J Biomech 37:1647-53. 2004
    ..Force patterns can also serve as input data for mechanical stimulation of tissue-engineered constructs in culture. Such approaches are expected to help accelerate tendon repair after injury...
  29. pmc Modeling variation in tumors in vivo
    James R Stringer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267 0524, USA
    Proc Natl Acad Sci U S A 102:2408-13. 2005
    ..Although genetic instability appeared to have occurred in most tumors, large clusters were much more common than expected based on instability alone...
  30. ncbi Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation
    David L Butler
    Department of Biomedical Engineering, 840 Engineering Research Center, Colleges of Engineering and Medicine, University of Cincinnati, 2901 Woodside Drive, Cincinnati, Ohio 45221 0048, USA
    J Orthop Res 26:1-9. 2008
    ..Our contributions in the area of tendon functional tissue engineering have the potential to create functional load-bearing repairs that will revolutionize surgical reconstruction after tendon and ligament injury...
  31. ncbi Effects of cell-to-collagen ratio in mesenchymal stem cell-seeded implants on tendon repair biomechanics and histology
    Natalia Juncosa-Melvin
    Noyes Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, OH 45221, USA
    Tissue Eng 11:448-57. 2005
    ..Current repairs achieved higher maximum forces than in previous studies and without ectopic bone, but will need to achieve sufficient stiffness as well to be effective in the in vivo range of loading...
  32. ncbi Effects of cell-to-collagen ratio in stem cell-seeded constructs for Achilles tendon repair
    Natalia Juncosa-Melvin
    Noyes Tissue Engineering and Biomechanics Laboratories, Department of Biomedical Engineering, University of Cincinnati, Ohio 45221 0048, USA
    Tissue Eng 12:681-9. 2006
    ....
  33. ncbi Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 66:95-106. 2006
    ....
  34. ncbi Precancer in mice: animal models used to understand, prevent, and treat human precancers
    Robert D Cardiff
    The UCD Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
    Toxicol Pathol 34:699-707. 2006
    ..These studies suggest that genetically engineered mice are very useful preclinical models for chemoprevention and therapy...
  35. ncbi The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice
    Amy E Moseley
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 278:5317-24. 2003
    ..These data demonstrate that the Na,K-ATPase alpha2 isoform could be important in the modulation of neuronal activity in the neonate...
  36. ncbi Effect of age on collagen fibril diameter in rabbit patellar tendon repair
    Angela M Sklenka
    Department of Pathology, Quantitative Analysis Operations Management, University of Cincinnati, Cincinnati, Ohio, USA
    Comp Med 56:8-11. 2006
    ..This study found that collagen fibril diameter was not altered with increasing age in the healing rabbit patellar tendon...

Research Grants1

  1. Cancer Center Tumor Phenotyping Core
    Gregory Boivin; Fiscal Year: 2006
    ..Expansion of personnel and availability of supply dollars will allow this core to serve numerous investigators in the cancer community. ..