Raymond Boissy

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Vitiligo: current medical and scientific understanding
    R E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    G Ital Dermatol Venereol 146:69-75. 2011
  2. ncbi request reprint DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency
    Raymond E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Exp Dermatol 14:601-8. 2005
  3. pmc Frontiers and controversies in the pathobiology of vitiligo: separating the wheat from the chaff
    Raymond E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Exp Dermatol 18:583-5. 2009
  4. pmc Melanocyte-specific proteins are aberrantly trafficked in melanocytes of Hermansky-Pudlak syndrome-type 3
    Raymond E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0592, Cincinnati, OH 45267 0592, USA
    Am J Pathol 166:231-40. 2005
  5. ncbi request reprint On the etiology of contact/occupational vitiligo
    Raymond E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Pigment Cell Res 17:208-14. 2004
  6. ncbi request reprint Melanosome transfer to and translocation in the keratinocyte
    Raymond E Boissy
    Department of Dermatology and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Exp Dermatol 12:5-12. 2003
  7. ncbi request reprint Comparative efficacy and safety of deoxyarbutin, a new tyrosinase-inhibiting agent
    Saja H Hamed
    University of Cincinnati College of Pharmacy, Cincinnati, OH 45267, USA
    J Cosmet Sci 57:291-308. 2006
  8. ncbi request reprint Effect of deoxyarbutin on melanogenesis: in vivo comparison with other melanogenesis inhibitor
    Saja H Hamed
    Department of Dermatology, University of Cincinnati College of Pharmacy, Cincinnati, Ohio, USA
    J Cosmet Sci 55:118-9. 2004
  9. pmc Melanocytes derived from patients with Hermansky-Pudlak Syndrome types 1, 2, and 3 have distinct defects in cargo trafficking
    Bonnie Richmond
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Invest Dermatol 124:420-7. 2005
  10. ncbi request reprint Uveal melanocytes do not respond to or express receptors for alpha-melanocyte-stimulating hormone
    Li Li
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0592, USA
    Invest Ophthalmol Vis Sci 47:4507-12. 2006

Research Grants

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Vitiligo: current medical and scientific understanding
    R E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    G Ital Dermatol Venereol 146:69-75. 2011
    ..Headway is being made in understanding the etiology of vitiligo that should culminate in new and improved therapies...
  2. ncbi request reprint DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency
    Raymond E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Exp Dermatol 14:601-8. 2005
    ..These data demonstrate that dA has potential tyrosinase inhibitory activity that can result in skin lightening and may be used to ameliorate hyperpigmentary lesions...
  3. pmc Frontiers and controversies in the pathobiology of vitiligo: separating the wheat from the chaff
    Raymond E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Exp Dermatol 18:583-5. 2009
    ..Future research will more precisely define the multiple biological events that regulate development of vitiligo...
  4. pmc Melanocyte-specific proteins are aberrantly trafficked in melanocytes of Hermansky-Pudlak syndrome-type 3
    Raymond E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0592, Cincinnati, OH 45267 0592, USA
    Am J Pathol 166:231-40. 2005
    ..These results suggest that a specific subset of melanocyte proteins are aberrantly trafficked throughout the HPS-3 melanocyte and may be responsible for the reduction in melanin synthesis...
  5. ncbi request reprint On the etiology of contact/occupational vitiligo
    Raymond E Boissy
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Pigment Cell Res 17:208-14. 2004
    ..Genetic inability of melanocytes to tolerate and/or respond to the oxidative stress may underlie the etiology of contact/occupational vitiligo...
  6. ncbi request reprint Melanosome transfer to and translocation in the keratinocyte
    Raymond E Boissy
    Department of Dermatology and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0592, USA
    Exp Dermatol 12:5-12. 2003
    ..UVR can upregulate expression of PAR-2 and lectin-binding receptors and increase phagocytic activity of cultured keratinocytes. Therefore, many cellular and molecular events that occur after melanogenesis contribute to skin color...
  7. ncbi request reprint Comparative efficacy and safety of deoxyarbutin, a new tyrosinase-inhibiting agent
    Saja H Hamed
    University of Cincinnati College of Pharmacy, Cincinnati, OH 45267, USA
    J Cosmet Sci 57:291-308. 2006
    ..These results demonstrate that dA is a potentially safe, effective, and reversible tyrosinase inhibitor...
  8. ncbi request reprint Effect of deoxyarbutin on melanogenesis: in vivo comparison with other melanogenesis inhibitor
    Saja H Hamed
    Department of Dermatology, University of Cincinnati College of Pharmacy, Cincinnati, Ohio, USA
    J Cosmet Sci 55:118-9. 2004
  9. pmc Melanocytes derived from patients with Hermansky-Pudlak Syndrome types 1, 2, and 3 have distinct defects in cargo trafficking
    Bonnie Richmond
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Invest Dermatol 124:420-7. 2005
    ..These data demonstrate that the three initially identified subtypes of human HPS exhibit distinct defects in the trafficking of various melanocyte-specific proteins...
  10. ncbi request reprint Uveal melanocytes do not respond to or express receptors for alpha-melanocyte-stimulating hormone
    Li Li
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0592, USA
    Invest Ophthalmol Vis Sci 47:4507-12. 2006
    ..This study was designed to examine the evidence that alpha-melanocyte-stimulating hormone (alpha-MSH), which is thought to be the mediator of UV response in the skin, has any role to play in uveal melanocytes...
  11. ncbi request reprint Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts
    Penkanok Sriwiriyanont
    Skin Sciences Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45267 0592, USA, Department of Dermatology, Tokyo Medical University, Japan
    Lab Invest 86:1115-25. 2006
    ..These findings establish an in vivo interaction between SCF and ET-1 with regard to their capacity to effect an increase in skin pigmentation...
  12. pmc A role for tyrosinase-related protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes: Implications for vitiligo
    Prashiela Manga
    Department of Dermatology, University of Cincinnati, PO Box 670592, Cincinnati, OH 45267 0592, USA
    Am J Pathol 169:1652-62. 2006
    ..We hypothesize that melanocytes in vitiligo demonstrate reduced ability to withstand oxidative stress due, partly, to a disruption in MITF regulation of Tyrp1...
  13. ncbi request reprint Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible
    Amanda Greatens
    Department of Dermatology, University of Cincinnati, Cincinnati, OH, USA
    Exp Dermatol 14:498-508. 2005
    ..These results suggest that lectins and niacinamide at concentrations that do not affect cell viability are reversible inhibitors of melanosome transfer...
  14. pmc Membranous complexes characteristic of melanocytes derived from patients with Hermansky-Pudlak syndrome type 1 are macroautophagosomal entities of the lysosomal compartment
    Justin W Smith
    Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Pigment Cell Res 18:417-26. 2005
    ..These results confirm that membranous complexes of HPS-1 melanocytes are macroautophagosomal representatives of the lysosomal compartment...
  15. pmc A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve
    Tilat A Rizvi
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0521, USA
    J Neurosci 22:9831-40. 2002
    ..Thus, the adult nerve glial cell phenotype is maintained after nerve injury by response to cytokines, through neurofibromin...
  16. ncbi request reprint Vitiligo: a manifestation of apoptosis?
    Carol L Huang
    Department of Dermatology, University of Cincinnati, Pavilion A, Ohio 45267 0523, USA
    Am J Clin Dermatol 3:301-8. 2002
    ..The study of apoptosis, mechanisms of its induction, and the ways to block apoptosis, is one possible way to find both the causes of depigmentation and medications to prevent its progression...
  17. pmc Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation
    Ana Luisa Kadekaro
    Department of Dermatology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0592, USA
    FASEB J 24:3850-60. 2010
    ..Our findings highlight the molecular mechanisms by which the melanocortin 1 receptor genotype controls genomic stability of and the mutagenic effect of ultraviolet radiation on human melanocytes...
  18. ncbi request reprint Functional analysis of keratinocytes in skin color using a human skin substitute model composed of cells derived from different skin pigmentation types
    Yasuko Yoshida
    Kao Biological Science Laboratories, Haga, Tochigi, Japan
    FASEB J 21:2829-39. 2007
    ..light skin derived keratinocytes. These data suggest that our HSS is a promising melanogenic model that demonstrates the role of the keratinocyte in regulating in part both melanogenesis and distribution of transferred melanosomes...
  19. doi request reprint Production of the soluble form of KIT, s-KIT, abolishes stem cell factor-induced melanogenesis in human melanocytes
    Shinya Kasamatsu
    Kao Biological Science Laboratories, Tochigi, Japan
    J Invest Dermatol 128:1763-72. 2008
    ..Journal of Investigative Dermatology (2008) 128, 1763-1772; doi:10.1038/jid.2008.9; published online 31 January 2008...
  20. ncbi request reprint Improper trafficking of melanocyte-specific proteins in Hermansky-Pudlak syndrome type-5
    Amanda Helip-Wooley
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 1851, USA
    J Invest Dermatol 127:1471-8. 2007
    ..We conclude that early stage melanosome formation and Pmel17 trafficking are preserved in HPS5-deficient cells. Tyrosinase and TYRP1 are mistrafficked, however, and fail to be efficiently delivered to melanosomes of HPS-5 melanocytes...
  21. pmc Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation
    Runsheng Wang
    Huffington Center on Aging and Departments of Molecular and Human Genetics and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:353-8. 2006
    ..Our results identify Tyr and related proteins as physiological substrates of PS and link gamma-secretase activity with intracellular protein transport...
  22. pmc Association of the Hermansky-Pudlak syndrome type-3 protein with clathrin
    Amanda Helip-Wooley
    Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    BMC Cell Biol 6:33. 2005
    ..HPS type-3 (HPS-3) results from mutations in the HPS3 gene, which encodes a 1004 amino acid protein of unknown function that contains a predicted clathrin-binding motif (LLDFE) at residues 172-176...
  23. pmc 4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo
    Tara M Kroll
    Department of Pathology Oncology Institute, Loyola University, Chicago, Illinois 60153, USA
    J Invest Dermatol 124:798-806. 2005
    ..Stressed melanocytes may mediate DC activation through release of HSP70, and DC effector functions appear to play a previously unappreciated role in progressive vitiligo...
  24. ncbi request reprint Hermansky-Pudlak syndrome: vesicle formation from yeast to man
    Marjan Huizing
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1851, USA
    Pigment Cell Res 15:405-19. 2002
    ..Pursuit of the mechanism of mammalian vesicle formation and trafficking, impaired in HPS, relies upon investigation of these mouse models as well as studies of protein complexes involved in yeast vacuole formation...
  25. ncbi request reprint Nipple connective tissue and its development: insights from the K14-PTHrP mouse
    Arman Abdalkhani
    Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405 4401, USA
    Mech Dev 115:63-77. 2002
    ....

Research Grants9

  1. ON THE ROLE OF THE HPS GENE PRODUCT IN MELANOCYTES
    Raymond Boissy; Fiscal Year: 2002
    ..These studies will contribute to our knowledge of cellular trafficking in general and the pathophysiology of HPS in specific. ..
  2. PHENOLS/CATECHOLS IN OCCUPATIONAL/CONTACT VITILIGO SKIN
    Raymond Boissy; Fiscal Year: 2002
    ....
  3. 2004 National Vitiligo Foundation Scientific Conference
    Raymond Boissy; Fiscal Year: 2004
    ..In addition, mini-symposiums will be organized for each of the sessions. ..