John Bohnsack

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Profiling anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis
    Anne E Tebo
    Department of Pediatrics and Human Genetics, Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA, 30322, USA
    Pediatr Rheumatol Online J 10:29. 2012
  2. pmc Elevated serum levels of soluble CD154 in children with juvenile idiopathic arthritis
    Sampath Prahalad
    Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
    Pediatr Rheumatol Online J 6:8. 2008
  3. pmc Population structure of invasive and colonizing strains of Streptococcus agalactiae from neonates of six U.S. Academic Centers from 1995 to 1999
    John F Bohnsack
    University of Utah Health Sciences Center, Department of Pediatrics, 50 North Medical Dr, Salt Lake City, UT 84132, USA
    J Clin Microbiol 46:1285-91. 2008
  4. ncbi request reprint Phylogenetic classification of serotype III group B streptococci on the basis of hylB gene analysis and DNA sequences specific to restriction digest pattern type III-3
    J F Bohnsack
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Infect Dis 183:1694-7. 2001
  5. pmc Serotype III Streptococcus agalactiae from bovine milk and human neonatal infections
    John F Bohnsack
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Emerg Infect Dis 10:1412-9. 2004
  6. pmc Long-range mapping of the Streptococcus agalactiae phylogenetic lineage restriction digest pattern type III-3 reveals clustering of virulence genes
    John F Bohnsack
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Infect Immun 70:134-9. 2002
  7. doi request reprint A 6-year-old child with Fever of unknown origin, anemia, and abdominal pain
    Andrew Zeft
    Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah, Salt Lake City, UT 84158, USA
    J Pediatr 153:283-6, 286.e1. 2008
  8. doi request reprint Anakinra for systemic juvenile arthritis: the Rocky Mountain experience
    Andrew Zeft
    Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah 84158, USA
    J Clin Rheumatol 15:161-4. 2009
  9. ncbi request reprint Familial aggregation of juvenile idiopathic arthritis
    Sampath Prahalad
    University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Arthritis Rheum 50:4022-7. 2004
  10. pmc Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis
    Sampath Prahalad
    Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158 1289, USA
    Arthritis Rheum 58:2147-52. 2008

Research Grants

  1. VIRULENCE FACTORS OF GROUP B STREPTOCOCCI
    John Bohnsack; Fiscal Year: 1999
  2. VIRULENCE FACTORS OF GROUP B STREPTOCOCCI
    John Bohnsack; Fiscal Year: 2000
  3. VIRULENCE FACTORS OF GROUP B STREPTOCOCCI
    John Bohnsack; Fiscal Year: 2001

Collaborators

Detail Information

Publications25

  1. pmc Profiling anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis
    Anne E Tebo
    Department of Pediatrics and Human Genetics, Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA, 30322, USA
    Pediatr Rheumatol Online J 10:29. 2012
    ..abstract:..
  2. pmc Elevated serum levels of soluble CD154 in children with juvenile idiopathic arthritis
    Sampath Prahalad
    Department of Pediatrics, University of Utah, Salt Lake City, UT, USA
    Pediatr Rheumatol Online J 6:8. 2008
    ..Our objectives were to determine if sCD154 is elevated in JIA, and to examine correlations between sCD154 and other inflammatory cytokines...
  3. pmc Population structure of invasive and colonizing strains of Streptococcus agalactiae from neonates of six U.S. Academic Centers from 1995 to 1999
    John F Bohnsack
    University of Utah Health Sciences Center, Department of Pediatrics, 50 North Medical Dr, Salt Lake City, UT 84132, USA
    J Clin Microbiol 46:1285-91. 2008
    ..7% of colonizing lineages. These results are consistent with those for other geographic regions that demonstrate the highly clonal nature of GBS infecting and colonizing human neonates...
  4. ncbi request reprint Phylogenetic classification of serotype III group B streptococci on the basis of hylB gene analysis and DNA sequences specific to restriction digest pattern type III-3
    J F Bohnsack
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    J Infect Dis 183:1694-7. 2001
    ..These data further validate the RDP-based subclassification of GBS and suggest that lineage-specific genes will be identified, which account for the differences in virulence among the lineages...
  5. pmc Serotype III Streptococcus agalactiae from bovine milk and human neonatal infections
    John F Bohnsack
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Emerg Infect Dis 10:1412-9. 2004
    ..These results support the assertion that human and bovine GBS are largely unrelated and provide further insight into the genetic relation between human and bovine GBS...
  6. pmc Long-range mapping of the Streptococcus agalactiae phylogenetic lineage restriction digest pattern type III-3 reveals clustering of virulence genes
    John F Bohnsack
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Infect Immun 70:134-9. 2002
    ..These findings suggest that the genetic variation that distinguishes the RDP type III-3 strains from other serotype III strains occurs largely within localized areas of the genome containing known or putative virulence genes...
  7. doi request reprint A 6-year-old child with Fever of unknown origin, anemia, and abdominal pain
    Andrew Zeft
    Department of Pediatrics, Division of Immunology and Rheumatology, University of Utah, Salt Lake City, UT 84158, USA
    J Pediatr 153:283-6, 286.e1. 2008
  8. doi request reprint Anakinra for systemic juvenile arthritis: the Rocky Mountain experience
    Andrew Zeft
    Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah 84158, USA
    J Clin Rheumatol 15:161-4. 2009
    ....
  9. ncbi request reprint Familial aggregation of juvenile idiopathic arthritis
    Sampath Prahalad
    University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Arthritis Rheum 50:4022-7. 2004
    ..To estimate the degree of familial aggregation of juvenile idiopathic arthritis (JIA), determine whether the aggregation of JIA and the aggregation of type 1 diabetes mellitus (type 1 DM) overlap, and identify multiplex JIA pedigrees...
  10. pmc Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis
    Sampath Prahalad
    Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158 1289, USA
    Arthritis Rheum 58:2147-52. 2008
    ..Single-nucleotide polymorphisms (SNPs) in CTLA4 have been implicated in susceptibility to several autoimmune disorders, including JIA. This study was undertaken to test 3 functional CTLA4 variants for association with JIA...
  11. pmc D8/17 and CD19 expression on lymphocytes of patients with acute rheumatic fever and Tourette's disorder
    Julie L Weisz
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Clin Diagn Lab Immunol 11:330-6. 2004
    ....
  12. ncbi request reprint Lack of association between birth order and juvenile idiopathic arthritis
    Sampath Prahalad
    University of Utah, Salt Lake City, UT, USA
    Arthritis Rheum 48:2989-90. 2003
  13. ncbi request reprint Equivalence of high-virulence clonotypes of serotype III group B Streptococcus agalactiae (GBS)
    Katherine E Fleming
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN, USA
    J Med Microbiol 53:505-8. 2004
    ..HVC and RDP type III-3 represent the same genetically related group of bacteria. The characteristic growth differences of virulent strains of type III GBS, however, are not directly attributable to differences in fba...
  14. ncbi request reprint Correlation of phylogenetic lineages of group B Streptococci, identified by analysis of restriction-digestion patterns of genomic DNA, with infB alleles and mobile genetic elements
    Shinji Takahashi
    Division of Microbiology, Joshi Eiyoh University, Chiyoda, Sakado, Saitama, Japan
    J Infect Dis 186:1034-8. 2002
    ..These molecular markers can be used to identify GBS populations and to correlate RDP types and phylogenetic lineages identified by different methods...
  15. doi request reprint Phylogenetic relationships among Streptococcus agalactiae isolated from piscine, dolphin, bovine and human sources: a dolphin and piscine lineage associated with a fish epidemic in Kuwait is also associated with human neonatal infections in Japan
    Joyce J Evans
    United States Department of Agriculture, Agricultural Research Service, Aquatic Animal Health Research Laboratories, Chestertown, MD 21620, USA
    J Med Microbiol 57:1369-76. 2008
    ..Comparative genomics of piscine, human and bovine GBS could help clarify those genes important for host tropism, the emergence of unique pathogenic clones and whether these hosts act as reservoirs of one another's pathogenic lineages...
  16. pmc Phylogenetic lineages of invasive and colonizing strains of serotype III group B Streptococci from neonates: a multicenter prospective study
    Feng Ying C Lin
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    J Clin Microbiol 44:1257-61. 2006
    ..51, 95% confidence interval = 1.02 to 6.20). These data support the hypothesis that ST-17 complex GBS are more virulent than other serotype III GBS...
  17. ncbi request reprint A unique serine-rich repeat protein (Srr-2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype III Streptococcus agalactiae
    Kyle N Seifert
    Department of Biology, James Madison University, Harrisonburg, VA 22807, USA
    Microbiology 152:1029-40. 2006
    ..These results indicate that the RDP III-3/ST-17 lineage expresses Srr-2 and is highly virulent in an in vivo model of neonatal sepsis...
  18. pmc Subtractive hybridization identifies a novel predicted protein mediating epithelial cell invasion by virulent serotype III group B Streptococcus agalactiae
    Elisabeth E Adderson
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Infect Immun 71:6857-63. 2003
    ....
  19. pmc Multilocus sequence typing system for group B streptococcus
    Nicola Jones
    Nuffield Department of Clinical Laboratory Sciences, Institute for Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 41:2530-6. 2003
    ..A web site for GBS MLST was set up and can be accessed at http://sagalactiae.mlst.net. The GBS MLST system offers investigators a valuable typing tool that will promote further investigation of the population biology of this organism...
  20. ncbi request reprint Beta-hemolysin-independent induction of apoptosis of macrophages infected with serotype III group B streptococcus
    Glen C Ulett
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Infect Dis 188:1049-53. 2003
    ..Thus, apoptosis in GBS-infected macrophages is dependent not on beta-hemolysin but on a factor coregulated with beta-hemolysin by glucose...
  21. pmc Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity
    April Bingham
    From Office of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland 20892 1301, USA
    Medicine (Baltimore) 87:70-86. 2008
    ..Further study is warranted to investigate the pathogenesis of acquired LD in patients with DM...
  22. pmc L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway
    Youko Aoyagi
    Division of Microbiology, Joshi Eiyoh University, Sakado, Saitama 350 0288, Japan
    Infect Immun 76:179-88. 2008
    ..We concluded that L-ficolin/MASP complexes bind to GBS primarily through an interaction with NeuNAc of CPS...
  23. pmc Cryopyrin-associated autoinflammatory syndrome: a new mutation
    Andrew Zeft
    Ann Rheum Dis 66:843-4. 2007
  24. pmc A novel streptococcal surface protease promotes virulence, resistance to opsonophagocytosis, and cleavage of human fibrinogen
    Theresa O Harris
    Division of Infectious Disease, Children s Hospital and Regional Medical Center, and University of Washington, Seattle, Washington, USA
    J Clin Invest 111:61-70. 2003
    ..Taken together, the results suggest that cleavage of fibrinogen by CspA may increase the lethality of GBS infection, potentially by protecting the bacterium from opsonophagocytic killing...
  25. ncbi request reprint Role of L-ficolin/mannose-binding lectin-associated serine protease complexes in the opsonophagocytosis of type III group B streptococci
    Youko Aoyagi
    Division of Microbiology, Joshi Eiyoh Kagawa Nutrition University, Sakado, Saitama 350 0288, Japan
    J Immunol 174:418-25. 2005
    ..C3b deposited by this lectin pathway forms alternative pathway C3 convertase C3bBb whose activity is enhanced by CPS-specific IgG2, leading to increased opsonophagocytic killing by further deposition of C3b on the GBS...

Research Grants4

  1. VIRULENCE FACTORS OF GROUP B STREPTOCOCCI
    John Bohnsack; Fiscal Year: 1999
    ..This approach will ultimately contribute to understanding the molecular basis of disease caused by GBS, and help devise strategies for preventing and treating this important cause of serious human neonatal bacterial infection. ..
  2. VIRULENCE FACTORS OF GROUP B STREPTOCOCCI
    John Bohnsack; Fiscal Year: 2000
    ..This approach will ultimately contribute to understanding the molecular basis of disease caused by GBS, and help devise strategies for preventing and treating this important cause of serious human neonatal bacterial infection. ..
  3. VIRULENCE FACTORS OF GROUP B STREPTOCOCCI
    John Bohnsack; Fiscal Year: 2001
    ..This approach will ultimately contribute to understanding the molecular basis of disease caused by GBS, and help devise strategies for preventing and treating this important cause of serious human neonatal bacterial infection. ..