NICOLAAS IDA BOHNEN

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc In vivo neurochemical imaging of olfactory dysfunction in Parkinson's disease
    Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, MI, USA
    J Neural Transm 120:571-6. 2013
  2. pmc Heterogeneity of cholinergic denervation in Parkinson's disease without dementia
    Nicolaas I Bohnen
    Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, Michigan 48105 9755, USA
    J Cereb Blood Flow Metab 32:1609-17. 2012
  3. doi request reprint Effectiveness and safety of 18F-FDG PET in the evaluation of dementia: a review of the recent literature
    Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0028, USA
    J Nucl Med 53:59-71. 2012
  4. doi request reprint Diagnostic performance of clinical motor and non-motor tests of Parkinson disease: a matched case-control study
    N I Bohnen
    Department of Neurology, University of Pittsburgh Medical School VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Eur J Neurol 15:685-91. 2008
  5. pmc Age-associated leukoaraiosis and cortical cholinergic deafferentation
    N I Bohnen
    VA Ann Arbor Healthcare System, GRECC, MI, USA
    Neurology 72:1411-6. 2009
  6. pmc History of falls in Parkinson disease is associated with reduced cholinergic activity
    N I Bohnen
    Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor 48105 9755, USA
    Neurology 73:1670-6. 2009
  7. pmc Grooved pegboard test as a biomarker of nigrostriatal denervation in Parkinson's disease
    Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, MI 48109 0028, USA
    Neurosci Lett 424:185-9. 2007
  8. ncbi request reprint Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's disease
    Nicolaas I Bohnen
    Dept of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurol 254:84-90. 2007
  9. pmc Cortical cholinergic denervation is associated with depressive symptoms in Parkinson's disease and parkinsonian dementia
    N I Bohnen
    Department of Neurology, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 78:641-3. 2007
  10. pmc The cholinergic system and Parkinson disease
    Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, MI, USA
    Behav Brain Res 221:564-73. 2011

Research Grants

Detail Information

Publications27

  1. pmc In vivo neurochemical imaging of olfactory dysfunction in Parkinson's disease
    Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, MI, USA
    J Neural Transm 120:571-6. 2013
    ..We will discuss also the utility of olfactory testing as an early screening test for neurodegeneration...
  2. pmc Heterogeneity of cholinergic denervation in Parkinson's disease without dementia
    Nicolaas I Bohnen
    Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, Michigan 48105 9755, USA
    J Cereb Blood Flow Metab 32:1609-17. 2012
    ..Results also show independent cognitive effects for both cholinergic and dopaminergic system changes in nondemented PD subjects...
  3. doi request reprint Effectiveness and safety of 18F-FDG PET in the evaluation of dementia: a review of the recent literature
    Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0028, USA
    J Nucl Med 53:59-71. 2012
    ..Findings are in line with recently revised diagnostic criteria of AD that for the first time recognize the unique role of biomarker evidence in disease definition...
  4. doi request reprint Diagnostic performance of clinical motor and non-motor tests of Parkinson disease: a matched case-control study
    N I Bohnen
    Department of Neurology, University of Pittsburgh Medical School VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Eur J Neurol 15:685-91. 2008
    ..The aim of the present study was to compare the accuracy of various clinical motor and non-motor tests for the diagnosis of PD...
  5. pmc Age-associated leukoaraiosis and cortical cholinergic deafferentation
    N I Bohnen
    VA Ann Arbor Healthcare System, GRECC, MI, USA
    Neurology 72:1411-6. 2009
    ..To investigate the relationship between age-associated MRI leukoaraiosis or white matter hyperintensities (WMH) and cortical acetylcholinesterase (AChE) activity...
  6. pmc History of falls in Parkinson disease is associated with reduced cholinergic activity
    N I Bohnen
    Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor 48105 9755, USA
    Neurology 73:1670-6. 2009
    ..To investigate the relationships between history of falls and cholinergic vs dopaminergic denervation in patients with Parkinson disease (PD)...
  7. pmc Grooved pegboard test as a biomarker of nigrostriatal denervation in Parkinson's disease
    Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, MI 48109 0028, USA
    Neurosci Lett 424:185-9. 2007
    ..These findings indicate that there is both a statistical "floor" and "ceiling" effect for the most affected striatal and body sides that must be considered when employing imaging as an outcome measure in clinical trials in PD...
  8. ncbi request reprint Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's disease
    Nicolaas I Bohnen
    Dept of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurol 254:84-90. 2007
    ..Assessment of selective olfactory deficits may be used as a simplified olfactory screening test in the evaluation of subjects with possible PD...
  9. pmc Cortical cholinergic denervation is associated with depressive symptoms in Parkinson's disease and parkinsonian dementia
    N I Bohnen
    Department of Neurology, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 78:641-3. 2007
    ..To investigate the relationship between ratings of depressive symptoms and in vivo cortical acetylcholinesterase (AChE) activity in subjects with Parkinson's disease (PD) and parkinsonian dementia (PDem)...
  10. pmc The cholinergic system and Parkinson disease
    Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, MI, USA
    Behav Brain Res 221:564-73. 2011
    ....
  11. ncbi request reprint Postural control, gait, and dopamine functions in parkinsonian movement disorders
    Nicolaas I Bohnen
    Department of Radiology and Neurology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI 48106, USA
    Clin Geriatr Med 22:797-812, vi. 2006
    ..This article reviews the latest clinically relevant literature relating postural control, gait, and dopamine in patients who have parkinsonian movement disorders...
  12. ncbi request reprint Age-associated striatal dopaminergic denervation and falls in community-dwelling subjects
    Nicolaas I Bohnen
    Department of Veterans Affairs VA Ann Arbor Healthcare System, Geriatric Research, Education, and Clinical Center GRECC, Ann Arbor, MI, USA
    J Rehabil Res Dev 46:1045-52. 2009
    ..07, p < 0.05). Findings indicate that AASDD does not explain isolated self-reported falls in community-dwelling subjects. However, it may be a contributing factor in the small subgroup of subjects with recurrent falls...
  13. pmc Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease
    Nicolaas I Bohnen
    Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Brain 133:1747-54. 2010
    ..Greater deficits in odour identification may identify patients with Parkinson's disease at risk for clinically significant cognitive impairment...
  14. doi request reprint Cerebral glucose metabolic features of Parkinson disease and incident dementia: longitudinal study
    Nicolaas I Bohnen
    Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0028, USA
    J Nucl Med 52:848-55. 2011
    ..Longitudinal studies in nondemented Parkinson disease (PD) subjects offer an opportunity to study the earliest regional cerebral subcortical and cortical metabolic changes underlying incident dementia in this disorder...
  15. pmc Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson's disease
    Nicolaas I Bohnen
    Department of Radiology and Neurology, University of Michigan, Ann Arbor, MI 48105 9755, USA
    Brain 134:2358-65. 2011
    ..Comorbid white matter disease is a greater determinant of axial motor impairment than nigrostriatal dopaminergic denervation...
  16. pmc Selective hyposmia in Parkinson disease: association with hippocampal dopamine activity
    Nicolaas I Bohnen
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Neurosci Lett 447:12-6. 2008
    ..These findings indicate that mesolimbic dopamine innervation of the hippocampus may be a determinant of selective hyposmia in PD...
  17. ncbi request reprint Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia
    N I Bohnen
    Department of Radiology, University of Pittsburgh Medical School, PA 15213, USA
    J Neurol 253:242-7. 2006
    ..14, ns). We conclude that cortical cholinergic denervation in PD and parkinsonian dementia is associated with decreased performance on tests of attentional and executive functioning...
  18. ncbi request reprint Increased ventral striatal monoaminergic innervation in Tourette syndrome
    R L Albin
    Department of Neurology, The University of Michigan Medical School, Ann Arbor, USA
    Neurology 61:310-5. 2003
    ..Excessive striatal dopaminergic innervation is suggested to underlie Tourette syndrome (TS). Prior imaging and postmortem studies yield conflicting data...
  19. ncbi request reprint Striatal dopaminergic denervation and gait in healthy adults
    R Cham
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
    Exp Brain Res 185:391-8. 2008
    ..We conclude that dopaminergic physiology influences certain aspects of gait independent of age-related changes. The findings of this study may augur novel therapeutic approaches to treating gait disorders in the elderly...
  20. pmc Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease
    N I Bohnen
    University of Pittsburgh, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Neurol Neurosurg Psychiatry 76:315-9. 2005
    ..To determine in vivo cortical acetylcholinesterase (AChE) activity and cognitive effects in subjects with mild Alzheimer's disease (AD, n = 14) prior to and after 12 weeks of donepezil therapy...
  21. ncbi request reprint White matter hyperintensities and cortical acetylcholinesterase activity in parkinsonian dementia
    G A Marshall
    Department of Neurology, University of Pittsburgh and Veterans Affairs Medical Center, Pittsburgh, PA, USA
    Acta Neurol Scand 113:87-91. 2006
    ..To investigate the relationship between the severity of white matter hyperintensities (WMH) and cortical acetylcholinesterase (AChE) activity in parkinsonian dementia (PDem)...
  22. ncbi request reprint Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study
    Nicolaas I Bohnen
    Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Neurol 60:1745-8. 2003
    ..We hypothesized that patients with PDem would have cholinergic deficits that were similar to or greater than those of patients with AD...
  23. ncbi request reprint Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease
    Nicolaas I Bohnen
    Department of Neurology, University of Pittsburgh Medical School, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neurosci Lett 380:127-32. 2005
    ..Similar findings were present when the analysis was limited to the temporal cortex. Cortical AChE activity is more robustly associated with functions of attention and working memory compared to performance on primary memory tests in AD...
  24. ncbi request reprint Spared caudal brainstem SERT binding in early Parkinson's disease
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Ann Arbor VA, Ann Arbor, MI, USA
    J Cereb Blood Flow Metab 28:441-4. 2008
    ..There was no asymmetry of diminished SERT binding. DASB binding in the medulla was relatively spared, inconsistent with the description of early prominent pathologic study in these caudal brainstem nuclei...
  25. ncbi request reprint Striatal dopamine denervation and sensory integration for balance in middle-aged and older adults
    Rakie Cham
    Department of Bioengineering, University of Pittsburgh, 3700 O Hara Street, 749 Benedum Hall, Pittsburgh, PA 15213, USA
    Gait Posture 26:516-25. 2007
    ..Striatal dopaminergic activity decreases with normal aging...
  26. ncbi request reprint Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease
    Nicolaas I Bohnen
    Department of Radiology, Division of Nuclear Medicine, The University of Michigan Medical School, Ann Arbor, 48109 0028, USA
    J Cereb Blood Flow Metab 26:1198-212. 2006
    ..We conclude that (+)-[(11)C]DTBZ-PET imaging displays many properties necessary of a PD biomarker...
  27. ncbi request reprint Effects of donepezil on compulsive hypersexual behavior in Parkinson disease: a single case study
    Larry S Ivanco
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Ther 12:467-8. 2005
    ..A trial with donepezil led to significant amelioration of the compulsive behavior without adverse motor effects...

Research Grants1