Vijay Boggaram

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. ncbi request reprint Regulation of lung surfactant protein gene expression
    Vijay Boggaram
    Department of Molecular Biology, University of Texas Health Center at Tyler, 11937, US Highway 271, Tyler, TX 75708 3154, USA
    Front Biosci 8:d751-64. 2003
  2. pmc Transcriptional regulation of SP-B gene expression by nitric oxide in H441 lung epithelial cells
    Vijay Boggaram
    Center for Biomedical Research, Univ of Texas Health Science Center at Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 299:L252-62. 2010
  3. ncbi request reprint Regulation of surfactant protein gene expression by hyperoxia in the lung
    Vijay Boggaram
    Department of Molecular Biology, The University of Texas Health Center at Tyler, Tyler, TX 75708 3154, USA
    Antioxid Redox Signal 6:185-90. 2004
  4. doi request reprint Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) gene regulation in the lung
    Vijay Boggaram
    Department of Molecular Biology, The University of Texas Health Science Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Clin Sci (Lond) 116:27-35. 2009
  5. pmc Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells
    Aparajita Das
    Center for Biomedical Research, The University of Texas Health Center at Tyler, 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 301:L427-40. 2011
  6. ncbi request reprint Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity
    Loretta Sparkman
    Dept of Molecular Biology, University of Texas Health Center at Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 290:L351-8. 2006
  7. pmc The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells
    Hemakumar Chandru
    Department of Molecular Biology, University of Texas Health Center at Tyler, 11937 US Highway 271 Tyler, TX 75708 3154, USA
    Gene 391:150-60. 2007
  8. ncbi request reprint Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells
    Loretta Sparkman
    Department of Molecular Biology, University of Texas Health Center at Tyler, Tyler, Texas 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 287:L764-73. 2004
  9. ncbi request reprint Nitric oxide inhibits surfactant protein B gene expression in lung epithelial cells
    Darrell Salinas
    Department of Molecular Biology, University of Texas Health Center at Tyler, Tyler, Texas 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1153-65. 2003
  10. ncbi request reprint Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression
    Aparajita Das
    Department of Molecular Biology, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 292:L74-84. 2007

Research Grants

  1. REGULATION OF LUNG SURFACTANT PROTEIN B GENE EXPRESSION
    Vijayakumar Boggaram; Fiscal Year: 2001
  2. REGULATION OF LUNG SURFACTANT PROTEIN B GENE EXPRESSION
    Vijayakumar Boggaram; Fiscal Year: 2006

Collaborators

  • Aparajita Das
  • Loretta Sparkman
  • Hemakumar Chandru
  • Darrell Salinas
  • Sunil Acharya
  • Koteswara Rao Gottipati
  • Joseph L Alcorn
  • James B McKnight
  • Kiflu Berhane

Detail Information

Publications10

  1. ncbi request reprint Regulation of lung surfactant protein gene expression
    Vijay Boggaram
    Department of Molecular Biology, University of Texas Health Center at Tyler, 11937, US Highway 271, Tyler, TX 75708 3154, USA
    Front Biosci 8:d751-64. 2003
    ..Surfactant protein promoter function is dependent on the combinatorial actions of multiple transcription factors, and thyroid transcription factor 1 (TTF-1/Nkx2.1) is a common positive regulator of surfactant protein promoter activity...
  2. pmc Transcriptional regulation of SP-B gene expression by nitric oxide in H441 lung epithelial cells
    Vijay Boggaram
    Center for Biomedical Research, Univ of Texas Health Science Center at Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 299:L252-62. 2010
    ..NO inhibits TTF-1 levels and activity to decrease SP-B expression. NO inhibition of SP-B expression could be a mechanism by which surfactant dysfunction occurs in inflammatory lung diseases...
  3. ncbi request reprint Regulation of surfactant protein gene expression by hyperoxia in the lung
    Vijay Boggaram
    Department of Molecular Biology, The University of Texas Health Center at Tyler, Tyler, TX 75708 3154, USA
    Antioxid Redox Signal 6:185-90. 2004
    ..A limited number of studies have indicated that the increased tissue expression of surfactant protein mRNAs is associated with increased levels of surfactant proteins in the bronchoalveolar lavage...
  4. doi request reprint Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) gene regulation in the lung
    Vijay Boggaram
    Department of Molecular Biology, The University of Texas Health Science Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Clin Sci (Lond) 116:27-35. 2009
    ..Recent studies have implicated TTF-1 as a lineage-specific proto-oncogene for lung cancer...
  5. pmc Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells
    Aparajita Das
    Center for Biomedical Research, The University of Texas Health Center at Tyler, 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 301:L427-40. 2011
    ..Because TTF-1 serves as a positive regulator for surfactant protein gene expression, TNF-α inhibition of TTF-1 expression could have important implications for the reduction of surfactant protein levels in diseases such as ARDS...
  6. ncbi request reprint Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity
    Loretta Sparkman
    Dept of Molecular Biology, University of Texas Health Center at Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 290:L351-8. 2006
    ..Chemical inhibitors of de novo ceramide synthesis and sphingomyelin hydrolysis had no effect on TNF-alpha inhibition of SP-B promoter activity and mRNA levels, suggesting that ceramide does not play a role in the inhibition...
  7. pmc The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells
    Hemakumar Chandru
    Department of Molecular Biology, University of Texas Health Center at Tyler, 11937 US Highway 271 Tyler, TX 75708 3154, USA
    Gene 391:150-60. 2007
    ..These data show that increases in the intracellular S1-P partly mediate TNF-alpha induction of IL-8 gene expression in H441 lung epithelial cells via ERK and p38 MAPK signaling pathways and increased AP-1 DNA binding...
  8. ncbi request reprint Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells
    Loretta Sparkman
    Department of Molecular Biology, University of Texas Health Center at Tyler, Tyler, Texas 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 287:L764-73. 2004
    ..NO induction of IL-8 gene expression could be a significant contributing factor in the initiation and induction of inflammatory response in the respiratory epithelium...
  9. ncbi request reprint Nitric oxide inhibits surfactant protein B gene expression in lung epithelial cells
    Darrell Salinas
    Department of Molecular Biology, University of Texas Health Center at Tyler, Tyler, Texas 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1153-65. 2003
    ..These data imply that reduced SP-B expression due to elevated NO levels can contribute to lung injury...
  10. ncbi request reprint Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression
    Aparajita Das
    Department of Molecular Biology, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 292:L74-84. 2007
    ....

Research Grants8

  1. REGULATION OF LUNG SURFACTANT PROTEIN B GENE EXPRESSION
    Vijayakumar Boggaram; Fiscal Year: 2001
    ....
  2. REGULATION OF LUNG SURFACTANT PROTEIN B GENE EXPRESSION
    Vijayakumar Boggaram; Fiscal Year: 2006
    ..Such information may facilitate the development of newer therapies to treat lung dysfunction due to SP-B deficiency that occurs under conditions of elevated nitric oxide production in the lung. ..