Alexei A Bogdanov

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Protected Graft Copolymer (PGC) in Imaging and Therapy: A Platform for the Delivery of Covalently and Non-Covalently Bound Drugs
    Alexei A Bogdanov
    1 University of Massahcusetts Medical School, Worcester MA
    Theranostics 2:553-76. 2012
  2. ncbi request reprint The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores
    Valeri Metelev
    The Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Biosyst 9:2447-53. 2013
  3. pmc Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes
    Alexei A Bogdanov
    The Laboratory of Molecular Imaging Probes S6 434, Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Mol Biosyst 8:2166-73. 2012
  4. pmc Molecular magnetic resonance contrast agents for the detection of cancer: past and present
    Alexei Bogdanov
    Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Oncol 38:42-54. 2011
  5. doi request reprint Merging molecular imaging and RNA interference: early experience in live animals
    Alexei A Bogdanov
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 104:1113-23. 2008
  6. ncbi request reprint Synthesis and testing of a binary catalytic system for imaging of signal amplification in vivo
    Alexei Bogdanov
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 18:1123-30. 2007
  7. pmc Optical imaging of the adoptive transfer of human endothelial cells in mice using anti-human CD31 monoclonal antibody
    Alexei A Bogdanov
    S2 804, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pharm Res 24:1186-92. 2007
  8. ncbi request reprint Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer
    Hye Won Kang
    Department of Radiology, Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA
    Lab Invest 86:599-609. 2006
  9. doi request reprint Fluorescent macromolecular sensors of enzymatic activity for in vivo imaging
    Alexei A Bogdanov
    Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Prog Mol Biol Transl Sci 113:349-87. 2013
  10. pmc A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo
    Mohammed S Shazeeb
    Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Imaging 11:433-43. 2012

Research Grants

  1. NOVEL TYROSINASE MUTANTS AS IMAGING MARKER GENES
    Alexei Bogdanov; Fiscal Year: 2002
  2. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2009
  3. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2007
  4. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2006
  5. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2005
  6. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei A Bogdanov; Fiscal Year: 2010
  7. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2005
  8. Transcription Factor Reporter Technology
    Alexei Bogdanov; Fiscal Year: 2006
  9. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2004
  10. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2003

Collaborators

Detail Information

Publications17

  1. pmc Protected Graft Copolymer (PGC) in Imaging and Therapy: A Platform for the Delivery of Covalently and Non-Covalently Bound Drugs
    Alexei A Bogdanov
    1 University of Massahcusetts Medical School, Worcester MA
    Theranostics 2:553-76. 2012
    ..This review summarizes the experience accumulated by various research groups that chose to use PGC as a drug delivery platform...
  2. ncbi request reprint The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores
    Valeri Metelev
    The Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Biosyst 9:2447-53. 2013
    ....
  3. pmc Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes
    Alexei A Bogdanov
    The Laboratory of Molecular Imaging Probes S6 434, Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Mol Biosyst 8:2166-73. 2012
    ..We anticipate that the observed effects will be instrumental for developing sensors enabling non-invasive imaging in cells that undergo activation of NF-κB...
  4. pmc Molecular magnetic resonance contrast agents for the detection of cancer: past and present
    Alexei Bogdanov
    Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Oncol 38:42-54. 2011
    ..We review herein the most notable examples, illustrating major trends in the development of specific probes for high-resolution imaging in molecular oncology...
  5. doi request reprint Merging molecular imaging and RNA interference: early experience in live animals
    Alexei A Bogdanov
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 104:1113-23. 2008
    ....
  6. ncbi request reprint Synthesis and testing of a binary catalytic system for imaging of signal amplification in vivo
    Alexei Bogdanov
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 18:1123-30. 2007
    ..The conjugates were tested in vivo using a SPECT imaging experiment, which demonstrated the accumulation of 111In-labeled 5-HT-DTPA substrate at the site containing both conjugates...
  7. pmc Optical imaging of the adoptive transfer of human endothelial cells in mice using anti-human CD31 monoclonal antibody
    Alexei A Bogdanov
    S2 804, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pharm Res 24:1186-92. 2007
    ..The goal of the study was testing the feasibility of optical imaging of human endothelial cells implanted in mice...
  8. ncbi request reprint Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer
    Hye Won Kang
    Department of Radiology, Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA
    Lab Invest 86:599-609. 2006
    ....
  9. doi request reprint Fluorescent macromolecular sensors of enzymatic activity for in vivo imaging
    Alexei A Bogdanov
    Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Prog Mol Biol Transl Sci 113:349-87. 2013
    ....
  10. pmc A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo
    Mohammed S Shazeeb
    Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Imaging 11:433-43. 2012
    ..Bis-HTrp-DTPA(Gd) should offer improvements for MRI of MPO-mediated inflammation in vivo, especially in high-field MRI, which requires a higher dose of contrast agent...
  11. pmc Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study
    Michael J DeLeo
    Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Radiology 252:696-703. 2009
    ..To demonstrate the feasibility of using a myeloperoxidase (MPO)-specific paramagnetic magnetic resonance (MR) contrast agent to identify active inflammation in an animal model of common carotid artery (CCA) aneurysm...
  12. ncbi request reprint A paramagnetic contrast agent with myeloperoxidase-sensing properties
    Manel Querol
    University of Massachusetts Medical School, 55 Lake Avenue, Worcester, Massachusetts 01655, USA
    Org Biomol Chem 4:1887-95. 2006
    ..We expected that upon activation by MPO/H2O2 L1-Gd3+ would not only oligomerise but also bind to other macromolecules present in the media and that the overall process will give rise to a net T1-weighted MRI signal increase...
  13. ncbi request reprint Myeloperoxidase activity imaging using (67)Ga labeled substrate
    Manel Querol Sans
    Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Mol Imaging Biol 7:403-10. 2005
    ....
  14. ncbi request reprint Detection of early antiangiogenic effects in human colon adenocarcinoma xenografts: in vivo changes of tumor blood volume in response to experimental VEGFR tyrosine kinase inhibitor
    Young Ro Kim
    Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA 01655, USA
    Cancer Res 65:9253-60. 2005
    ..MRI measurements were corroborated by using isotope and correlative histology experiments. Our results show that steady-state MRI is highly sensitive to early antiangiogenic effects caused by small molecule drugs...
  15. pmc Near-infrared fluorescent oligodeoxyribonucleotide reporters for sensing NF-kappaB DNA interactions in vitro
    Surong Zhang
    Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts, USA
    Oligonucleotides 18:235-43. 2008
    ..NF-kappaB p50 exhibited the protective effect on FRET between NIR fluorochromes linked to the complementary strands of the reporter duplex...
  16. ncbi request reprint Noninvasive magnetic resonance imaging of microvascular changes in type 1 diabetes
    Zdravka Medarova
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Room 2301, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Diabetes 56:2677-82. 2007
    ..Consequently, the ability to noninvasively monitor the dynamics of the pancreatic microvasculature would aid in early diagnosis and permit the assessment, design, and optimization of individualized therapeutic intervention strategies...
  17. pmc Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment
    Alexei A Bogdanov
    Center for Molecular Imaging Research, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Neoplasia 4:228-36. 2002
    ....

Research Grants14

  1. NOVEL TYROSINASE MUTANTS AS IMAGING MARKER GENES
    Alexei Bogdanov; Fiscal Year: 2002
    ..The long-term goal of this research is to explore and develop novel and useful bifunctional "imaging/therapeutic marker genes" for in vivo use. ..
  2. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2009
    ..These tools will have applications for tracking the molecules that are linked to the abnormal cells. This research will help scientists and physicians to detect these cells and follow their response to medicines. ..
  3. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2007
    ..These tools will have applications for tracking the molecules that are linked to the abnormal cells. This research will help scientists and physicians to detect these cells and follow their response to medicines. ..
  4. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2006
    ....
  5. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2005
    ....
  6. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei A Bogdanov; Fiscal Year: 2010
    ..These tools will have applications for tracking the molecules that are linked to the abnormal cells. This research will help scientists and physicians to detect these cells and follow their response to medicines. ..
  7. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2005
    ....
  8. Transcription Factor Reporter Technology
    Alexei Bogdanov; Fiscal Year: 2006
    ..abstract_text> ..
  9. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2004
    ....
  10. MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGING
    Alexei Bogdanov; Fiscal Year: 2003
    ....
  11. Molecular Imaging Probes for Reporting on Vascular Oxidative Response
    Alexei A Bogdanov; Fiscal Year: 2010
    ....