MICHAEL L BOEHNKE

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
  2. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
  3. pmc Accurate inference of relationships in sib-pair linkage studies
    M Boehnke
    Department of Biostatistics, University of Michigan, Ann Arbor 48109 2029, USA
    Am J Hum Genet 61:423-9. 1997
  4. pmc Genetic association mapping based on discordant sib pairs: the discordant-alleles test
    M Boehnke
    Department of Biostatistics, University of Michigan, Ann Arbor, MI USA
    Am J Hum Genet 62:950-61. 1998
  5. ncbi request reprint Lod scores for gene mapping in the presence of marker map uncertainty
    H M Stringham
    Department of Biostatistics, University of Michigan, Ann Arbor, USA
    Genet Epidemiol 21:31-9. 2001
  6. ncbi request reprint Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample
    A D Skol
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
    Am J Med Genet B Neuropsychiatr Genet 118:8-15. 2003
  7. ncbi request reprint The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences
    J A Douglas
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109-2029, USA
    Diabetes 50:886-90. 2001
  8. ncbi request reprint Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators
    R M Watanabe
    University of Michigan, School of Public Health, Department of Biostatistics, Ann Arbor, Mich 48109 2029, USA
    Hum Hered 49:159-68. 1999
  9. ncbi request reprint Cosegregation of open-angle glaucoma and the nail-patella syndrome
    P R Lichter
    Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA
    Am J Ophthalmol 124:506-15. 1997
  10. ncbi request reprint Localization of the homolog of a mouse craniofacial mutant to human chromosome 18q11 and evaluation of linkage to human CLP and CPO
    A J Griffith
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, 48109, USA
    Genomics 34:299-303. 1996

Research Grants

  1. Identifying Genes for Type 2 Diabetes: FUSION
    Michael Boehnke; Fiscal Year: 2007
  2. Identifying Genes for Type 2 Diabetes: FUSION
    Michael Boehnke; Fiscal Year: 2008

Collaborators

  • RICHARD NATHAN BERGMAN
  • Thomas A Buchanan
  • J A Douglas
  • John Richards
  • L C Brody
  • T Valle
  • S V Faraone
  • M T Tsuang
  • A J Griffith
  • S B Gruber
  • J Tuomilehto
  • S Ghosh
  • DOUGLAS E VOLLRATH
  • N J Cox
  • MIRIAM MEISLER
  • Chang-En Yu
  • J G Eriksson
  • P R Lichter
  • Daniel Burgess
  • DEBBY WEN TSUANG
  • S V Farone
  • Toby Johnson
  • Robert Clarke
  • Nicholas J Wareham
  • Michael R Erdos
  • Marika Kaakinen
  • Dorret I Boomsma
  • Cornelia M van Duijn
  • Michael Stumvoll
  • Ozren Polasek
  • Debbie A Lawlor
  • Andrew A Hicks
  • Gudmar Thorleifsson
  • Nigel W Rayner
  • Alan F Wright
  • Valgerdur Steinthorsdottir
  • Steven A McCarroll
  • Francis S Collins
  • Caroline S Fox
  • Torben Hansen
  • Sven Bergmann
  • Serena Sanna
  • Johanna Kuusisto
  • Antti Jula
  • Nicholas J Timpson
  • Goncalo R Abecasis
  • Albert Hofman
  • Veikko Salomaa
  • Nicole L Glazer
  • Anne U Jackson
  • Kari Stefansson
  • Fredrik Karpe
  • Paul Elliott
  • Harry Campbell
  • Nabila Bouatia-Naji
  • George Davey Smith
  • Bo Isomaa
  • Unnur Thorsteinsdottir
  • Neelam Hassanali
  • Hugh Watkins
  • Jing Hua Zhao
  • Veronique Vitart
  • Richard M Watanabe
  • Reedik Magi
  • Lori L Bonnycastle
  • Anke Tonjes
  • Caroline Hayward
  • Josee Dupuis
  • Fernando Rivadeneira
  • Stefan R Bornstein
  • Ian N M Day
  • Jouke Jan Hottenga
  • Christopher J Groves
  • Mark I McCarthy
  • Timothy M Frayling
  • Irene Pichler
  • Lyle J Palmer
  • Jaakko Kaprio
  • Lu Qi
  • Anna Liisa Hartikainen
  • Erik Ingelsson
  • Ines Barroso
  • Aimo Ruokonen
  • Benjamin F Voight
  • G Bragi Walters
  • Amanda J Bennett
  • Jian An Luan
  • Seppo Koskinen
  • Ulla Sovio
  • Tiinamaija Tuomi

Detail Information

Publications14

  1. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
    ..Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation...
  2. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  3. pmc Accurate inference of relationships in sib-pair linkage studies
    M Boehnke
    Department of Biostatistics, University of Michigan, Ann Arbor 48109 2029, USA
    Am J Hum Genet 61:423-9. 1997
    ..We compare our method to related methods of relationship inference that have been suggested. Finally, we demonstrate the value of excluding non-full sibs in a genetic linkage study of non-insulin-dependent diabetes mellitus...
  4. pmc Genetic association mapping based on discordant sib pairs: the discordant-alleles test
    M Boehnke
    Department of Biostatistics, University of Michigan, Ann Arbor, MI USA
    Am J Hum Genet 62:950-61. 1998
    ..Finally, we discuss advantages and disadvantages of the DSP design for genetic association mapping...
  5. ncbi request reprint Lod scores for gene mapping in the presence of marker map uncertainty
    H M Stringham
    Department of Biostatistics, University of Michigan, Ann Arbor, USA
    Genet Epidemiol 21:31-9. 2001
    ....
  6. ncbi request reprint Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample
    A D Skol
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
    Am J Med Genet B Neuropsychiatr Genet 118:8-15. 2003
    ..The 8 and 13 repeat alleles were previously identified to be positively associated with schizophrenia by Wei and Hemmings [2000: Nat Genet 25:376-377] and Sklar et al. [2001: Nat Genet 28:126-128], respectively...
  7. ncbi request reprint The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences
    J A Douglas
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109-2029, USA
    Diabetes 50:886-90. 2001
    ..033), systolic blood pressure (P = 0.021), and diastolic blood pressure (P = 0.045). These findings support a role for the PPAR-gamma2 Pro12Ala variant in the etiology of type 2 diabetes and the insulin resistance syndrome...
  8. ncbi request reprint Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators
    R M Watanabe
    University of Michigan, School of Public Health, Department of Biostatistics, Ann Arbor, Mich 48109 2029, USA
    Hum Hered 49:159-68. 1999
    ..We conclude that there is strong evidence for modest heritability of Minimal-Model-derived NIDDM-related quantitative traits in unaffected spouses and offspring of Finnish affected sibling pairs...
  9. ncbi request reprint Cosegregation of open-angle glaucoma and the nail-patella syndrome
    P R Lichter
    Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA
    Am J Ophthalmol 124:506-15. 1997
    ..To evaluate two families ascertained only for the presence of glaucoma in which both nail-patella syndrome and glaucoma occur in several generations and to determine whether the two diseases are genetically related...
  10. ncbi request reprint Localization of the homolog of a mouse craniofacial mutant to human chromosome 18q11 and evaluation of linkage to human CLP and CPO
    A J Griffith
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, 48109, USA
    Genomics 34:299-303. 1996
    ..Obligatory recombinants were observed in 8 of the families, and negative lod scores from the other families indicated that these disorders are not linked to the chromosome 18 loci...
  11. pmc Autosomal dominant nanophthalmos (NNO1) with high hyperopia and angle-closure glaucoma maps to chromosome 11
    M I Othman
    Department of Opthalmology, University of Michigan, Ann Arbor, MI, USA
    Am J Hum Genet 63:1411-8. 1998
    ..A cloned copy of the gene will enable examination of the relationship, if any, between nanophthalmos and less severe forms of hyperopia and between nanophthalmos and other conditions in which angle-closure glaucoma is a feature...
  12. pmc Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects
    K N Conneely
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Diabetologia 47:1782-8. 2004
    ..The aim of this study was to analyse variants of the resistin gene for association with type 2 diabetes and related traits in a Finnish sample...
  13. ncbi request reprint Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies
    J A Douglas
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 28:361-4. 2001
    ..We show that, particularly when phenotyping is expensive, conversion-based haplotyping can be more efficient and cost-effective than standard genotyping...
  14. ncbi request reprint Localization of the gene for ATP citrate lyase (ACLY) distal to gastrin(GAS) and proximal to D17S856 on chromosome 17q12-q21
    F J Couch
    University of Michigan, Department of Internal Medicine, Ann Arbor
    Genomics 21:444-6. 1994
    ..1 by PCR on a panel of radiation hybrids. The radiation hybrid panel indicates that the most likely position of ACLY on 17q21.1 is between gastrin (GAS) and D17S856 at a distance of 170-290 kb from the GAS locus...

Research Grants2

  1. Identifying Genes for Type 2 Diabetes: FUSION
    Michael Boehnke; Fiscal Year: 2007
    ..Methods developed and lessons learned in FUSION will also be useful in the study of other complex genetic diseases. ..
  2. Identifying Genes for Type 2 Diabetes: FUSION
    Michael Boehnke; Fiscal Year: 2008
    ..Methods developed and lessons learned in this study will be useful in the study of other complex genetic diseases. ..