Edgar C Boedeker

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Vaccines for enterotoxigenic Escherichia coli: current status
    Edgar C Boedeker
    Center for Vaccine Development University of Maryland, Baltimore, Maryland 21201, USA
    Curr Opin Gastroenterol 21:15-9. 2005
  2. pmc The possible influence of LuxS in the in vivo virulence of rabbit enteropathogenic Escherichia coli
    Chengru Zhu
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vet Microbiol 125:313-22. 2007
  3. pmc Protection against hemorrhagic colitis in an animal model by oral immunization with isogeneic rabbit enteropathogenic Escherichia coli attenuated by truncating intimin
    Tonia S Agin
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, 21201, USA
    Infect Immun 73:6608-19. 2005
  4. pmc Development of a live oral attaching and effacing Escherichia coli vaccine candidate using Vibrio cholerae CVD 103-HgR as antigen vector
    Rogeria Keller
    Center for Vaccine Development and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Microb Pathog 48:1-8. 2010
  5. ncbi request reprint Towards a vaccine for attaching/effacing Escherichia coli: a LEE encoded regulator (ler) mutant of rabbit enteropathogenic Escherichia coli is attenuated, immunogenic, and protects rabbits from lethal challenge with the wild-type virulent strain
    Chengru Zhu
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Vaccine 24:3845-55. 2006
  6. pmc Shiga toxin 1 interaction with enterocytes causes apical protein mistargeting through the depletion of intracellular galectin-3
    Marina Laiko
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Cell Res 316:657-66. 2010
  7. ncbi request reprint Delivery of heterologous protein antigens via hemolysin or autotransporter systems by an attenuated ler mutant of rabbit enteropathogenic Escherichia coli
    Chengru Zhu
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Vaccine 24:3821-31. 2006
  8. pmc Serine protease EspP from enterohemorrhagic Escherichia Coli is sufficient to induce shiga toxin macropinocytosis in intestinal epithelium
    Julie In
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 8:e69196. 2013
  9. pmc Use of a continuous-flow anaerobic culture to characterize enteric virulence gene expression
    Fernando Ruiz-Perez
    Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    Infect Immun 72:3793-802. 2004
  10. pmc Effect of zinc in enteropathogenic Escherichia coli infection
    John K Crane
    Department of Medicine, Division of Infectious Diseases, University at Buffalo, Buffalo, New York 14214, USA
    Infect Immun 75:5974-84. 2007

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Vaccines for enterotoxigenic Escherichia coli: current status
    Edgar C Boedeker
    Center for Vaccine Development University of Maryland, Baltimore, Maryland 21201, USA
    Curr Opin Gastroenterol 21:15-9. 2005
    ..Nevertheless, currently there is no effective ETEC vaccine. This review evaluates the current status of ETEC vaccine development...
  2. pmc The possible influence of LuxS in the in vivo virulence of rabbit enteropathogenic Escherichia coli
    Chengru Zhu
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vet Microbiol 125:313-22. 2007
    ..It appears that the luxS gene is not essential for in vivo pathogenicity by rEPEC where exogenous QS signals are present in the gut. The impact of AI-2 provided by multicopy plasmid on bacterial virulence is discussed...
  3. pmc Protection against hemorrhagic colitis in an animal model by oral immunization with isogeneic rabbit enteropathogenic Escherichia coli attenuated by truncating intimin
    Tonia S Agin
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, 21201, USA
    Infect Immun 73:6608-19. 2005
    ..coli strains shows promise for the development of effective vaccines to prevent EHEC infection in humans and animals...
  4. pmc Development of a live oral attaching and effacing Escherichia coli vaccine candidate using Vibrio cholerae CVD 103-HgR as antigen vector
    Rogeria Keller
    Center for Vaccine Development and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Microb Pathog 48:1-8. 2010
    ..V. cholerae CVD 103-HgR shows promise as a vector to deliver antigens and confer protection against AEEC pathogens...
  5. ncbi request reprint Towards a vaccine for attaching/effacing Escherichia coli: a LEE encoded regulator (ler) mutant of rabbit enteropathogenic Escherichia coli is attenuated, immunogenic, and protects rabbits from lethal challenge with the wild-type virulent strain
    Chengru Zhu
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Vaccine 24:3845-55. 2006
    ..It remains to be determined whether such regulatory mutants can protect against infection with A/E bacteria of differing serotypes affecting different hosts...
  6. pmc Shiga toxin 1 interaction with enterocytes causes apical protein mistargeting through the depletion of intracellular galectin-3
    Marina Laiko
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Cell Res 316:657-66. 2010
    ..Conceivably, depletion of galectin-3 from enterocytes and subsequent apical protein mistargeting might even provide a means whereby other pathogens might alter intestinal epithelial absorption and produce diarrhea...
  7. ncbi request reprint Delivery of heterologous protein antigens via hemolysin or autotransporter systems by an attenuated ler mutant of rabbit enteropathogenic Escherichia coli
    Chengru Zhu
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Vaccine 24:3821-31. 2006
    ..With this system, secreted proteins may be more effective than cell-associated antigens in generating protection...
  8. pmc Serine protease EspP from enterohemorrhagic Escherichia Coli is sufficient to induce shiga toxin macropinocytosis in intestinal epithelium
    Julie In
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 8:e69196. 2013
    ..Mechanisms important for this macropinocytic pathway could suggest new potential therapeutic targets for Shiga toxin-induced disease. ..
  9. pmc Use of a continuous-flow anaerobic culture to characterize enteric virulence gene expression
    Fernando Ruiz-Perez
    Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    Infect Immun 72:3793-802. 2004
    ..Our data provide new insights into regulation of virulence genes in EAEC and suggest the utility of intestinal simulation cultures in characterizing enteric gene regulation...
  10. pmc Effect of zinc in enteropathogenic Escherichia coli infection
    John K Crane
    Department of Medicine, Division of Infectious Diseases, University at Buffalo, Buffalo, New York 14214, USA
    Infect Immun 75:5974-84. 2007
    ..Some of the beneficial effects of zinc on EPEC infection appear to be due to the action of the metal on EPEC bacteria as well as on the host...
  11. ncbi request reprint Pathogenesis and treatment of Shiga toxin-producing Escherichia coli infections
    Antonio Serna
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
    Curr Opin Gastroenterol 24:38-47. 2008
    ..We will summarize the literature on incidence and outcomes of these infections, and then review the pathogenesis to explain the current recommendations against antibiotic use and to suggest alternative therapies...
  12. pmc The QseC sensor kinase: a bacterial adrenergic receptor
    Marcie B Clarke
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 103:10420-5. 2006
    ..Given the role that this system plays in bacterial virulence, further characterization of this unique signaling mechanism may be important for developing novel classes of antimicrobials...