Ann M Bode

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Naproxen Induces Cell-Cycle Arrest and Apoptosis in Human Urinary Bladder Cancer Cell Lines and Chemically Induced Cancers by Targeting PI3K
    Mi Sung Kim
    The Hormel Institute University of Minnesota, 801 16th Avenue NE, Austin, MN 55912
    Cancer Prev Res (Phila) 7:236-45. 2014
  2. ncbi request reprint Inducible covalent posttranslational modification of histone H3
    Ann M Bode
    Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    Sci STKE 2005:re4. 2005
  3. pmc The enigmatic effects of caffeine in cell cycle and cancer
    Ann M Bode
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Lett 247:26-39. 2007
  4. pmc Signal transduction molecules as targets for cancer prevention
    Ann M Bode
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Sci Signal 2:mr2. 2009
  5. pmc Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation
    Zhiwei He
    Hormel Institute, The University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 47:172-83. 2008
  6. pmc Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation
    Hong Gyum Kim
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Res 68:2538-47. 2008
  7. pmc The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEK
    Ki Won Lee
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Int J Cancer 123:2487-96. 2008
  8. doi request reprint Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation
    Feng Zhu
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 71:393-403. 2011
  9. ncbi request reprint Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation
    Ke Yao
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 67:8725-35. 2007
  10. ncbi request reprint Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha
    Hong Seok Choi
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 280:13545-53. 2005

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Naproxen Induces Cell-Cycle Arrest and Apoptosis in Human Urinary Bladder Cancer Cell Lines and Chemically Induced Cancers by Targeting PI3K
    Mi Sung Kim
    The Hormel Institute University of Minnesota, 801 16th Avenue NE, Austin, MN 55912
    Cancer Prev Res (Phila) 7:236-45. 2014
    ..Naproxen also caused apoptosis and inhibited Akt phosphorylation in rat urinary bladder cancers induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine. Cancer Prev Res; 7(2); 236-45. ©2013 AACR. ..
  2. ncbi request reprint Inducible covalent posttranslational modification of histone H3
    Ann M Bode
    Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    Sci STKE 2005:re4. 2005
    ..In addition, the interdependence of phosphorylation and acetylation will be discussed in light of data showing patterns of inducible modification at specific genes...
  3. pmc The enigmatic effects of caffeine in cell cycle and cancer
    Ann M Bode
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Lett 247:26-39. 2007
    ....
  4. pmc Signal transduction molecules as targets for cancer prevention
    Ann M Bode
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Sci Signal 2:mr2. 2009
    ....
  5. pmc Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation
    Zhiwei He
    Hormel Institute, The University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 47:172-83. 2008
    ..Inhibition of Fyn kinase activity is a novel and important mechanism that may be involved in EGCG-induced inhibition of cell transformation...
  6. pmc Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation
    Hong Gyum Kim
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Res 68:2538-47. 2008
    ..Thus, MSK1 is required for tumor promoter-induced cell transformation through its phosphorylation of histone H3 at Ser(10) and AP-1 activation...
  7. pmc The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEK
    Ki Won Lee
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Int J Cancer 123:2487-96. 2008
    ....
  8. doi request reprint Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation
    Feng Zhu
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 71:393-403. 2011
    ..Thus, the RSK2/H2AX signaling pathway negatively regulates the RSK2/histone H3 pathway and therefore maintains normal cell proliferation...
  9. ncbi request reprint Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation
    Ke Yao
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 67:8725-35. 2007
    ..Furthermore, knockdown of NFAT3 enhanced Ras-JNK1 or JNK2-induced foci formation in NIH3T3 cells. Taken together, these results provided direct evidence for the anti-oncogenic potential of the NFAT3 transcription factor...
  10. ncbi request reprint Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha
    Hong Seok Choi
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 280:13545-53. 2005
    ....
  11. pmc Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation
    Yong Yeon Cho
    The Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Cancer Res 69:272-81. 2009
    ..These results showed that the Cdk3/c-Jun signaling axis plays an important role in EGF-stimulated cell proliferation and cell transformation...
  12. ncbi request reprint T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation
    Sang Muk Oh
    Hormel Institute, University of Minnesota, Austin, Minnesota
    Cancer Res 67:5186-94. 2007
    ..These studies might also provide a novel molecular mechanism for the role of TOPK in UVB-mediated skin carcinogenesis...
  13. pmc Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity
    Kyung Mi Lee
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Biochem Pharmacol 80:2042-9. 2010
    ..Taken together, these results suggest that kaempferol is a potent chemopreventive agent against skin cancer through its inhibitory interaction with Src...
  14. pmc Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis
    Ann M Bode
    The Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 69:905-13. 2009
    ..The data suggest that, although a great deal of interest has focused on TRPV1 as a target for pain relief, the chronic blockade of this pain receptor might increase the risk for cancer development...
  15. ncbi request reprint p38 Mitogen-activated protein kinase regulation of JB6 Cl41 cell transformation promoted by epidermal growth factor
    Zhiwei He
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 278:26435-42. 2003
    ....
  16. pmc COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation
    Feng Zhu
    Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 66:5729-36. 2006
    ..These results indicated that this function of CSK controls cell proliferation under normal growth conditions and may have implications for CSK loss of function in carcinogenesis...
  17. pmc A regulatory mechanism for RSK2 NH(2)-terminal kinase activity
    Yong Yeon Cho
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Res 69:4398-406. 2009
    ..These results indicate that targeting RSK2 with natural compounds, such as kaempferol, might be a good strategy for chemopreventive or chemotherapeutic application...
  18. doi request reprint Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer
    Yan Ming Xu
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 70:3218-27. 2010
    ..The interaction between ERK8 and c-Jun seems to increase the tumorigenic properties of HCT15 colorectal cancer cells. Thus, ERK8-regulated signaling might serve as a potential therapeutic target in colorectal cancer...
  19. pmc T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway
    Shengqing Li
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 286:29601-9. 2011
    ..Notably, the absence of TOPK in mice resulted in a striking increase in skin inflammation. Therefore, we conclude that TOPK has a protective function in solar UV light-induced inflammation...
  20. pmc Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity
    Hong Seok Choi
    Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    FASEB J 22:113-26. 2008
    ....
  21. ncbi request reprint Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells
    Feng Zhu
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Gastroenterology 133:219-31. 2007
    ....
  22. ncbi request reprint Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells
    Feng Zhu
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 25:1847-52. 2004
    ..Overall, our results reveal that MSK1 and ERKs, like p38 kinase and JNKs, are required for ATF2 phosphorylation (Thr71) in the UVC response...
  23. pmc Tumor necrosis factor receptor-associated factor family protein 2 is a key mediator of the epidermal growth factor-induced ribosomal S6 kinase 2/cAMP-responsive element-binding protein/Fos protein signaling pathway
    Cong Peng
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 287:25881-92. 2012
    ..In addition, TRAF2 is overexpressed in colon cancer and required for colon cancer development, suggesting that TRAF2 might be a potential molecular target for cancer prevention and treatment...
  24. pmc RSK2 mediates NF-{kappa}B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway
    Cong Peng
    The Hormel Institute, University of Minnesota, 801 16th Ave N E, Austin, MN 55912, USA
    FASEB J 24:3490-9. 2010
    ..The net result is an increased NF-kappaB activity, which serves as a mechanism for RSK2 blockade of TNF-alpha-induced apoptosis and enhanced cell survival...
  25. pmc Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2
    Margarita Malakhova
    Department of Cellular and Molecular Biology, The Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America
    PLoS ONE 4:e8044. 2009
    ..The presence of a unique betaB-sheet insert in the N-lobe suggests a different type of activation mechanism for RSK2...
  26. pmc T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:29138-46. 2010
    ..Phosphorylation of Prx1 (Ser-32) by TOPK prevents UVB-induced apoptosis in RPMI7951 melanoma cells through regulation of Prx1 peroxidase activity and blockade of intracellular H(2)O(2) accumulation...
  27. pmc Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation
    Yong Yeon Cho
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Res 67:8104-12. 2007
    ..These results showed that RSK2 is a key regulator for cell transformation induced by tumor promoters such as EGF and TPA...
  28. ncbi request reprint Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1
    Ki Won Lee
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 28:1918-27. 2007
    ..Overall, these results indicated that myricetin has potent anticancer-promoting activity and mainly targets MEK signaling, which may contribute to the chemopreventive potential of several foods including red wines...
  29. ncbi request reprint Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway
    Nam Joo Kang
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    J Biol Chem 282:32856-66. 2007
    ..These findings are the first to reveal a molecular basis for the anticancer action of equol and may partially account for the reported chemopreventive effects of soybean...
  30. ncbi request reprint Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase
    Zhiwei He
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 280:2446-54. 2005
    ..These results indicate that Fyn kinase plays a key role in the UVB-induced phosphorylation of histone H3 at serine 10...
  31. pmc Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine
    Ki Won Lee
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 68:946-55. 2008
    ..Docking data suggested that quercetin, but not resveratrol, formed a hydrogen bond with the backbone amide group of Ser(212), which is the key interaction for stabilizing the inactive conformation of the activation loop of MEK1...
  32. ncbi request reprint A selective small-molecule inhibitor of c-Jun N-terminal kinase 1
    Ke Yao
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    FEBS Lett 583:2208-12. 2009
    ..These results demonstrate that AV-7 is an isoform selective small-molecule inhibitor of JNK1 activity, which might be developed as a therapeutic against diabetes...
  33. pmc Involvement of the paxillin pathway in JB6 Cl41 cell transformation
    Yasuaki Tatsumi
    Hormel Institute, University of Minnesota, Austin, Minnesota
    Cancer Res 66:5968-74. 2006
    ..These results clearly provided evidence that paxillin regulates c-Jun protein level and plays a key role in cell transformation most likely through the regulation of c-Jun stability...
  34. ncbi request reprint The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity
    Bu Young Choi
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, USA
    Nat Struct Mol Biol 12:699-707. 2005
    ..This, in turn, interferes with cell transformation promoted by the H-Ras-JNK-c-Jun-AP-1 signaling axis...
  35. pmc MST1 promotes apoptosis through phosphorylation of histone H2AX
    Weihong Wen
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:39108-16. 2010
    ..Taken together, our data indicated that H2AX is a substrate of MST1, which functions to induce apoptotic chromatin condensation and DNA fragmentation...
  36. ncbi request reprint The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction
    Yong Yeon Cho
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 65:3596-603. 2005
    ..The RSK2-p53-histone H3 complex may likely contribute to chromatin remodeling and cell cycle regulation...
  37. pmc 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase
    Dong Eun Lee
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:21458-66. 2010
    ..These insights into the biological actions of 7,3',4'-THIF provide a molecular basis for the possible development of new chemoprotective agents...
  38. pmc Tpl2 is a key mediator of arsenite-induced signal transduction
    Kyung Mi Lee
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 69:8043-9. 2009
    ..Our results show that Tpl2 plays a key role in arsenite-induced COX-2 expression and PGE(2) production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-kappaB/AP-1 in JB6 P+ cells...
  39. doi request reprint The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer
    Sung Keun Jung
    The Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA
    Carcinogenesis 35:123-30. 2014
    ..Taken together, these results indicate that acacetin is an ATP-competitive PI3-K inhibitor and a promising agent for melanoma chemoprevention. ..
  40. pmc Tumor suppressor p16(INK4a) inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction
    Mee Hyun Lee
    The Hormel Institute, University of Minnesota, MN 55912, USA
    J Cell Sci 126:1744-52. 2013
    ..We conclude that the interaction of p16(INK4a) with eEF1A2, and subsequent downregulation of the expression and function of eEF1A2 is a novel mechanism explaining the anti-proliferative effects of p16(INK4a)...
  41. pmc CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo
    Dong Joon Kim
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 34:1134-43. 2013
    ..Overall, these results suggest that these novel MEK inhibitors might be used for chemotherapy or prevention...
  42. ncbi request reprint Dactylone inhibits epidermal growth factor-induced transformation and phenotype expression of human cancer cells and induces G1-S arrest and apoptosis
    Sergey N Fedorov
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 67:5914-20. 2007
    ..Therefore, these data showed that application of dactylone and related compounds may lead to decreased malignant cell transformation and/or decreased tumor cell proliferation...
  43. pmc Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Clin Cancer Res 12:6884-93. 2006
    ..We investigated the role of TOPK in arsenic-induced apoptosis in RPMI7951 human melanoma cells...
  44. pmc P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation
    Tingting Li
    The Hormel Institute, University of Minnesota, 801 16th Avenue North East, Austin, MN 55912, USA
    Carcinogenesis 32:659-66. 2011
    ..These results indicated that PAK2/c-Jun signaling plays an important role in EGF-induced cell proliferation and transformation...
  45. pmc Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase
    Nam Joo Kang
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    J Biol Chem 283:20664-73. 2008
    ..Notably, procyanidin B2 exerted stronger inhibitory effects compared with PD098059 (a well known pharmacological inhibitor of MEK) on MEK1 activity and neoplastic cell transformation...
  46. pmc Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells
    Young Jin Jeon
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:28126-33. 2010
    ....
  47. ncbi request reprint The intermediate filament protein vimentin is a new target for epigallocatechin gallate
    Svetlana Ermakova
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 280:16882-90. 2005
    ....
  48. doi request reprint MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes
    Tae Gyu Lim
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN, 55912, USA Advanced Institutes of Convergence Technology, Seoul National University, Suwon, 443 270, Republic of Korea WCU Biomodulation Major, Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul, 151 921, Republic of Korea
    Biochem Pharmacol 86:896-903. 2013
    ..Computer modeling supported our observation that MLK3 is a novel target of biochanin A. These results suggest that biochanin A exerts chemopreventive effects by suppressing sUV-induced COX-2 expression mediated through MLK3 inhibition. ..
  49. pmc Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulation
    Hideya Mizuno
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 45:204-12. 2006
    ..In addition, TF-3 inhibited EGF-induced anchorage-independent cell transformation. Overall, our results indicate that TF-3 might exert chemopreventive effects through the downregulation of the EGFR...
  50. doi request reprint ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4
    Myoung Ok Kim
    The Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Nat Struct Mol Biol 19:283-90. 2012
    ..Overall, our data provide a molecular basis for the role of ERK1 and ERK2 in regulating Klf4-mediated mouse embryonic stem cell self-renewal...
  51. pmc Identification of an Aurora kinase inhibitor specific for the Aurora B isoform
    Hua Xie
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 73:716-24. 2013
    ..The expression of phospho-histone H3, phospho-Aurora B, and Ki-67 was also suppressed in the HOI-07 treatment group. Taken together, we identified HOI-07 as a specific Aurora B inhibitor, which deserves further investigation...
  52. doi request reprint Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth
    Dong Joon Kim
    The Hormel Institute, University of Minnesota, Minneapolis, Minnesota 55912, USA
    Cancer Res 72:3060-8. 2012
    ..Our findings therefore show that HI-TOPK-032 is a specific inhibitor of TOPK both in vitro and in vivo that may be further developed as a potential therapeutic against colorectal cancer...
  53. pmc Coffee phenolic phytochemicals suppress colon cancer metastasis by targeting MEK and TOPK
    Nam Joo Kang
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 32:921-8. 2011
    ..These results suggest that coffee and CaA target MEK1 and TOPK to suppress colon cancer metastasis and neoplastic cell transformation...
  54. pmc The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development
    Duo Zheng
    Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 68:3992-8. 2008
    ..These data provide direct evidence indicating that the CB1/2 receptors play a key role in UV-induced inflammation and skin cancer development...
  55. pmc Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression
    Nam Joo Kang
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 30:321-30. 2009
    ..These results suggested that this compound could act as a potent chemopreventive agent against skin cancer...
  56. ncbi request reprint Post-translational modification of p53 in tumorigenesis
    Ann M Bode
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, USA
    Nat Rev Cancer 4:793-805. 2004
    ..A thorough understanding of p53 will be extremely useful in the development of new strategies for treating and preventing cancer, including restoration of p53 function and selective killing of tumours with mutant TP53...
  57. pmc Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines
    Xiang Li
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 286:22291-9. 2011
    ..Our data indicate that highly expressed PAK2 mediates chemotherapeutic resistance in human breast invasive ductal carcinoma by negatively regulating caspase-7 activity...
  58. pmc Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation
    Hong Seok Choi
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 65:5818-27. 2005
    ..These results indicate that the phosphorylation of histone H3 at Ser10 is an essential regulatory mechanism for EGF-induced neoplastic cell transformation...
  59. pmc Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3
    Chengrong Lu
    Hormel Institute, University of Minnesota, Austin, 55912, USA
    Mol Cell 23:121-32. 2006
    ....
  60. doi request reprint Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K
    Jong Eun Kim
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 4:582-91. 2011
    ..Overall, these results indicate that isorhamnetin has potent anticancer activity and it primarily targets MEK and PI3-K, which might contribute to the chemopreventive potential of certain foods...
  61. pmc Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs
    Jixia Li
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 33:459-65. 2012
    ..Furthermore, a loss-of-function ERK2 mutation inhibited the effectiveness of the quercetin-3-methyl ether. Overall, these results indicated that quercetin-3-methyl ether exerts potent chemopreventive activity by targeting ERKs...
  62. pmc Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability
    Cong Peng
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 286:6946-54. 2011
    ..Finally, RSK2 blocks Fas-induced apoptosis through its phosphorylation of caspase-8. These data provide a direct link between RSK2 and caspase-8 and identify a novel molecular mechanism for caspase-8 modulation by RSK2...
  63. ncbi request reprint A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development
    Yong Yeon Cho
    Hormel Institute University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 64:3855-64. 2004
    ..These results are the first to indicate that MLTK-alpha plays a key role in neoplastic cell transformation and cancer development...
  64. ncbi request reprint The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 26:331-42. 2005
    ..We also show an inhibitory effect of theaflavins and EGCG on UVB-induced STAT1 (Ser727), ERKs, JNKs, PDK1 and p90RSK2 phosphorylation...
  65. doi request reprint Phosphorylation of Sox2 cooperates in reprogramming to pluripotent stem cells
    Chul Ho Jeong
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Stem Cells 28:2141-50. 2010
    ..Overall, our studies provide new insights into the regulatory mechanism of Sox2 in ESCs and also provide a direct link between phosphorylation events and somatic cell reprogramming...
  66. doi request reprint Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1
    Jung Hyun Shim
    The Hormel Institute, University of Minnesota, Austin, MN 55912 3679, USA
    Cancer Prev Res (Phila) 3:670-9. 2010
    ..Overall, these results strongly indicate that EGCG suppresses lung tumorigenesis through its binding with G3BP1...
  67. pmc Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling
    Nam Joo Kang
    Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 1:522-31. 2008
    ..Together, these findings suggested that the targeted inhibition of Raf1 and MEK activities and COX-2 expression by delphinidin contribute to the chemopreventive potential of fruits and vegetables...
  68. ncbi request reprint Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells
    Akira Kaji
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 37:138-48. 2003
    ..Thus, we conclude that PFTalpha is not a specific p53 inhibitor in JB6 cells but is a potential activator of p53-mediated signaling and apoptosis...
  69. pmc Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation
    Duo Zheng
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 68:7650-60. 2008
    ..These results clearly showed that the cdk3-ATF1 signaling axis is critical for cell proliferation and transformation...
  70. pmc Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation
    Sung Young Lee
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 285:29525-34. 2010
    ..Taken together, our findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr(16) by Chk1...
  71. doi request reprint Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A₄hydrolase
    Naomi Oi
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 70:9755-64. 2010
    ..Our findings identify LTA(4)H as a functionally important target for mediating the anticancer properties of resveratrol...
  72. pmc Phosphorylation of histone H2B serine 32 is linked to cell transformation
    Andy T Y Lau
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 286:26628-37. 2011
    ....
  73. pmc Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases
    Jixia Li
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 72:260-70. 2012
    ..Taken together, our results identify norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer...
  74. ncbi request reprint Direct inhibition of insulin-like growth factor-I receptor kinase activity by (-)-epigallocatechin-3-gallate regulates cell transformation
    Ming Li
    Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912, USA
    Cancer Epidemiol Biomarkers Prev 16:598-605. 2007
    ..Our findings are the first to show that the IGF-IR is a novel binding protein of EGCG and thus may help explain the chemopreventive effect of EGCG on cancer development...
  75. ncbi request reprint NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2
    Guangming Liu
    Hormel Institute, University of Minnesota, Austin 55912, USA
    J Biol Chem 278:2124-30. 2003
    ..Based on our results, we propose that the inhibition of AP-1 activity by COX-2 inhibitors NS-398 or piroxicam may occur by a mechanism that is independent of COX-2...
  76. pmc 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells
    Qing Zhao
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 280:26735-42. 2005
    ..Taken together, our data provide direct evidence suggesting that 2-AG may have a novel role in cell transformation and carcinogenesis in a signaling pathway involving CB1/2 and activation of Fyn, ERKs, and AP-1...
  77. ncbi request reprint Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells
    Faqing Tang
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 45:861-70. 2006
    ..These data suggest that the direct inhibition of p53 functional activation is one of the mechanisms through which arsenite interferes with p53 function, and thus may be a significant mechanism for the co-carcinogenic effects of arsenite...
  78. pmc Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationship
    Evgeny A Rogozin
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Carcinogenesis 29:1228-34. 2008
    ..2 or 62.0%, respectively. Collectively, these results indicated that the number of carbons at R1 and R3 is important for the antitumor-promoting activity of the trialkylxanthines and xanthine 70 might be a promising anticancer agent...
  79. pmc Resveratrol directly targets COX-2 to inhibit carcinogenesis
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 47:797-805. 2008
    ..Notably, cells deficient in COX-2 were unresponsive to RSVL or RSVL-2. These data suggest that the anticancer effects of RSVL or RSLV-2 might be mediated directly through COX-2...
  80. pmc Evaluation of cancer-preventive activity and structure-activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian Aplidium glabrum, and its synthetic analogs
    Sergey N Fedorov
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, Minnesota 55912, USA
    Pharm Res 23:70-81. 2006
    ..3-Demethylubiquinone Q2 was isolated from the ascidian Aplidium glabrum. The cancer-preventive properties and the structure-activity relationship for 3-demethylubiquinone Q2 and 12 of its synthetic analogs are reported...
  81. ncbi request reprint Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1
    Zhiwei He
    Hormel Institute, University of Minnesota, Austin 55912, USA
    J Biol Chem 278:10588-93. 2003
    ....
  82. ncbi request reprint [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase
    Chul Ho Jeong
    The Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 69:5584-91. 2009
    ..Collectively, these findings indicate a crucial role of LTA(4)H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA(4)H for the prevention of colorectal cancer...
  83. ncbi request reprint Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51))
    Tatyana A Zykova
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 28:1543-51. 2007
    ..These data may lead to the use of these signaling molecules as targets to develop more effective chemopreventive agents with fewer side effects to control UV-induced skin cancer...
  84. pmc The functional contrariety of JNK
    Ann M Bode
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 46:591-8. 2007
    ..Specifically in this review, we examine evidence regarding whether the JNKs proteins might play distinctive roles in cellular processes associated with carcinogenesis...
  85. ncbi request reprint Signal transduction pathways in cancer development and as targets for cancer prevention
    Ann M Bode
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Prog Nucleic Acid Res Mol Biol 79:237-97. 2005
  86. ncbi request reprint Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways
    Jixia Li
    The Hormel Institute, University of Minnesota, 801 16 Ave N E, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 4:1190-7. 2011
    ....
  87. pmc Breaking the NF-κB and STAT3 alliance inhibits inflammation and pancreatic tumorigenesis
    Young Joon Surh
    The Hormel Institute, University of Minnesota, 801 16th Avenue Northeast, Austin, MN 55912 3679
    Cancer Prev Res (Phila) 3:1379-81. 2010
    ....
  88. ncbi request reprint Dialogue between ERKs and JNKs: friendly or antagonistic?
    Zigang Dong
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Mol Interv 3:306-8. 2003
  89. pmc Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1
    Darya V Urusova
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 4:1366-77. 2011
    ..Overall, these results showed that EGCG directly suppresses the tumor-promoting effect of Pin1...
  90. doi request reprint Update on Cancer Prevention Research in the United States and China: the 2009 China--U.S. Forum on Frontiers of Cancer Research
    Ann M Bode
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Prev Res (Phila) 3:1630-7. 2010
    ..This perspective presents an overview of the progress being made in cancer prevention in China and the United States...
  91. ncbi request reprint Requirement of ATM in UVA-induced signaling and apoptosis
    Yiguo Zhang
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 277:3124-31. 2002
    ..Therefore, these results suggest that ATM, like p53, is involved in the UVA-induced apoptosis to suppress carcinogenesis...
  92. ncbi request reprint The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects
    Ann M Bode
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Crit Rev Oncol Hematol 42:5-24. 2002
    ..The primary purpose of this review is to examine recent findings, from this laboratory and others, that focus on the molecular mechanisms of arsenic's actions in cell transformation and as a therapeutic agent...
  93. pmc RSK2 mediates muscle cell differentiation through regulation of NFAT3
    Yong Yeon Cho
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 282:8380-92. 2007
    ..Multinucleated myotube differentiation was inhibited by small interfering RNA against RSK2, ERK1/2, or NFAT3. These results demonstrate that RSK2 is an important kinase for NFAT3 in mediating myotube differentiation...
  94. ncbi request reprint Mitogen-activated protein kinase activation in UV-induced signal transduction
    Ann M Bode
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Sci STKE 2003:RE2. 2003
    ..Progress in understanding the mechanisms of UV-induced signal transduction could lead to the use of these protein kinases as specific targets for the prevention and control of skin cancer...
  95. ncbi request reprint Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation
    Guangming Liu
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 277:8810-6. 2002
    ..The p38/MSK1 pathway, but not PI3-kinase or Akt, is required for mediating the UVB-induced 4E-BP1 phosphorylation...
  96. ncbi request reprint Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3
    Yiguo Zhang
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 278:12650-9. 2003
    ..Additionally, RSK2-mediated phosphorylation of STAT3 (Ser(727)) was further determined to be required for basal and UVA-stimulated STAT3 transcriptional activities...
  97. ncbi request reprint Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
    Qing Bai She
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 62:1343-8. 2002
    ..These results suggest that JNK1 is a crucial suppressor of skin tumor development...
  98. ncbi request reprint Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways
    Zhiwei He
    Hormel Institute, University of Minnesota, 801 16th Avenue N E, Austin, MN 55912, USA
    Cancer Res 63:4396-401. 2003
    ..Cleaved caspase 3 was also increased in a time- and dose-dependent manner. These data show that a low concentration of caffeine can induce p53-dependent apoptosis in JB6 cells through the Bax and caspase 3 pathways...
  99. ncbi request reprint The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation
    Zigang Dong
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Mol Carcinog 45:416-21. 2006
    ....
  100. ncbi request reprint Cancer prevention by food factors through targeting signal transduction pathways
    Ann M Bode
    University of Minnesota, Hormel Institute, Austin, Minnesota 55912, USA
    Nutrition 20:89-94. 2004
  101. ncbi request reprint Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells
    Nanyue Chen
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912
    Cancer Res 62:1300-4. 2002
    ..These results suggest that JNK1 and JNK2 proteins have different roles in modulating cell function...